third is the POPS device of TransMedics, Inc. In contrast to the others, the POPS device is designed to operate at 37ºC and it is being studied at the University of ...
Journal of
Regenerative Medicine & Tissue Engineering Research Article
Open Access
Ex vivo evaluation of porcine livers post-hypothermic machine perfusion at 4-6ºC and 12-14ºC Kelvin G.M. Brockbank1,2,3, Charles Y. Lee4, Elizabeth D. Greene1, Zhenzhen Chen1, Lindsay K. Freeman1 and Lia H. Campbell1 Abstract Background: The goal of our research is the development of a clinical hypothermic machine perfusion method and device for liver preservation during storage and transport prior to transplantation. The purpose of this study was comparison of two hypothermic temperature ranges. Methods: Heart beating donor pig livers with 2h of static cold storage on ice were employed. Thirteen experimental livers were perfused, at either 4-6ºC or 12-14ºC with oxygenation, employing a prototype device. They were compared with six control 2h static cold stored livers during normothermic ex vivo blood perfusion. Physiological measurements and biochemical perfusate analyses were performed to assess the impact of storage conditions on liver functions. Statistics were assessed by one way analysis of variance, p
