Glucose stimulation, medium - PLOS

2 downloads 0 Views 315KB Size Report
1.03. 3-hydroxyoctanoate. 26613. HMDB01954. 0.85. Inositol Metabolism myo-inositol ... Nicotinate and Nicotinamide. Metabolism nicotinamide. C00153. 936.
Glucose stimulation, medium Pathway

Sub Pathway

Glycine, Serine and Threonine Metabolism

Alanine and Aspartate Metabolism

Glutamate Metabolism

Histidine Metabolism Lysine Metabolism Phenylalanine Metabolism

Tyrosine Metabolism

Biochemical Name glycine betaine serine N-acetylserine threonine N-acetylthreonine alanine N-acetylalanine aspartate N-acetylaspartate (NAA) asparagine N-acetylasparagine glutamate glutamine N-acetylglutamate N-acetylglutamine pyroglutamine histidine lysine phenylalanine N-acetylphenylalanine phenylpyruvate tyrosine phenol sulfate o-Tyrosine N-formylphenylalanine

Tryptophan Metabolism

Amino Acid

Peptide

Carbohydrate

KEGG C00037 C00719 C00065 C00188 C00041 C02847 C00049 C01042 C00152 C00025 C00064 C00624 C02716 C00135 C00047 C00079 C03519 C00166 C00082 C02180

PUBCHEM

HMDB

750 247 5951 65249 6288 152204 5950 88064 5960 65065 6267 99715 611 5961 70914 182230 134508 6274 5962 6140 74839 997 6057 74426 91482 759256

HMDB00123 HMDB00043 HMDB00187 HMDB02931 HMDB00167

HMDB00929 HMDB00687 HMDB11756 HMDB00695 HMDB00678 HMDB00754 HMDB00172 HMDB03736 HMDB00883 HMDB00019 HMDB00336 HMDB00696 HMDB11745 HMDB02005 HMDB00574 HMDB00731 HMDB00192 HMDB00996 HMDB02757 HMDB00517 HMDB00294 HMDB03374 HMDB04225 HMDB00162 HMDB01539

HMDB00161 HMDB00766 HMDB00191 HMDB00812 HMDB00168 HMDB06028 HMDB00148 HMDB00641 HMDB01138 HMDB06029 HMDB00177 HMDB00182 HMDB00159 HMDB00512 HMDB00205 HMDB00158 HMDB60015 HMDB06050

tryptophan leucine N-acetylleucine 4-methyl-2-oxopentanoate isovalerylglycine Leucine, Isoleucine and Valine beta-hydroxyisovalerate Metabolism isoleucine 3-methyl-2-oxovalerate valine 3-methyl-2-oxobutyrate 3-hydroxyisobutyrate methionine N-acetylmethionine* methionine sulfoxide Methionine, Cysteine, SAM and Taurine cysteine Metabolism cysteine s-sulfate cystine cysteine sulfinic acid 3-sulfo-L-alanine arginine urea ornithine Urea cycle; Arginine and Proline 2-oxoarginine* Metabolism proline dimethylarginine (SDMA + ADMA) N-acetylproline* trans-4-hydroxyproline creatine* Creatine Metabolism creatinine

C00078 C00123 C02710 C00233

C01157 C00300 C00791

6305 6106 70912 70 546304 69362 6306 47 6287 49 87 6137 448580 158980 5862 115015 67678 109 72886 232 1176 6262 558 145742 123831 322640 5810 586 588

Guanidino and Acetamido Metabolism 4-guanidinobutanoate 5-oxoproline Glutathione Metabolism 2-hydroxybutyrate/2-hydroxyisobutyrate gamma-glutamylglutamine gamma-glutamylisoleucine Gamma-glutamyl Amino Acid gamma-glutamylleucine gamma-glutamylvaline Acetylated Peptides phenylacetylglycine glucose Glycolysis, Gluconeogenesis, and pyruvate Pyruvate Metabolism lactate glycerate ribitol Pentose Metabolism

C01035 C01879

500 7405

HMDB03464 HMDB00267

C05283

150914 14253342 151023 7015683 68144 79025 1060 612 752 6912

HMDB11738 HMDB11170 HMDB11171 HMDB11172 HMDB00821 HMDB00122 HMDB00243 HMDB00190 HMDB00139 HMDB00508

C00407 C00671 C00183 C00141 C06001 C00073 C02712 C02989 C00097 C05824 C00491 C00606 C00506 C00062 C00086 C00077 C03771 C00148 C03626

C05598 C00031 C00022 C00186 C00258 C00474

HMDB00725 HMDB00064 HMDB00562

Fold Change Glucose Control 0.96 0.92 0.96 1.04 0.91 1.16 0.96 1.15 0.93 1.09 0.93 1.69 0.96 0.97 1.57 1.21 0.98 0.93 0.91 0.95 1.37 0.62 0.92 1.08 1.06 0.98 0.94 0.96 1.10 0.66 1.03 0.65 0.98 0.63 0.93 0.73 0.70 0.93 1.00 1.43 0.90 0.96 1.00 1.61 1.00 0.97 0.40 0.91 1.00 0.95 0.94 1.00 1.43 1.00 1.02 0.55 0.93 1.09 0.90 0.78 0.93 0.93 0.96 1922.07 1.42 0.94 1.15 1.01

