Glomerular Function Time Trends in Long-Term

Glomerular Function Time Trends in Long-Term Survivors of Childhood Cancer: A Longitudinal Study Renée L. Mulder (1), Sebastiaan L. Knijnenburg (1)*, Ronald B. Geskus (2), Elvira C. van Dalen (1), Helena J.H. van der Pal (1,3), Caro C.E. Koning (4), Antonia H. Bouts, (5), Huib N. Caron (1), Leontien C.M. Kremer (1) (1) Department of Pediatric Oncology, Emma Children’s Hospital/Academic Medical Center, Amsterdam, the Netherlands (2) Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, the Netherlands (3) Department of Medical Oncology, Academic Medical Center, Amsterdam, the Netherlands (4) Department of Radiation Oncology, Academic Medical Center, Amsterdam, the Netherlands (5) Department of Pediatric Nephrology, Emma Children’s Hospital/Academic Medical Center, Amsterdam, the Netherlands * Joint first authorship with Renée L. Mulder

INTRODUCTION Impaired glomerular function is one of the treatment-related morbidities affecting childhood cancer survivors (CCS). It is unclear whether glomerular function deteriorates or recovers in CCS. The aim of this study was to evaluate time trends and associated risk factors of glomerular function in long-term CCS. METHODS

The cohort consisted of all five-year CCS treated in the EKZ/AMC between 1966 and 2003. Outcomes included repeated observations of estimated glomerular filtration rate (GFR) and glomerular dysfunction (GFR