GOBLET CELL HYPERPLASIA REQUIRES HIGH BICARBONATE ...

Supplementary Material

GOBLET CELL HYPERPLASIA REQUIRES HIGH BICARBONATE TRANSPORT TO SUPPORT MUCIN RELEASE

Giulia Gorrieri, Paolo Scudieri, Emanuela Caci, Marco Schiavon, Valeria Tomati, Francesco Sirci, Francesco Napolitano, Diego Carrella, Ambra Gianotti, Ilaria Musante, Maria Favia, Valeria Casavola, Lorenzo Guerra, Federico Rea, Roberto Ravazzolo, Diego Di Bernardo, Luis J.V. Galietta

Supplementary Figure 1. Detection of CFTR and TMEM16A. The figure shows full-length western blots from the experiments presented in Figure 1.

2

Supplementary Figure 2. Detection of proteins upregulated by IL-4. Representative confocal microscope images reporting localization and extent of expression of TMEM16A, SLC26A4, CA2, SLC12A2, and ATP12A in control and IL-4 treated cells. Where indicated, expression of cilia (tubulin) and MUC5AC is also shown. Images are of larger size (scale bar: 50 µm) with respect to those shown in Fig. 3. It should be noted that confocal SLC12A2 images were taken at a height closer to basal side. Therefore, MUC5AC, which is more localized towards the apical pole of cells, is less visible. 3

Supplementary Figure 3. Upregulation of SLC26A4 and carbonic anhydrase 2. Images show representative western blots to detect expression of SLC26A4 (pendrin), carbonic anhydrase 2 (CA2), and GAPDH in cells (BE37) treated with and without IL-4 for 72 hrs. The results are representative of three similar experiments.

4

Supplementary Figure 4. Pharmacological inhibition of anion transport. (A) Representative trace showing additive effects caused by sequential addition of bumetanide, S0859, and acetazolamited on cells treated with IL-4 for 72 hrs. (B) Summary of inhibition caused by pharmacological modulators on CFTR-dependent secretion. Data are reported as % inhibition of total CFTR-dependent current. ***, p < 0.001 (n = 8; BE37 cells). (C) Summary of inhibition caused by pharmacological modulators on Ca2+-activated secretion. Data are reported as the peak of UTP-dependent current measured in the various conditions. *, p < 0.05; **, p < 0.01; ***, p < 0.001 (n = 8; BE37 cells). (D) Pharmacological analysis of CFTR-dependent secretion. Prior addition of CFTRinh-172 prevents the activation by CPT-cAMP and eliminates the inhibitory response to bumetanide, S0859, and acetazolamide. As shown in the inset, the transient activation elicited by S0859 was strongly inhibited by CaCCinh-A01.

5

Supplementary Figure 5. Goblet cell hyperplasia in submerged cells. Representative images (three images per condition) showing detection of cilia (magenta) and MUC5AC (red) in cultured bronchial epithelia kept under air-liquid condition or after addition of fluid (150 µl) on the apical side (submerged condition) for 48 hours. As previously described (ref. 14), IL-4 (72 hours) markedly reduces the number of ciliated cells and increases the number of goblet cells. Scale bar: 50 µm.

6

Supplementary Figure 6. Electrogenic amino acid transport. (A,B) Representative traces and bar graphs showing the dose-dependent increase in transepithelial current induced by apical application of lysine (A) or arginine (B). Experiments were done in the presence of amiloride (10 µM) and CFTRinh-172 (10 µM). **, p < 0.01 vs untreated cells (n = 3; BE37 cells).

7

Supplementary Table 1 6 hours treatment with IL‐4 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48

id_chip 210809_s_at 209301_at 220622_at 206026_s_at 206172_at 206432_at 206932_at 206262_at 207328_at 210001_s_at 203913_s_at 219764_at 211478_s_at 211548_s_at 206529_x_at 218804_at 203914_x_at 206025_s_at 205630_at 203717_at 211549_s_at 219564_at 214981_at 219334_s_at 208350_at 212942_s_at 204614_at 203434_s_at 221223_x_at 208605_s_at 219728_at 214539_at 204463_s_at 205880_at 219508_at 219531_at 202237_at 206070_s_at 209267_s_at 213880_at 219619_at 207820_at 207414_s_at 212909_at 203716_s_at 205466_s_at 219142_at 219869_s_at

entrez_gene POSTN CA2 LRRC31 TNFAIP6 IL13RA2 HAS2 CH25H ADH1C ALOX15 SOCS1 HPGD FZD10 DPP4 HPGD SLC26A4 ANO1 HPGD TNFAIP6 CRH DPP4 HPGD KCNJ16 POSTN OBFC2A CSN1S1 KIAA1199 SERPINB2 MME CISH NTRK1 MYOT SERPINB10 EDNRA PRKD1 GCNT3 CEP72 NNMT EPHA3 SLC39A8 LGR5 DIRAS2 ADH1A PCSK6 LYPD1 DPP4 HS3ST1 RASL11B SLC39A8

signed_ratio 53.13546009 27.11271383 25.12822349 14.29279637 13.20023991 13.1506566 12.36677254 11.72963485 10.642624 9.644127879 8.226463946 8.193579896 8.077645423 7.961116887 7.836767172 7.703179252 7.564008879 7.2873543 7.082005871 6.571797411 6.350015926 6.006725542 5.9506005 5.758603472 5.570472478 5.547756014 5.523381276 5.500197391 5.428768459 5.270939949 5.089773063 4.909537478 4.831141201 4.559101436 4.435722502 4.426988021 4.425032085 4.3790527 4.327213482 4.317519946 4.215626724 4.112738819 4.070948248 3.929813815 3.895226585 3.855214447 3.854061666 3.800009409

FDR 4.67301E-05 6.79594E-06 3.09575E-06 0.000494296 4.28889E-05 3.54774E-06 2.72265E-06 1.39746E-06 9.71102E-05 1.11438E-05 1.70158E-05 6.24785E-06 3.59425E-06 9.11163E-06 0.001414337 2.75805E-05 1.19641E-05 0.000634773 0.005483914 5.72509E-05 0.000185858 0.002377799 0.052571872 4.66015E-05 0.020323331 2.14352E-05 9.47168E-05 0.000278061 4.00736E-06 0.000140256 2.35105E-05 7.68583E-06 8.1754E-05 0.000287812 3.91045E-05 5.82603E-06 0.000246407 0.006955423 6.20622E-06 0.000522132 0.000165577 0.000848415 2.71858E-06 1.0178E-05 5.24077E-05 1.45083E-06 5.20735E-05 0.00022389

