Medical Science Monitor, vol. 17, no. 3, pp.132â139. Yarnell P. (1976), Aphasia outcome in stroke: a clinical neuroradiological correla1on. Stroke, vol. 7, no.
Effects of a combined rTMS and CIAT intervention on patients with chronic post-stroke aphasia
1 2 1 1 1 1 1 Joseph C. Griffis , Jennifer Vannest , Jane B. Allendorfer , Rodolphe Nenert , Amber Mar&n , Victor Mark , Jerzy P. Szaflarski 1University of Alabama at Birmingham, Birmingham, AL, 2Cincinna& Children's Hospital Medical Center, Cincinna&, OH
Results
Introduc)on
Methods 13 pa&ents with chronic aphasia (4 female, mean age = 51 years, mean &me since stroke = 3.1 years) received a combined interven&on involving 10 daily 1-‐hour long group CIAT sessions with individualized goals tailored to the linguis&c level of each pa&ent. Pa&ents completed an NPT baKery that included the Western Aphasia BaKery (WAB), Boston Naming Test (BNT), Seman&c Fluency Test (SFT), Controlled Oral Word Associa&on Test (COWAT), and Peabody Picture Vocabulary Test (PPVT). All pa&ents received daily rTMS (iTBS protocol; Szaflarski et al., 2011) (applied to each pa&ent's fMRI language "hot-‐spot" as iden&fied with the fMRI task) 30-‐45 minutes prior to CIAT interven&on. T1-‐weighted anatomical and func&onal MRI scans were acquired from each pa&ent pre-‐ and post-‐ interven&on. Lesion masks were created with the lesion_gnb tool for SPM12 (Griffis et al. 2015). Func&onal MRI data were collected while pa&ents performed the block design SDTD task. Pa&ents performed 2 runs with 5 SD blocks and 6 TD blocks each. During the SD blocks, pa&ents decided if auditorily presented animal names met the criteria “na&ve to the united States” and “commonly used by humans”. During the TD blocks, pa&ents decided if sequences of modulated tones contained 2 750 Hz tones. fMRI data from each pa&ent were slice-‐&me corrected, realigned/re-‐ sliced, normalized to MNI template space using the longitudinal tool in SPM12, smoothed with an 8mm full width half-‐maximum Gaussian kernel, and fit with a general linear model. Changes in NPT were assessed using dependent samples t-‐tests and considered significant for p
