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Figure4-Source data 2 - eLife Sciences
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Figure4-Source data 2 - eLife Sciences
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100. MK2206.
Afatinib
.
Afatinib
+MK2206. Drug Log [µM]. %. A. TP no rm aliz ed to. D. M. S. O. -2. -1. 0. 1. 0. 50. 100. MK2206.
Afatinib
.
Afatinib
+MK2206.
Figure 4-Source data 2
Combination therapy: EGFRi & AKTi P18T
P18T KRASG12D Afatinib MK2206 Afatinib+MK2206
50
0
-1
Drug Log [µM]
0
50
-1
Drug Log [µM]
-2
(n = 5/ 3/ 1)
0
-1
Drug Log [µM]
0
Dacomitinib MK2206 Dacomitinib+MK2206
50
0
1
1
(n = 4/ 2/ 1)
100
% ATP normalized to DMSO
% ATP normalized to DMSO
1
Dacomitinib MK2206 Dacomitinib+MK2206
-2
Afatinib MK2206 Afatinib+MK2206
50
0
-2
100
0
100
% ATP normalized to DMSO
% ATP normalized to DMSO
100
-2
(n = 7/ 3/ 2)
-1
Drug Log [µM]
0
1
(n = 4/ 2/ 1)
Combination therapy: EGFRi & PI3Ki P18T
P18T KRASG12D Dacomitinib BYL719 Dacomitinib+BYL719
50
0
100
% ATP normalized to DMSO
% ATP normalized to DMSO
100
-2
-1
Drug Log [µM]
0
50
0
1
Dacomitinib BYL719 Dacomitinib+BYL719
-2
(n = 7/ 2/ 2)
-1
Drug Log [µM]
0
1
(n = 4/ 1/ 1)
Combination therapy: EGFRi & MEKi & AKTi P18T
P18T KRASG12D Afatinib Selumetinib MK2206 Afatinib+Selumetinib+MK2206
50
0
-2
-1
Drug Log [µM]
0
1
(n = 5/ 8/ 3/ 1)
Afatinib
100
% ATP (normalized to DMSO)
% ATP (normalized to DMSO)
100
Selumetinib MK2206 Afatinib+Selumetinib+MK2206
50
0
-2
-1
Drug Log [µM]
0
1
(n = 4/ 6/ 2/ 1)
Combination therapy: MEKi & AKTi P18T
P18T KRASG12D
Selumetinib MK2206 Selumetinib+MK2206
50
0
-2
-
-1
0
-3
-2
Drug Log [µM]
-1
50
-2
-1
Drug Log [µM]
0
-2
-4
-1
0
Drug Log [µM]
Trametinib Log [µM] -3
-1 Trametinib MK2206 Trametinib+MK2206
50
0
1
1
(n = 6/ 2/ 2)
-2
100
% ATP normalized to DMSO
% ATP normalized to DMSO
0
1
Selumetinib MK2206 Selumetinib+MK2206
50
(n = 8/ 3/ 3)
Trametinib MK2206 Trametinib+MK2206
100
0
100
% ATP (normalized to DMSO)
% ATP (normalized to DMSO)
100
(n = 3/ 3/ 2)
-2
-1
Drug Log [µM]
0
1
(n = 2/ 2/ 1)
Combination therapy: MEKi & PI3Ki P18T
P18T KRASG12D
0
-2
-4
-1
Drug Log [µM]
Trametinib Log [µM] -3
0
-2
% ATP normalized to DMSO
-1 Trametinib BYL719 Trametinib+BYL719
100
50
0
-2
-1
Drug Log [µM]
0
1
0
1
(n = 3/ 2/ 2)
Selumetinib BYL719 Selumetinib+BYL719
50
(n = 8/ 2 / 2)
-2
-4
-1
0
Drug Log [µM]
Trametinib Log [µM] -3
-2
1
(n = 6/ 1/ 1)
-1 Trametinib BYL719 Trametinib+BYL719
100
% ATP normalized to DMSO
% ATP (normalized to DMSO)
50
100
% ATP (normalized to DMSO)
Selumetinib BYL719 Selumetinib+BYL719
100
50
0
-2
-1
Drug Log [µM]
0
1
(n = 2/ 1/ 1)
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