Hay Supplementary Excel spreadsheet 1

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Agtr1b-Rn02132799_s1. 2. AGTR2. Agtr2-Rn00560677_s1. 19.97. 1.31. 4. AGTRL1. Agtrl1-Rn00580252_s1. 19.81. 0.88. 4. ALOX12. Alox12-Rn01461082_m1.
Supplementary excel spreadsheet 1. Expression [∆C(t)] data for all GPCRs, control genes and GPCR-associated genes.

Name (alternative name) ACTB ADCYAP1R1 (PAC1R) ADMR (GPR182) ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 ADRBK1 ADRBK2 AGTR1A AGTR1B AGTR2 AGTRL1 ALOX12 ALOX5 ARBP AVPR1A AVPR1B AVPR2 B2M BAI1 BAI2 BAI3 BDKRB1 BDKRB2 BLR1 (CXCR5) BRS3 C3AR1 C5R1 CALCR CALCRL CASR CCBP2 CCKAR CCKBR CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL2 CD97 CELSR1 CELSR2 CELSR3 CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CMKLR1 CMKOR1 (ACKR3)

Assay specific identifier Actb-Rn00667869_m1 Adcyap1r1-Rn00591653_m1 Admr-Rn00583993_s1 Adora1-Rn00567668_m1 Adora2a-Rn00583935_m1 Adora2b-Rn00567697_m1 Adora3-Rn00563680_m1 Adra1a-Rn00567876_m1 Adra1b-Rn01471343_m1 Adra1d-Rn00577931_m1 Adra2a-Rn00562488_s1 Adra2b-Rn00593312_s1 Adra2c-Rn00593341_s1 Adrb1-Rn00824536_s1 Adrb2-Rn00560650_s1 Adrb3-Rn00565393_m1 Adrbk1-Rn00562822_m1 Adrbk2-Rn00563688_m1 Agtr1a-Rn02758772_s1 Agtr1b-Rn02132799_s1 Agtr2-Rn00560677_s1 Agtrl1-Rn00580252_s1 Alox12-Rn01461082_m1 Alox5-Rn00563172_m1 Arbp-Rn00821065_g1 Avpr1a-Rn00583910_m1 Avpr1b-Rn01490541_m1 Avpr2-Rn00569508_g1 B2m-Rn00560865_m1 Bai1-Rn01504966_m1 Bai2-Rn01518987_m1 Bai3-Rn01511743_m1 Bdkrb1-Rn02064589_s1 Bdkrb2-Rn00597384_m1 Blr1-Rn02132880_s1 Brs3-Rn00596103_m1 C3ar1-Rn02134018_s1 C5r1-Rn02134203_s1 Calcr-Rn00587525_m1 Calcrl-Rn00562334_m1 Casr-Rn00566496_m1 Ccbp2-Rn02347939_s1 Cckar-Rn00562164_m1 Cckbr-Rn00565867_m1 Ccr1-Rn00571950_s1 Ccr2-Rn00573193_s1 Ccr3-Rn02134292_s1 Ccr4-Rn00591783_s1 Ccr5-Rn02132969_s1 Ccr6-Rn02534497_s1 Ccr7-Rn02758813_s1 Ccr8-Rn02067284_s1 Ccr9-Rn02129940_s1 Ccrl2-Rn01746782_g1 Cd97-Rn01432801_m1 Celsr1-Rn01502465_m1 Celsr2-Rn01521510_m1 Celsr3-Rn00668040_m1 Chrm1-Rn00589936_s1 Chrm2-Rn02532311_s1 Chrm3-Rn00560986_s1 Chrm4-Rn01512605_s1 Chrm5-Rn02758749_s1 Cmklr1-Rn00573616_s1 Cmkor1-Rn02134053_s1

