Dr. Neal Lane Then - Sustainable Nanotechnology Organization

NBIC2

Nanotechnology Today Mike Roco National Science Foundation and National Nanotechnology Initiative

UCSB, November 3, 2013

2030

2020

2010

2000

nano1

Topics •

2000-2030 view of NT development

•

Convergence trends

•

Global investment in nanotechnology: indicators and characteristics

Related publications 1. “Nanotechnology: From Discovery to Innovation and Socioeconomic Projects: 2010-2020” (M.C. Roco; CEP, 2011a) 2. “The Long View of Nanotechnology Development: the NNI at 10 Years” (M.C. Roco, J. Nanopart.. Res.; 2011b) 3. “Nanotechnology Research Directions for Societal Needs in 2020” (Roco, Mirkin and Hersam; Springer, 2011c) 4. “Mapping Nanotechnology Innovation and Knowledge: Global and Longitudinal Patent and Literature” (Chen, Roco, 2009) 5. “Convergence of Knowledge, Technology and Society: Beyond NBIC” (Roco, Bainbridge, Tonn, Whitesides; Springer,2013)

Trends • Nanotechnology is an essential megatrends in S&E the most exploratory field as a general foundation as compared to IT and BIO • Nanotechnology continues exponential growth by vertical Science to Technology transition, horizontal expansion to areas as agriculture/textiles, and spin-off areas (~20) as nanophotonics/metamaterials/spintronics • Nanotechnology promises to become the primary S&T platform for investments and venture funds once design and manufacturing methods are established MC Roco, Nov 3, 2013

Foundational tools/technology (NBIC) platform

Brain simulation Cyber networking Personalized education..

Nanobioinformatics DNA computing Proteomics, ….

Neuromorphic engng. Synapses to mind Smart environments, ..

Nanobiomedicine Synthetic biology Bio-photonics, ….

Nanotechnology Spin-offs : Nanophotonics, plasmonics, metamaterials, nanofluidics, …..

MC Roco, Nov 3, 2013

Vision inspired research is essential for the long-term view of nanotechnology High Low

Relevance for the advancement of knowledge

Modified Stokes diagram Pure Basic Research (Bohr)

Use-inspired Basic Research (Pasteur))

Empirical, less useful (Merlin)

Pure Applied Research (Edison)

Low use

Vision-inspired Basic Research

(added in CKTS, 2013)

Known use

New use

Relevance for applications Ref: “Convergence of Knowledge, Technology and Society: Beyond NBIC” (Springer,2013) [5]


2000-2020 Convergence-Divergence cycle for global nanotechnology development (Convergence report NBIC2 [5)

Knowledge confluence Disciplines Bottom-up & top-down Materials Medical, .. Sectors

(convergence / divergence)

Innovation spiral

Assembly of interacting parts Control of matter at the nanoscale

New applications & business

Four NT Generations

Creative phase

New Products, Applications $3 T New expertise and methods

Tools & Methods

a

Spin-off disciplines, and productive sectors

Decision-making

b Integration/

Fusion phase

c Innovation d Outcome phase

phase MC Roco, Nov 3, 2013

Nanotechnology: from discovery to innovation and socioeconomic projects and convergence nano1 (2000-2010)

(2010-2020) NBIC1&2 (2002-2030)

NT Definition

1999

1999

2010

2002, 2013

30 year vision: changing focus and priorities (www.wtec.org/nano2/ , www.wtec.org/NBIC2-report/)


Higher uncertainty & risk

Increase Control at the Nanoscale, Complexity & Integration

IRGC Nanotechnology Project TIMELINE FOR BEGINNING OF INDUSTRIAL PROTOTYPING AND NANOTECHNOLOGY COMMERCIALISATION: FIVE GENERATIONS OF PRODUCTS AND PRODUCTION PROCESSES

2-Nov-13

ESTABLISHING THE IRGC

5th: Converging Technologies

8 MC Roco, Nov 3, 2013

2013 main trend: third generation of nanotechnology processes to fundamentally new products Examples: Building nanomachines and nanosystems • Building-up polymeric atomic/nanomodular architectures by design, such as artificial muscle (U. Penn.) • Biomaterials assembled with atomic precision, such as virus-based piezoelectric energy generators (UCB) • DNA nanotechnology, such as programmable nanomechanical assembly line (CUNY) • Building photosynthesis nanosystems, such as solar nano-forest (DOE)


