4Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Brasilia, Brazil ..... Garnacho-Montero, J., T. Albado-Pallas, M. Palomar-.
American Journal of Infectious Diseases, 2012, 8 (4), 175-180
ISSN: 1553-6203 ©2012 Science Publication doi:10.3844/ajidsp.2012.175.180 Published Online 8 (4) 2012 (http://www.thescipub.com/ajid.toc)
FACTORS ASSOCIATED WITH MORTALITY AMONG PATIENTS WITH CENTRAL VENOUS CATHETER-RELATED BLOODSTREAM INFECTION IN AN INTENSIVE CARE UNIT 1
3
Priscilla Roberta Silva Rocha, 2Marcelo de Oliveira Maia, 2Gisele Brocco Magnan, Juliano Carregaro, 1,4Francisco de Assis Rocha Neves and 1,4Angelica Amorim Amato 1
Postgraduate Program in Health Sciences, Faculty of Health Sciences, University of Brasilia, Brasilia, Brazil 2 Hospital Santa Luzia, Brasilia, Brazil 3 Department of Biology, Anhanguera Faculty, Brasilia, Brazil 4 Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Brasilia, Brazil
Received 2012-08-19, Revised 2012-11-30; Accepted 2012-11-30
ABSTRACT Central venous catheterization is a common practice in the management of critically ill patients and is associated with various complications, such as Bloodstream Infections (BSI), which are major determinants of increased morbidity, mortality and healthcare expenses. Few studies have addressed factors that predict mortality in patients with this complication. The aim of this study was to investigate factors associated with mortality in patients with Central Venous Catheter (CVC)-related BSI in an intensive care unit of a tertiary care hospital in the Federal District, Brazil. This was a retrospective and observational study, in which all CVC-related BSI that occurred between January 2008 and December 2010 were reviewed. We obtained demographic, clinical, biochemical and microbiological data from medical records and investigated its association with mortality during ICU stay. There were 4,504 ICU admissions during the study period and 68 were complicated by CVC-related BSI (4.09 per 1000 catheter-days), most due to gram-negative organisms (45.6%). Overall mortality was 59.7%. Death risk was significantly associated with mechanical ventilation (OR 27.8, 95% CI 3.28-250, p
