Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia,1 and Heska Corporation,. Fort Collins ... the host. Infected patients present with subacute regional ... (This work was presented in part at the 13th Sesqui-Annual. Meeting ...
Characterization of Human Immunoglobulin (Ig) Isotype and IgG Subclass Response to Bartonella henselae Infection SVENA L. MCGILL,1 RUSSELL L. REGNERY,1
AND
KEVIN L. KAREM2*
Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia,1 and Heska Corporation, Fort Collins, Colorado2 Received 15 June 1998/Returned for modification 5 August 1998/Accepted 31 August 1998
Serologic parameters of cat scratch disease (CSD) were evaluated by Western blot analysis. Sera from patients with serologically confirmed CSD antigen were screened for immunoglobulin (Ig) isotype-specific as well as IgG subclass-specific reactivity against Bartonella henselae whole-cell antigen. Bartonella-negative control sera were used to determine baseline antibody activity. Heterogeneous B. henselae-specific IgG reactivity with numerous protein bands, ranging from >150 to
