Apr 30, 2008 - Bloomberg School of Public Health and School of Medicine .... same research technologist trained in cardiac echocardiography was devoted to ...
PageArticles 1 of 55 in PresS. Am J Physiol Regul Integr Comp Physiol (April 30, 2008). doi:10.1152/ajpregu.00697.2007
Exposure to Inhaled Particulate Matter Impairs Cardiac Function in Senescent Mice Clarke G. Tankersley1, Hunter C. Champion3, Eiki Takimoto3, Kathleen Gabrielson2, Djahida Bedja2, Vikas Misra1, Hazim El-Haddad3, Richard Rabold1, Wayne Mitzner1. The Johns Hopkins University. Bloomberg School of Public Health and School of Medicine Departments of Environmental Health Sciences1, Comparative Medicine2 and Cardiology3 Baltimore, MD 21205.
Running Title: Cardiac dysfunction in aged PM-exposed mice Please address correspondences to: Clarke G. Tankersley, Ph.D. Division of Physiology Bloomberg School of Public Health The Johns Hopkins University 615 N. Wolfe St., Rm E7612 Baltimore, MD 21205
Abstract Daily exposure to particulate matter (PM) is known to adversely affect cardiac function and is also known to be exaggerated with senescence. This study tests the hypothesis that cardiac function is uniquely altered by PM exposure in senescent mice. A mechanism for PM-induced cardiac effects is also postulated by examining the activity of nitric oxide synthase (NOS) and the generation of reactive oxygen species (ROS) in heart tissue. Echocardiography is performed in awake 18- and 28-month (mos) old mice at baseline and immediately following 3-hr exposures to either filtered air (FA) or carbon black (CB; ~400 g/m3) on four days. At 28-mos, left ventricular diameter at end-systole and end-diastole is significantly (P