49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101

204464_s_at 220745_at 205952_at 212741_at 209340_at 204388_s_at 202238_s_at 204389_at 220192_x_at 206382_s_at 210118_s_at 57588_at 204121_at 209955_s_at 214404_x_at 201925_s_at 205818_at 219090_at 216504_s_at 217523_at 203650_at 206942_s_at 219648_at 206343_s_at 219734_at 212158_at 204491_at 205206_at 203980_at 218510_x_at 213106_at 213441_x_at 218532_s_at 209606_at 216005_at 203435_s_at 210139_s_at 211906_s_at 212944_at 216258_s_at 204041_at 210314_x_at 220317_at 205876_at 213164_at 204337_at 220780_at 213107_at 219987_at 205579_at 202207_at 211361_s_at 206060_s_at

EDNRA 3.779092898 IL19 3.700480982 KCNK3 3.69971649 MAOA 3.688926012 UAP1 3.678817285 MAOA 3.590477402 NNMT 3.509244098 MAOA 3.451533088 SPDEF 3.359506613 BDNF 3.312749282 IL1A 3.28418073 SLC24A3 3.284100752 GADD45G 3.250189281 FAP 3.206492161 SPDEF 3.174037107 CD55 3.162111965 DBC1 3.093278912 SLC24A3 2.96807723 SLC39A8 2.919161387 CD44 2.916843736 PROCR 2.864718703 PMCH 2.816307465 MREG 2.79547826 NRG1 2.789565343 SIDT1 2.751450073 SDC2 2.723960177 PDE4D 2.718956238 KAL1 2.710081008 FABP4 2.690086471 FAM134B 2.685441219 ATP8A1 2.658903316 SPDEF 2.629474787 FAM134B 2.60155365 CYTIP 2.588530058 TNC 2.574417093 MME 2.548051711 PMP22 2.546510619 SERPINB4 2.500861062 SLC5A3 2.49057321 SERPINB13 2.489570555 MAOB 2.476538916 TNFSF13 2.466448329 LRAT 2.459072449 LIFR 2.450664579 SLC5A3 2.447468976 RGS4 2.442296967 PLA2G3 2.441548438 TNIK 2.436115395 LOC100288413 2.432573152 HRH1 2.385179778 ARL4C 2.37368889 SERPINB13 2.362894918 PTPN22 2.347521467

4.20919E-06 5.69463E-05 0.007071631 1.0063E-05 3.02218E-06 4.29753E-05 7.35174E-05 0.000148257 7.49175E-06 0.000617586 4.99825E-06 0.000116209 0.003917743 0.001318688 1.05816E-05 4.75228E-06 4.20145E-05 5.73062E-05 0.000115865 3.24076E-05 0.000120812 6.85833E-05 6.62305E-05 3.6386E-05 2.07555E-05 0.000204235 5.30891E-05 5.16923E-05 0.003049933 0.003473052 7.46147E-05 6.78308E-05 0.000904523 0.003082736 0.000165949 0.001308149 0.000475381 0.000165821 1.77842E-05 0.000387256 0.000933419 3.35144E-05 0.001215036 0.000481694 2.37603E-05 0.013880341 0.000896027 2.66977E-05 0.001043184 4.31506E-05 2.99587E-05 0.000312444 0.001384574

102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154

207526_s_at 219836_at 214787_at 206756_at 211362_s_at 215446_s_at 205185_at 206135_at 202437_s_at 205381_at 205190_at 220260_at 209500_x_at 205214_at 218935_at 219727_at 205027_s_at 211828_s_at 202134_s_at 202037_s_at 201109_s_at 205590_at 202206_at 209499_x_at 209930_s_at 202436_s_at 203560_at 220049_s_at 217272_s_at 205969_at 211495_x_at 220266_s_at 218854_at 213721_at 218943_s_at 203058_s_at 212192_at 202435_s_at 203060_s_at 212154_at 209747_at 214068_at 201926_s_at 204341_at 221011_s_at 205267_at 202208_s_at 212188_at 203821_at 221841_s_at 218886_at 216235_s_at 46323_at

IL1RL1 2.344758174 ZBED2 2.344017493 DENND4A 2.340657672 CHST7 2.338029298 SERPINB13 2.330005559 LOX 2.299547841 SPINK5 2.29912994 ST18 2.29765354 CYP1B1 2.296632557 LRRC17 2.287645633 PLS1 2.284632377 TBC1D19 2.269508616 TNFSF12-TNFSF13 2.263152142 STK17B 2.262695173 EHD3 2.261245252 DUOX2 2.256052061 MAP3K8 2.25215713 TNIK 2.252123483 WWTR1 2.250308068 SFRP1 2.236288742 THBS1 2.231682274 RASGRP1 2.208311046 ARL4C 2.202447875 TNFSF12-TNFSF13 2.20148989 NFE2 2.190665072 CYP1B1 2.188575063 GGH 2.16342202 PDCD1LG2 2.161550953 SERPINB13 2.155850893 AADAC 2.152793425 TNFSF12-TNFSF13 2.136928034 KLF4 2.134662387 DSE 2.125594831 SOX2 2.11584369 DDX58 2.110981483 PAPSS2 2.110270059 KCTD12 2.10761437 CYP1B1 2.103984806 PAPSS2 2.096505979 SDC2 2.092843033 TGFB3 2.088957027 BEAN1 2.084457426 CD55 2.078613862 TRIM16 2.070566616 LBH 2.052539574 POU2AF1 2.048360972 ARL4C 2.047481021 KCTD12 2.038031919 HBEGF 2.035040787 KLF4 2.032793143 PAK1IP1 2.032062896 EDNRA 2.029128636 CANT1 2.028805811

0.004186207 5.70911E-05 4.73787E-05 0.00010757 0.000237464 2.97065E-05 0.008084906 0.002196061 0.016264795 0.000353853 1.71895E-05 5.15701E-05 2.77678E-05 0.001005117 0.000218586 6.83992E-05 0.001747947 0.00038298 0.002844638 0.000598974 0.00105969 0.015763959 9.44575E-05 7.06438E-05 0.000510352 0.009261461 0.000809138 0.003049266 0.000507756 0.002251521 0.00022948 0.001359804 0.000237399 9.86753E-05 0.033983277 0.000295924 0.000627363 0.004599292 9.31757E-05 0.000357159 9.43863E-05 0.001007102 0.000319209 0.000254845 0.000349178 0.00035861 0.000404643 0.00035382 0.000181377 0.001332142 0.000128839 0.003518849 0.000413163

