Helmer C, Portet F, Amouyel P, Lathrop M, Elbaz A, Durr A,. Martinez M, Brice A ... Pedersen NL (2010) Reaching the limits of genome-wide signifi- cance in ...
Mol Neurobiol DOI 10.1007/s12035-014-8946-8
Identifying the Association Between Alzheimer’s Disease and Parkinson’s Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network Guiyou Liu & Xinjie Bao & Yongshuai Jiang & Mingzhi Liao & Qinghua Jiang & Rennan Feng & Liangcai Zhang & Guoda Ma & Zugen Chen & Guangyu Wang & Renzhi Wang & Bin Zhao & Keshen Li
Received: 18 August 2014 / Accepted: 20 October 2014 # Springer Science+Business Media New York 2014
Abstract Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the first and second most common neurodegenerative diseases in the elderly. Shared clinical and pathological features have been reported. Recent large-scale genome-wide association studies (GWAS) have been conducted and reported a number of AD and PD variants. Until now, the underlying genetic mechanisms for all these newly identified PD variants as well as the association between AD and PD are still unclear exactly. We think that PD variants may contribute to AD and
PD by influence on brain gene expression. Here, we conducted a systems analysis using (1) AD and PD variants (P
