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Brazilian Journal of Medical and Biological Research (1998) 31: 1113-1118 Gender differences in aspirin-esterase activities ISSN 0100-879X
1113
Gender differences in the activities of aspirin-esterases in rat tissues M.A.C. Benedito
Departamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil
Abstract Correspondence M.A.C. Benedito Departamento de Psicobiologia EPM, UNIFESP Rua Botucatu, 862, 1o andar 04023-062 São Paulo, SP Brasil Fax: 55 (011) 572-5092 Research supported by FINEP and AFIP. Publication supported by FAPESP.
Received October 17, 1997 Accepted June 10, 1998
The activities of aspirin (acetylsalicylic acid)-esterases were measured in several tissues (liver, kidney, adrenal glands, brain and serum) from adult male and female Wistar rats. In males, both aspirin-esterase I (assayed at pH 5.5) and II (assayed at pH 7.4) activities were higher in liver homogenates when compared to females (aspirin-esterase I: males 48.9 ± 4.8 (N = 8) and females 29.3 ± 4.2 (N = 8) nmol of salicylic acid formed min-1 mg protein-1; aspirin-esterase II: males 41.4 ± 4.1 (N = 8) and females 26.1 ± 4.5 (N = 8) nmol of salicylic acid formed min-1 mg protein-1, P
