Figure S1. - PLOS

a HMHA-1

b PTPRC

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PB Imm Apc Mal

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Li Ki Lu Dig Hea Sk EC

c KLK2

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d GAPD

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e ITGB2

f FLT3

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g Prediction of HMHA-1 epitopes Gene: HMHA1 SNP: RH139

RefSeq mRNA seq: NM_012292.2 dbSNP ID: rs_1801284

G P * E T *G V C V A* R P P *G PP PA NRF G L E K L K E C V L R D D L L E A R R P R A L R N L R S V C C VT T S L R P AA R G ARF ARF

HMHA1 (HA-1) V V S S

L L V V

R H C C

D D C C

D D V M

L L T T

L L T T

E E S S

A A L L

S

S B

B R

R N

N

23 23 20 20

23 6 23 80 20 2 20 2

S

BS

R B

N R

N

29 29 V V

20 29 20 29 20 20

20 20

29 31

29 31

15 15 * 57 * 55 *

62 70 57 70 55

70 70

6 71 71 80 15 15 2 16131613 2 14501450

5’gagggccttgagaaacttaaggagtgtgtgttgcgtgacgacctccttgaggcccgccgcccgcgggcc 3’ 5’gagggccttgagaaacttaaggagtgtgtgttgcatgacgacctccttgaggcccgccgcccgcgggcc 3’

A L R N L R S V C C MT T S L R P AA R G G L E K L K E CV L HD D L L E A RR P R ARF G P * E T * G V C V A * R P P * G P P P A ARF

NRF

h Prediction of ITGB2 epitopes Gene: ITGB2 SNP: KE630

RefSeq mRNA seq: NM_000211.3 dbSNP ID: rs_2230531

L T LW Q V H L L R R V P E V R K G P L W NRF S P C G K Y I S C A E C L K F E K G P F G H P V A S T S P A P SA * S S K R A P L G ARF ARF

5’ccctcaccctgtggcaagtacatctcctgcgccgagtgcctgaagttcgaaaagggcccctttgggaag 3’ 5’ccctcaccctgtggcaagtacatctcctgcgccaagtgcctgaagttcgaaaagggcccctttgggaag 3’

H P V A S T S P A P SA * S S K R A P L G NRF S P C G K Y I S C A K C L K F E K G P F G ARF L T L W Q V H L L R Q V P E V R K G P L W ARF

Supplementary Figure 1

ITGB2 H H V V W W H T T

L L H H Q Q L L L

L L L L V V L W W

VR VR L L H H R Q Q

PR PQ R R L L Q V V

EV EV R Q L L V H H

VP VP V V R R P L L

E E P P R Q E L L

V V E E V V V VR VR

R K R *V Q *V

* ** **