155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200

204126_s_at 213172_at 205465_x_at 205501_at 203759_at 205180_s_at 211020_at 215719_x_at 38037_at 204404_at 214014_at 205192_at 210553_x_at 209602_s_at 213109_at 212976_at 221732_at 204298_s_at 207455_at 220948_s_at 204475_at 220121_at 205532_s_at 205533_s_at 201981_at 212565_at 202079_s_at 204352_at 204589_at 204818_at 220658_s_at 205273_s_at 206354_at 216598_s_at 212196_at 204863_s_at 202236_s_at 219630_at 214621_at 218684_at 216252_x_at 36564_at 209604_s_at 212572_at 205042_at 221840_at

CDC45 TTC9 HS3ST1 PDE10A ST3GAL4 ADAM8 GCNT2 FAS HBEGF SLC12A2 CDC42EP2 MAP3K14 PCSK6 GATA3 TNIK LRRC8B CANT1 LOX P2RY1 ATP1A1 MMP1 LINS CDH6 CDH6 PAPPA STK38L TRAK1 TRAF5 NUAK1 HSD17B2 ARNTL2 PITRM1 SLCO1B3 CCL2 IL6ST IL6ST SLC16A1 PDZK1IP1 GYS2 LRRC8D FAS RNF19B GATA3 STK38L GNE PTPRE

2.018608066 2.016220702 2.009392356 2.00526763 1.99043285 1.987845964 1.97442318 1.971712468 1.968956581 1.968102483 1.966583321 1.966041959 1.963798724 1.960854472 1.95999037 1.95405778 1.953830581 1.950243495 1.947607843 1.947304705 1.93779331 1.92698651 1.922591909 1.920406659 1.900789746 1.900705741 1.893236118 1.887408512 1.886893182 1.886718489 1.869846618 1.869129034 1.857204873 1.856608727 1.856275409 1.85531555 1.849820919 1.843796072 1.842285306 1.83948326 1.832607812 1.8324646 1.832281347 1.830818099 1.830118855 1.823111148

0.002161849 8.16867E-05 0.000724332 0.010829266 0.000808584 0.000876112 0.000974734 0.001200084 0.000917207 0.00031212 0.000253966 0.002591454 0.001195554 0.00805965 0.000839542 0.006938914 9.72993E-05 0.00036819 0.003790792 2.24174E-05 0.003281271 0.011540939 0.000417624 0.000575025 0.001234766 0.001528836 0.002001585 0.001787432 0.001003659 0.000715481 0.000328468 0.000270684 0.003011714 0.026081674 0.00015214 0.001415216 0.000713667 0.000218293 0.002549529 0.000185949 0.003920129 0.00100931 0.000617147 0.004095531 0.000460277 0.00142337


id_chip 210809_s_at 209301_at 207328_at 220622_at 206932_at 211478_s_at 206172_at 206262_at 214539_at 206529_x_at 208605_s_at 208350_at 203717_at 203716_s_at 203913_s_at 219764_at 218804_at 206343_s_at 205630_at 211548_s_at 203914_x_at 203434_s_at 211549_s_at 209267_s_at 218585_s_at 206432_at 219334_s_at 219564_at 212942_s_at 219869_s_at 210001_s_at 219619_at 205034_at 206382_s_at 219728_at 209955_s_at 204614_at 219142_at 221223_x_at 219508_at 211122_s_at 206026_s_at 209773_s_at 209340_at 206942_s_at 204464_s_at 216504_s_at 203153_at

entrez_gene POSTN CA2 ALOX15 LRRC31 CH25H DPP4 IL13RA2 ADH1C SERPINB10 SLC26A4 NTRK1 CSN1S1 DPP4 DPP4 HPGD FZD10 ANO1 NRG1 CRH HPGD HPGD MME HPGD SLC39A8 DTL HAS2 OBFC2A KCNJ16 KIAA1199 SLC39A8 SOCS1 DIRAS2 CCNE2 BDNF MYOT FAP SERPINB2 RASL11B CISH GCNT3 CXCL11 TNFAIP6 RRM2 UAP1 PMCH EDNRA SLC39A8 IFIT1

signed_ratio 161.7079419 25.50883151 25.49549221 25.41418488 18.70160447 16.5750696 15.48827622 14.67205061 14.22621466 12.49880914 12.06883776 11.95164317 11.58120395 10.00833935 9.447743228 9.409627848 9.005955725 8.677864748 8.129608516 7.897305959 7.817075163 7.664059345 7.617036182 7.520316485 7.163272666 7.062890991 6.470853177 6.317757775 6.200055931 6.160263443 5.926521388 5.56085629 5.438308216 5.38541114 5.270847294 4.960418332 4.918603494 4.899128842 4.862075814 4.802656709 4.788108872 4.665152741 4.51061735 4.505040088 4.492824871 4.449098938 4.438677715 4.400353

FDR 0.000206453 7.36537E-06 0.000122393 8.86395E-07 1.13191E-05 1.00565E-06 6.1581E-05 0.000277224 8.77264E-07 0.002983057 1.62213E-05 0.000756751 6.99255E-06 1.39756E-05 7.16489E-07 8.98365E-07 9.65086E-05 2.5985E-06 0.001464871 9.80942E-07 2.22559E-06 2.40319E-06 1.72399E-06 8.18253E-07 0.017605138 0.002320864 1.82168E-05 8.52851E-06 5.48171E-05 5.59933E-06 2.6913E-06 0.000413092 0.002901046 1.09659E-05 1.65032E-06 0.000122292 1.13703E-06 5.39046E-05 1.75875E-06 0.000182938 0.470407367 0.000738067 0.176059455 4.1758E-06 0.000128434 4.37352E-05 0.000114179 0.162730072

49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101

210521_s_at 57588_at 212909_at 204463_s_at 219090_at 214981_at 201890_at 219836_at 203650_at 202237_at 205466_s_at 203435_s_at 212158_at 203980_at 212154_at 211906_s_at 204121_at 210163_at 204388_s_at 206354_at 204389_at 220192_x_at 219531_at 206070_s_at 220780_at 219727_at 220651_s_at 220745_at 216258_s_at 205969_at 207414_s_at 203290_at 203560_at 204415_at 201925_s_at 210314_x_at 202411_at 209606_at 214404_x_at 205880_at 209500_x_at 207820_at 204491_at 209499_x_at 212741_at 205818_at 210118_s_at 207367_at 213441_x_at 206835_at 205952_at 203967_at 205190_at

