Grants Index 2007

B IOMEDICAL S CIENCES

$17,373,751 Total Paid: $6,070,996 Total Transferred/Cancelled: $2,300,311 Total Approved:

C AREER AWARDS

IN THE

B IOMEDICAL S CIENCES

Derek W. Abbott, M.D., Ph.D. Regulation of innate immunity via non-traditional ubiquitin linkages Case Western Reserve University School of Medicine Paid: $50,000 Geoffrey K. Aguirre, M.D., Ph.D. fMRI studies of the process architecture of face perception University of Pennsylvania School of Medicine Paid: $165,750 Karl Mark Ansel, Ph.D. Endogenous RNA interference and gene silencing in T cell differentiation Harvard Medical School Paid: $29,000 Vahe Bandarian, Ph.D. Biosynthesis of deazapurine secondary metabolites University of Arizona Paid: $58,000 Aaron P. Batista, Ph.D. Neural gating within the cerebral cortex during sensory-motor behavior University of Pittsburgh Approved: $10,840.40 ($64,000 of the award to the original award for a future faculty appointment was transferred/cancelled. $64,000 of the award to Stanford University was approved and paid.)

2007 GR ANTS INDEX

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B IOMEDICAL S CIENCES – C ONTINUED

Thomas G. Bernhardt, Ph.D. Coordinating cell division and chromosome segregation in Escherichia coli Harvard Medical School Approved: $29,000 Paid: $55,250 ($29,000 of the original award to Case Western Reserve University School of Medicine was transferred/cancelled.) Bradley E. Bernstein, M.D., Ph.D. Proteomic studies of post-translational histone modifications Harvard Medical School Paid: $50,000 Ben E. Black, Ph.D. Epigenetic mechanisms for centromere specification University of Pennsylvania School of Medicine Approved: $1,473.34 Paid: $165,750 Michael D. Blower, Ph.D. Analysis of the role of RNA in spindle assembly Harvard Medical School Paid: $110,500 David L. Brody, M.D., Ph.D. Amyloid-beta and apolipoprotein E in traumatic brain injury Washington University School of Medicine Paid: $165,750 Thomas R. Clandinin, Ph.D. Dissecting neuronal target selection in the Drosophila visual system Stanford University School of Medicine Approved: $62,132.14 Paid: $62,132.14 William (Bil) M. Clemons, Ph.D. Structural studies of complexes involved in protein translocation and synthesis California Institute of Technology Paid: $165,750

2

burroughs wellcome fund

Leah E. Cowen, Ph.D. Hsp90 and the evolution of pathogens and their hosts University of Toronto Faculty of Medicine Paid: $100,000 Nika N. Danial, Ph.D. Integration of glycolysis and apoptosis by the pro-apoptotic protein BAD Harvard Medical School Paid: $55,250 Jeremy S. Dasen, Ph.D. Role of Hox proteins in sensory-motor neuronal connectivity and identity New York University School of Medicine Paid: $192,000 Justin L. Gardner, Ph.D. Flexible sensory representations in human visual cortex New York University Faculty of Arts and Science Paid: $58,000 Levi A. Garraway, M.D., Ph.D. Linking genetic alterations to tumor dependencies in human melanoma Dana-Farber Cancer Institute Paid: $110,500 Matthew C. Gibson, Ph.D. Design principles in metazoan epithelia: the molecular control of growth and form Stowers Institute for Medical Research Paid: $100,000 Ruben L. Gonzalez Jr., Ph.D. Single-molecule fluorescence studies of eukaryotic translation initiation and regulation Stanford University School of Medicine Approved: $3,489.45 Paid: $3,489.45 ($19,333 of the award to Stanford University School of Medicine was transferred/cancelled. $19,333 of the award to Columbia University was approved. $110,500 of the award to Columbia University was paid. $3,489.45 of the award to Columbia University was transferred/cancelled.)

