Influence of eye biometrics and corneal micro-structure on ... - PLOS

1 downloads 0 Views 6MB Size Report
May 4, 2017 - Robert Iskander1. 1 Department of Biomedical ...... Patel S V, McLaren JW, Hodge DO, Bourne WM. Normal Human Keratocyte Density and ...
RESEARCH ARTICLE

Influence of eye biometrics and corneal micro-structure on noncontact tonometry Danilo A. Jesus1*, Małgorzata Majewska1, Patrycja Krzyżanowska-Berkowska2, D. Robert Iskander1 1 Department of Biomedical Engineering, Wroclaw University of Science & Technology, Wroclaw, Poland, 2 Department of Ophthalmology, Wroclaw Medical University, Wroclaw, Poland * [email protected]

a1111111111 a1111111111 a1111111111 a1111111111 a1111111111

Abstract

Purpose

OPEN ACCESS Citation: Jesus DA, Majewska M, KrzyżanowskaBerkowska P, Iskander DR (2017) Influence of eye biometrics and corneal micro-structure on noncontact tonometry. PLoS ONE 12(5): e0177180. https://doi.org/10.1371/journal. pone.0177180 Editor: Sanjoy Bhattacharya, Bascom Palmer Eye Institute, UNITED STATES Received: January 17, 2017 Accepted: April 23, 2017 Published: May 4, 2017 Copyright: © 2017 Jesus et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information file. Funding: This work was supported by the Marie Curie Innovative Training Networks, Ageing Eye, AGEYE, 608049 and partially funded by National Science Centre, Poland, Grant No: 2014/15/B/ST7/ 05220. Competing interests: The authors have declared that no competing interests exist.

Tonometry is widely used as the main screening tool supporting glaucoma diagnosis. Still, its accuracy could be improved if full knowledge about the variation of the corneal biomechanical properties was available. In this study, Optical Coherence Tomography (OCT) speckle statistics are used to infer the organisation of the corneal micro-structure and hence, to analyse its influence on intraocular pressure (IOP) measurements.

Methods Fifty-six subjects were recruited for this prospective study. Macro and micro-structural corneal parameters as well as subject age were considered. Macro-structural analysis included the parameters that are associated with the ocular anatomy, such as central corneal thickness (CCT), corneal radius, axial length, anterior chamber depth and white-to-white corneal diameter. Micro-structural parameters which included OCT speckle statistics were related to the internal organisation of the corneal tissue and its physiological changes during lifetime. The corneal speckle obtained from OCT was modelled with the Generalised Gamma (GG) distribution that is characterised with a scale parameter and two shape parameters.

Results In macro-structure analysis, only CCT showed a statistically significant correlation with IOP (R2 = 0.25, p