FETUB 4.398125222 SLC24A3 4.321759217 LYPD1 4.234099855 EDNRA 4.16812373 SLC24A3 4.16783532 POSTN 4.149640933 RRM2 4.067560207 ZBED2 4.016580278 PROCR 3.984136988 NNMT 3.981625022 HS3ST1 3.906747859 MME 3.885947304 SDC2 3.811571209 FABP4 3.789928479 SDC2 3.738142919 SERPINB4 3.720461863 GADD45G 3.547201879 CXCL11 3.499037409 MAOA 3.472312534 SLCO1B3 3.437770141 MAOA 3.428348534 SPDEF 3.42098703 CEP72 3.381531004 EPHA3 3.379188946 PLA2G3 3.36346336 DUOX2 3.341836425 MCM10 3.331924083 IL19 3.313021148 SERPINB13 3.283144668 AADAC 3.275656122 PCSK6 3.257355057 HLA-DQA1 3.226034423 GGH 3.217168197 IFI6 3.213167001 CD55 3.199792263 TNFSF13 3.138444808 IFI27 3.113120803 CYTIP 3.108183862 SPDEF 3.105399242 PRKD1 3.056285968 TNFSF12-TNFSF13 3.03893323 ADH1A 3.032142864 PDE4D 2.99620754 TNFSF12-TNFSF13 2.980894376 MAOA 2.969838475 DBC1 2.954596008 IL1A 2.923701424 ATP12A 2.919893729 SPDEF 2.902932526 STATH 2.895595633 KCNK3 2.887356096 CDC6 2.882434933 PLS1 2.882370735

9.48071E-05 0.000122486 7.9953E-05 4.8487E-06 0.000113182 7.28569E-05 0.117262696 6.18568E-05 0.000347102 5.12537E-05 2.38397E-05 3.34547E-05 0.000358237 0.206789748 0.002018764 1.13059E-05 0.000306764 0.382500119 3.75327E-05 1.0709E-05 8.95547E-05 3.81324E-05 1.48001E-05 0.002784962 0.001576505 0.000851814 0.012730563 0.000269422 7.8153E-06 1.59258E-05 4.75976E-06 0.387987776 7.7579E-06 0.081177454 0.000104582 6.1835E-05 0.006612317 0.001205805 3.25898E-05 0.000162333 7.2452E-05 0.000102693 0.000944034 6.85609E-05 0.00048956 5.47073E-05 3.19953E-05 0.02864551 0.000117774 0.000101467 0.014837513 0.000305282 5.98085E-06

102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154

213721_at 206025_s_at 207526_s_at 217523_at 202037_s_at 214068_at 205381_at 219795_at 208126_s_at 213975_s_at 219148_at 211495_x_at 202238_s_at 218532_s_at 211362_s_at 219493_at 206693_at 211990_at 215103_at 204529_s_at 218935_at 201292_at 201627_s_at 205206_at 204114_at 218943_s_at 204126_s_at 210559_s_at 201291_s_at 214787_at 204146_at 204404_at 209875_s_at 211991_s_at 205860_x_at 211814_s_at 218510_x_at 208510_s_at 201626_at 220658_s_at 221011_s_at 218681_s_at 213537_at 203968_s_at 205890_s_at 204341_at 220133_at 203213_at 205533_s_at 214452_at 205027_s_at 201926_s_at 211361_s_at

SOX2 2.858229791 TNFAIP6 2.850368205 IL1RL1 2.827084015 CD44 2.80574532 SFRP1 2.770540882 BEAN1 2.738790847 LRRC17 2.669087286 SLC6A14 2.649377806 CYP2C18 2.633622833 LYZ 2.632619712 PBK 2.621361335 TNFSF12-TNFSF13 2.62107117 NNMT 2.618271367 FAM134B 2.609287825 SERPINB13 2.597469714 SHCBP1 2.59698135 IL7 2.588525601 HLA-DPA1 2.583359434 CYP2C18 2.579022754 TOX 2.571926335 EHD3 2.567741236 TOP2A 2.545320154 INSIG1 2.544174609 KAL1 2.523125912 NID2 2.516635305 DDX58 2.490410361 CDC45 2.483266858 CDK1 2.477435395 TOP2A 2.469110325 DENND4A 2.458303329 RAD51AP1 2.458272122 SLC12A2 2.452242786 SPP1 2.447669787 HLA-DPA1 2.426772175 FOLH1 2.420867047 CCNE2 2.420428263 FAM134B 2.415554296 PPARG 2.414240139 INSIG1 2.41167118 ARNTL2 2.408466978 LBH 2.406530253 SDF2L1 2.406114295 HLA-DPA1 2.396351222 CDC6 2.388439541 GABBR1 2.385552752 TRIM16 2.381883356 ODAM 2.376787091 CDK1 2.375308974 CDH6 2.356781701 BCAT1 2.350893367 MAP3K8 2.347893654 CD55 2.344559413 SERPINB13 2.335292033

0.000329112 0.004137169 0.080052266 7.76121E-05 4.34097E-05 0.001311452 8.30964E-05 5.99406E-06 0.0016167 0.011885234 0.034309666 0.000166006 9.13006E-05 8.31529E-05 5.18141E-05 8.16044E-05 0.000828554 0.175087779 0.000674826 0.007264702 0.000357964 0.300800504 0.016397748 0.000164071 0.000674782 0.000358151 3.59535E-05 0.063935322 0.339559333 5.09484E-05 0.000550238 0.00027305 0.006907511 0.230945521 0.000544956 0.000340266 0.00011102 9.04041E-05 0.012104875 6.11199E-05 0.001851363 2.7477E-05 0.065467074 0.000127135 6.19799E-05 0.000321848 0.003977367 0.100889117 0.000100129 0.000722237 6.2341E-05 0.001724002 1.99366E-05

155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200

205185_at 204929_s_at 220260_at 205909_at 206756_at 221841_s_at 209930_s_at 221060_s_at 202206_at 219429_at 213880_at 218886_at 205532_s_at 212157_at 219987_at 205968_at 205084_at 215363_x_at 217272_s_at 213107_at 219684_at 210602_s_at 219983_at 221521_s_at 205214_at 202207_at 210004_at 219258_at 205024_s_at 220266_s_at 204475_at 218662_s_at 200973_s_at 220049_s_at 213106_at 201625_s_at 205590_at 202201_at 220446_s_at 207165_at 205042_at 201930_at 204026_s_at 206391_at 205379_at 210305_at