Mean

Detected in (n) of 4 samples

S.D. 7.18 18.66 17.72 13.77 16.80 17.90 23.16

0.61 0.99 0.59 0.80 0.84 0.85 1.51

18.17 20.19 18.89 20.70 19.01 20.70 19.55

1.30 0.55 0.76 0.78 0.81 0.93 1.15

15.09 17.01 19.37

1.30 0.49 0.39

19.97 19.81 22.11 19.47 10.98 17.40

1.31 0.88 0.61 0.74 0.93 0.78

8.98 17.26 18.34 18.31 20.41 15.29 19.91

0.81 0.44 0.39 0.78 0.84 0.71 1.31

18.80 19.61 21.24 19.45 16.93 21.02 19.39 19.37 22.54 21.74

0.85 0.27 0.78 0.62 1.17 1.55 0.97 0.79 1.56 0.85

22.94 21.87

0.49 1.55

21.59

1.12

19.27 13.56 16.59 15.33 14.70 19.64 16.93 20.73 19.04 21.16 20.59 20.96

0.73 0.66 0.41 0.38 0.77 1.54 0.40 1.48 0.38 1.03 1.12

4 4 4 4 4 4 3 0 4 4 4 4 4 4 4 0 4 3 3 2 4 4 4 4 4 4 2 0 4 4 4 4 4 4 4 0 4 4 4 4 4 4 4 4 4 4 2 3 4 2 3 2 2 4 4 4 4 4 4 4 4 3 4 3 4

Supplementary excel spreadsheet 1. Expression [∆C(t)] data for all GPCRs, control genes and GPCR-associated genes.

CNR1 CNR2 CRCP CRHR1 CRHR2 CX3CR1 CXCR3 CXCR4 CYSLTR1 CYSLTR2 DRD1 DRD2 DRD3 DRD4 DRD5 EDG1 (S1PR1) EDG2 (LPAR1) EDG5 (S1PR2) EDG6 (S1PR4) EDG7 (LPAR3) EDG8 (S1PR5) EDNRA EDNRB ELTD1 EMR1 EMR4 F2R (PAR1) F2RL1 (PAR2) F2RL2 (PAR3) F2RL3 (PAR4) FFAR1 FPR1 FRZB FSHR FZD1 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD9 GABBR1 GABBR2 GALR1 GALR2 GALR3 GAPDH GCGR GHRHR GHSR GIPR GLP1R GLP2R GNRHR GPBAR1 GPR1 GPR101 GPR103 (QRFPR) GPR108 GPR109a (NIACR1) GPR110 GPR112 GPR113 GPR114 GPR115

Cnr1-Rn02758689_s1 Cnr2-Rn01637601_m1 Crcp-Rn00586593_m1 Crhr1-Rn00578611_m1 Crhr2-Rn00575617_m1 Cx3cr1-Rn02134446_s1 Cxcr3-Rn02134090_s1 Cxcr4-Rn00573522_s1 Cysltr1-Rn00586294_s1 Cysltr2-Rn00824657_s1 Drd1a-Rn02043440_s1 Drd2-Rn00561126_m1 Drd3-Rn00567568_m1 Drd4-Rn00564071_m1 Drd5-Rn01640412_s1 Edg1-Rn02758712_s1 Edg2-Rn00588435_m1 Edg5-Rn02130568_s1 Edg6-Rn01408085_s1 Edg7-Rn00576734_m1 Edg8-Rn00572952_s1 Ednra-Rn00561137_m1 Ednrb-Rn00569139_m1 Eltd1-Rn00574184_m1 Emr1-Rn01527631_m1 Emr4-Rn01528000_m1 F2r-Rn00564113_m1 F2rl1-Rn00588089_m1 F2rl2-Rn01490118_m1 F2rl3-Rn00587480_m1 Ffar1-Rn00824686_s1 Fpr1-Rn01441684_s1 Frzb-Rn01746979_m1 Fshr-Rn01648507_m1 Fzd1-Rn01755425_s1 Fzd2-Rn00597004_s1 Fzd3-Rn00596479_m1 Fzd4-Rn00433382_m1 Fzd5-Rn00598007_s1 Fzd6-Rn01767781_m1 Fzd7-Rn01441548_m1 Fzd9-Rn00596271_s1 Gabbr1-Rn00578911_m1 Gabbr2-Rn00582550_m1 Galr1-Rn02132426_s1 Galr2-Rn01773918_m1 Galr3-Rn02132531_s1 Gapdh-Rn99999916_s1 Gcgr-Rn00597158_m1 Ghrhr-Rn00563377_m1 Ghsr-Rn00821417_m1 Gipr-Rn00562325_m1 Glp1r-Rn00562406_m1 Glp2r-Rn00573037_m1 Gnrhr-Rn00578981_m1 Gpbar1-Rn01400316_s1 Gpr1-Rn00564179_s1 Gpr101-Rn02084654_s1 Gpr103-Rn01461881_m1 Gpr108-Rn01527548_m1 Gpr109a-Rn00710718_s1 Gpr110-Rn01511913_m1 Gpr112-Rn01402090_s1 Gpr113-Rn01468546_m1 Gpr114-Rn01536695_m1 Gpr115-Rn01511951_m1

