INTRODUCTION HYPOTHESIS & OBJECTIVES ...

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Department of Biomedical Engineering, University of Miami, Coral Gables, FL ... This study was supported by the University of Miami; Support for student travel.
EFFECT OF ANISOTROPY, COMPRESSIVE STRAIN, AND TISSUE REGION ON ELECTRICAL CONDUCTIVITY IN PORCINE MENISCUS Kleinhans KL; McMahan JB; Jackson AR Orthopaedic Biomechanics Laboratory Department of Biomedical Engineering, University of Miami, Coral Gables, FL

INTRODUCTION •

Electrical conductivity is a tissue property which depends on ion concentrations and diffusivities in the tissue, which are functions of both tissue composition and structure



Previous studies have found linear correlation between water content and electrical conductivity in cartilaginous tissues1-4



Meniscal degeneration associated with osteoarthritis (OA)



Information regarding electromechanical and ion transport properties essential for understanding tissue degeneration and causes of OA

HYPOTHESIS & OBJECTIVES Long Term Goals

• •

RESULTS

To quantify electromechanical and transport properties in meniscus tissue (i.e., conductivity, diffusion, etc.) To better understand the pathophysiology of meniscal degeneration and related OA in the knee

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Overall Hypothesis



Electrical conductivity is dependent on tissue water volume fraction and is anisotropic and strain-dependent in meniscus fibrocartilage

Study Objectives



To determine the anisotropic, strain-dependent, and region-specific electrical conductivity in porcine meniscus tissue and correlate the results with the tissue water volume fraction

MATERIALS & METHODS





Both anisotropy and compression significantly (p