SPINK5 2.324107842 VAMP5 2.320156295 TBC1D19 2.312188166 POLE2 2.309748163 CHST7 2.307332181 KLF4 2.30586912 NFE2 2.303072653 TLR4 2.291814488 ARL4C 2.289964504 FA2H 2.288235764 LGR5 2.285696061 PAK1IP1 2.284179058 CDH6 2.281858323 SDC2 2.281133039 LOC100288413 2.278751327 KCNS3 2.272206765 BCAP29 2.272102359 FOLH1 2.261366504 SERPINB13 2.257377696 TNIK 2.251211644 RTP4 2.248358218 CDH6 2.227793486 HRASLS 2.226961662 GINS2 2.222220289 STK17B 2.221947032 ARL4C 2.219010557 OLR1 2.212261909 TIPIN 2.209542565 RAD51 2.207455643 KLF4 2.202944459 MMP1 2.201500086 NCAPG 2.193717688 TSPAN3 2.189822947 PDCD1LG2 2.183699097 ATP8A1 2.182901746 INSIG1 2.181512972 RASGRP1 2.180776933 BLVRB 2.176753572 CHST4 2.171464692 HMMR 2.167799725 GNE 2.163037025 MCM6 2.162061748 ZWINT 2.152593352 RARRES1 2.143550479 CBR3 2.140465097 PDE4DIP 2.126649713

7.21273E-05 4.40018E-05 3.82029E-05 0.004376949 0.000100828 0.000211269 0.000336319 0.000305001 9.11182E-05 0.0018171 0.001607956 5.37115E-05 0.000203289 0.000743492 0.000127961 0.000548448 0.000102439 0.000913182 1.06642E-05 8.3084E-05 0.001174673 0.000421133 0.000133836 0.006125894 7.24652E-05 4.80756E-05 0.000220168 0.000205964 0.028853779 0.000300815 0.002604205 0.042421899 7.82843E-05 0.000229513 0.000195759 0.063748474 0.002018919 8.17424E-05 0.003629351 0.111889238 0.000203385 0.002087467 0.000908423 0.000228216 0.00027992 0.000217902


id_chip 210809_s_at 220622_at 214539_at 210521_s_at 211478_s_at 209301_at 218804_at 206932_at 207328_at 203717_at 206529_x_at 203716_s_at 206343_s_at 206432_at 208605_s_at 203434_s_at 206942_s_at 203913_s_at 211548_s_at 204614_at 203914_x_at 211549_s_at 209267_s_at 219869_s_at 219764_at 205860_x_at 206382_s_at 203650_at 215363_x_at 219564_at 206224_at 209606_at 210001_s_at 212942_s_at 205969_at 204121_at 209955_s_at 206262_at 211906_s_at 203435_s_at 219619_at 219728_at 208126_s_at 208350_at 219508_at 220192_x_at 219142_at 219334_s_at

entrez_gene POSTN LRRC31 SERPINB10 FETUB DPP4 CA2 ANO1 CH25H ALOX15 DPP4 SLC26A4 DPP4 NRG1 HAS2 NTRK1 MME PMCH HPGD HPGD SERPINB2 HPGD HPGD SLC39A8 SLC39A8 FZD10 FOLH1 BDNF PROCR FOLH1 KCNJ16 CST1 CYTIP SOCS1 KIAA1199 AADAC GADD45G FAP ADH1C SERPINB4 MME DIRAS2 MYOT CYP2C18 CSN1S1 GCNT3 SPDEF RASL11B OBFC2A

signed_ratio 298.2118122 47.1807145 25.53323975 23.53432606 20.43143859 20.11999037 18.24175809 15.62187254 15.15914251 15.11233556 14.8364986 13.19121532 13.13982073 11.69408438 11.14286958 11.0535531 10.35443331 9.492079693 8.655828045 8.228217019 8.211079771 7.914807719 7.829019207 7.523348121 7.200166618 7.178844679 7.137004983 7.013228183 6.779430188 6.313797134 6.259539407 6.085882624 6.037840242 6.026552777 5.822510445 5.795555661 5.682450057 5.370923415 5.216959711 5.170319574 4.931160318 4.874209712 4.842995222 4.825172691 4.698663184 4.662048425 4.588716982 4.577525927

FDR 2.09835E-05 3.09147E-06 0.000232669 0.000321173 4.40387E-06 1.47462E-05 2.89208E-05 2.56301E-06 4.08263E-06 4.08277E-06 1.92083E-06 1.7552E-06 2.48674E-06 1.36559E-05 1.87319E-05 9.26357E-07 0.000126439 3.12462E-06 2.32525E-06 0.000130572 2.1742E-06 1.01867E-05 2.0223E-05 1.42804E-05 2.10773E-06 0.00045755 0.000971797 0.000405079 0.004504382 0.000190734 0.009800355 0.000249704 1.90656E-05 1.51084E-05 0.002267034 0.002473959 0.000551739 0.000186152 9.45804E-06 2.7688E-05 0.011143598 0.002075538 4.0322E-05 0.003308302 0.000500005 4.00111E-05 2.03063E-05 8.55175E-05

49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101

219727_at 206172_at 201859_at 219918_s_at 214404_x_at 212158_at 216504_s_at 214068_at 204388_s_at 221223_x_at 205630_at 218542_at 204389_at 209340_at 219148_at 215103_at 220745_at 214981_at 207367_at 203980_at 216258_s_at 209555_s_at 212154_at 213974_at 57588_at 212741_at 205466_s_at 207165_at 206026_s_at 211362_s_at 210314_x_at 219100_at 206354_at 203560_at 218662_s_at 204491_at 214452_at 204464_s_at 219795_at 217523_at 209500_x_at 204162_at 201884_at 201925_s_at 219090_at 209709_s_at 205659_at 205880_at 209773_s_at 213441_x_at 218663_at 201926_s_at 202237_at

DUOX2 4.573504756 IL13RA2 4.495591407 SRGN 4.468586247 ASPM 4.380605835 SPDEF 4.325290369 SDC2 4.309853413 SLC39A8 4.282145558 BEAN1 4.250704479 MAOA 4.218528373 CISH 4.20533446 CRH 4.199993117 CEP55 4.192004086 MAOA 4.182063409 UAP1 4.164442461 PBK 4.149305297 CYP2C18 4.146284417 IL19 4.139325951 POSTN 4.135635757 ATP12A 4.091974106 FABP4 4.058694081 SERPINB13 4.053803894 CD36 3.985305716 SDC2 3.977291947 ADAMTSL3 3.967016657 SLC24A3 3.911328808 MAOA 3.891191741 HS3ST1 3.854215088 HMMR 3.840534839 TNFAIP6 3.797444912 SERPINB13 3.737353563 TNFSF13 3.690262683 OBFC1 3.633396063 SLCO1B3 3.620075522 GGH 3.597109147 NCAPG 3.592034918 PDE4D 3.545247609 BCAT1 3.542895645 EDNRA 3.532521126 SLC6A14 3.517038598 CD44 3.488896755 TNFSF12-TNFSF13 3.483868669 NDC80 3.445287461 CEACAM5 3.443119917 CD55 3.423048695 SLC24A3 3.409592176 HMMR 3.397067667 HDAC9 3.36353568 PRKD1 3.345251952 RRM2 3.332007021 SPDEF 3.330009744 NCAPG 3.280511228 CD55 3.275188012 NNMT 3.259079004

