Figura de las VH

Download PDF
1 downloads 0 Views 156KB Size Report
Comment
F--SSYP. AP. YSD. YTG. Մ. < .. [1. 1. І .. AP. YTD. < .. NTG. UUTU♡.
IGHV1S10 IGHV3S3

IGHV2S7 vh ψIGHV

IGHV2S5

IG H

IGHV1S13

IGHV1S5 IGHV1S4

5S 2 IGHV

2 V4S IGH IGHV4S1 IGH V4 S3

IG H V1 S IGH V1S 3 2

vh ψIGHV IGHV3S2

11

V1 S

7 IGHV1S1 4 S V1 IGH

vh ψIGHV

IGHV4S2

V1 S

IG H

IGHV2S8

12 1S HV IG 1S 8 IGHV IGHV1S18

IG H

IGHV1S12

13 IGHV1S 9 1S HV IG

IGHV4S3 IGHV1S6

1S HV IG

6

IGHV1S11

IGHV2S6

V5 S1

1 IGHV

IGHV5S1

IGHV1S7

IGHV1S5 IG HV 1S 10

S 14

IGHV1S9 IGHV1S8

IGHV1S14

IGHV2S4

IGHV2S9

IGHV2S3

IGHV6S1

IGHV4S1

IGHV3S4

6S IGHV

IGH

IGHV6S2

IGHV1S3

V6S 1

3

ψIGHV vh

6S HV IG

ψIGHVvh

IGHV3S1

2

IGHV1S15

IGHV2S2 IGHV1S2

IGHV5S2 S5 V2 I GH IGHV2S1 IGH V2S 2

IGHV1S1

IGHV6S3

vh ψIGHV

vh ψIGHV

Zone 2

Zone 1

IGHV gene

CDR1 (29-36)

FR1 (1-28)

1 |

10 |

Zone 3

20 |

30 |

IG HV 2S

S4

vh ψIGHV

V3 IGH

IGHV5S3

6 2S HV IG 3 2S HV IGIGHV2S7 IGIGHV HV 2S 8 2S 9

IGHV2S1 vh ψIGHV

4

1 V3S IGH IGHV 3 S2 IG HV 3S 3

0.1

Zone 5

Zone 4

FR2 (37-53)

40 |

FR3 (63-100)

CDR2 (54-62)

50 |

60 |

70 |

80 |

CDR3 (101-103)

90 |

100 |

IGHV1S1 IGHV1S2 IGHV1S3 IGHV1S4 IGHV1S5 IGHV1S6 IGHV1S7 IGHV1S8 IGHV1S9 IGHV1S10 IGHV1S11 IGHV1S12 IGHV1S13 IGHV1S14 IGHV1S15

: : : : : : : : : : : : : : :

