Accepted Manuscript Effectiveness of Exercise Training on Exercise Tolerance, Physical Function, and Quality of Life in Elderly People Undergoing Hemodialysis: a Systematic Review and Meta-analysis Ryota Matsuzawa, PhD, Keika Hoshi, PhD, Kei Yoneki, MS, Manae Harada, MS, Takaaki Watanabe, MS, Takahiro Shimoda, MS, Shuhei Yamamoto, PhD, Atsuhiko Matsunaga, PhD PII:
S2468-0249(17)30169-9
DOI:
10.1016/j.ekir.2017.06.008
Reference:
EKIR 179
To appear in:
Kidney International Reports
Received Date: 17 January 2017 Revised Date:
25 May 2017
Accepted Date: 14 June 2017
Please cite this article as: Matsuzawa R, Hoshi K, Yoneki K, Harada M, Watanabe T, Shimoda T, Yamamoto S, Matsunaga A, Effectiveness of Exercise Training on Exercise Tolerance, Physical Function, and Quality of Life in Elderly People Undergoing Hemodialysis: a Systematic Review and Meta-analysis, Kidney International Reports (2017), doi: 10.1016/j.ekir.2017.06.008. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Effectiveness of Exercise Training on Exercise Tolerance,
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Physical Function, and Quality of Life in Elderly People
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Undergoing Hemodialysis: a Systematic Review and
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Meta-analysis
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Ryota Matsuzawa, PhD1, Keika Hoshi, PhD2, Kei Yoneki, MS3, Manae Harada,
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MS3, Takaaki Watanabe, MS3, Takahiro Shimoda, MS3, Shuhei Yamamoto, PhD4,
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and Atsuhiko Matsunaga, PhD3
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1
Department of Rehabilitation, Kitasato University Hospital, Sagamihara, Japan.
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Department of Hygiene, Kitasato University School of Medicine, Sagamihara, Japan.
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Department of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato
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University, Sagamihara, Japan.
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Department of Rehabilitation, Shinshu University Hospital, Nagano, Japan.
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Corresponding author: Ryota Matsuzawa, PhD, Department of Rehabilitation,
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Kitasato University Hospital, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa
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252-0375, Japan
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Tel: +81-42-778-8413; Fax: +81-42-778-9872; E-mail:
[email protected]
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Acknowledgments: This study was supported by a JSPS KAKENHI (Grant Number
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16K16466). We thank all of the investigators and contributors to our study.
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A running headline: Exercise in Elderly Hemodialysis Patients
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Registration Number: PROSPERO 2015: CRD42015020701 1
ACCEPTED MANUSCRIPT
Abstract
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Introduction: Previous reviews have indicated the effectiveness of exercise in people
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on hemodialysis. However, these analyses did not take into account whether the subjects
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were elderly. Here, we performed a systematic review of the effects of exercise training
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in elderly people on hemodialysis, and updated the evidence of exercise for people on
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hemodialysis by adding recent research data.
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Methods: We searched 8 electronic databases up to June 2016. Inclusion criteria were
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as follow: randomized controlled trial, English publication, subjects aged 18 and over
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on hemodialysis, evaluation of physical function as an outcome from exercise
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intervention. We defined elderly as the subjects aged 60 years and older. The main
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outcomes were exercise tolerance (peak/max VO2) and walking ability (6-minute walk
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distance). Secondary outcomes were lower extremity muscle strength and quality of life
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(QoL).
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Results: After screening of 10923 references, 30 comparisons were entered into the
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analysis. However, because we found only one study treated elderly subjects, we could
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not perform a meta-analysis for these people. For general hemodialysis population,
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supervised exercise training was shown to significantly increase peak/max VO2
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(standard mean difference [SMD], 0.62; 95%CI 0.38-0.87; P