2007 GR ANTS INDEX

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Or P. Gozani, M.D., Ph.D. Regulation of chromatin remodeling events by nuclear phosphoinositides Stanford University Paid: $165,750 Ira M. Hall, Ph.D. Investigation of DNA copy-number fluctuation and epigenetic inheritance using genomic microarrays Cold Spring Harbor Laboratory Paid: $29,000 Chyi-Song Hsieh, M.D., Ph.D. Determining the antigen specificity of CD25+ CD4+ regulatory T cells Washington University School of Medicine Paid: $50,000 ($11,641.56 of the award to Washington University School of Medicine was transferred/cancelled. $11,641.56 of the award to the University of Washington was approved and paid.) James D. Jontes, Ph.D. Role of protocadherins in neural development studied in living zebrafish embryos Ohio State University Paid: $100,000 Susan M. Kaech, Ph.D. Investigation of the mechanisms that regulate memory CD8 T cell development Yale University School of Medicine Paid: $110,500 Alla Y. Karpova, Ph.D. Using molecular inactivators of synaptic transmission to study cortical function and its modulation by subcortical systems in health and disease Cold Spring Harbor Laboratory Approved: $58,000 Paid: $58,000 ($58,000 of the award for a future faculty appointment was transferred/cancelled.) Leslie S. Kean, M.D., Ph.D. Innate immunity and transplantation tolerance: Defining the role of natural killer (NK) cells in allograft rejection Emory University School of Medicine Paid: $100,000

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Dennis H. Kim, M.D., Ph.D. Genetic analysis of innate immunity in Caenorhabditis elegans Massachusetts Institute of Technology Paid: $141,564 Steven T. Kosak, Ph.D. Genomic organization of hematopoietic differentiation University of Washington Approved: $58,000 Paid: $58,000 ($58,000 of the award for a future faculty appointment was transferred/cancelled.) Cheng-Yu Lee, Ph.D. Genetic regulation of neural stem cell self-renewal University of Michigan-Ann Arbor Paid: $110,500 Anthony Leonardo, Ph.D. Neuronal population dynamics underlying the retinal code for motion Harvard University Paid: $29,000 Brian C. Lewis, Ph.D. Modeling tumor initiation, progression and metastasis using tissue-specific somatic gene transfer University of Massachusetts Medical School Paid: $59,199 George Y. Liu, M.D., Ph.D. Role of Group B Streptococcal hemolysin/cytolysin and pigment in the pathogenesis of invasive neonatal infections University of California-Los Angeles Approved: $53,295.12 Paid: $128,000 Anna K. Majewska, Ph.D. Imaging rapid plasticity in the visual cortex University of Rochester Approved: $49,962.42 Paid: $165,750

2007 GR ANTS INDEX

5


Margaret E. McLaughlin, M.D. Effects of heterotypic cell interactions and blood-born signals on tumors of the nervous system ($326,000 of the award for a future faculty appointment was transferred/cancelled.) Aaron W. McGee, Ph.D. Inhibition of plasticity in the adult central nervous system by Nogo-66 receptor signaling Yale University School of Medicine Paid: $29,000 Marc D. Meneghini, Ph.D. Regulating chromatin domains in yeast and during animal development ($1,847.20 of the award to the University of Toronto Faculty of Medicine was transferred/ cancelled. $1,847.20 of the award to the University of California-San Francisco was awarded and paid.) Kakoli Mitra, Ph.D. Probing the dynamics of protein integration into and translocation across membranes using fluorescence spectroscopy and cryo-electron microscopy State University of New York-Albany Paid: $12,000 Vamsi K. Mootha, M.D. Genomic approaches to mitochondrial biogenesis Harvard Medical School Paid: $100,000 Lev Z. Osherovich, Ph.D. Insulin signaling in neurodegenerative protein misfolding diseases University of California-San Francisco School of Medicine Paid: $87,000 Stephanie A. Pangas, Ph.D. Defining the role of TGFb superfamily in ovarian cancer through mouse models Baylor College of Medicine Paid: $29,000 Catherine L. Peichel, Ph.D. Genetic and molecular basis of reproductive isolation of threespine sticklebacks Fred Hutchinson Cancer Research Center Paid: $58,000

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Bijan Pesaran, Ph.D. Cortical mechanisms for hand-eye coordination New York University Paid: $110,500 Michael G. Poirier, Ph.D. A study of DNA accessibility within nucleosome arrays Ohio State University Approved: $15,960 Paid: $55,250 Margot E. Quinlan, Ph.D. Collaboration between two actin nucleators—Spir and Capu University of California-San Francisco Paid: $29,000 Oliver J. Rando, M.D., Ph.D. Time scales of epigenetic inheritance: How and why University of Massachusetts Medical School Approved: $29,000 Paid: $110,500 ($29,000 of the original award to Harvard University was transferred/cancelled.) David E. Reich, Ph.D. Applying population genetics to find genes for common diseases Harvard Medical School Paid: $100,000 Jeremy F. Reiter, M.D., Ph.D. Tectonic: discovery of novel signal directing mammalian development University of California-San Francisco Paid: $110,500 Kyu Y. Rhee, M.D., Ph.D. Enzymes of intermediary metabolism in Mycobacterium tuberculosis: Anti-mycobacterial targets of nitric oxide Weill Medical College of Cornell University Paid: $110,500 Noah A. Rosenberg, Ph.D. Efficient genome-based inference of ancestry for use in genetic association studies University of Michigan Medical School Paid: $110,500

