Mar 21, 2014 - Early response monitoring to neoadjuvant chemotherapy in osteosarcoma using ..... The Wilcoxon signed rank test was used for paired ..... Byun BH, Kong CB, Park J, Seo Y, Lim I, Choi CW, et al. Initial. Metabolic Tumor ...
Eur J Nucl Med Mol Imaging (2014) 41:1553–1562 DOI 10.1007/s00259-014-2746-2
ORIGINAL ARTICLE
Early response monitoring to neoadjuvant chemotherapy in osteosarcoma using sequential 18 F-FDG PET/CT and MRI Byung Hyun Byun & Chang-Bae Kong & Ilhan Lim & Byung Il Kim & Chang Woon Choi & Won Seok Song & Wan Hyeong Cho & Dae-Geun Jeon & Jae-Soo Koh & Soo-Yong Lee & Sang Moo Lim
Received: 2 January 2014 / Accepted: 21 February 2014 / Published online: 21 March 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Purpose We evaluated the potential of sequential fluorine-18 fluorodeoxyglucose (18 F-FDG) positron emission tomography (PET)/computed tomography (CT) and MRI (PET/MRI) after one cycle of neoadjuvant chemotherapy to predict a poor histologic response in osteosarcoma. Methods A prospective study was conducted on 30 patients with osteosarcoma treated with two cycles of neoadjuvant chemotherapy and surgery. All patients underwent PET/MRI before, after one cycle, and after the completion of neoadjuvant chemotherapy, respectively. Imaging parameters [maximum standardized uptake value (SUVmax), metabolic tumor
Electronic supplementary material The online version of this article (doi:10.1007/s00259-014-2746-2) contains supplementary material, which is available to authorized users. B. H. Byun : I. Lim : B. I. Kim : C. W. Choi : S. M. Lim Departments of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Republic of Korea C.
