AT SANGLAH GENERAL HOSPITAL BALI. Sri Yenni Trisnawa= GS, Thomas Eko Purwata, IGN Purna Putra, AABN Nuartha,. AAA Putri Laksmidewi, Anna MG ...
HIGH LEVEL OF HBA1C IN TYPE-2 DIABETES MELLITUS AS RISK FACTOR FOR PERIPHERAL DIABETIC NEUROPATHY AT SANGLAH GENERAL HOSPITAL BALI Sri Yenni Trisnawa, GS, Thomas Eko Purwata, IGN Purna Putra, AABN Nuartha, AAA Putri Laksmidewi, Anna MG Sinardja, I Putu Eka Widyadharma, IA Sri Wijayan, Department of Neurology, School of Medicine, Udayana University/Sanglah Teaching Hospital, Denpasar, Bali, Indonesia
ABSTRACT
AIMS
Peripheral Diabe,c Neuropathy (PDN) is common complica,on of Type-2 Diabetes Mellitus (T2DM). PDN account for disability and morbidity of pa,ents. also decreased quality of life significantly. Prevalence of PDN is high, approximately 50% of T2DM, especially in uncontrolled blood glycemic index pa,ents. This condi,on determined from the HbA1C level in blood. The aim of this study is to know that high level of HbA1C in T2DM is a risk factor for PDN.
METHODS A case-control study was conducted in T2DM pa,ents who came to Diabe,c and Neurology Outpa,ent clinics during April un,l August 2014. Pa,ents who suffered from PDN defined as cases and pa,ents without PDN as controls. PDN was evaluated by Michigan Diabe,c Neuropathy Score. Data analysis using chi-square with significance level p < 0,05.
RESULTS
High level of HbA1C in T2DM as risk factor for PDN.
KEYWORDS: Type 2 DM, HbA1C, Peripheral Diabe,c Neuropathy Table 1. CharacterisGcs of Research Subject
Gender • Male • Female EducaGon • Elementary • Junior High School • Senior High School • University OccupaGon • Civil servant • Employee • Bussinessman • Farmer • etc
14 12 10 8 6
2
CONCLUSIONS
Age (mean±SD)
16
4
A total number of 86 eligible subjects were devided into case and control groups, with each group consisted of 43 pa,ents. There were 31 (72.1.%) pa,ents in case group with high HbA1c level compared to 15 (34.9 %) in control group (p< 0.001) with OR 4.82; CI 95% (1.931-12.041).
Variabel
PDN Stage
PDN (+)
PDN (-)
n % 56.05±6.34
n % 51.6±8.56
22 21
5.2 48.8
22 21
0 Stage 1
10 7 6 8 12
27.9 14.0 34.9 23.3 23.3 16.3 14.0 18.6 27.9
9 4 20 10
Normal HbA1c Level High ≥ 55 years Age < 55 years Yes Obesity No ≥5 years DM Dura,on