2007 GR ANTS INDEX

7


Pardis C. Sabeti, M.D., D.Phil. Evolutionary genomics and its applications to human disease Massachusetts Institute of Technology Paid: $58,000 Alvaro Sagasti, Ph.D. Development of morphological diversity in trigeminal sensory neurons University of California-Los Angeles Approved: $22,506 Paid: $165,750 Alan Saghatelian, Ph.D. Identifying functional connections between the proteome and metabolome by global metabolite profiling Harvard University Approved: $15,221.23 Paid: $110,500 Annette E. Salmeen, D.Phil. Reactive oxygen species as temporal coordinators of cell signaling pathways Stanford University School of Medicine Approved: $58,000 Paid: $87,000 ($58,000 of the award for a future faculty appointment was transferred/cancelled.) Erica O. Saphire, Ph.D. Structural studies of Ebola viral pathogenesis Scripps Research Institute Paid: $50,000 Maria A. Schumacher, Ph.D. Structural biology of cell growth, development, and regulation University of Texas M.D. Anderson Cancer Center Paid: $52,728.42 Shu-ou Shan, Ph.D. Mechanism of signal recognition particle-mediated protein targeting California Institute of Technology Paid: $128,000 Michael D. Shapiro, Ph.D. Genetic and developmental basis of skeletal diversity in ninespine sticklebacks University of Utah Approved: $116,000 Paid: $64,000 ($58,000 of the award Stanford University School of Medicine was transferred/cancelled.)

8


Donald C. Sheppard, M.D. Isolation and characterization of genes involved in morphogenesis and virulence of Aspergillus fumigatus McGill University Paid: $64,000 Upinder Singh, M.D. Transcriptional control in Entamoeba histolytica Stanford University School of Medicine Approved: $2,500 Paid: $2,500 Michele M. Solis, Ph.D. Telencephalic pattern generator for song ($384,000 of the original award for a future faculty appointment was transferred/cancelled.) Collin M. Stultz, M.D., Ph.D. Conformational free energy landscape of collagen and its relationship to atherosclerotic plaque rupture Massachusetts Institute of Technology Paid: $110,500 Benjamin P. Tu, Ph.D. Logic of the yeast metabolic cycle University of Texas Southwestern Medical Center-Dallas Paid: $58,000 Sinisa Urban, Ph.D. Exploring the role of rhomboid signalling in development and disease Johns Hopkins University School of Medicine Approved: $53,804.97 Paid: $110,500 Amy J. Wagers, Ph.D. Dynamic circulation of hematopoietic stem cells: implications for stem cell function Joslin Diabetes Center Paid: $55,250 Loren D. Walensky, M.D., Ph.D. Targeting protein interactions in vivo using chemically reinforced helical peptides Harvard Medical School Paid: $165,750

2007 GR ANTS INDEX

9


David M. Weinstock, M.D. Defining individual DNA double-strand break repair capacity using zinc-finger nucleases Memorial Sloan-Kettering Cancer Center Paid: $29,000 Hong Zhang, Ph.D. Harvard Medical School ($58,000 of the original award was transferred/cancelled. $442,000 of the award for a future faculty appointment was transferred/cancelled.) Karen M. Zito, Ph.D. Regulation of synapse formation in the mammalian cortex University of California-Davis Approved: $3,141.24 Paid: $111,141.24 Total Awarded for program: Total Paid for program: Cancellations/Transfers:

$739,148.07 $5,664,743.01 $1,600,311.21

C AREER AWARDS

M EDICAL S CIENTISTS

FOR

Jonathan Paul Alexander, M.D., Ph.D. Isolation of a putative alveolar stem cell population and analysis of its role in development, maintenance, and repair of the lung epithelium University of California-San Francisco Approved: $190,000 ($510,000 approved for future faculty appointment.) Robert Baloh, M.D., Ph.D. Mechanism of peripheral neuropathy from Mitofusin 2 mutations Washington University Approved: $700,000 James Elliott Bradner, M.D. Design and characterization of highly potent inhibitors of HDAC6 Harvard University Approved: $95,000 ($605,000 approved for future faculty appointment.)

