From the 1Department of Medicine, University of Ottawa, Ottawa, Canada; the 2School of Human Kinetics, ...... sistance exercise for 6â12 months free of charge ...
Add a little more activity until you reach at least 30 minutes a day, 5 days a week. Easy steps to be more active l. Put
RESEARCH DESIGN AND METHODSâTen participants with type 2 ... menopausal women) with type 2 diabetes ... rived in the laboratory at 8:00 A.M. after a.
cise guidelines of the American College of. Sports Medicine and the American Dia- betes Association (15), which state that exercise should be performed at ...
cise guidelines of the American College of. Sports Medicine and the American ..... from the San Luigi Gonzaga Diabetes. Study. J Clin Endocrinol Metab 2006;91 ...
Sports Medicine by: Ann Albright, Ph.D., R.D. (Chairperson); Marion. Franz, M.S., R.D. ...... Guide to Diabetes and Exercise, N. Ruderman and J. Devlin. (Eds.).
A Thesis Presented to the Faculty of the Graduate School at the ... Abstract. Type
2 diabetes (T2D) and the associated impaired glycemic control greatly.
activity and weight loss) can prevent type 2 diabetes. Despite sedentary lifestyle and obesity being the two important lifestyle risk factors for type 2 diabetes [3],.
Additional measures are needed to encourage regular physical activity and improve dietary habits in this population. Diabetes Care 25:1722â1728, 2002.
May 13, 2017 - exercise in subjects with type 2 diabetes. ..... tive effects of diabetic neuropathy on peripheral motor nerve ..... J Cachexia Sarcopenia Muscle.
mellitus (IDDM) [1]. In the type 1 diabetes, dysfunction of pancreatic beta-cells leads to a deficiency of insulin production. About half of type 1 patients are ...
Sep 30, 2011 - the development of obesity. ..... factor or PBEF) is a newly discovered adipocyte hor- .... Orlistat, a gastrointestinal lipase inhibitor drug, has.
Jan 9, 2008 - the health benefits of exercise in type 2 diabetes, a recently published .... grants from the Dutch Ministry of Health, Welfare and Sport (S. F. E..
Feb 14, 2017 - of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, ...... [32] A. O. Akanji, E. Osifo, M. Kirk, and T. D. Hockaday, âThe.
Dec 24, 2014 - and 5Research Service, Harry S. Truman Memorial Veterans Affairs ...... Tobin LW, Kiens B, Galbo H. The effect of exercise on postprandial.
betes mellitus. A total of 25 subjects (20-70 years) were recruited to participate in two 60-minute instructed Tai Chi exercise ... Keywords: Mind-body exercise, hemoglobin A1C, fasting blood glucose. ... only improved fitness, health, and relaxation
Dec 24, 2014 - Total, exogenous, and endogenous triac- ylglycerol (TAG) responses to the dinner meal with pre- or postdinner resistance exercise or no.
of patients with diabetes, PAD, or both was determined using near-infrared spectroscopy (NIRS). ... The relative deoxygenation and oxygenation recovery times measured by ... A table elsewhere in this issue shows conventional and Syste`me Internationa
Lund University, Faculty of Medicine Doctoral Dissertation Series 2010:72 ...
tolerance (IGT) and with type 2 diabetes (T2D) was the influence of insulin
sensitivity ... in female diabetic subjects is related to exercise intensity, whereas
the red
May 29, 2009 - Aretaeus of Cappadocia described the term diabetes (di- abaınein) as 'â¦a wonderful affection, not very frequent among menâ¦' [1]. However ...
exercise stress test is greatest when test results are ... have abnormal stress tests, either by stress ECG, stress ..... Health Decisions program (http://www.
Sep 7, 2017 - Senhui Weng,1 Boqing Wang,1 Shuliang Ji,1 and Wei Wu2 ...... identified have compared Baduanjin versus Tai Chi, jogging, or other common ...
developed type 2 diabetes compared to today because overweight, obesity, and
... (http://diabetes.niddk.nih.gov/dm/pubs/preventionprogra · m/) found a lifestyle ...
College of Health and Human Services. San Diego State University. Portland ..... uc tio n. 0. â10. â20. â30. â40. â50. Deaths. Related to. Diabetes. All-Cause.
