experimental & clinical cardiology

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1Department of Infectious Diseases, The Persian Gulf Tropical Medicine Research Centre, Bushehr. Ù§. University of Medical Sciences, Bushehr, Iran.
EXPERIMENTAL & CLINICAL CARDIOLOGY

Volume 20, Issue 5, 2014

Title: "Serum Homocysteine Levels Are Associated with Infectious Burden: the Persian Gulf Healthy Heart Study" Authors: Katayoun Vahdat, Afshin Ostovar, Fahimeh Hadavand , Mohammad Reza Pourbehi , Majid Assadi , Mohammad Reza Kalantarhormozi , Kamyar Asadipooya, Mohammad Javad Haeri , Shokrollah Farrokhi , Sina Dobaradaran and Iraj Nabipour How to reference: Serum Homocysteine Levels Are Associated with Infectious Burden: the Persian Gulf Healthy Heart Study/Katayoun Vahdat, Afshin Ostovar, Fahimeh Hadavand , Mohammad Reza Pourbehi , Majid Assadi , Mohammad Reza Kalantarhormozi , Kamyar Asadipooya, Mohammad Javad Haeri , Shokrollah Farrokhi , Sina Dobaradaran and Iraj Nabipour/Exp Clin Cardiol Vol 20 Issue5 pages 3503-3526 / 2014

Serum Homocysteine Levels Are Associated with Infectious Burden: the Persian Gulf Healthy Heart...

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Serum Homocysteine levels are associated with infectious

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burden: The Persian Gulf Healthy Heart Study

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Katayoun Vahdat, MD 1 , Afshin Ostovar , MD, MPH1, Fahimeh Hadavand, MD 1, Mohammad Reza Pourbehi , MD2 , Majid Assadi, MD3, Mohammad Reza Kalantarhormozi , MD3, Kamyar Asadipooya, MD4, Mohammad Javad Haeri, MD1, Shokrollah Farrokhi, PhD, MD5, Sina Dobaradaran, PhD5, Iraj Nabipour, MD5*

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Department of Infectious Diseases, The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran 2

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Department of Cardiovascular Diseases, The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran

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Funding: This study was supported in part by a grant from a joint Ministry of Health and World Health Organization Regional Office for the Eastern Mediterranean fund (A/C: 02.01.01.01.ACS 2002–03) and Bushehr Province Research Committee.

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Correspondence should be address to Iraj Nabipour, MD, The Persian Gulf Tropical Medicine Research Center, Boostan 19 Alley, Imam Khomeini Street, Postal Code: 7514763448, Bushehr, I.R. Iran

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Tel: +98 771 2541827

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Fax: +98 771 2541828

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E-mail: [email protected]

The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran

Department of Endocrinology, Department on Internal Medicine, Kansas University Medical Center, Kansas City, USA Department of Biochemistry, The Persian Gulf Marine Biotechnology Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran

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Exp Clin Cardiol, Volume 20, Issue 5, 2014 - Page 3503

Serum Homocysteine Levels Are Associated with Infectious Burden: the Persian Gulf Healthy Heart...

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Abstract

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Objectives: Circulating homocysteine and infectious burden are independent risk factors for

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cardiovascular disease. The infectious burden was defined as the number of infectious

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pathogens to which an individual has been exposed. The association of serum homocysteine

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levels with infectious burden has not yet demonstrated.

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Methods: Sera of 1754 participants of the Persian Gulf Healthy Heart Study were evaluated for

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total homocysteine levels and IgG antibodies to Chlamydia pneumoniae, Helicobacter pylori,

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cytomegalovirus, or herpes simplex virus type 1 using enzyme-linked immunosorbent assays.

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Results: Circulating homocysteine concentration showed significant associations with

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Chlamydia pneumonia (β=0.19, P