Early response monitoring to neoadjuvant ... - Springer Link
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Early response monitoring to neoadjuvant ... - Springer Link
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Eur J Nucl Med Mol Imaging (2014) 41:1553–1562 DOI 10.1007/s00259-014-2746-2
ORIGINAL ARTICLE
Early response monitoring to neoadjuvant chemotherapy in osteosarcoma using sequential 18 F-FDG PET/CT and MRI Byung Hyun Byun & Chang-Bae Kong & Ilhan Lim & Byung Il Kim & Chang Woon Choi & Won Seok Song & Wan Hyeong Cho & Dae-Geun Jeon & Jae-Soo Koh & Soo-Yong Lee & Sang Moo Lim
Received: 2 January 2014 / Accepted: 21 February 2014 / Published online: 21 March 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Purpose We evaluated the potential of sequential fluorine-18 fluorodeoxyglucose (18 F-FDG) positron emission tomography (PET)/computed tomography (CT) and MRI (PET/MRI) after one cycle of neoadjuvant chemotherapy to predict a poor histologic response in osteosarcoma. Methods A prospective study was conducted on 30 patients with osteosarcoma treated with two cycles of neoadjuvant chemotherapy and surgery. All patients underwent PET/MRI before, after one cycle, and after the completion of neoadjuvant chemotherapy, respectively. Imaging parameters [maximum standardized uptake value (SUVmax), metabolic tumor
Electronic supplementary material The online version of this article (doi:10.1007/s00259-014-2746-2) contains supplementary material, which is available to authorized users. B. H. Byun : I. Lim : B. I. Kim : C. W. Choi : S. M. Lim Departments of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Republic of Korea C.