18.01

1.32

16.98 19.48 19.68 22.46 22.17 16.81 22.42 22.46

0.68 0.85 1.45 1.32 0.98 1.25 2.95 1.68

13.43 22.24

1.45 1.70

21.10 17.30 14.43 20.39 20.75 16.07

0.69 1.12 1.04 0.57 0.73 0.95

16.92 15.45

2.56 0.58

19.71

3.01

16.98 17.50 14.66 20.81 20.14 21.11 18.25

3.28 2.44 0.57 2.35 0.26 0.70 1.11

19.48 17.13 14.77 16.55 16.81 15.97 15.63 20.07 13.07 15.05 15.82 16.36

0.89 0.70 0.58 0.88 0.77 1.09 0.66 0.95 0.45 0.46 0.80 0.25

7.95 20.48 20.06 21.58 21.10 21.44 21.71 20.13 19.17

0.82 0.65 1.71 1.06 1.96 0.20 1.94 2.57 0.82

21.68

1.19

17.55 20.09

0.87 1.87

22.22

1.01

3 2 4 4 4 4 4 4 4 4 2 4 3 2 3 4 4 4 4 2 3 4 2 4 1 4 4 4 3 3 4 4 1 4 4 4 4 4 4 4 3 3 4 4 3 2 4 4 3 3 4 3 4 4 4 1 4 1 4 4 1 4 1 4 2

Supplementary excel spreadsheet 1. Expression [∆C(t)] data for all GPCRs, control genes and GPCR-associated genes.

GPR116 GPR119 GPR12 GPR120 (FFAR4) GPR123 GPR125 GPR126 GPR128 GPR135 GPR137b GPR139 GPR141 GPR143 GPR149 GPR151 GPR153 GPR155 GPR156 GPR157 GPR158 GPR160 GPR162 GPR173 GPR175 (TPRA1) GPR176 GPR19 GPR20 GPR22 GPR25 GPR26 GPR27 GPR3 GPR30 (GPER) GPR33 GPR34 GPR35 GPR37 GPR37L1 GPR4 GPR41 (FFAR3) GPR43 (FFAR2) GPR44 (PTGDR2) GPR50 GPR56 GPR58 (TAAR2) GPR6 GPR61 GPR64 GPR68 GPR77 (C5AR2) GPR83 GPR85 GPR87 GPR88 GPR89 GPR97 GPRC5A GPRC5B GPRC5C GPRC6A GRM1 GRM2 GRM3 GRM4 GRM5 GRM6

