Methods. Thirteen patients with ALF were included. Cytosorb® was applied in combination with standard continuous veno-venous hemofiltration. Demographic ...
The potential utility of a hemoadsobtion column (CytoSorb®) in patients with acute liver failure Dana Tomescu, Mihai Popescu Dept. of Anaesthesia and Critical Care, Fundeni Clinical Institute, Bucharest, Romania “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Introduction Acute liver failure (ALF) represents a life-threatening condition that requires highly specialized treatment in dedicated intensive care units. The aim of our study was to assess the clinical and paraclinical effects of a hemoadsorption column (Cytosorb®) in patients with ALF.
Methods. Thirteen patients with ALF were included. Cytosorb® was applied in combination with standard continuous veno-venous hemofiltration. Demographic variables, SIRS criteria and SOFA score were noted at inclusion. Clinical variables (hepatic encephalopathy, Glasgow coma score, urine output), hemodynamic variables (mean blood pressure, heart rate, vasopressor support) and paraclinical results (pH, bilirubin, creatinine, leucocyte count, platelet count, procalcitonine, C-reactive proteine) were recorded before and after each Cytosorb® session.
Results. The patients mean age was 46 ±17 years. At the time of ICU admission, the patients presented a median of 2 [1-4] SIRS criteria and a median of 3 [1-4] organ dysfunctions. We observed a statistically significant decrease in bilirubin levels from a mean of 23.6±12.9 to 17.8±11.2 mg/dL (p=0.02). Although we observed a slight decrease in creatinine (0.86±0.45 from 0.93±0.21 mg/dL, p=0.128), C-reactive protein (55.1±28.4 from 69.7±25.31mg/L, p=0.542) and procalcitonine (0.92±0.45 from 1.32±1.02 ng/ml, p=0.498), these were not statistically significant. Also we observed an increase in Glasgow coma scale of 2 points, from a median of 9 [3-14] points to a median of 11 points [3-15] (p=0.362).
ILTS 2018
Conclusion The use of CytoSorb ® in patients with ALF has been associated with improved liver function. Although we observed a positive trend in organ dysfunction, due to the low number of included patients, we could not reach a statistical significant conclusion. LB-P-047
Latebreaker Dana Tomescu
DOI: 10.3252/pso.eu.ILTS2018.2018
Poster presented at:
