Transcriptional repression in euchromatin. JMJD2C/GASC. 1. KDM4C di-,tri-. Reduced heterochromatin in vivo. Putative oncogene. EuHMTase/GL. P. KMT1D.
Histone H3
Arg2
Histone methyltransferases
Substrate
Function
CARM1/PRMT 4
a-di-
Transcriptional activation.
PRMT6 MLL1/HRX/ALL 1 KMT2A
a-di-
Transcriptional repression
MLL2/HRX2
KMT2B
tri-
MLL3
KMT2C
Transcriptional activation.
MLL4/ALR
KMT2D
Transcriptional activation.
MLL5
KMT2E
Transcriptional activation. Cell cycle arrest.
SET1A
KMT2F
mono-,di-,tri-
Transcriptional activation.
SET1B
KMT2G
tri-
Transcriptional activation.
ASH1/ASH1L
KMT2H
tri-
Transcriptional activation.
SET7/9
KMT7
mono-
Lys4
SMYD3
Arg8
PRMT5/SKB1
Transcriptional activation. Control of Hox gene. Transcriptional activation. Control of Hox gene.
Arg17 Arg26
s-di-
Transcriptional repression.
SUV39H1
KMT1A
di-,tri-
Transcriptional repression. Heterochromatic silencing.
SUV39H2
KMT1B
di-,tri-
Transcriptional silencing during meiosis.
Function
JMJD6 JARID1A/RBP 2 KDM5A
di-
Cellular differentiation and proliferation during development.
di-,tri-
Transcriptional repression. Rb-interacting protein.
JARID1B/PLU1 KDM5B JARID1C/SMC X KDM5C JARID1D/SMC Y KDM5D
mono-,di-,tri-
Transcriptional repression. Transcriptional repression. X-linked mental retardation.
di-,tri-
Transcriptional repression. Male specific antigen.
LSD1/BHC110 KDM1 JHDM1B/FBXL 10 KDM2B
mono-,di-
Transcriptional repression. Transcriptional repression. Repression of rRNA genes.
di-,tri-
tri-,
G9a KMT1C EuHMTase/GL P KMT1D
mono-,di-
Transcriptional repression in euchromatin.
SETDB1/ESET KMT1E
tri-
di-,tri-
Transcriptional repression. Genome integrity.
di-,tri-
Heterochromatin formation.
di-,tri-
Reduced heterochromatin in vivo. Putative oncogene.
di-,tri-
Transcriptional repression in euchromatin.
JMJD2D KDM4D JMJD1A/JHDM 2A KDM3A JMJD1B/JHDM 2B KDM3B
mono-,di-
Transcriptional activation and repression.
Transcriptional repression.
LSD1/BHC110 KDM1
mono-,di-
Transcriptional activation.
UTX
KDM6A
tri-
JMJD3 JHDM1A/FBXL 11 JHDM1B/FBXL 10 JMJD2A/JHDM 3A
KDM6B
tri-
KDM2A
mono-,di-,
KDM2B
mono-,di-
Transcriptional repression in euchromatin.
RIZ1/PRDM2 KMT8 CARM1/PRMT 4 CARM1/PRMT 4
a-di-
Transcriptional activation.
a-di-
Transcriptional activation.
EZH2
tri-
Initiation of gene silencing.
KMT6
SET2
KMT3A
tri-
NSD1
KMT3B
SMYD2
KMT3C
ASH1
KMT2H
mono-,di-
DOT1L
KMT4
di-,tri-
JMJD2A/JHDM 3A KDM4A JMJD2B KDM4B JMJD2C/GASC 1 KDM4C
Lys27 Associate with 3' end of transcribed genes.
Lys36 Lys79
Substrate
Transcriptional activation.
SETDB2/CLL8 KTM1F Lys9
Histone demethylases
Regulated during the cell cycle. Telomere silencing.
KDM4A
di-,tri-
JMJD2B KDM4B JMJD2C/GASC 1 KDM4C
di-,tridi-,tri-
Transcriptional activation. Essential for proper development. Transcriptional activation. Essential for proper development.
Transcriptional repression. Genome integrity.
Reduced heterochromatin in vivo. Putative oncogene.
Histone H4
Arg3
Lys20
Histone methyltransferases
Substrate
Function
PRMT1
a-di-
Transcriptional activation. Heterochromatic silencing.
PRMT5/SKB1
s-di-
Transcriptional repression (?).
SUV420H1
KMT5B
di-(?),tri-
Transcriptional repression. Heterochromatic silencing.
SUV420H2 PRSET7/SET8
KMT5C
di-(?),tri-
Transcriptional repression. Heterochromatic silencing.
KMT5A
mono-
Cell-cycle-dependent transcriptional silencing.
Histone demethylases JMJD6
Substrate
Function
di-
Cellular differentiation and proliferation during development.