VDGQTLTESESAVKRPGESHRLTCSASGFSF--SSYR--MSWVRQAPGKGLEWIAFIYSDSSGMFYSESVKNRFTISRDNSRQQLYLQMNSLRAEDSAVYYCAR-VDGQTLTESESVVKRPGESHRLTCSASGFTF--SSYY--MGWIRQAPGKGLEWIAYIYTGSSSMYYSESVKNRFIISRDDSRQQLYLQMNSLRAEDSAVYYCAR-VDGQTLTESESEVRRPGESHRLTCSASGFTF--SSYH--MGWVRQAPGKGLEWIAYIYTDSSGIFYSESVKNRFTISRDNSRQQLYLQMNSLRAEDSAVYYCAR-VDGQTLTESESVVKRPGESHRLTCSASGFTF--SSYY--MAWVRQAPGKGLEWIAWINTGSSSMYYSESVKNRFTISRDNSRQQLYLQMNSLRAEDSAVYYCARRIRGQTLTESESVVKRPGEPHKLTCTYSGFS---GTPD--IAWIRQPAGKGLEWIAYISSGSS-IYYSESVKNRFTISRDNSRKQVYLQMNSLRAEDSAVYYCAR-IRGQTLTESESVVRRPGEPHKLTCTYSGFS---GDYW--NAWIRQPAGKGLEWIATISPDSSGIYYSESMKNRFTISRDNSRKQVYLQMNSLRAEDSAVYYCAR-VDGQTLTESESVVKRPGESHRLTCSASGFTF--SSYQ--MSWIRQAPGEGLEWIAFI--DVTSIYYSESVKNRFTISRDNSRQQLYLQMNSLRVEDSAVYYCARRIRGQTLTESESVVKSPGEPHKLTCTYSGFS---SDPY--IAWIRQAAGKGLEWIAYISSGSSSIYYSESVKNRFTISRDNSRQQVYLQMNSLRAEDSAVYYCAQ-IDGQTLIQSESVVKRPGESNRLTCSPSGIDF--SSYA--MSWIRQAPGKGLEWIAYISSGSGSIYYSESVKNRFTISRDNSRQQLYLQMNSLRAEDSAVYYCAR-IRGQTLTESESVVKRPGEPHKLTCTYSGFS---GDPS--IAWIRQPAGKGLEWIAYINSGSNYIYYSESVKNRFTISRDNGRKQVYLQMNSLRAEDSAVYYCAR-VDGQTLTESESEVKSPGESHRLTCSASGFPF--SSYR--MAWIRQAPGKGLEWIAWINTGSSSIFYSESVKNRFTISRDNSRQEVYLQMNILRAEDSAVYYCAR-TESQTLTESESAVKRPGESEKLTCTYSGFS---GVPY--IAWIRQAAGKQLEWIAYINPGSSGIYYSESVKNRFTISRDNSRKQVYLQMNSLRAEDSAVYYCAR-VDGQSLIQSKSVIKRPGESHRLTCSASGFTF--SSYG--MSWIRQAPGKGLEWIAYIY-DSSGI-YPESVKNRFTISRDNSRQQVYLQMNSLRAEDSAVYYCAR-TEGQTLTESESVVRRPGESHKLTCTYSGFS---NDYW--NAWIRQAAGKGLEWVATISHSSSYISYSESVKNRFTISRDNSRKQVYLQMNSLRAEDSAVYYCAR-ERKKALTESETVVKRPGESHKLTCTYSGFS---GDQH--IAWIRQPAGKGLEWIAYISSGSSSISYSESVKNRFTISRDNSRKQVYLQMNSLRAEDSAVYYCAR--

IGHV2S1. IGHV2S2 IGHV2S3 IGHV2S4 IGHV2S5 IGHV2S6 IGHV2S7 IGHV2S8 IGHV2S9

: : : : : : : : :

VKCEQLTQPASVSLQPGERLTITCQVSYSL----SYY--TGWIRQPAGKGLEWIGIKYTG-DSH-YKDSLKNKFSIDLDSSNNRVTLNGQNMQPEDSAVYFCARW-VKCEQLTQPASVSLQPGQSLTITCQVSYSLG---SY---TAWIRQPAGKGLEWIGMKHTG-ASY-YKDSLKNKFSIDLDSSNNRVTLNGQNMQPEDSAVYFCARR-VKCEQLTQPASVSLQPGQRLTITCQVSYSVS---SYW--TAWIRQTAGKGLEWIGMKYTG-ASY-YKDSLKNKFSIDLDSSNNRVTLNGQNMQPEDSAVYFCARVTVKCEQLTQPASESLQPGERLTITCQVSYSVS---SYY--TAWIRQPAGKGLEWIGSECVGCTKY-YKDSLKNKFSMTLDSSNKRVTLNGQNMQPEDSAVYFCARD-VKCEQLTQPDSVSLQPGERLTITCQVSYSLS---SYY--TGWIRQPAGKGLEWIGIKHTG-ASH-YKDSLKNKFSIDLDSSNKRVTLNGKNMQPEDSAVYFCARR-VKCEQLTQPDSVSLQPGQRLTITCQVSYSVS---SYW--TGWIRQPAGKGLEWIGSERVGYAKY-YKDSLKNKFSIDLDSSNNRVTLKGQNMQAEDSAVYFCARH-VKCEQLTQPASVSLQPGERLTITCQVSYSVS---SYR--TAWIRQPAGKGLEWIGMRYTG-DSY-YKDSLKNKFSIDLDSSNNRVTLNGQNMQPEDSAVYFCARE-VKCEQLTQPASVSLQPGQRLTITCQVSYSLG---YY---TAWIRQPAGKGLEWIGMRYTG-GSH-YKDSLKNKFSIDLDSSNNRVTLNGQNMQPEDSAVYFCARR-AKCEQL--PVSESLQPGERLTITCQVSYSVG---SYH--TAWIRQPAGKGLEWIGMKYTG-GSY-YKDSLKNKFSIDLDSSNNRVTLNGQNMQPEDSAVYFCARR--