Gpr116-Rn00594813_m1 Gpr119-Rn00710979_m1 Gpcr12-Rn00578096_s1 Gpr120-Rn01759772_m1 Gpr123-Rn01479352_m1 Gpr125-Rn01453013_m1 Gpr126-Rn01440591_m1 Gpr128-Rn01763466_m1 Gpr135-Rn00710992_s1 Gpr137b-Rn01520974_m1 Gpr139-Rn02395972_m1 Gpr141-Rn00710951_m1 Gpr143-Rn01771058_m1 Gpr149-Rn00594153_m1 Gpr151-Rn00710829_s1 Gpr153-Rn00805220_g1 Gpr155-Rn01515087_m1 Gpr156-Rn00596194_m1 Gpr157-Rn01518936_m1 Gpr158-Rn01526544_m1 Gpr160-Rn02072535_s1 Gpr162-Rn01459205_m1 Gpr173-Rn00573884_s1 Gpr175-Rn02532400_g1 Gpr176-Rn01513747_m1 Gpr19-Rn02758803_s1 Gpr20-Rn00573607_s1 Gpr22-Rn01769077_m1 Gpr25-Rn01483210_s1 Gpr26-Rn00593732_m1 Gpr27-Rn00576563_s1 Gpr3-Rn00596622_s1 Gpr30-Rn01643280_s1 Gpr33-Rn02585962_g1 GPR34-Rn02585733_s1 Gpr35-Rn02748664_s1 Gpr37-Rn00589441_m1 Gpr37l1-Rn00595762_m1 Gpr4-Rn02585915_s1 Gpr41-Rn01457614_g1 Gpr43-Rn02345824_s1 Gpr44-Rn02349421_s1 Gpr50-Rn01281711_m1 Gpr56-Rn00596082_m1 Gpr58-Rn01537308_s1 Gpr6-Rn02133976_s1 Gpr61-Rn01518477_m1 Gpr64-Rn00710487_m1 Gpr68-Rn02758831_s1 Gpr77-Rn02376766_s1 Gpr83-Rn00589686_m1 Gpr85-Rn00573873_s1 Gpr87-Rn02758902_s1 Gpr88-Rn02133938_s1 Gpr89-Rn01533624_m1 Gpr97-Rn01536580_m1 Gprc5a-Rn01459296_m1 Gprc5b-Rn01507963_m1 Gprc5c-Rn02758862_s1 Gprc6a-Rn01433573_m1 Grm1-Rn00566625_m1 Grm2-Rn01447672_m1 Grm3-Rn01755352_m1 Grm4-Rn00674340_m1 Grm5-Rn00566628_m1 Grm6-Rn00709483_m1

16.81

1.42

21.88 21.29 16.03 16.79 16.41

1.84 0.93 0.69 0.48 0.41

23.36 15.75 17.24 23.24

0.97 0.46 0.47 0.17

15.43 19.35 20.05 15.15 16.96 18.19 15.03 21.72 15.74 18.41

0.53 0.67 0.91 0.76 0.42 0.51 0.82 1.41 0.51 0.72

16.56 18.44 21.75 19.05 21.72 16.41 18.36 19.95 19.76 24.42 20.03 17.40 17.55 18.17 18.87

0.57 0.60 1.60 0.83 1.23 1.08 0.65 0.93 0.94 1.78 0.76 0.77 0.27 1.73 0.57

21.99 20.35 12.94

3.15 1.05 0.46

19.89 16.69 15.00 17.66 17.98 18.01 20.15 21.26 18.62 22.60 18.96 17.20 16.08

1.15 0.71 0.74 1.02 0.72 0.88 1.25 1.49 3.23 2.06 1.94 1.27 0.93

20.17 18.69 22.97

1.14 0.66 1.25

4 1 4 4 4 3 4 1 3 4 4 3 1 4 4 4 4 4 4 4 4 4 4 1 4 4 4 4 4 3 4 3 4 3 4 3 3 4 4 2 1 4 4 4 1 2 4 4 4 4 4 4 4 4 3 4 3 4 3 1 2 2 4 4 4 2

Supplementary excel spreadsheet 1. Expression [∆C(t)] data for all GPCRs, control genes and GPCR-associated genes.

GRM7 GRM8 GRPR GUSB HCRTR1 HCRTR2 HMBS HPGD HPRT1 HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR5B HTR6 HTR7 ICAM1 IL8RA (CXCR1) IL8RB (CXCR2) KISS1R KNG1 LANCL1 LGR4 LGR5 LGR7 (RXFP1) LGR8 (RXFP2) LHCGR LOC306792 (S1PR3) LOC362068 (VLGR1) LOC498289 (OPN3) LPHN1 LPHN2 LPHN3 LTA4H LTB4R LTB4R2 LTC4S MAPK1 MAPK14 MAS1 MC2R MC3R MC4R MC5R MCHR1 MGC112790 (FZD8) MRGA10 (MRGPRX3) MRGPRB MRGPRB1 MRGPRB2 (MRGPRX1) MRGPRB5 MRGPRB8 MRGPRC (MRGPRX1) MRGPRD MRGPRE MRGPRF MRGPRG