Helical porous column (membrane channel mimic)

Building-up polymeric atomic and nanomodular architectures

Dendrimersome (cell membrane mimic, drug delivery) Dendrimer

Janus dendrimer

Dendronized polymer

Ex: use of dendronized polymers for nanoscale motors Artificial muscle

V. Percec, U. Penn


Bioparticles assembling with atomic precision Virus-based Piezoelectric Energy Generators S.-W. Lee, UC-Berkeley

6.6 nm 880 nm

Side view

Vertical view

Piezoelectric devices (> 0.1 mWatt/cm2) can power a LCD screen MC Roco, Nov 3, 2013

2013 main trend: third generation of nanotechnology processes to fundamentally new products Examples: Cost-effective 3-D nanosystems • Giant Spin Hall Effect devices applied to build nonvolatile memory and spintronics circuits (Cornell U.) • Nanoelectronic scaffolding supports living tissue: Cyborg-like tissue monitors cells (Harvard-MIT team) • Economic nano colloid assembling for three-dimensional nanostructures, such as 3-D patterns (Northeastern U.) • Additive selfassembling on roll-to-roll process (U. Mass) • DNA memory (Harvard U.)


A Materials Research Science and Engineering Center Program Highlight

Newly discovered “giant” spin Hall effect enables simple and efficient magnetic memory “ Giant” spin Hall effect that allows electrical currents to “write” information of tiny room-temperature magnets. Current flowing through a thin tantalum layer leads to a deflection of electron spins that is large enough to flip the magnetization of a neighboring magnet. When no current flows, the magnet stays in place even if the device is powered off — the memory is non-volatile. Cornell Unoversity: L. Liu, C.-F. Pai, Y. Li, H. W.

Tseng, D. C. Ralph, R. A. Buhrman, Science Dec. 2012 http://www.ccmr.cornell.edu, Research supported in part by NSF-1120296

(a) Spin switch

(b) Circuit built from spin switches

Symbol

NEW LOGIC CIRCUITS FOR SPINTRONICS

(a)The spin switch is a Write-Read pair that is predicted to have gain arising from the use of the Giant Spin Hall Effect for writing. (b)A gate logic circuit, showing three Read units driving three input devices 1, 2 and 3 respectively which drive device 4 which in turn drives two output devices 5 and 6. Purdue University. S. Datta, Appl. Phys. Lett. 101, 252411 (2012)


Carbon nano - models for nano R&D. Ex: 1D (nanotube), 2D materials (graphene), devices and nanosystems

Nanotube Computer

Illustration: Wong and Mitra, September 2013, Stanford U. Nano-enabled integrated system with nanotubes that can perform a general set of computer programs proposed to replace the current transistor technology


“Stick-on tattoos” Nanoelectronic tattoo to monitor brain, heart and muscles (NSEC at UIUC). Credit: J. Rogers, University of Illinois (2012)


Cyborg-like Tissue Monitors Cells Nanoelectronic scaffolding supports living tissue Lieber, Langer et al. (Harvard U, MIT) have constructed a material that merges nanoscale electronics with biological tissues into a mesh of transistors and cells - The cyborg-like tissue supports cell growth while simultaneously monitoring the activities of those cells, drug effects

SEM images of a mesh nanoES/alginate scaffold, top (I) and side (II) views. The epoxy ribbons from nanoES are false-colored in brown for clarity

- It may be a step toward prosthetics that communicate directly with the nervous system, and tissue implants that sense and respond to injury or disease (Nature Materials, Aug 2012) MC Roco, Nov 3, 2013

3-D nanostructure manufacturing process using nano-colloids (Northeastern U.,

Manufacturing of 3-D nanostructures using directed nanoparticle assembly process. (A and B) NPs suspended in aqueous solution are (A) assembled and (B) fused in the patterned via geometries under an applied AC electric field. (C) Removal of the patterned insulator film after the assembly process produces arrays of 3-D nanostructures on the surface. (D) Scanning electron microscopy (SEM) image of gold nanopillar arrays. MC Roco, Nov 3, 2013