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Clark C. Chen, M.D., Ph.D. Molecular basis and therapeutic implications of genome instability during brain tumor progression Harvard Medical School ($700,000 approved for future faculty appointment.) Arlene Dent, M.D., Ph.D. Acquisition of immunity to blood stage Falciparum malaria in infants Case Western Reserve University Approved: $95,000 ($605,000 approved for future faculty appointment.) Mahalia Sabrina Desruisseaux, M.D. Neuroparasitology: neurological complications of cerebral malaria Albert Einstein College of Medicine of Yeshiva University Approved: $95,000 ($605,000 approved for future faculty appointment.) Jay F. Dorsey, M.D., Ph.D. Identification of mSin3b and Mad4 as novel p53 target genes directing p53-mediated transcriptional repression University of Pennsylvania Approved: $95,000 ($605,000 approved for future faculty appointment.) Benjamin Levine Ebert, M.D., Ph.D. Genomic approaches to disorders of erythroid differentiation Harvard Medical School Approved: $700,000 Brian Todd Edelson, M.D., Ph.D. Macrophage and dendritic cell development Washington University Approved: $95,000 ($605,000 approved for future faculty appointment.) Rene L. Galindo, M.D., Ph.D. Genetic dissection of the Rhabdomyosarcoma initiator PAX-FKHR and PAX-related signaling in skeletal muscle development University of Texas Southwestern Medical Center-Dallas Approved: $700,000

2007 GR ANTS INDEX

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Darnell Kaigler, D.D.S., Ph.D. Cell therapy for the treatment of alveolar bone defects University of Michigan-Ann Arbor Approved: $95,000 ($605,000 approved for future faculty appointment.) Michael Z. Lin, M.D., Ph.D. Elucidating mechanisms of synaptic plasticity and learning by visualizing and controlling local protein turnover University of California-San Diego Approved: $95,000 ($605,000 approved for future faculty appointment.) Roger Lo, M.D., Ph.D. Melanoma in the skin: initiation, progression, and crosstalk with dermal fibroblasts University of California-Los Angeles Approved: $95,000 ($605,000 approved for future faculty appointment.) Emanual Maverakis, M.D. gC399tr an inhibitor of autoimmunity University of California-Davis Approved: $190,000 ($510,000 approved for future faculty appointment.) Eric Matthew Morrow, M.D., Ph.D. Identification of autism genes in special founder populations using high-density SNP microarrays Harvard Medical School Approved: $47,500 ($652,500 approved for future faculty appointment.) Christopher Newton-Cheh, M.D. Genomic dissection of QT interval duration and sudden death Harvard Medical School Approved: $95,000 ($605,000 approved for future faculty appointment.)

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Dao Nguyen, M.D. Stringent response in Pseudomonas aeruginosa biofilm formation and antibiotic tolerance University of Washington Approved: $95,000 ($605,000 approved for future faculty appointment.) Anil Potti, M.D. Gene expression patterns coupled with signatures of oncogenic pathway deregulation provide a novel approach to targeted therapeutics in non-small cell lung carcinoma Duke University Medical Center Approved: $700,000 Frank J. Probst, M.D., Ph.D. Generation of mouse models for X-linked diseases Baylor College of Medicine Approved: $190,000 ($510,000 approved for future faculty appointment.) Alice Shaw, M.D., Ph.D. Novel biomarkers and targeted therapies for human lung cancer: translation from a mouse model Massachusetts Institute of Technology Approved: $700,000 ($700,000 of the original award to Massachusetts Institute of Technology was transferred/cancelled.) Joseph C. Wu, M.D., Ph.D. Molecular and cellular mechanisms of cardiac regeneration Stanford University Approved: $700,000 Mark Nan Wu, M.D., Ph.D. Identification of novel genes that regulate sleep in Drosophila melanogaster University of Pennsylvania Approved: $190,000 ($510,000 approved for future faculty appointment.) Total Awarded for program: $15,400,000.00 Total Paid for program: $0.00 Cancellations/Transfers: $700,000.00