Grm7-Rn00578996_m1 Grm8-Rn00573505_m1 Grpr-Rn01420745_m1 Gusb-Rn00566655_m1 Hcrtr1-Rn00565032_m1 Hcrtr2-Rn00565155_m1 Hmbs-Rn00565886_m1 Hpgd-Rn00577775_m1 Hprt-Rn01527840_m1 Hrh1-Rn00566691_s1 Hrh2-Rn00564216_s1 Hrh3-Rn00585276_m1 Hrh4-Rn00590929_m1 Htr1a-Rn00561409_s1 Htr1b-Rn01637747_s1 Htr1d-Rn00563397_s1 Htr1f-Rn00573147_s1 Htr2a-Rn00568473_m1 Htr2b-Rn00568450_m1 Htr2c-Rn00562748_m1 Htr4-Rn00563402_m1 Htr5a-Rn00565746_m1 Htr5b-Rn01408872_m1 Htr6-Rn00577615_m1 Htr7-Rn00576048_m1 Icam1-Rn00564227_m1 Il8ra-Rn00570857_s1 Il8rb-Rn02130551_s1 Kiss1r-Rn00576940_m1 Kng1-Rn01774062_gH Lancl1-Rn01786013_m1 Lgr4-Rn00597924_m1 Lgr5-Rn01509662_m1 Lgr7-Rn01495351_m1 Lgr8-Rn01412901_m1 Lhcgr-Rn00564309_m1 LOC306792-Rn02758880_s1 LOC362068-Rn01494079_m1 LOC498289-Rn01412492_m1 Lphn1-Rn01431550_m1 Lphn2-Rn00593014_m1 Lphn3-Rn00590803_m1 Lta4h-Rn01503878_m1 Ltb4r-Rn00572209_s1 Ltb4r2-Rn00586282_s1 Ltc4s-Rn01497055_g1 Mapk1-Rn00671828_m1 Mapk14-Rn00578842_m1 Mas1-Rn00562673_s1 Mc2r-Rn02082290_s1 Mc3r-Rn02585847_s1 Mc4r-Rn01491866_s1 Mc5r-Rn01491260_s1 Mchr1-Rn00755896_m1 MGC112790-Rn01526420_s1 Mrga10-Rn01477013_s1 Mrgprb4-Rn02131116_s1 Mrgprb1-Rn02349870_s1 Mrgprb2-Rn02349909_s1 Mrgprb5-Rn02131089_s1 Mrgprb8-Rn02349886_g1 Mrgprc-Rn00597171_s1 Mrgprd-Rn01785783_s1 Mrgpre-Rn02345719_s1 Mrgprf-Rn01479620_m1 Mrgprg-Rn01786298_s1

14.66 18.21 21.52 16.77 21.77 20.97 17.76 21.32 16.36 18.36 21.15 20.29 25.40 19.82 16.59 18.78 19.27 16.30 20.92 23.53 17.62 19.36 16.65

0.68 0.68 1.81 0.38 1.36 1.15 1.14 2.00 0.24 0.77 2.02 0.88 0.18 1.34 0.66 1.08 1.20 0.54 1.30 1.18 1.04 0.79 0.88

19.97 14.45

1.27 0.68

24.00 23.51 22.96 13.56 14.53 17.82 19.36

0.38 0.81 1.56 0.92 0.80 0.82 0.72

22.37 14.44 17.71 18.45 13.58 15.49 14.07 16.67 22.19 22.10

0.81 0.78 0.81 0.64 0.59 0.88 0.77 0.50 1.46 1.10

12.47 16.44 20.16 21.93 22.13 22.48 21.30 18.58 14.97 14.85 20.90 21.79 22.46 17.77 20.80 15.95 18.40 15.35 17.10 19.09

0.63 0.76 1.50 0.47 0.93 0.45 1.61 0.95 0.94 1.04 0.76 1.61 0.63 0.92 1.55 0.61 1.10 0.48 0.50 1.68

4 4 3 4 4 4 3 4 3 4 3 4 3 4 4 4 4 4 3 3 4 4 4 2 4 4 1 3 3 3 4 4 4 4 1 3 4 4 4 4 3 4 4 4 4 2 4 4 4 3 3 3 3 4 4 4 4 3 4 4 3 4 4 3 4 3

Supplementary excel spreadsheet 1. Expression [∆C(t)] data for all GPCRs, control genes and GPCR-associated genes.