Additive selfassembling on roll-to-roll process (U. Mass. – Amherst, J. Watkins)

Additive-driven self assembly yields well ordered periodic assemblies of nanoparticle polymer hybrids (left) while R2R nanoimprint lithography produces sub-100 nm device patterns 70 nm grating pattern shown (right). MC Roco, Nov 3, 2013

PACMON Vision Personal and Community Environmental Monitoring (PACMON)

 Goal: better air-quality detection:  Should be portable, sensitive, low-cost, low-power  Something that people can use easily  “Personal Environmental Monitors” do exist:  They work and allow for people to gather much better information about their environment  Yet, today’s personal monitors are too bulky, heavy, noisy, and run for only 8 hours at a time State-of-the-art personal environmental monitor

The COINS personal environmental monitor will have high detection sensitivity, fit on a bracelet, and run for months at a time MC Roco, Nov 3, 2013

12-atom and DNA data memory systems

2000: NNI goal for ~2025 - all information from Library of Congress in a device of size of sugar cube 1cm cube (Pres. Clinton) – was labeled as too ambitious

Jan 2012: 12 atom structure,

DNA system (2012)

2000 NNI goal for ~2025

IBM; store it in 1cm cube

(Science, 2012)

Aug 2012: DNA system could store it in about 1mm cube

(Science, 2012) MC Roco, Nov 3, 2013

Nanotechnology for Aerospace: Integration of five nanosystems on a future civilian

Future aircraft designs include nanocomposite materials for ultra-lightweight multifunctional airframes; “morphing” airframe and propulsion structures in wing-body that can change their shape; resistance to ice accretion; with carbon nanotube wires; networks of nanotechnology based sensors for reduced emissions and noise and improved safety

Design by NASA and MIT for a 354 passenger commercial aircraft that would be available for commercial use in 2030-2035 and would enable a reduction in aircraft fuel consumption by 54% over a Boeing 777 baseline aircraft (Nano2020 Report, 2011, cover page [3])


2000-2010 Context – Nanotechnology in the World

Changing international context: National government investments 1997-2007 (estimation NSF) W. Europe

+ additional spin-off R&D investments

Japan USA Others Total

2012

2011

2010

2009

2008

2007

2006

2005

2003

2002

2001

2000

1999

IWGN

2004

Industry $ > Public $ (2006)

NNI (2000)

1998

10000 9000 8000 7000 6000 5000 4000 3000 2000 1000 0

1997

(million $ / year)

R&D FUNDING

federal/national government R&D funding (NNI definition)

3rd Generation Seed funding NNI Preparation 1st Generation products 2nd Generation 1991 - 1997 vision/benchmark passive nanostructures active nanostructures nanosystems

Rapid, uneven growth per countries. Increase role of BRIC countries MC Roco, Nov 3, 2013

NNI Investment 2001-2013 210 2.0

1.8 180 1.6 150

1.4

$ Billions

1.2 120 1.0

90

0.8

60 0.6

0.4

30

0.2 0.00

2001

2002

2003

2004

2005

2006

2007

2008

2009

2010

2011

2012

2013

• All numbers shown above are actual spending, except 2012, which is estimated spending and 2013, which is requested amount for next year. • FY ‘09 figure shown here does not include ~$500 million in ARRA funding. MC Roco, Nov 3, 2013

Updated Table 1 from (2011a) [1]

2010- 2020

Estimates show an average growth rate of key nanotechnology indicators . World (US)

People -primary workforce

WoS papers

2000

~ 60,000 (25,000)

2010

Patents applic.