Exercise and Type 2 Diabetes
Larry S. Verity, PhD, FACSM School of Exercise & Nutritional Sciences College of Health and Human Services San Diego State University
Characteristics of Type 1 & Type 2 Diabetes Mellitus
Portland 2011 - T2DM
1
Rate of New Cases of Type 1 & Type 2 Diabetes among Youth < 20 yrs
Portland 2011 - T2DM
Estimated Growth in Type 2 Diabetes: US Population From 2000-2050 Type 2 DM
Year Bagust A, et al. Diabetes, 50 [Suppl 2], A205, 2001 Portland 2011 - T2DM
2
Age-adjusted % of U.S. Adults Who Were Obese or Who Had Diagnosed Diabetes Obesity (BMI ≥30 kg/m2) 1994
No Data
26.0%
Diabetes 1994
No Data
2009
2000
9.0%
CDC‟s Division of Diabetes Translation. National Diabetes Surveillance System available at http://www.cdc.gov/diabetes/statistics
Portland 2011 - T2DM
Diabetes Prevalence: Age and Ethnicity 20-39
40-49
50-59
60-74
75+
25
Percentage (%)
20 15 10 5 0 White - NH
Black - NH
Hispanic
Native Am/Al
Portland 2011 - T2DM
3
Natural History of Type 2 Diabetes Years from diagnosis
-10
0
-5
Onset
10
5
15
Diagnosis
Insulin resistance Insulin secretion
Postprandial glucose Fasting glucose
Microvascular complications
Macrovascular complications (65% die of CVD) Pre-diabetes Type 2 diabetes Ramlo-Halsted BA, Edelman SV. Prim Care. 1999;26:771-789; Nathan DM. N Engl J Med. 2002;347:1342-1349
Portland 2011 - T2DM
Stages of Type 2 Diabetes 100
MonoTherapy
75
b-Cell Function (% b)
Combination Oral Therapy
50
Type 2 Diabetes Phase I Type 2 Diabetes Phase II
25
0 -12 -10
-6
-2
0
2
6
Insulin Phase III 10
14
Years From Diagnosis Portland 2011 - T2DM
Based on data of UKPDS 16: Diabetes. 1995.
4
Cardiometabolic Risk - Graphic Overweight / Obesity Age
Genetics
Insulin Resistance Insulin Resistance ? Syndrome Lipids BP Glucose
Abnormal Lipid Metabolism LDL ApoB HDL Trigly.
Cardiometabolic Risk Global Diabetes / CVD Risk
Age, Race, Gender, Family History
Smoking Inflammation Hypercoagulation
Unhealthy Eating Physical Inactivity
Hypertension
Proportion of Patients with Cardiovascular Disease Increases with Duration of Diabetes 48%
29% 21%
24%
15%
≤2
3-5
6-9
10-14
15+
Years after DM Diagnosis Harris, S et al.; Type 2 Diabetes and Associated Complications in Primary Care in Canada: The Impact of Duration of Disease on Morbidity Load. CDA 2003. Portland 2011 - T2DM
5
Contemporary Diabetes Care Team Approach Physician(s) Diabetologist
Exercise Professional
Management Team Diabetes Educator
Registered Dietician
Portland 2011 - T2DM
Management of Diabetes Mellitus: Therapeutic Steps in Management • Medical management • Use of medications to manage glucose • oral agents and/or • insulin
Portland 2011 - T2DM
• Frequent monitoring of blood glucose • Proper diet and exercise
6
Mechanisms of Action of Pharmacologic Agents for Diabetes
Portland 2011 - T2DM
Summary of Pharmacologic Incretin Actions on Different Target Tissues Heart
insulin sensitivity of diabetes medications glucose control for type 2 Predictor of successful weight management Aids in managing other Cardiometabolic risks • Hypertension • Dyslipidemia • Obesity, Body weight/fat and morphology
Clinical trials examined prevention of type 2 diabetes LIFESTYLE was very effective Physical activity > 150 mins/wk MNT for diabetes Strategies for success
Is the DPP an effective „model‟ for secondary prevention? Portland 2011 - T2DM
8
Diabetes Incidence Rates by Ethnicity
Cases/100 person-yr
Lifestyle
Metformin
Placebo
12
8
4
0 Caucasian (n=1768)
African American (n=645)
Hispanic (n=508)
American Indian (n=171)
Asian (n=142)
The DPP Research Group, NEJM 346:393-403, 2002
Portland 2011 - T2DM
Diabetes Incidence Rates by BMI Cases/100 person-yr
16
Lifestyle
Metformin
Placebo
12 8 4 0
24 < 30
30 < 35
(n=1045)
(n=995)
> 35 (n=1194)
Body Mass Index (kg/m2) Portland 2011 - T2DM
The DPP Research Group, NEJM 346:393-403, 2002
9
DPP: Weight Loss and Physical Activity Placebo
Metformin
Lifestyle P 1,500 - 2,000 At least 150 mins/wk
Type (aerobic)
Resistance Frequency > 3 d/wk
Intensity
moderate
Repetitions
8-10 per exercise
Sets
> 3 sets per exercise
Type
major muscle groups: 810 exercises
Portland 2011 - T2DM
10
Association Between Insulin Sensitivity and Physical Exercise: The IRAS Study
Portland 20112011 - T2DM ACE Mtng
Portland 20112011 - T2DM ACE Mtng
11
Effect of Physical Activity on Glucose Control HbA1c % is lowered