MRGPRH MTNR1A MTNR1B NMBR NMUR1 NMUR2 NPBWR1 NPFFR1 NPFFR2 NPY1R NPY2R NPY5R NTSR1 NTSR2 OLR396 OPN1MW OPN1SW OPN4 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OXGR1 OXTR P2RY1 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 PGK PPIA PPIB PPYR1 PRLHR PROKR1 PROKR2 PTAFR PTGDR PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PTGIS PTGS1 PTGS2 PTHR1 PTHR2 RAMP1 RAMP2 RAMP3 RGD1559926 (GPR142) RGD1560339 (LGR6) RGD1560455 RGD1560731 (GPR146) RGD1561336 (LPAR2) RGD1562580 (LPAR5) RGD1563245 (GPR161) RGD1563887 (GPRC5D) RGD1564154 (NPSR1) RGR RHO

Mrgprh-Rn02131079_s1 Mtnr1a-Rn01488022_m1 Mtnr1b-Rn01447987_m1 Nmbr-Rn00680847_m1 Nmur1-Rn00821165_g1 Nmur2-Rn00574013_m1 Nbpwr1-Rn01772104_s1 Npffr1-Rn00574170_m1 Npffr2-Rn00576846_m1 Npy1r-Rn01402912_g1 Npy2r-Rn00576733_s1 Npy5r-Rn02089867_s1 Ntsr1-Rn01415846_m1 Ntsr2-Rn00575514_m1 Olr396-Rn01783389_g1 Opn1mw-Rn00585560_m1 Opn1sw-Rn00578824_m1 Opn4-Rn01450371_m1 Opn5-Rn00710997_m1 Oprd1-Rn00561699_m1 Oprk1-Rn01448892_m1 Oprl1-Rn00440563_m1 Oprm1-Rn01430371_m1 Oxgr1-Rn02039992_s1 Oxtr-Rn00563503_m1 P2ry1-Rn00562996_m1 P2ry12-Rn02133262_s1 P2ry13-Rn02345727_s1 P2ry14-Rn02532502_s1 P2ry2-Rn02070661_s1 P2ry4-Rn02133903_s1 P2ry6-Rn02134326_s1 Pgk1-Rn00821429_g1 Ppia-Rn00690933_m1 Ppib-Rn00574762_m1 Ppyr1-Rn00580848_s1 Prlhr-Rn00594908_s1 Prokr1-Rn00517546_m1 Prokr2-Rn00594500_m1 Ptafr-Rn02132919_s1 Ptgdr-Rn00824628_m1 Ptger1-Rn00565349_m1 Ptger2-Rn00579419_m1 Ptger3-Rn00562282_m1 Ptger4-Rn00583420_m1 Ptgfr-Rn00565423_m1 Ptgir-Rn01764022_m1 Ptgis-Rn00694611_m1 Ptgs1-Rn00566881_m1 Ptgs2-Rn01483828_m1 Pthr1-Rn00571596_m1 Pthr2-Rn00579427_m1 Ramp1-Rn01427056_m1 Ramp2-Rn00824652_g1 Ramp3-Rn00571815_m1 RGD1559926-Rn02101008_s1 RGD1560339-Rn01490727_m1 RGD1560455-Rn02758918_s1 RGD1560731-Rn02758935_s1 RGD1561336-Rn01420531_m1 RGD1562580-Rn02758966_s1 RGD1563245-Rn01771973_m1 RGD1563887-Rn01492991_m1 RGD1564154-Rn01524824_m1 Rgr-Rn01754438_m1 Rho-Rn00583728_m1

20.36 19.03

0.63 0.89

21.89 22.70

0.71 2.12

21.19 21.67 18.20 15.40 17.20 20.12 19.78 20.48

0.68 1.11 1.00 0.84 0.36 0.33 0.25 1.01

22.67

1.57

19.88 25.25 19.60 18.90 15.88 15.64 24.03 21.83

0.77 2.22 1.13 1.01 0.49 0.73 0.95 0.76

21.59 18.96 17.25 17.50 24.20 15.53 9.56 14.54 21.30 18.51 15.04 14.77 22.37 18.44 18.84 19.16 20.24 17.51 18.40 13.30 20.00 20.40 14.75

0.45 1.02 0.73 0.74 1.48 0.20 0.58 0.60 0.92 2.00 0.80 0.80 1.57 1.08 1.41 0.87 1.39 0.79 0.94 0.60 1.27 2.54 0.61

21.52 18.22 15.87 15.70

1.28 1.01 0.78 0.90

20.42 21.53 19.95 18.79 15.15 14.59

2.50 1.10 0.65 1.80 0.99 0.81

23.96

1.61

19.47

0.66

4 3 1 4 3 0 4 4 4 4 4 4 4 4 1 3 1 4 3 4 4 4 4 3 3 2 2 3 4 4 4 3 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 3 4 4 3 2 4 4 4 4 4 4 0 3 0 4

Supplementary excel spreadsheet 1. Expression [∆C(t)] data for all GPCRs, control genes and GPCR-associated genes.