(Espacenet)

Final Products Market

18,085 (5,342)

1,197 (405)

~ 600,000 (220,000)

78,842 (17,978)

2000 - 2010

~ 25% (~23%)

~ 16% (~13%)

2015

~ 2,000,000 (800,000)

~ $1,000B ($400B)

2020

~ 6,000,000 (2,000,000)

~ $3,000B ($1,000B)

(actual) (actual) average growth

estimation in 2000 Roco Bainbridge 2001

extrapolation Nano2020 report

R&D Funding

Venture Capital

~ $30 B ($13 B)

~ $1.2 B ($0.37 B)

~ $0.21 B ($0.17 B)

~ 20,000 (3.400)

~ $300 B ($110 B)

~ $18 B ($4.1 B)

~ $1.3 B ($1.0 B)

~ 33% (~24%)

~ 25% (~24%)

~ 31% (~27%)

~ 30% (~35%)

public + private


20012013

NNI expenditures have grown ~ 4 times

NNI budget: $1,770M (2013 est.) / $464M (2001 Actual) ~ 4 times NNI at NSF: $435M (2013 est.) / $97M (2001 Actual) ~ 4.5 times Fundamental NS&E remains the main focus, with increased attention to innovation, manufacturing, societal implications Nanomanufacturing in 2013 Request: 5% of all NNI; 12.1% at NSF Nano EHS: NNI has increased from 4% in 2011 to 6% in 2013 est. NSF has ~ 7 % in the last five years Nano penetration is time-staggered. In 2012: ~11% in NSF awards, ~5% in all papers, ~2% in USPTO patents, ~ 1% in Nano market/US GDP MC Roco, Nov 3, 2013

Nanotechnology publications in the World of Science (WoS) 1990 - 2012

“Title-abstract” search for nanotechnology by keywords (Chen and Roco, 2013, based on [4]) 30,000 28,000

Publications

26,000

USA

24,000

Japan

22,000

EU27

20,000

China

18,000

Korea

16,000 14,000

2000-2012 Worldwide annual growth rate ~ 16% U.S. ~ 29.5% in 2001-2005

U.S. ~ 20.5% in 2012

12,000 10,000 8,000 6,000 4,000 2,000 0

1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012

Rapid, uneven growth per countries U.S. contribution from 29% in 2005 to ~20% in 2012 (about -1.3% per year) MC Roco, July 23 2013

Percent contribution by country to WoS nanotechnology publications in Science, Nature, and Proc. NAS, 1991-2012 “Title-abstract” search for nanotechnology by keywords (Chen and Roco 2013, based on [4]) Fig II-5. Different countries' contributions in top 3 journals' nanotechnology paper publications (title-abstract search)

100.00% 90.00%

USA Japan P.R. China Germany France

U.S. ~ 66% in 2012

80.00% 70.00% 60.00% 50.00%

U.S. ~ 50% in 2000

40.00% 30.00% 20.00%

2012

2011

2010

2009

2008

2007

2006

2005

2004

2003

2002

2001

2000

1999

1998

1997

1996

1995

1994

1993

1992

0.00%

1991

10.00%

U.S. maintain the lead in highly cited publications

28


Nanotechnology citations all papers Percentage of world share offor citations of paper publications in WoS in 10 specialized journals WoS in March 2013

“Title-abstract” search for nanotechnology by keywords (Chen and Roco 2013, based on [4])) 0.600

USA

China

Japan

Korea

Japan

EU27 EU25

Percentage of world share of citations

0.500

U.S. ~ 51% in 2000 U.S. ~ 33% in 2010

0.400

0.300

0.200

EU ~ 21% in 2010 EU ~ 28% in 2000

0.100

0.000

2002

2003

2004

2005

2006

2007

2008

2009

2010

MC Roco, July 23 2013

U.S. citations in 10 specialized journals from 51% in 2004 to 33% in 2012

Total number of nanotechnology patent applications per year Number of Patent Applications

25000 20000 15000 10000 5000

Year All applications 1991 2001 2012

224 2,163 21,868

USA at USPTO All applications ~ 15% in 2012 Non-overlapping applications

Non-overlapping Applications 224 2,095 19.578 USA at USPTO ~ 35% in 2000

0

Year

Longitudinal evolution of the total number of nanotechnology patent applications in the 15 repositories per year (1991–2012) MC Roco, Nov 3, 2013

