Apr 19, 2018 - Posters (Sunday) .... with quality of life or symptoms among those with prolonged ... of life and positively related to symptoms in both groups.
S204 Posters (Sunday) IL-10 = −0.44, P = .282, (IFN)-γ = −21.08, P = .124, TNFsR1 = −19.56, P = .845, IL1sR1 = 28.41, P = .375. Conclusion: There were no statistical significant changes in the measurement of peripheral cytokines after 3 weeks of antipsychotic treatment. The nonsignificant changes were mostly in proinflammatory direction. It is possible that the anti-inflammatory effects of antipsychotic treatment found in previous studies appear after treatment for more than 3 weeks.
SU118. COGNITIVE IMPAIRMENT AND CLOZAPINE RESPONSE IN TREATMENTRESISTANT SCHIZOPHRENIA—A CROSSSECTIONAL STUDY Shinichiro Nakajima*,, Yusuke Iwata2, Eric Plitman2, Jun Ku Chung2, Philip Gerretsen2, Wanna Mar2, Vincenzo De Luca2, Gary Remington2, and Ariel Graff-Guerrero2 1 Keio University; 2Centre for Addiction and Mental Health; University of Toronto Background: Response to clozapine is proposed to be a marker by which patients with schizophrenia can be stratified into biologically distinct subgroups. While cognitive impairment is a core symptom of schizophrenia, few studies have examined the relationship between cognitive function and response to clozapine in patients with treatment-resistant schizophrenia. Methods: This study included 16 patients with schizophrenia who responded to clozapine (age: 43.2 ± 11.9 y; female 37.5%), 19 patients who did not respond to clozapine (44.6 ± 11.3 y; 26.3%), and 19 healthy controls (HC) (44.1 ± 12.5 y; 31.6%). Participants were age and sex matched. The following cognitive assessments were administered: Executive Interview (EXIT), Finger Tapping (FT), Grooved Pegboard (GP), Letter Fluency (F, A, and S) (LF), Letter-Number Span (LNS), Mini-Mental Status Exam (MMSE), Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), Stroop Test, Trail Making Test A and B (TMT), and Wechsler Test of Adult Reading (WTAR). Cognitive functions were compared among the 3 groups using analyses of variance with a significant P-value less than 0.0022 (0.05/23). If there was a significant difference among them, post hoc Tukey’s tests were conducted with a significant P-value less than 0.0038 (0.05/13). Results: PANSS total, positive subscale, and global subscale scores were higher in nonresponders than in responders (P < .001, P < .001, and P < .001, respectively). Significant differences were found in scores of WTAR, EXIT, RBANS Immediate Memory, Visuospatial/Constructional, Language, Attention, and Delayed Memory domains, GP, LF F test, LNS, Stroop Color-Word tests, and TMT B among the 3 groups (P < .001, P ≤ .001, P < .001, P = .001, P < .001, P < .001, P < .001, P < .001, P = .001, P < .001, P < .001, P < .001, respectively). No differences were found in MMSE, FT, LF A and S tests, Stroop Color test, and TMT A scores, and score ratios of Stroop Color and Color-Word tests and TMT A and B. Among these 13 domains, there was no domain where any difference was found between responders and nonresponders. WTAR, EXIT, RBANS Language domain, LF F test, and Stroop Color-Word test scores were lower in nonresponders than HC without any significant differences among other comparisons. Both responders and nonresponders performed significantly worse than HC on RBANS Total scale, Immediate Memory, Visuospatial/Constructional, Attention, and Delayed Memory domains, GP, LNS, and TMT B without any significant differences between responders and nonresponders. Conclusion: Regardless of response to clozapine, patients with treatmentresistant schizophrenia appear to have impairments in attention, processing speed, working memory, cognitive control/executive function, and visual learning. These results are consistent with the finding that cognitive symptoms are generally unresponsive to antipsychotic treatment.
SU119. INTERNALIZED STIGMA IN ADULTS WITH EARLY-PHASE VS PROLONGED PSYCHOSIS Ruth Firmin1, Jenifer Vohs2, Lauren Luther3, Philip Yanos4, Bethany Leonhardt2, and Paul Lysaker*, 1 Yale School of Medicine; 2Indiana University School of Medicine; 3 Indiana University; Purdue University; 4John Jay College of Criminal Justice, City University of New York; 5Roudebush VA Medical Center and the Indiana University School of Medicine Background: While internalized stigma is associated with negative outcomes among those with prolonged psychosis, surprisingly little work has focused on when in the course of one’s illness stigma is internalized and the impact of internalization on symptoms or quality of life over the course of the illness. Therefore, this study investigated whether (1) internalized stigma is greater among those later in the course of psychosis and (2) whether internalized stigma has a stronger negative relationship with quality of life or symptoms among those with prolonged compared to early-phase psychosis. Methods: Individuals with early-phase (n = 40) and prolonged psychosis (n = 71) who were receiving outpatient services at an early-intervention clinic and a VA medical center, respectively, completed self-report measures of internalized stigma and interview-rated measures of symptoms and quality of life. Results: Controlling for education, race, and sex differences, internalized stigma was significantly greater among those with prolonged compared to early-phase psychosis. Internalized stigma was negatively related to quality of life and positively related to symptoms in both groups. Furthermore, the magnitude of the relationship between cognitive symptoms and internalized stigma was significantly greater among those with early-phase psychosis. Stereotype endorsement, discrimination experiences, and social withdrawal also deferentially related to symptoms and quality of life across the 2 samples. Conclusion: Findings suggest that internalized stigma is an important variable to incorporate into models of early psychosis. Further, internalized stigma may be a possible treatment target among those in their early phase of psychosis.
SU120. URBAN UPBRINGING INFLUENCES RESPONSE TO SOCIAL FEEDBACK Imke Lemmers-Jansen*, Anne-Kathrin Fett, and Lydia Krabbendam VU Amsterdam Background: Growing up in an urban environment is associated with a higher incidence of schizophrenia. The effects of urbanicity seem particularly pronounced during development. It has been hypothesized that urbanicity could be a proxy for social stress, which might account for disturbed social interactions and trust in the disorder. Yet, how urbanicity affects trust and the dynamics of social interactions in schizophrenia has not been investigated experimentally. Previous studies have suggested that a key feature of disturbed trust in schizophrenia is a lack of sensitivity to the behavior of others. We hypothesized that higher exposure to urban environment during development is associated with a greater insensitivity to social signals. Methods: We used 2 multiround trust games to measure the trust during repeated social interactions and basic trust toward unknown others. Twenty-four adolescents with nonaffective psychosis and 24 agematched healthy controls (mean age 19.6, SD = 1.6) played the 20-round trust games with a preprogrammed cooperative (returning more) and unfair partner (returning less than invested), to probe under which
International Congress on Schizophrenia Research Downloaded from https://academic.oup.com/schizophreniabulletin/article-abstract/43/suppl_1/S204/3076060 by guest on 19 April 2018