2007 GR ANTS INDEX

13


H ITCHINGS -E LION F ELLOWSHIP Daniel Durocher, Ph.D. Role of FHA domains during DNA damage signaling University of Toronto Approved: $14,603.28 Paid: $14,603.28 Total Awarded for program: Total Paid for program:

$14,603.28 $14,603.28

O THER G R ANTS In addition to making competitive awards, BWF makes noncompetitive grants for activities that are closely related to our major focus areas.These grants are intended to enhance the general environment for research in the targeted areas. CAREER DEVELOPMENT OF POSTDOCTORAL SCIENTISTS American Society of Plant Biologists Support for the development of laboratory management activities as part of the BWF-Howard Hughes Medical Institute Partners in Scientific Management Program Paid: $1,000 Association for Women in Science Support for three interns Approved: $10,500 Paid: $10,500 Biotechnology Institute Support for the Minority Fellows program Approved: $10,000 Paid: $10,000 Biotechnology Institute Support for 2007 Minority Programs Approved: $2,000 Paid: $2,000 California State University-East Bay Support for the College of Science Scholarship Fund Approved: $1,500 Paid: $1,500 Center for Science and Media Support for the Graduate Program Search/Rankings Tool Approved: $50,000 Paid: $50,000

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Commission on Professionals in Science and Technology Support for 2007 Approved: $5,000 Paid: $5,000 Federation of American Societies for Experimental Biology Support for the conference “Lysophospholipid Mediators in Health and Disease” Approved: $5,000 Paid: $5,000 Federation of American Societies for Experimental Biology General support for FASEB's diversity program Approved: $10,000 Paid: $10,000 Gairdner Foundation Support for three major symposiums to bring internationally recognized biomedical scientists (Gairdner awardees) to Canada Approved: $150,000 Gordon Research Conferences Support for the conference “Signal Transduction in the Nucleus” Approved: $10,000 Paid: $10,000 Gordon Research Conferences Support for the conference on Antigen Cross-Presentation Approved: $10,000 Paid: $10,000 Medical College of Wisconsin Support for a midwest regional postdoc meeting “Put your Ph.D. to work: a career symposium for scientists” Approved: $5,000 Paid: $5,000 National Academy of Sciences Support for a national conference “University Management of Intellectual Property: Lessons from a Generation of Bayh-Dole” Approved: $25,000 Paid: $25,000 National Postdoctoral Association Support for the 2007 National Institute of Environmental Health Sciences Biomedical Career Fair Approved: $2,000 Paid: $2,000

2007 GR ANTS INDEX

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National Postdoctoral Association Support for travel awards for attendees to the annual meeting Approved: $3,000 Paid: $3,000 Society for Neuroscience Support for postdoctoral travel to the annual meeting Approved: $15,000 Paid: $15,000 Society for the Study of Reproduction Support for 2007 activities of the Minority Affairs Committee Approved: $12,000 Paid: $12,000 Total Awarded for program: Total Paid for program:

$326,000.00 $177,000.00

MEDICAL SCIENCES Marine Biological Laboratory Support for the course “Biology of the Inner Ear: Experimental and Analytical Approaches” Approved: $23,000 Paid: $23,000 University of Massachusetts-Amherst Support for science and engineering education and workforce conference in Massachusetts Approved: $15,000 Paid: $15,000 Total Awarded for program: Total Paid for program:

$38,000.00 $38,000.00

REPRODUCTIVE SCIENCE Marine Biological Laboratory Support for the 2007, 2008, and 2009 sessions of the Frontiers in Reproduction course Paid: $160,650 Marine Biological Laboratory Support for the 2006 Frontiers in Reproduction course planning Approved: $5,000 Paid: $5,000

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Marine Biological Laboratory Support for travel expenses for the 10th annual Frontiers in Reproduction symposium Approved: $5,000 Paid: $5,000 University of California-San Francisco Support for travel expenses for BWF awardees and Reproductive Scientist Development Program scholars attending the research conference Approved: $6,000 Paid: $6,000 University of California-San Francisco School of Medicine Support for a Reproductive Scientist Development Program junior faculty scholar Approved: $240,000 Washington University School of Medicine Support for the BWF research consortium on preterm birth Approved: $600,000 Total Awarded for program: Total Paid for program:

$856,000.00 $176,650.00

2007 GR ANTS INDEX

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