Impact of apathy on healthrelated quality of life in ...

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Jun 15, 2011 - Cruces,'' Bilbao, Vizcaya); José Manuel Fernández-Garcıa and Luis ... (Getafe University Hospital, Getafe, Madrid); Fernando Alonso-Frech ... González (Hospital ''Ciudad de Jaén,'' Jaén, Jaén); Carlos Sánchez-Ortiz.



Impact of Apathy on Health-Related Quality of Life in Recently Diagnosed Parkinson’s Disease: The ANIMO Study Julia´n Benito-Leo´n, MD, PhD,1,2,3* Esther Cubo, MD, PhD,4 and Carlos Coronell, MD, PhD,5 on behalf of the ANIMO Study Group 1 Department of Neurology, University Hospital ‘‘12 de Octubre’’, Madrid, Spain Centro de Investigacio´n Biome´dica en Red sobre Enfermedades Neurodegenerativas, Madrid, Spain 3 Department of Medicine, Faculty of Medicine, Complutense University, Madrid, Spain 4 Department of Neurology, Hospital ‘‘General Yagu¨e,’’ Burgos, Spain 5 Medical Advising Department, Boehringer Ingelheim Espan˜a, Barcelona, Spain


A B S T R A C T : The impact of apathy on healthrelated quality of life (HRQOL) in recently diagnosed Parkinson’s disease (PD) has not been systematically investigated. The objective of this cross-sectional survey (ANIMO study) was to examine the contribution of apathy to HRQOL in a Spanish sample of recently diagnosed PD patients. PD patients, diagnosed within 2 years of inclusion, were recruited at 102 outpatient clinics in 82 communities throughout Spain. Apathy was quantified using the Lille Apathy Rating Scale and HRQOL with the EuroQol-5D questionnaire. A mean EuroQol-5D index score of 0.89 obtained from population references in Spain was used as the cutoff for this study. The relationship between apathy and the dichotomized EuroQol-5D index score (0.50, moderate if 0.35–0.50, and weak if

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