Nanotechnology patents at US Patent and Trade Office (USPTO) 1991-2012 “Title-abstract” search of nanotechnology by keywords (Chen and Roco 2013, based on [4]))

All countries

55% (USA) 70% U.S. patent authors maintain the lead at USPTO in 2012 U.S. patent authors from ~80% in 1996 to 52% in 2012 (about -1.7% per year) MC Roco, Nov 3, 2013

Percentage rate of penetration of nanotechnology in NSF awards, WoS papers and USPTO patents (1991-2012) (update Encyclopedia Nanoscience, Roco, 2013)

2012 Top 20 nano J. ~ 12%

Nanotechnology NSF Award / Paper / Patent Percentage

14% 13%

Top 20 Journals' Nano Paper Percentage

12%

3 Selected Journals' Nano Paper Percentage

11%

Title-claims SearchNano Nano Patent Percentage Title-claim Search's Paper Percentage

10%

NSF Nano New Award Percentage

9% 8% 7%

2012 NSF grants ~ 12%

All documents were searched by keywords in the title/ abstract/ claims

2012 All journals ~ 5%

6% 5% 4%

2012 USPTO patents ~ 1.9%

3% 2% 1%

2012 Market /US GDP ~0.9%

0%

1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012

Year MC Roco, Nov 3 2013

2012 papers on active and nanosys >25%

NNI “signature initiatives” 2011-2013

Sustainable Nanomanufacturing Nanoelectronics for 2020 and Beyond Nanotechnology for Solar Energy Nanotechnology-enabled Sensors to Assess Health and the Environment Nanotechnology Knowledge Infrastructure Nanoscale Sensors for Health and Environment MC Roco, Nov 3, 2013

Examples of other activities at NSF 2011 - 2013

Core research in: BIO, CISE, E.H.R., ENG, GEO, MPS, SBE Recompete Network for Computational Nanotechnology (2012) and National Nanotechnology Infrastructure Network (2013-) Nanosystems Engineering Research Centers $3-4 M/year per center for 5+5 yrs.; Support innovation Science and Technology Centers $5M/year per center for 5+5 yrs Environmental, Health and Safety (EHS) (~7% of NSF NNI) New programs for interaction with industry GOALI, PFI, SBIR/STTR, I-Corps, Collaboration industry groups Part of Converging Knowledge and Technologies MC Roco, Nov 3, 2013

NSF’s NSE awards per capita, by state (FY 2001-2012) U.S. average amount = $21 / capita $13.77

$13.28 $16.14

$10.79

$5.25 $22.24

$14.00 $18.04

$27.76

$21.35 $29.92

$5.71 - $15.14 ------------------VT  $31.21 ------NH - $14.52 $11.59 $16.28  $39.47  ------MA - $83.23 $32.54 $14.62 $60.94 -------RI -- $19.36 ---------CT $32.80  $18.73  ------------------NJ - $16.7 $30.62 $25.20 ------------DE - $42.98  $37.90  $9.31 ------MD - $21.92 $13.53 ----------------------DC - $82.56  $11.35  $11.76 $16.06 $10.41 $14.16 $17.28 $18.17 $13.98 $19.97 $11.43 $11.37 $12.88 $23.86 $12.25

HI - $1.73 AK - $4.37

$7.01 PerCap ACT Nano Amt. FY01-12 11.35 - 13.53 20 countries; data>standing in 2008) MARKET INCORPORATING NANOTECHNOLOGY ($B)

10000

Two orders of magnitude growth in 20 years

1000 100 10

~ $250B ~ $120B

~ $40B

$1T by 2015

$3T by 2020

NT in the main stream

Final products incorporating nanotechnology in the world

~ $91B , U.S.

2000

2009

World annual rate of increase ~ 25%; Double each ~ 3 years

1

2000 2000

2005 2005

2015 2015

2010 2010

2020 2020

Roco &Bainbridge (2000-2015) Deutche Bank (2005) Lux Research (2009) Mith. Res. Inst. (2005)

YEAR

Nanosystems by design Active nanostructures Passive nanostructures

Rudimentary Reference: Roco and Bainbridge, Springer, 2001

Complex MC Roco, Nov 3, 2013

Decade increase rates in nanotechnology for USPTO patents and WoS publications

(decade increase rate = number of items in 2001-2010 / the number of items in 1991-2000) Country

Total USPTO patents 1991-2010

Decade increase rate

U.S.

