Oct 9, 2013 - If the gut microbiota differences among AD and PDD-NOS and HC children are ... Pervasive Developmental Disorder Not Otherwise Specified .
Fecal Microbiota and Metabolome of Children with Autism and Pervasive Developmental Disorder Not Otherwise Specified Maria De Angelis1*, Maria Piccolo1, Lucia Vannini2,3, Sonya Siragusa1, Andrea De Giacomo4, Diana Isabella Serrazzanetti2, Fernanda Cristofori5, Maria Elisabetta Guerzoni3, Marco Gobbetti1, Ruggiero Francavilla5 1 Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy, 2 Inter-departmental Centre for Industrial Agri-Food Research, University of Cesena, Cesena, Italy, 3 Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy, 4 Child Neurological and Psychiatric Unit, Department of Neurological and Psychiatric Sciences, University of Bari Aldo Moro, Bari, Italy, 5 Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy
Abstract This study aimed at investigating the fecal microbiota and metabolome of children with Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and autism (AD) in comparison to healthy children (HC). Bacterial tagencoded FLX-titanium amplicon pyrosequencing (bTEFAP) of the 16S rDNA and 16S rRNA analyses were carried out to determine total bacteria (16S rDNA) and metabolically active bacteria (16S rRNA), respectively. The main bacterial phyla (Firmicutes, Bacteroidetes, Fusobacteria and Verrucomicrobia) significantly (P
