Programme (s) on which the course is given: M.B & B. Ch ... Medical Biochemistry
and Molecular Biology for 2nd year undergraduate medical students. *Lecture: ...
To enable the student to illustrate and or describe the metabolic pathways of
macronutrients , ..... Textbook of biochemistry for medical students Lippincott's.
Template for Course Specifications Faculty: Department:
Medicine Medical Biochemistry Department
Course Specifications Programme (s) on which the course is given: Major or minor element of programmes: Code of the course Department offering the course: Academic year / level: Date of specification approval:
M.B & B. Ch Major CHEM-2 Medical Biochemistry Department 2nd year undergraduate students 25/10/2009 (Department assembly approval)
a- Basic information Title:
Medical Biochemistry and Molecular Biology for 2nd year undergraduate medical students
*Lecture:
3 hours/week (for 25 weeks
Tutorial
--
Practical
2.5 hours/week (for 24 weeks)
Total:
5.5
(hour/week)
* See time plan b- Professional Information
1- Overall Aims of Course To enable the student to be oriented with the biochemical importance of macro- and micronutrients as well as the structure and functions of enzymes. To enable the student to illustrate and or describe the metabolic pathways of macronutrients , micronutrients and nucleotides. To enable the student to point-out hereditary and acquired metabolic disturbances and their biochemical laboratory and clinical outcomes. To enable the student to point-out the bioenergetics of the concerned metabolic pathways under different physiological circumstances and their integrator regulations with other working metabolic pathways. To enable the student to describe major body fluids composition and their clinical impact. To enable the student to interpret medical laboratory reports.
2- Intended Learning Outcomes of Course (ILOs) a- Knowledge and Understanding (K) By the end of the course ,student should be able to : a1a2a3-
Define the metabolic pathways of carbohydrates , lipids, proteins, nucleotides and their micromolecules and their interrelation. lllustrate the steps and regulatory mechanisms of these pathways. Point out the related metabolic disorders and their clinical prints on biochemical and molecular basis.
1
a4a5a6a7a8a9a10-
Describe micronutrients, their biochemical, clinical and laboratory importance and deficiency manifestations of each. Describe the components of some body fluids; blood ,urine ,Semen , CSF and sweat. Explain different mechanisms of hormonal action. Understand biochemical thermodynamics and biological oxidation process and know its application. Understand how foreign materials be handled at the cellular level. Identify biochemical process in different cellular organelles and their modification. Gain knowledge about different globular protein especially heme and its metabolism.
b- Intellectual Skills (I) By the end of the course ,student should be able to : b1b2b3b4b5-
Interpret symptoms, signs and biochemical laboratory findings of some metabolic disorders. Interpret urine report outcome. Point out the clinical significance of determination of plasma levels of glucose, total proteins, albumin, creatinine and uric acid and some enzymes. Diagnose the type of abnormality of pathological glucose tolerance curve. Point-out the etiology of metabolic disturbance in a given case study report.
c- Professional and Practical Skills (P) By the end of the course ,student should be able to : c1 c2 c3 c4 c5
Identify the physical and chemical characters of normal urine under different physiological conditions. Perform chemical tests to detect abnormal constituents of urine. Estimate serum levels of glucose, total proteins, albumin, creatinine and uric acid by colorimetric methods. Assess glucose tolerance by glucose tolerance test. Demonstrate plasma protein separation by electrophoresis
d- General and Transferable Skills (T) By the end of the course ,student should be able to : d1 d2
Catch the spirit of team work and be able to work in group with statistical increase in self directed learning attitude . Manage time effectively and use informational technologies during learning.
3- Contents Practical/
2
Topic Biological oxidation Carbohydrate Metabolism Lipid Metabolism Diabetes Mellitus General protein Metabolism Amino acid Metabolism Heme Metabolism Purine & pyrimidine Metabolism Metabolic Interrelation Minerals Body Fluids Mechanism of hormonal action Xenobiotic metabolism Cell organelles Student presentation Total
No. of hours 7 18 15 7 8 19 9 5 3 8 16 5 2 1 12 135
Lectures 5 12 12 3 4 9 5 3 3 6 5 5 2 1 0 75
small groups 2 6 3 4 4 10 4 2 0 2 11 0 0 0 12 60
3a- Topics: 1- Biological oxidation, and Bioenergetics 2- Metabolism of xenobiotics 3- Tricarboxylic acid cycle :steps, regulation, and importance. 4- Metabolism of carbohydrates:Dietary carbohydrates, digestion and absorption,pathways of glucose oxidation,glycogen metabolism, gluconeogenesis, special metabolism of fructose, galactose and aminosugars, pathological aspects of carbohydrates metabolism and their clinical importance with special emphasis on diabetes mellitus and biochemistry of insulin and other disorders of carbohydrates metabolism and their clinical importance . 5- Metabolism of lipid: Dietary lipids, digestion and absorption, metabolism of triacylglycerol, fatty acid metabolism, metabolism of: eicosanoids, conjugated lipids, cholesterol, ketone bodies, classification and disorders of plasma lipoproteins. Pathological aspects of lipid metabolism and their clinical implication. 6- Metabolism of proteins: Dietary proteins, digestion and absorption, general aspect of protein metabolism, metabolism of ammonia, metabolism of individual amino acids with related errors of metabolism, pathological aspects of protein and amino acid metabolism and their clinical implications. 7- metabolism of Heme: Synthesis of porphyrins and heme, catabolism, hyperbilirubinemia and porphyrias. 8- metabolism of purines and pyrimidines:Digestion and absorption, of nucleic acids, biosynthesis and catabolism of purines and pyrimidines with the related errors of metabolism (including gout) and synthetic base analogues and their clinical use. 9- Metabolic integration: Metabolic changes, adaptation and regulation during starve-feed cycle, aerobic and anaerobic exercises, diabetes mellitus pregnancy and lactation. Special metabolism of ethyl alcohol and its pathological sequelae.