IGHV3S1. IGHV3S2 IGHV3S3 IGHV3S4

: : : :

VDSIDLIQPDSKVVQTGQSLTISCQVSGYSLTDG---YATGWIRQREGKPMDWIFYQWGSSSGSFHQNDALKNKFSYSRDTSAGTVTITGQNLQPEDTAVYYCVRRVDSIDLIQPDSKVVQPGQSLNISCQVSGYSLTDGS--YATGWIRQREGKPMYWIFYQWG--GGSFYQYDALKNKFSHSRDTSAGTVTITGQNLQPEDTAVYYCVRRVDSIDLIQPDSKVVQPGQSLTISCQVSGYSLTDSTYGYATGWIRQREGKPMDWIFHIY--YDGSSNQNDALKNKISHSRDTSAGTVTITGQNLQPEDTAVYYCVRMVDSIDLIQPDSKVVQPGQSLTISCQVSGYSLTDNS--YATGWIRQREGKPMDWISHQWG--GGNFYQNDALKNKFSYSRDTSAGTVTITGQNLQPEDTAVYYCVRR-

IGHV4S1. : -----LQKIRVSLSRPGESHRLTCSASGFTF--SSYR--MSWIRQAPGKGLEWIAYISTYSDPI-YYSQSVQGRFSISRDDSSSKVYLQMNSLRMEDTAVYYCART-IGHV4S2 : VDGQTLTESESVVKRPGESHRLTCSPSGFTF--SSYG--MAWIRQAPGKGLEWIAYIGTSSSPI-SYSQSVQGRFSISRDDSCSKVYPQMNSLRMEDTAVYYCARR-IGHV4S3 : VDGQTLTESESVVKRPGESHRLTCSASGFTF--SSYG--MNWVRQAPGKGLEWIAYICTSSSPI-YYSQSVQGRFSISRDDSSSKLYLQMNSLRMEDTAVYYCARR--

IGHV5S1. : ---WSIT----AVKTPGESHRLTCTTSGFDFRG----SVWNWIRQTPGKGLEWISLVHTSSS-PIYYSESVKNRFTISRDDSSSKVYLQMSNLKAEDTAMYYCAEEIGHV5S2 : ---WSITESEAAVKTPGESHRLTCTTSGFGFRG----SVWNWIRQTHGKGLEWIALVHTSSS-PIYYSESVKNRFTIFRDDSSSKVYPQMSNLKAEDTAMYYCAEE-

IGHV6S1. : LSQIKLDQSPNVVKRPGETVKMSCVCSGFDMTD----YNIHWIRQKPGRALEWIGFMDAGNN-DPTYSSSFQNRFLMTEVVSSSSQYLEISSLTAEDSAEYFCARQIGHV6S2 : LSQIKMDQSPNVVKRPGETVKMSCVCSGFSMTS----FYIHWIRQKPGRALEWIGFMNAGSN-SPTYSSSFQDRVIMTEVVSSSSQYLEISSLTAEDSAVYFCARKIGHV6S3 : LSQIKLDQSPNVVKRRGESVKMSCVCSGFKMTE----YFIHWIRQKPGRALEWIGYMDTGKN-SPTYSSSFQGRFLMTEVVSSSSQYLEISSLTAEDSAVYFCARQ-