Pentose Metabolism Carbohydrate Glycogen Metabolism Fructose, Mannose and Galactose Metabolism Aminosugar Metabolism

Energy

TCA Cycle

Oxidative Phosphorylation Medium Chain Fatty Acid Long Chain Fatty Acid Polyunsaturated Fatty Acid (n3 and n6)

Fatty Acid, Dicarboxylate Lipid Fatty Acid, Monohydroxy Inositol Metabolism Phospholipid Metabolism Phosphatidylcholine (PC) Glycerolipid Metabolism Mevalonate Metabolism Purine Metabolism, (Hypo)Xanthine/Inosine containing

ribonate arabonate/xylonate maltose fructose mannitol/sorbitol mannose erythronate N-acetylglucosamine/N-acetylgalactosamine citrate aconitate [cis or trans] alpha-ketoglutarate succinate fumarate malate phosphate caproate (6:0) heptanoate (7:0) caprylate (8:0) erucate (22:1n9)

C01685

5460677

HMDB00867

C00208 C00095 C00794 C00159

C00158

10991489 5984 5780 18950 2781043 24139 311

HMDB00163 HMDB00660 HMDB00247 HMDB00169 HMDB00613 HMDB00215 HMDB00094

C00026 C00042 C00122 C00149 C00009 C01585 C17714 C06423 C08316

51 1110 444972 525 1061 8892 8094 379 5281116

HMDB00208 HMDB00254 HMDB00134 HMDB00156 HMDB01429 HMDB00535 HMDB00666 HMDB00482 HMDB02068

linolenate [alpha or gamma; (18:3n3 or 6)] glutarate (pentanedioate) 2-hydroxyglutarate maleate azelate (nonanedioate) 3-hydroxyhexanoate 3-hydroxyoctanoate myo-inositol choline choline phosphate* 1-palmitoyl-2-oleoyl-GPC (16:0/18:1) glycerol* glycerophosphoglycerol 3-hydroxy-3-methylglutarate inosine hypoxanthine xanthine

C06426 C00489 C02630 C01384 C08261

HMDB03073 HMDB00661 HMDB00606 HMDB00176 HMDB00784

C00116 C03274 C03761 C00294 C00262 C00385

5280934 743 43 444266 2266 151492 26613 892 305 1014 6436017 753 439964 1662 6021 790 1188

HMDB00355 HMDB00195 HMDB00157 HMDB00292

0.76 1.05 0.81 0.94 0.94 1.03 0.85 2.84 0.94 1.00 0.92 1.00 1.01 0.82 1.50 0.77 0.70

C00147

190

HMDB00034

0.72

guanine

C00242

764

HMDB00132

0.47

orotate uridine pseudouridine 2'-deoxyuridine* cytidine 2'-deoxycytidine

C00295 C00299 C02067 C00526 C00475 C00881

967 6029 15047 13712 6175 13711

HMDB00226 HMDB00296 HMDB00767 HMDB00012 HMDB00089 HMDB00014

1.11 1.56 0.83 1.00 1.00 1.49

thymidine

C00214

5789

HMDB00273

0.90

nicotinamide pantothenate threonate gulonate* alpha-tocopherol benzoate p-cresol sulfate maltol gluconate erythritol* stachydrine streptomycin penicillin G salicylate sulfate HEPES phenol red thioproline

C00153 C00864 C01620 C00257 C02477 C00180

936 6613 151152 9794176 14985 243 4615423 8369 10690 222285 115244 5999 5904 338 1118 23831 4766 93176

HMDB01406 HMDB00210 HMDB00943 HMDB03290 HMDB01893 HMDB01870 HMDB11635 HMDB30776 HMDB00625 HMDB02994 HMDB04827

0.77 1.10 0.63 1.00 0.80 1.21 0.89 1.05 1.97 1.00 0.71 0.80 0.09 1.07 1.00 1.05 0.92 1.13

Purine Metabolism, Adenine containing adenine Purine Metabolism, Guanine containing Nucleotide

Pyrimidine Metabolism, Orotate containing Pyrimidine Metabolism, Uracil containing Pyrimidine Metabolism, Cytidine containing Pyrimidine Metabolism, Thymine containing Nicotinate and Nicotinamide Metabolism Pantothenate and CoA Metabolism Ascorbate and Aldarate Metabolism Tocopherol Metabolism Benzoate Metabolism

Food Component/Plant

Drug

Chemical

C00137 C00114 C00588

C11918 C00257 C00503 C10172 C05551 C00805 C00059 C12600

HMDB01954 HMDB00211 HMDB00097 HMDB01565 HMDB07972 HMDB00131

HMDB15186 HMDB01895 HMDB01448

2.46 2.48 1.10 97.73 5.83 1.82 1.48 0.63 0.71 0.96 1.13 0.68 1.05 1.25 1.04 1.52 0.76 0.98 0.84