Experimental Renal Failure in the Rat Modulates Cardiac Na,K

Experimental Na,K-ATPase Jos#{233} Carlos Shelley

Teixeira

Renal Failure in the Rat Modulates a2 mRNA but Not Protein1’2 da

A. Grubman,

Silva,

Jr, Xiao-Jie

Nicolaos

Shi, Conrado

E. Madias,

and

A. Johns,

Ronald

Douglas

different

from

D.M. Jefferson. Departments cine, New England Medical of Physiology, Tufts University ton, MA

ouabain-binding and $ subunits.

Boston.

(J. Am.

of Pediatrics, New England University School of Medi-

MA

Soc.

Nephrol.

1994;

increased

In acute

also

were

renal

by

failure,

significantly

24 ± 5; no

a2

and

decreased

44 ± 8;

$2,

change

in the

of high-affinity

(3H)

sites, or the level of Na,K-ATPase a2 a1 mRNA and subunit levels were 44%

(0.05

respectively.