90,655

2.88

Japan

18,027

3.68

Germany

4,845

4.40

France

3,557

2.32

South Korea

2,818

19.13

Total WoS publications 1991-2010

Decade increase rate

U.S.

155,548

4.81

China

98,949

18.34

Japan

58,655

4.62

Germany

52,141

4.55

France

34,951

4.74

Country

Ref:: Chen, Roco et al. “Global Nanotechnology Development from 1991 to 2012: patents, scientific publications, and effect of NSF funding”, J. Nanoparticle Research, 2013, Vol. 15, Paper 1951, Tables 2 and 5 MC Roco, Nov 3, 2013

Article citations by NSF Principal Investigators

Chen at al. (2012)

NSF-funded PIs (1991-2010) have a higher number of citations (166 in average) than researchers in other groups: IBM, UC, US (32 in average), Entire world Set (26 in average), Japan, European, Others Ref:: Chen, Roco et al. “Global Nanotechnology Development from 1991 to 2012: patents, scientific publications, and effect of NSF funding”, J. Nanoparticle Research, 2013, Vol. 15, Paper 1951, Fig. 8


Number of patent citations by NSF P.I.-Inventors

Chen at al. (2012)

NSF-funded PI-Inventors (1991-2010) have more citations (31 in average) than inventors in the TOP10, UC, IBM, US (9 in average), Entire World Set (7 in average), Japan, Others, and European group Ref:: Chen, Roco et al. “Global Nanotechnology Development from 1991 to 2012: patents, scientific publications, and effect of NSF funding”, J. Nanoparticle Research, 2013, Vol. 15, Paper 1951, Fig. 8


(A) 2000-2010 S&T Outcomes • Remarkable scientific discoveries than span better understanding of the smallest living structures, uncovering the behaviors and functions of matter at the nanoscale, and creating a library of 1D - 4D nanostructured building blocks for devices and systems; Towards periodical table for nanostructures.

• New S&E fields have emerged such as: spintronics (2001), plasmonics

(2004), metamaterials, carbon nanoelectronics, molecules by design, nanofluidics, nanobiomedicine, nanoimaging, nanophotonics, opto-genetics, synthetic biology, branches of nanomanufacturing, and nanosystems

• Technological breakthroughs in advanced materials, biomedicine,

catalysis, electronics, and pharmaceuticals; expansion into energy resources and water filtration, agriculture and forestry; and integration of nanotechnology with other emerging areas such as quantum information systems, neuromorphic engineering, and synthetic and system nanobiology

(B) 2000-2010: Ten highly promising products incorporating nanotechnology

• Catalysts • Transistors and memory devices • Structural applications (coatings, hard materials, CMP) • Biomedical applications (detection, implants,.) • Treating cancer and chronic diseases • Energy storage (batteries), conversion and utilization • Water filtration • Video displays • Optical lithography and other nanopaterning methods • Environmental applications Leading to new industries, some with safety concerns: cosmetics, food, disinfectants,.. After 2010 nanosystems: nano-radio, tissue engng., fluidics, plastic muscle, bio based en. generation, etc.

Leading U.S. cities with corporate entries in the U.S.

(i.e. company has products, articles and/or patents), 1991-2011 Total US – 6,811 corporations (universities and non-profits excluded)

Sample survival: - 50% large companies – all survive in the interval - 33% SME survive - 5% SME acquired - 3.5% SME become subsidiary - 3% SME out of business - 5.5% SME no information available

Personal Comm.: J. Youtie, P. Shapira, and Y. Li (Georgia Tech, NSF’s Center for Nanotechnology in Society CNS-ASU), Records of July 2013 in the EPO Worldwide Patent Statistical Database (PATSTAT) and WoS articles MC Roco, Nov 3, 2013

About 100 major NNI centers, networks, user facilities


National Nanomanufacturing Network (2006- ) Its core: Four Nanomanufacturing NSECs

