experiment, whereas no significant differences were observed in the activities of GPx, catalase and the MDA level. ... Endogenous antioxidant enzymes such as SOD, GPx and catalase .... Glutathione peroxidase measurement was determined.
Malaysian Journal of Biochemistry and Molecular Biology (2006) 14, 7-12
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Effects of Ginger Extract (Zingiber officinale Roscoe) on Antioxidant Status of Hepatocarcinoma Induced Rats Norliza Ahmad1, Suhaniza Sulaiman1, Nor Ashikeen Mukti1, Nor Azian Murad2, Noor Aini Abd Hamid1 and Yasmin Anum Mohd Yusof1 1
Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Centre of Lipids, Engineering and Applied Research, Universiti Teknologi Malaysia, Kuala Lumpur, Malaysia 2
Abstract Ginger or Zingiber officinale which is used in traditional medicine has been found to possess antioxidant effect that can control the generation of free radicals. Free radical level has been reported to be high in cancer cells. The aim of this study was to observe the effect of ginger extract on antioxidant status in rats induced with liver cancer. Twenty-six male Wistar rats were divided into 5 groups: 2 control groups were fed with normal rat chow and olive oil respectively. Treatment groups consisted of rats fed with ginger extract at 100 mg/kg body weight (ginger group), rats induced with liver cancer by choline deficient diet plus ethionine in drinking water (CDE group) and rats with CDE diet plus ginger extract (CDE + ginger group) . Blood samples were taken from the orbital sinus at 0 and 8 weeks of experiment for the determination of antioxidant enzyme activities and MDA level. Comparison between the control group and the CDE group showed significant increase (p
