idweek 2015 poster abstracts

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Chang Jang, MD5; 1Infectious Disease, Chonnam National University Hospital,. Gwang Ju, South Korea; 2Infectious Disease, Chonnam National University ...
IDWEEK 2015 POSTER ABSTRACTS 213. Clinical Characteristics and Prognosis of Candida Prosthetic Joint Infections Uh Jin Kim, MD1; Tae Hoon Oh, MD2; Ji Eun Kim, MD3; Hee Kyung Kim, MD4; Joon Hwan Ahn, MD5; Seung Ji Kang, MD4; Kyung Hwa Park, MD5; Sook in Jung, MD5; Jong Hee Shin, PHD6; Kyung Soon Park, PHD7; Jeong Geun Seon, PHD7; HeeChang Jang, MD5; 1Infectious Disease, Chonnam National University Hospital, Gwang Ju, South Korea; 2Infectious Disease, Chonnam National University Hospital, Gwang Ju, South Korea; 3Chonnam National University Hospital, Gwang Ju, South Korea; 4Chonnam National University Hwasun Hospital, Hwasun-Gun, South Korea; 5 Chonnam National University Medical School, Gwangju, South Korea; 6Laboratory Medicine, Chonnam National University Medical School, Gwang-ju, South Korea; 7 Orthopedic Surgery, Center for Joint Disease at Chonnam National University Hwasun Hospital, Hwasun-Gun, South Korea Session: 43. Candida Infection Thursday, October 8, 2015: 12:30 PM

Background. Candida prosthetic joint infections are rare and its clinical characteristics and prognosis are still unclear. We retrospectively analyzed the clinical characteristics and prognosis of candida prosthetic joint infections. Methods. 17 patients treated with candida prosthetic joint infections in 2 tertiary hospitals in South Korea between 2006 and 2013 were evaluated. 43 Patients with S. aureus prosthetic joint infections and 29 patients with S. epidermidis from the same hospitals were also evaluated. This was a retrospective cohort study, with a followup of at least 1 year and 6months or until the patient died. Results. Candida and S. epidermidis prosthetic joint infections showed lower level of serum C-reactive protein (CRP) (mg/dL) compared to S. aureus prosthetic joint infections significantly (median 3.0 versus 3.0 versus 6.0, p = 0.029). White blood cell (WBC) (mm3) count from joint fluid of Candida prosthetic joint infections was also lower than S. aureus prosthetic joint infections (median 4045 versus 65128, p = 0.012). The relapse rate of candida prosthetic joint within the first 24 weeks of follow-up was lower than S. aureus and S. epidermidis prosthetic joint infections (6% versus 17% versus 29% p = 0.085). Nonetheless, the relapse rate increased after 24 weeks. At the total follow up of 1 year and 6months, the relapse rate of Candida prosthetic joint infections was better than S. aures prosthetic joint infections but worse than S. epidermidis prosthetic joint infections.(35% versus 41% versus 17%, p = 0.09). Conclusion. Serum CRP and joint fluid WBC may provide useful information in differentiating microorganism in prosthetic joint infections especially between Candida and staphylococcal species. The relapse rate of the Candida prosthetic joint infections was lower than staphylococcal prosthetic joint infections at a follow-up period of 24 weeks. Howevere, the relapse rate increased after 24 weeks. Therefore, long-term follow-up should be considered for those with candida prosthetic joint infections. Disclosures. All authors: No reported disclosures.

Open Forum Infectious Diseases 2015;2:71–536 © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/ by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact [email protected]. DOI: 10.1093/ofid/ofv133

Poster Abstracts



OFID 2015:2 (Suppl 1)



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