NNN support will be closed in 2015 - need for continuity

• Center for Hierarchical Manufacturing (CHM) - U. Mass Amherst/UPR/MHC/Binghamton

• Center for High-Rate Nanomanufacturing (CHN) - Northeastern/U. Mass Lowell/UNH

• Center for Scalable and Integrated Nanomanufacturing (SINAM) - UC Berkeley/UCLA/UCSD/Stanford/UNC Charlotte

• Center for Nanoscale Chemical-Electrical-Mechanical Manufacturing Systems (Nano-CEMMS) - UIUC/CalTech/NC A&T

Open-access network www.nanomanufacturing.org

beta.internano.org

47

NIH Centers for Accelerated Innovations Integration with Federal Programs/Resources FDA

NCATS

BrIDGs

TRND

CTSA

Innovations Investigator initiated RPGs Institute initiated programs

•Regulatory Assistance

DOC

CMS

•IP assessment •Reimbursement •entrepreneurship strategy

De-risked Technology

Center Therapeutics Diagnostics

• Business • Regulatory Development Assistance • Project • IP Management • Feasibility • Non-Federal Capital Studies

Devices

Existing NonProfit Organization

Develop Technology

STTR ready

Technology Not Ready

Phase 0/1 Trials

NHLBI Technology Development Resources

SMARTT

GTRP

PACT

Clinical Research Networks

Existing ForProfit Organization

New Company

SBIR ready

University-Industry-government partnerships (Public-private hybrids)         

Grenoble nano-Micro Center, France, EU IMEC/ Aachen/ Eindhoven triangle, EU SILICON SAXONY, Germany, EU Nanoelectronics Research Initiative, U.S. Albany Nanotechnology Center, U.S. University-Industry-Gov. Tsukuba Nano Center Industrial Technology Research Institute, Taiwan Nanopolis Suzhou, China Science Park, Korea


Twelve opportunities for pre-competitive nanomanufacturing R&D 1. Guided molecular assembling on several length scales (using electric and magnetic fields, templating, imprinting, additive, chemical methods, etc.) 2. Modular and platform-based nanomanufacturing for nanosystems 3. Use micro/nano environments: microreactors, microfluidics, deskfactories 4. Designing molecules with new structures and functionalities 5. Nanobio-manufacturing - harnessing biology for nanomanufacturing (using living cells directly, borrowed, or bio-inspiration such as folding) 6. Manufacturing by nanomachines - advances catalysts, DNA machines, .. 7. Hierarchical nanomanufacturing - integrate in 3D, diff. materials, functions 8. Scale-up, high-rate, distributed continuum manufacturing processes 9. Standardized tools for measurements and manufacturing 10. Predictive simulation of nanomanufacturing processes 11. Predictive approach for toxicity of nanomaterials (ex: oxidative stress) 12. Development and use of nanoinformatics and intellectual property


Twelve global trends to 2020 Detailed description on: www.wtec.org/nano2/

• • • • • • • • • • • •

Theory, modeling & simulation: x1000 faster, essential design “Direct” measurements – x6000 brighter, accelerate R&D & use A shift from “passive” to “active” nanostructures/nanosystems Nanosystems, some self powered, self repairing, dynamic Penetration of nanotechnology in industry - toward mass use; catalysts, electronics; innovation– platforms, consortia Nano-EHS – more predictive, integrated with nanobio & env. Personalized nanomedicine - from monitoring to treatment Photonics, electronics, magnetics – new capabilities, integrated Energy photosynthesis, storage use – solar economic by 2015 Enabling and integrating with new areas – bio, info, cognition Earlier preparing nanotechnology workers – system integration Governance of nano for societal benefit - institutionalization MC Roco, Nov 3, 2013

Converging Knowledge, Technology and Society: Beyond Convergence of Nano-BioInfo-Cognitive Technologies, Springer , 2013

report available on

www.wtec.org/NBIC2-Report

convergence interviews on

http://www.wilsoncenter.org/convergence M.C. Roco, W.S. Bainbridge, B. Tonn and G. Whitesides, eds.