Estimating and improving protein interaction error rates

1 downloads 0 Views 269KB Size Report
[email protected]. George M. Church. Lipper Center for Computational Genetics. Harvard Medical School [email protected].
                             

 

                             !     

          !     "    !   #                             !            $                   !         "  !  !               !       " !                   %                    "       %         &         '   %         " !  !  ! !    

  !  ( )  (  *) %          !   %                      

    

                                                          

     !                           "                !           "  #        !   ! $               % ! & '  "   !                 "           

 



                       "  !         "          "          !

               (             )    *+,"            !                  #    *(,$ )    "          !

    

     "             -                    !          "                              )   !              !             '  "   

        "           ! "                   "    !       - !   !        !                  *.,"       */,   *0,               

     !12-      "  !   ! !             !           !   #             *.,$              !           #    *3,$"   

           !  )     "               # !   %   &  4     *5,$             */,    !                  " 

                

Proceedings of the 2004 IEEE Computational Systems Bioinformatics Conference (CSB 2004) 0-7695-2194-0/04 $20.00 © 2004 IEEE

!   )"    !        67    *8,       7  

               !  !          " !           

 7

   !      !       !           !         #     !   $" 

  !       7

        6 *9,"  :1 *+;,      *+/," ) //50      #       %) 

&        $"    > % &  8;3      ! ! #      %) &$*+,'        !              .53+       *+0,"     '     .3+8   *+3, B  + 

     7        (    !  )6     "  !     !#6 B .    $ B  (                               -      !"   

  !                !    #   ) ))  B  ($     )   D   

              - #                                        $"    )"))")))")D   

   )    !       

Proceedings of the 2004 IEEE Computational Systems Bioinformatics Conference (CSB 2004) 0-7695-2194-0/04 $20.00 © 2004 IEEE

 













 

 

 



 

 



 

 

 " % $   $   &!      "' (  )&$     "   !        "   *        

  $        +  "*$      $    &     "  '        &      '  (        ,       "     #  

       

    !    $"       )  ))  B  (     >           ))))DB!         7 )D"  !    -            B    !         " #                 $"   !                 !     '  "   !       J       "  !                

Proceedings of the 2004 IEEE Computational Systems Bioinformatics Conference (CSB 2004) 0-7695-2194-0/04 $20.00 © 2004 IEEE

        

 $%

  # 

  $%

  # 

  $%

()  "   )     ,,  +-  .  -  -  -/   01  23  +4   -     .5   4   55  4-  "+   5+  "-  1)0 6  7  45  "/  5  -   7  )  51  " 

 # 

!



 ?  !              (    !       !

                    !       K K         !         *+0,"*+5,"                    *+5,"*+8,"*+9,                   

 )  E    (0      .;  !       ! )6"C 7)  " !    9;I                               )   #    *+8,$ B ! "     !            L62+"    !    !12-   !"       (89   (80          L62+       )  "                    !   " #  $   L62+        C 7  "                #)6 $ 6                    !     #F5;9 +;+(9$" 

 !   !J                   " J  !    !    )      )        !  !      

*  "- !&    

  " 



     

$&' 

                               

                               

                               

                                    

                               

                               

                               

*+&  *+& *+& * +& * +& *+& * +& *+& *+&  *+& *+&  *+&  *+&  *+& * +& *+&  *+&  *+& *+& * +& *+& *+& *+& *+& * +& *+& *+& *+& *+& *+& *+& *+&

                      ! 

       !           !    (     @   

 

      !

          "      !      !

          )   

Proceedings of the 2004 IEEE Computational Systems Bioinformatics Conference (CSB 2004) 0-7695-2194-0/04 $20.00 © 2004 IEEE

'#!

'#! 

 

 

  

    

  

 



 

3 

 

 

3 







/8$ 8* ) :  ) :   9  $ 8* 8$ 8*                &                 &      '#!     '#!     '#!      '#!     3       3        3       3      5 8 

  

*    &   ! & &      "





 .            /   0 !&          "     &1 $       +   ! & "    $ ) 

   $  +     $

 $  &      " #$     "             "          E %  &!     !                     

"      %! & !   !             *(;, ? "           !    !     "               !        *(;,B .

    7             !  ! " !    )6      4          "      !

      ! "   %  &                 2  !       B

  2"            !    !            

      "    2    "          !      !         "    2F+        !  !     

           ) !          2 F (  . 

               "        

     !    ! !  

#



  

   (              #!  !

"   B     1  #B1$E   !       $  

      !  %)

N.(&%)   N.(&                  )  " 

     .(         !  %+&  %'+&       %! &         '    %(&         2F( !       ! !    "   %&        !    @ 

            "  

    #       (;I                    >    " '+  ) 

$  

   ! "   !  !          B  /"   !  !   B  (        *3, #%-&  B  /   >    !      $   /3I           C 7     !    )          !     C    !     !    ) 

  !  C 7            /.I"    

        !           # 6A => CD3 @ = > ' !#!@=>

) & ? &? & ?  & ?  B?  ? E?

+

 "A  F 8 #:  F8 A#'C FA! : '#!@

A()?-!C"+$ #!8?FA#AF8  @@C8 & #' 8#!  F!!%8#8*



8C !A# 8G# ?F# A C & ! #!@*



8C !H: #IJC #!# # ! #!  # !8*



 !        !  ! "            !                 2F.  !    #.  ''.$"      

              

 

  >      %  &     !               !!!# B  /"   ! !!$    2"    !           B     "          !                      #            "  %! &!         %  & !         $   '    >      !     "      !                             .       !          " !       !    !    "   )6    

Proceedings of the 2004 IEEE Computational Systems Bioinformatics Conference (CSB 2004) 0-7695-2194-0/04 $20.00 © 2004 IEEE

  !     +;";;;   "   !          7      !     4               !     

         !  !   "   

    !       !   "       !  !                2   !     !    4  *5,          "       (//9         !        #    

  

   E P-(P