0.000688051 0.05613616 0.000707588 0.00018976 4.06564E-05 0.007216761 0.000174594 0.001800996 1.79755E-05 0.000106415 0.000107245 0.000108275 0.000118097 6.46043E-06 0.000321138 2.31841E-05 0.001258039 0.000487982 0.00015561 0.120453622 0.00012995 0.056630961 0.005789269 0.000813977 0.000345677 0.000101467 9.35498E-06 0.000101055 0.002618793 0.000705937 9.86407E-05 0.000456639 0.000117206 8.25373E-05 0.000179523 0.000249339 8.02782E-05 8.25026E-05 0.000307605 0.002563885 3.32386E-05 9.43543E-05 0.000306676 0.000161639 0.000332685 0.00141203 0.000553566 0.000975727 0.003544541 0.0003584 0.001232652 0.000119627 0.000439007

102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154

209714_s_at 207526_s_at 206424_at 207317_s_at 211361_s_at 205190_at 217272_s_at 218943_s_at 204404_at 219531_at 218039_at 201858_s_at 205818_at 219493_at 205141_at 212909_at 206835_at 218802_at 206488_s_at 218963_s_at 210118_s_at 202411_at 204341_at 204962_s_at 202207_at 204463_s_at 219836_at 203418_at 221218_s_at 205158_at 201291_s_at 209499_x_at 203764_at 220133_at 218532_s_at 221841_s_at 211303_x_at 220779_at 205185_at 210601_at 203240_at 202037_s_at 221060_s_at 205533_s_at 210602_s_at 219734_at 213107_at 218510_x_at 206025_s_at 213397_x_at 212014_x_at 210916_s_at 219287_at

CDKN3 3.232033628 IL1RL1 3.222962546 CYP26A1 3.194703866 CASQ2 3.157791382 SERPINB13 3.131280524 PLS1 3.108144199 SERPINB13 3.102370968 DDX58 3.091812947 SLC12A2 3.075395984 CEP72 3.054832749 NUSAP1 3.027806719 SRGN 3.026035135 DBC1 3.024077128 SHCBP1 3.01595254 ANG 2.987128648 LYPD1 2.980205985 STATH 2.953405761 CCDC109B 2.949605369 CD36 2.928023829 KRT23 2.897217094 IL1A 2.896291739 IFI27 2.887611973 TRIM16 2.874641907 CENPA 2.87251424 ARL4C 2.868463577 EDNRA 2.859579496 ZBED2 2.856760693 CCNA2 2.85259048 TPK1 2.830177871 RNASE4 2.823812237 TOP2A 2.823729032 TNFSF12-TNFSF13 2.81293983 DLGAP5 2.808016015 ODAM 2.80763574 FAM134B 2.793717234 KLF4 2.755483039 FOLH1B 2.752907581 PADI3 2.748943079 SPINK5 2.747460774 CDH6 2.740446132 FCGBP 2.721616383 SFRP1 2.716781102 TLR4 2.704581725 CDH6 2.695233654 CDH6 2.692392386 SIDT1 2.691571745 TNIK 2.69135825 FAM134B 2.678628265 TNFAIP6 2.652907265 RNASE4 2.63224088 CD44 2.625700981 CD44 2.601985888 KCNMB4 2.594187596

0.001787012 0.034056712 0.000191264 0.034615872 0.000111471 4.78949E-05 0.000630598 0.000664229 0.000182031 0.000334762 0.001451674 0.004452472 0.002677641 0.000113556 0.006085333 0.000456999 0.000352066 0.002910319 0.033652844 0.000424556 0.000741291 0.001763299 0.002480041 0.001395559 0.000448051 7.27223E-05 0.00120168 0.000162488 0.000501817 0.0241454 0.000516671 0.000567922 0.000338862 0.011218703 0.000270046 0.002265998 0.007339388 0.001800218 0.000542493 0.007503274 0.107840555 0.000116859 0.001851121 0.004538295 0.004720587 0.002245499 0.000638738 0.000306742 0.006314985 0.013184395 0.000968009 0.000564212 0.001525576

155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200

207820_at 202503_s_at 202238_s_at 205381_at 214163_at 217080_s_at 203824_at 202206_at 220658_s_at 213226_at 218935_at 205034_at 207414_s_at 209835_x_at 202201_at 211828_s_at 204929_s_at 205042_at 211495_x_at 210413_x_at 204026_s_at 220266_s_at 201292_at 221011_s_at 206421_s_at 218009_s_at 205532_s_at 205214_at 204126_s_at 202516_s_at 217208_s_at 213880_at 205084_at 201890_at 204490_s_at 220260_at 205968_at 205046_at 209904_at 217882_at 201666_at 207826_s_at 204489_s_at 208510_s_at 218684_at 205379_at

ADH1A 2.592120255 KIAA0101 2.591139031 NNMT 2.588524326 LRRC17 2.581753788 HSPB11 2.567556616 HOMER2 2.567344535 TSPAN8 2.558105493 ARL4C 2.556040877 ARNTL2 2.553528179 CCNA2 2.542020964 EHD3 2.538505481 CCNE2 2.536683578 PCSK6 2.534559325 CD44 2.506575781 BLVRB 2.500143173 TNIK 2.497424474 VAMP5 2.492768399 GNE 2.475239253 TNFSF12-TNFSF13 2.474171624 SERPINB3 2.435829625 ZWINT 2.433483627 KLF4 2.43140635 TOP2A 2.424224042 LBH 2.417377226 SERPINB7 2.416599889 PRC1 2.402493219 CDH6 2.401100648 STK17B 2.400382583 CDC45 2.397528218 DLG1 2.391710273 DLG1 2.373457025 LGR5 2.37318103 BCAP29 2.368857099 RRM2 2.366426976 CD44 2.365519519 TBC1D19 2.363627511 KCNS3 2.36048555 CENPE 2.360382834 TNNC1 2.336777103 TMEM111 2.332329276 TIMP1 2.320919991 ID3 2.305169825 CD44 2.30115906 PPARG 2.299999181 LRRC8D 2.299649215 CBR3 2.290719215

