Clinical data (community-acquired â nosocomial infection, immune ... Keywords Escherichia coli, host factors, outcome, sepsis, severity, virulence determinants.
ORIGINAL ARTICLE
10.1111/j.1469-0691.2007.01775.x
Host and bacterial determinants of initial severity and outcome of Escherichia coli sepsis F. Jaure´guy1,6, E. Carbonnelle2,6, S. Bonacorsi3, C. Clec’h4, P. Casassus5, E. Bingen3, B. Picard1, X. Nassif 2,6 and O. Lortholary2,7 1
Hoˆpital Avicenne, AP-HP, UFR Sante´, Me´decine, Biologie Humaine, Universite´ Paris 13, 2Faculte´ de Me´decine Paris 5, Hoˆpital Necker-Enfants Malades, 3Hoˆpital Robert Debre´, AP-HP, Paris, 4Hoˆpital Avicenne, Service de Re´animation Me´dico-Chirurgicale, AP-HP, UFR Sante´, Me´decine, Biologie Humaine, Universite´ Paris 13, Bobigny, 5Service d’He´matologie, Hoˆpital Avicenne, AP-HP, UFR Sante´, Me´decine, Biologie Humaine, Universite´ Paris 13, Bobigny, 6INSERM Unite´ 570, Faculte´ de Me´decine Necker-Enfants Malades, Universite´ Paris 5 and 7CNRS URA3012, Institut Pasteur, Paris, France
ABSTRACT A 1-year prospective cohort study of all episodes of Escherichia coli bacteraemia in two French university hospitals was conducted to assess simultaneously the influence of host and bacterial determinants on the initial severity and outcome of E. coli sepsis. Clinical data (community-acquired ⁄ nosocomial infection, immune status, underlying disease, primary source of infection, severity sepsis scoring and outcome), phylogenetic groups (A, B1, D and B2), nine virulence factors (VFs) (papC, papGII, papGIII, sfa ⁄ foc, hlyC, cnf1, iucC, fyuA and iroN) and the antibiotic susceptibility of isolates were investigated. All VFs except iucC were significantly more prevalent (p
