Figure S1 - PLOS

Figure S1 STK35L1-Human STK35L1-Chimpanzee STK35L1-Cow STK35L1-Mouse STK35L1-Rat

MGHQESPLARAPAGGAAYVKRLCKGLSWREHVESHGSLGAQASPASAAAA----EGSATR MGHQESPLARAPAGGAAYVKRLCKGLSWREHVESHGSLGAQASPASAAAA----EGSATR MGHQEPPLARLRAGRAAYIKRLRKGLSWREHVESRGSPDAQLSPESTAAVTRAVAGAVAR MGHQESPLTRAAAGGAAYIKRLRKVLSWRELGDGHGNLEAEASPGSVAVITRAAPRRATR MGHQESPLTKVAAGGAAYIKRLRKVLSWRELEDSHGNLEAEASPGSAAVISGAAPRPATR

56 56 60 60 60

STK35L1-Human STK35L1-Chimpanzee STK35L1-Cow STK35L1-Mouse STK35L1-Rat

RARAATSRAARSRRQPGPGADHPQAGAPGGKRAARKWRCAGQVTIQGPAPPRPRAGRRDE RARATTSRAARSRRQPGPGADHPQAGAPGGKRAARKWRCAGQVTIQGPAPPRPRAGRRDE PTRAAASRAAPYPRQPCPGADHPQPGALGGKRAARKWKGAGQVTIQGPALPRPGAGRRDE SARLPASRPTRLCRQARLGTDHPPARAPRGNRFARKRNSAGQITIQGPAPPHLGARRRDE PTRLPASRPTRLCRQPGLGTDHPPARAPRGNRSARKRNSAGQITIQGTAPPHLRARRRDE

116 116 120 120 120

STK35L1-Human STK35L1-Chimpanzee STK35L1-Cow STK35L1-Mouse STK35L1-Rat

AGGARAAPLLLPPPPAAMETGK-DGARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDP AGGARAAPLLLPLPPAAMETGK-DGARRGTQSPERKRRSPVPRAPSTKLRPAAAAQAMDP AGGSRAAPLLLPPPPAAMETGEEDGARRGTQSPERKRRSPVPRALSAKLRPAAAAQAMDP ARGARAAPLLLPPPPAAMETGKENGARRGTKSPERKRRSPVQRVLCEKLRP--AAQAMDP AGGARAAPLLLPPPPAAMETGKENGARRRTKSPERKRRSPVQRVLCEKLRP--VAEAKDP

175 175 180 178 178

STK35L1-Human STK35L1-Chimpanzee STK35L1-Cow STK35L1-Mouse STK35L1-Rat

VAAEAPGEAFLARRRPEGGGG--SARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKI VAAEAPGEAFLARRRPEGGGG--SARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKI VAAEAPGEAYLARRRPEGGGG--SARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKI AGAEVPGEAFLARRRPDGGGGDVPARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKI AMAEVPGEAFLARRRPDGGGGDVPARPRYSLLAEIGRGSYGVVYEAVAGRSGAKVAVKKI

233 233 238 238 238

STK35L1-Human STK35L1-Chimpanzee STK35L1-Cow STK35L1-Mouse STK35L1-Rat

RCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVE RCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVE RCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVE RCDAPENVELALAEFWALTSLKRRHQNIVQFEECVLQRNGLAQRMSHGNKNSQLYLRLVE RCDAPENVELALAEFWALTSLKRRHQNIVQFEECVLQRNGLAQRMSHGNKNSQLYLRLVE

293 293 298 298 298

STK35L1-Human STK35L1-Chimpanzee STK35L1-Cow STK35L1-Mouse STK35L1-Rat

TSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHK TSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHK TSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHK TSLKGERILGYAEEPCYLWFVMEYCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHK TSLKGERILGYAEEPCYLWFVMEYCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHK

353 353 358 358 358

STK35L1-Human STK35L1-Chimpanzee STK35L1-Cow STK35L1-Mouse STK35L1-Rat

NHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLS NHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLS NHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNPDNKNVNVNKYWLS NHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLS NHIVHRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKDVNVNKYWLS

413 413 418 418 418

STK35L1-Chimpanzee STK35L1-Human STK35L1-Cow STK35L1-Mouse STK35L1-Rat

SACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEI SACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEI SACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEI SACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEI SACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEI

473 473 478 478 478

STK35L1-Human STK35L1-Chimpanzee STK35L1-Cow STK35L1-Mouse STK35L1-Rat

VPVGEALLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQVTCAA VPVGEALLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQVTCAA VPVGEALLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQVTCAA VPVGEALLENPKMELHIPQKRRTSMSEGVKQLLKDMLAANPQDRPDAFELETRMDQVTCAA VPVGEALLENPKMELHIPQKRRTSMSEGVKQLLKDMLAANPQDRPDAFELETRMDQVTCAA

534 534 539 539 539