Glycaemic Profiles of Children With Overweight and

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Aug 18, 2016 -
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received: 27 January 2016 accepted: 28 July 2016 Published: 18 August 2016

Glycaemic Profiles of Children With Overweight and Obesity in Freeliving Conditions in Association With Cardiometabolic Risk Jesse Rijks1,2, Kylie Karnebeek1,2, Jan-Willem van Dijk3, Elke Dorenbos1,2, Willem-Jan Gerver1,2, Pauline Stouthart1, Jogchum Plat2,4 & Anita Vreugdenhil1,2 Insulin resistance is common among children with overweight and obesity. However, knowledge about glucose fluctuations in these children is scarce. This study aims to evaluate glycaemic profiles in children with overweight and obesity in free-living conditions, and to examine the association between glycaemic profiles with insulin resistance and cardiovascular risk parameters. One hundred eleven children with overweight and obesity were included. 48-hour sensor glucose concentrations in freeliving conditions, fasting plasma and post-glucose load concentrations, serum lipid and lipoprotein concentrations, homeostatic model assessment of insulin resistance (HOMA-IR), and blood pressure were evaluated. Hyperglycaemic glucose excursions (≥7.8 mmol/L) were observed in 25% (n = 28) of the children. The median sensor glucose concentration was 5.0 (2.7–7.3) mmol/L, and correlated with fasting plasma glucose concentrations (rs = 0.190, p = 0.046), serum insulin concentrations (rs = 0.218, p = 0.021), and HOMA-IR (rs = 0.230, p = 0.015). The hyperglycaemic area under the curve (AUC) correlated with waist circumference z-score (rs = 0.455, p = 0.025), triacylglycerol concentrations (rs = 0.425, p = 0.024), and HOMA-IR (rs = 0.616, p