3
10- Minerals: Major elements (Ca-P-Mg-Na-K-Cl-S)and trace elements (Fe-Cu-Zn-Mn-Co-Cr-I) 11- Mechanism of hormonal action 12-Body fluids: Blood, urine, CSF, and sweat.
3b- Practical classes: 1- Urine report. 2- Colorimetric measurement of : plasma glucose, total proteins, albumin, cholesterol ,creatinine and uric acid. 3- Variations in glucose tolerance curve under different clinical condition 4- Case report studies applying the out-comes of previous parameters. 5- Haemolysis and haemoglobin derivatives. 6- Separation of plasma proteins by electrophoresis . 3c- Self learning (S. L.) activity: 2nd year medical students will be divided into 12 sections. Every section will be divided into 10 subgroups. Each one will be responsible for preparation and presentation of one of preset topic on recent issues related to applied Biochemistry and finally evaluated by staff members of the department.
4- Learning Methods 4.1-
Lectures: interactive lecture with audio-visual aids supplemented by data show.
4.2-
Practical classes: small group teaching with clinical demonstration, practice of laboratory skills and discussion in addition for virtual lab presentation for electrophoresis.
4.3-
Self learning: student presentations
Teaching plan: Lectures: 3 lectures per week ;one hour each according to the current time table in general lecture halls. Practical classes and tutorials: The students are divided into 24 groups. Each group has two hours-practical class once per week. in the student’s labs in biochemistry department
*Time plan: Item
Time schedule
Teaching hours
4
Total hours
Lectures
3 times/ week; one hour each between 8.00 a.m and 2.00 p.m
3 x 25weeks
75
Practical
2 hour every week
2 x 24 weeks
48
1 x 12 weeks
12
according to the current time table 1 hour every 2 weeks
S. L. activity
according to the current time table 135
Total
Achievement of course intended learning outcomes
Knowledge & understanding
Subject a1
a2
a3
a4
a5
a6
Biological oxidation Carbohydrate metabolism Diabetes Mellitus Lipid metabolism General protein metabolism Amino acid metabolism Heme metabolism Purine and pyrimidine metabolism Metabolic interrelation Minerals Body fluid Mechanism of hormonal action Xenobiotic metabolism Cell organelles
a7
a8
Professional
Intellectual skills a9
a10
b1
b2
b3
b4
b5
General& transferable skills
& practical skills c1
c2
c3
c4
c5
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5- Student Assessment Methods
Method/ tools
Item to be assessed
5
• •
Written examination
Assessment of knowledge & understanding
Oral examination
student presentation skills and student ability of analysis and application of knowledge
Practical examination
practical, general and problem solving skills
Student Presentation
ability of the student to search for knowledge, presenting it in an intellectual manner and by acting as a teamwork
Assessment Schedule Assessment 1 Assessment 2 Assessment 3 Assessment 4
week week week week
Summative exam Summative exam Summative exam Final summative exam
6 (November) 14 (January) 20 (March) 32 (May, re – held in September for those who fail to pass the final exam or postpone it
Assessment description: Examination Continuous summative Exams
Description Selection type items: (MCQ & cross matching and interpretive exercise). Supply type item: short answer.
7,5 (5%)
After 6 weeks from beginning of the academic year January After 6 weeks from beginning of the 2nd term
Final Practical
Oral
Marks
15 (10%) 7,5 (5%) A 3-hour written paper composed supply type item ( short answer & restricted response essay) Identify and write a complete report of provided urine sample, Sheet examination and presentation of students for S. L. Two oral examination station
75
25 20 150 marks
Total Weighting of Assessments Continuous summative examinations: November January
7,5 (5%) 15 (10%)
6
March Final written examination Oral Examination Practical work Other types of assessment (Student presentation)
7,5 (5%) 75 20 20 5
Total
150
Passing score:
The minimum passing score is 90 marks provided at least 30 marks are obtained in the final written exam.
Final grades for biochemistry:
EXCELLENT VERY GOOD GOOD PASS
≥ 85%, 75-
