Electrocardiographic profile of guinea pig heart

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Dec 5, 2014 - ginkgolides A (GA) and B (GB), and bilobalide (BB) were investigated in guinea pig heart mounted in Langendorff apparatus (Tyrode, 34 ± 0.1 ...
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Electrocardiographic profile of guinea pig heart submitted to Ginkgo biloba extract and its terpenoids SANTOS, A.C.O.; SOUZA, J.A.S.; CONDE-GARCIA, E.A.; SOUZA, A.A.; MENEZES-FILHO, J.E.R.; OLIVEIRA, E.D.; VASCONCELOS, C.M.L.* Laboratório de Biofísica do Coração, Departamento de Fisiologia Centro de Ciências Biológicas e da Saúde, Universidade Federal de Sergipe, São Cristóvão, Sergipe, Brazil. *Carla Vasconcelos, PhD, Cidade Universitária

Prof. “José Aloísio de Campos”, Av. Marechal Rondon, s/n, Jardim Rosa Elze, CEP 49.100-000, São Cristóvão, Sergipe, Brasil.

Tel.: +55 79 21056642, E-mail addresses: [email protected], [email protected]

ABSTRACT: Electrocardiographic effects produced by Ginkgo biloba extract (EGb) and by ginkgolides A (GA) and B (GB), and bilobalide (BB) were investigated in guinea pig heart mounted in Langendorff apparatus (Tyrode, 34 ± 0.1 oC, 95% O2, 5% CO2). Electrocardiographic parameters were evaluated in the conditions: 1) control with Tyrode and DMSO, 2) EGb (n=4), GA (n=5), GB (n=5) or BB (n=6), and 3) washout. The results showed that 0.1 and 1.0 mg/ml of EGb do not change the electrocardiographic parameters. However, 10 mg/ml of EGb increased the PR interval (PRi) at 21% (p