RLN3R1 (RXFP3) RPLP2 RRH SCTR SMO SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 SUCNR1 TAAR1 TAAR3 TAAR4 TAAR5 TAAR6 TAAR7a TAAR7b TAAR7c TAAR7d TAAR7e TAAR7g TAAR7h TAAR8a TAAR9 TACR1 TACR2 TACR3 TAS1R1 TAS1R2 TAS1R3 TBP TBXA2R TBXAS1 TFRC TM7SF3 TNF TNFRSF1A TNFRSF1B TNFRSF5 TRHR TSHR UBC UTS2R V1RC29 V1RC42 V1RM1 VCAM1 VIPR1 VIPR2 YWHAZ

Rln3r1-Rn02345897_s1 Rplp2-Rn01479927_g1 Rrh-Rn01521911_m1 Sctr-Rn00579585_m1 Smo-Rn00563043_m1 Sstr1-Rn02532012_s1 Sstr2-Rn01464950_g1 Sstr3-Rn02134439_s1 Sstr4-Rn00564741_s1 Sstr5-Rn02535169_s1 Sucnr1-Rn02084929_s1 Taar1-Rn00592484_s1 Taar3-Rn01409292_s1 Taar4-Rn00598093_s1 Taar5-Rn01537493_s1 Taar6-Rn01537238_s1 Taar7a-Rn00598113_s1 Taar7b-Rn01774315_sH Taar7c-Rn01774349_s1 Taar7d-Rn01774304_s1 Taar7e-Rn02749282_gH Taar7g-Rn01774293_sH Taar7h-Rn01774340_g1 Taar8a-Rn01409359_g1 Taar9-Rn00598326_s1 Tacr1-Rn00562004_m1 Tacr2-Rn00436896_m1 Tacr3-Rn00566955_m1 Tas1r1-Rn01516038_m1 Tas1r2-Rn01515494_m1 Tas1r3-Rn00590759_g1 Tbp-Rn01455648_m1 Tbxa2r-Rn00690601_m1 Tbxas1-Rn00562160_m1 Tfrc-Rn01474695_m1 Tm7sf3-Rn01492336_m1 Tnf-Rn99999017_m1 Tnfrsf1a-Rn01492348_m1 Tnfrsf1b-Rn00709830_m1 Tnfrsf5-Rn01423590_m1 Trhr-Rn00564882_m1 Tshr-Rn00563612_m1 Ubc-Rn01789812_g1 Uts2r-Rn00571932_s1 V1rc29-Rn02607150_sH V1rc42-Rn02348974_gH V1rm1-Rn02348959_s1 Vcam1-Rn00563627_m1 Vipr1-Rn02347738_m1 Vipr2-Rn00568267_m1 Ywhaz-Rn00755072_m1

22.63

1.60

21.70 22.31 18.20 20.85

1.81 1.12 0.67 0.75

22.53 21.02 23.42 22.26 21.88

0.85 0.37 2.33 0.77 1.08

18.82

1.26

23.66

1.00

22.74 23.67 24.29

1.08 0.31 1.22

18.73

1.16

21.85 21.63

1.71 0.81

22.54 17.97 21.33 19.38 15.56

0.12 0.09 0.50 0.82 1.04

21.13 13.84 16.97 23.45 21.52 19.69 16.15

1.45 0.26 0.82 1.66 1.49 0.87 0.51

22.62

0.22

18.11

1.38

21.62 11.49

2.08 0.66

3 2 4 4 4 4 2 4 3 4 4 4 2 3 2 3 2 3 3 3 2 0 2 2 1 4 2 4 4 1 3 3 4 4 3 2 3 4 4 3 4 4 4 2 1 4 1 4 1 3 4