B e b u lin 3 0. 0. 10. 20. 30. 0. 5 0. 100. 150. 200. 250. 300. Bebulin + Hepzyme. Profilnine + Hepzyme. Minutes n. M. T h ro m b in. High Dabigatran. P ro filn in e ...
Honickel et al.
Reversal of Dabigatran
Supplementary Material to Honickel et al. “Reversal of dabigatran anticoagulation
ex-vivo: Porcine study comparing prothrombin complex concentrates and idarucizumab” (Thromb Haemost 2015; 113.4)
Post Trauma
High Dabigatran
Low Dabigatran
H ig h D a b ig a t r a n
P o s t T ra u m a
L o w D a b ig a t r a n
n M T h r o m b in
n M T h r o m b in
250 200 150 100
300
300
250
250
n M T h r o m b in
300
200 150 100
150 100
50
50
50
0
0 0
10
20
0 0
30
10
20
B e r ip le x 3 0 C o fa c t + H e p z y m e
C o fa c t 3 0
30
0
C o fa c t 3 0
250
150 100
200 150 100
50
50
0
0 20
n M T h r o m b in
300
250
n M T h r o m b in
300
250 200
B e rip le x + H e p z y m e P o s t T ra u m a
200 150 100 50 0
30
0
10
M in u t e s
20
30
0
10
M in u te s
P r o th r o m p le x 3 0
P r o th ro m p le x + H e p z y m e
O c ta p le x 3 0
O c ta p le x + H e p z y m e
30
C o fa c t + H e p z y m e
B e r ip le x 3 0
C o fa c t + H e p z y m e H ig h D a b ig a t r a n
300
10
20
M in u t e s
B e rip le x + H e p z y m e
C o fa c t 3 0
L o w D a b ig a t r a n B e rip le x + H e p z y m e B e r ip le x 3 0
0
10
M in u te s
M in u t e s
n M T h r o m b in
200
20
30
M in u te s
P ro th r o m p le x 3 0
P r o th r o m p le x + H e p z y m e
P r o th r o m p le x 3 0
O c ta p le x 3 0
O c ta p le x + H e p z y m e
O c ta p le x 3 0
P r o th ro m p le x + H e p z y m e O c ta p le x + H e p z y m e P o st T rau m a
H ig h D a b ig a t r a n 300
300
250
250
250
200 150 100
200 150 100
50
50
0
0 0
10
20
30
n M T h r o m b in
300
n M T h r o m b in
n M T h r o m b in
L o w D a b ig a t r a n
200 150 100 50 0
0
10
20
30
0
10
20
30
M in u te s
M in u t e s
M in u t e s B e b u lin 3 0
B e b u lin + H e p z y m e
B e b u lin 3 0
B e b u lin + H e p z y m e
B e b u lin 3 0
B e b u lin + H e p z y m e
P r o f iln in e 3 0
P r o filn in e + H e p z y m e
P r o f iln in e 3 0
P r o filn in e + H e p z y m e
P r o f iln in e 3 0
P r o filn in e + H e p z y m e
Figure 6
Suppl. Figure 1: Representative curves of plasma thrombin generation before and after the addition of heparinase. Dabigatran dose-dependently inhibited thrombin generation. By adding three-factor PCCs and Beriplex or Cofact, dabigatran-induced inhibition of thrombin generation could be reversed. In contrast, Prothromplex and Octaplex only reversed thrombin generation after addition of heparinase. Therefore, thrombin generation was measured after the addition of heparinase to all samples. Representative curves are shown for “low dabigatran”, “high dabigatran” and “post trauma”.