0.000199664 0.000574762 0.001169516 0.001340533 0.029957392 0.005444986 0.030993483 0.000970143 0.000308357 0.000247408 0.000498233 0.000224816 0.000568689 0.00069114 0.00026149 0.001170302 0.000430933 0.000261364 0.000355847 0.000273813 0.000623148 0.013568556 0.001340451 0.000465379 0.000271611 0.00097354 0.003023213 0.001832396 0.000913467 0.001414948 0.004203765 0.007675212 0.002243499 0.001208245 0.000968319 0.000822027 0.006819801 0.002663065 0.047309768 0.000689428 0.175074594 0.000498304 0.001369973 0.001339388 0.000526454 0.002201924


id_chip 210809_s_at 210521_s_at 220622_at 214539_at 206224_at 206529_x_at 211478_s_at 209606_at 203717_at 203240_at 209301_at 207328_at 203716_s_at 205860_x_at 206932_at 201884_at 203913_s_at 211548_s_at 211549_s_at 203434_s_at 207367_at 218804_at 203914_x_at 204121_at 215363_x_at 206432_at 206942_s_at 219564_at 214981_at 219403_s_at 206343_s_at 203824_at 213975_s_at 206994_at 210107_at 206262_at 57588_at 208605_s_at 206382_s_at 220192_x_at 209555_s_at 210001_s_at 216881_x_at 208126_s_at 205141_at 219090_at 206424_at 205158_at

entrez_gene POSTN FETUB LRRC31 SERPINB10 CST1 SLC26A4 DPP4 CYTIP DPP4 FCGBP CA2 ALOX15 DPP4 FOLH1 CH25H CEACAM5 HPGD HPGD HPGD MME ATP12A ANO1 HPGD GADD45G FOLH1 HAS2 PMCH KCNJ16 POSTN HPSE NRG1 TSPAN8 LYZ CST4 CLCA1 ADH1C SLC24A3 NTRK1 BDNF SPDEF CD36 SOCS1 PRB4 CYP2C18 ANG SLC24A3 CYP26A1 RNASE4

signed_ratio 351.3891327 94.31071355 91.76579253 46.98172307 39.27397755 37.19121789 34.60171059 30.12625535 22.42640843 21.53614175 21.07256318 18.5685403 18.44863101 17.39930442 17.32952717 16.15705301 15.03897956 14.80206425 14.53157502 13.99761782 13.88696204 13.71188962 13.58975492 13.12812443 12.99624478 12.62183979 12.46647036 11.96877975 11.7927711 11.65083428 11.04821878 10.7926978 10.44245395 9.989388754 9.815702359 9.271420187 9.211339233 9.073920928 8.756392413 8.635160618 8.464698921 8.377097779 7.861107084 7.833872194 7.807502489 7.736553089 7.614507834 7.384666776

FDR 3.57205E-06 6.9655E-07 4.52924E-08 4.41581E-07 8.76725E-06 7.90259E-07 1.117E-06 1.01213E-06 1.77889E-06 0.000320572 1.75812E-06 2.16376E-06 4.53041E-07 8.17601E-07 1.3657E-05 8.81109E-07 8.45779E-06 1.78125E-06 1.02763E-05 1.54593E-07 8.50257E-07 2.16117E-06 2.04309E-06 2.2272E-06 8.5529E-07 0.003996647 1.30271E-06 0.000363872 1.00529E-05 3.70169E-07 5.81761E-07 7.53724E-07 2.30747E-06 0.002365357 0.00189741 2.25968E-05 0.000157462 1.52792E-05 7.75615E-05 2.97649E-07 2.7291E-06 3.79625E-07 0.019937746 7.37794E-07 5.16032E-05 0.000162282 3.93162E-05 2.19476E-05

49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101

209267_s_at 212942_s_at 206488_s_at 218532_s_at 203435_s_at 219727_at 204614_at 214404_x_at 206172_at 219764_at 215103_at 218510_x_at 213397_x_at 210597_x_at 211531_x_at 221874_at 207752_x_at 219508_at 205969_at 213974_at 219869_s_at 214907_at 201859_at 220779_at 220017_x_at 221223_x_at 204515_at 219100_at 201926_s_at 211303_x_at 204491_at 204389_at 204388_s_at 213441_x_at 214452_at 218976_at 212741_at 204404_at 212158_at 208555_x_at 207958_at 205466_s_at 201858_s_at 219334_s_at 210619_s_at 201925_s_at 214068_at 207820_at 209340_at 205676_at 206037_at 211906_s_at 220266_s_at

SLC39A8 KIAA1199 CD36 FAM134B MME DUOX2 SERPINB2 SPDEF IL13RA2 FZD10 CYP2C18 FAM134B RNASE4 PRB1 PRB1 KIAA1324 PRB1 GCNT3 AADAC ADAMTSL3 SLC39A8 CEACAM21 SRGN PADI3 CYP2C9 CISH HSD3B1 OBFC1 CD55 FOLH1B PDE4D MAOA MAOA SPDEF BCAT1 DNAJC12 MAOA SLC12A2 SDC2 CST2 UGT2A1 HS3ST1 SRGN OBFC2A HYAL1 CD55 BEAN1 ADH1A UAP1 CYP27B1 CCBL1 SERPINB4 KLF4

7.327859363 7.224226353 7.193859885 7.149862557 7.120409507 6.943438434 6.896825399 6.858826691 6.789643566 6.789150128 6.584360308 6.560819762 6.273718021 6.238394675 6.123726679 6.112749725 6.094747115 6.092953921 6.046113909 5.852083611 5.755516034 5.731220001 5.717929479 5.691398865 5.680880712 5.648092465 5.605150338 5.556214092 5.533423879 5.513316816 5.258260696 5.218443724 5.167705513 5.116605119 5.086859391 5.050663555 4.984875697 4.964436839 4.955752709 4.939117413 4.905029873 4.875300639 4.642902993 4.592044172 4.590372185 4.562644061 4.410026003 4.371393014 4.370822144 4.332938124 4.311052925 4.309092077 4.306017144

1.68174E-05 9.69222E-07 2.70602E-06 2.02322E-05 7.6054E-06 8.60824E-06 4.01659E-05 5.91768E-07 0.000156779 3.96125E-05 1.0196E-06 5.8757E-05 1.68014E-05 0.023316414 0.010567365 0.000466658 0.005952485 2.85513E-05 6.0322E-05 5.06818E-06 1.13687E-05 2.31384E-05 0.000120887 9.84119E-05 8.58696E-06 1.23043E-05 0.040849595 1.40507E-05 1.02841E-06 2.24272E-06 1.6845E-05 1.96948E-05 1.40403E-05 2.20398E-06 2.30605E-06 1.78691E-06 1.05251E-05 9.22079E-07 0.002758362 0.001727787 0.000331892 7.96367E-07 5.11378E-05 4.15231E-06 1.51788E-06 3.52973E-06 0.005944295 0.001503961 1.77291E-06 0.010956869 3.24292E-05 3.62245E-05 0.000318274

102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154

218943_s_at 204396_s_at 209904_at 221796_at 210314_x_at 219429_at 212233_at 203560_at 214385_s_at 216504_s_at 201666_at 209500_x_at 220446_s_at 206766_at 212154_at 205818_at 210029_at 203895_at 219619_at 205185_at 219728_at 203896_s_at 221841_s_at 221241_s_at 219795_at 217523_at 205267_at 217123_x_at 205042_at 209417_s_at 46323_at 212295_s_at 200628_s_at 213695_at 214303_x_at 221218_s_at 218802_at 200629_at 204284_at 220133_at 206421_s_at 203971_at 204241_at 204464_s_at 214971_s_at 219142_at 221060_s_at 205190_at 216605_s_at 211689_s_at 207414_s_at 219918_s_at 216258_s_at

DDX58 4.238024889 GRK5 4.194952011 TNNC1 4.145427404 NTRK2 4.135128187 TNFSF13 4.05473552 FA2H 4.05111113 MAP1B 4.041921538 GGH 3.990261559 MUC5AC 3.98167134 SLC39A8 3.978583691 TIMP1 3.971231838 TNFSF12-TNFSF13 3.963657574 CHST4 3.950758287 ITGA10 3.836388432 SDC2 3.805239531 DBC1 3.777167016 IDO1 3.77101294 PLCB4 3.766591463 DIRAS2 3.720428854 SPINK5 3.710453561 MYOT 3.676224075 PLCB4 3.672249494 KLF4 3.666025426 BCL2L14 3.647868204 SLC6A14 3.643543409 CD44 3.625152087 POU2AF1 3.624687085 PMCHL1 3.601612596 GNE 3.555414847 IFI35 3.552454349 CANT1 3.529956633 SLC7A1 3.512572329 WARS 3.504542639 PON3 3.498873949 MUC5AC 3.491261736 TPK1 3.471076099 CCDC109B 3.466946243 WARS 3.456074975 PPP1R3C 3.429867107 ODAM 3.40431198 SERPINB7 3.401417851 SLC31A1 3.38525767 ACOX3 3.383060487 EDNRA 3.373602868 ST6GAL1 3.34807012 RASL11B 3.326146971 TLR4 3.314593132 PLS1 3.312290812 CEACAM21 3.248837319 TMPRSS2 3.248033372 PCSK6 3.217397699 ASPM 3.208208711 SERPINB13 3.19900445

1.35647E-06 0.004955955 0.000454207 0.016154766 1.52751E-06 8.25447E-06 0.001714335 2.17093E-06 0.001756232 3.6533E-05 0.002886724 2.18785E-06 2.19197E-06 0.000957803 0.004556647 0.000718308 4.24779E-05 5.63044E-06 0.003789364 5.9724E-05 1.06466E-05 8.80722E-06 4.78142E-05 9.14215E-05 2.21321E-06 1.90034E-05 6.0636E-05 6.54882E-05 7.75965E-05 8.56038E-06 3.76658E-05 0.026622582 0.000174307 0.000383815 0.002345539 3.76185E-05 0.000104642 4.31461E-05 0.000195919 0.002517014 0.000169782 6.76919E-05 0.000565104 4.14179E-06 1.59736E-05 0.000521371 4.08855E-05 3.12009E-06 0.000114668 0.000138174 1.46964E-05 0.000233549 0.000173515

155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200

209696_at 221732_at 204242_s_at 209521_s_at 210602_s_at 204687_at 205552_s_at 205876_at 219597_s_at 204972_at 218963_s_at 209499_x_at 219148_at 204623_at 209930_s_at 210064_s_at 204463_s_at 210037_s_at 212290_at 205659_at 211361_s_at 204971_at 206354_at 221011_s_at 205630_at 211495_x_at 206835_at 202869_at 213663_s_at 202112_at 200973_s_at 205590_at 202411_at 214040_s_at 210601_at 202079_s_at 204929_s_at 205533_s_at 211362_s_at 205880_at 204753_s_at 202201_at 204017_at 204698_at 204161_s_at 204160_s_at

FBP1 3.187191932 CANT1 3.186916939 ACOX3 3.177120988 AMOT 3.166737763 CDH6 3.165865888 PARM1 3.159257358 OAS1 3.148928584 LIFR 3.143778652 DUOX1 3.143217721 OAS2 3.136909191 KRT23 3.135139959 TNFSF12-TNFSF13 3.120732912 PBK 3.119575595 TFF3 3.101011487 NFE2 3.096393827 UPK1B 3.08774194 EDNRA 3.081452315 NOS2 3.077074407 SLC7A1 3.066026101 HDAC9 3.06369845 SERPINB13 3.062127906 CSTA 3.054117051 SLCO1B3 3.045942636 LBH 3.04447676 CRH 3.043981733 TNFSF12-TNFSF13 3.03793202 STATH 3.032667154 OAS1 3.023344824 --3.023008859 VWF 3.001548846 TSPAN3 3.000412946 RASGRP1 2.960552116 IFI27 2.960098499 GSN 2.959697348 CDH6 2.937080256 TRAK1 2.913851911 VAMP5 2.90647273 CDH6 2.89784493 SERPINB13 2.870052258 PRKD1 2.869068301 HLF 2.865460996 BLVRB 2.864684457 KDELR3 2.859783603 ISG20 2.847005331 ENPP4 2.821796692 ENPP4 2.819094963

0.000383861 3.7205E-05 0.002024077 1.37569E-05 0.001223648 0.000943724 2.23536E-05 9.44122E-06 1.06307E-05 0.000809807 0.000230408 3.71677E-05 0.00019561 1.60949E-05 9.3514E-05 3.59413E-06 0.000196594 0.000119225 0.018015102 8.52102E-05 7.25857E-06 0.000107003 0.000167644 4.32016E-05 0.001081164 9.48575E-05 0.00210808 2.6872E-05 0.000397604 0.001200625 1.6525E-05 0.002417792 2.32264E-05 0.000474195 0.006407294 0.00075954 4.22532E-05 0.001511462 0.000131383 0.001474963 0.005925664 1.52181E-05 0.000484943 4.35995E-05 3.96898E-05 1.1569E-05