blood
15 APRIL 2007
䡠 VOLUME 109, NUMBER 8
COVER FIGURE
Iron-stained peripheral blood smear of an Abcb7 fl ⴙ Mx1-Cre mouse. Note the presence of siderotic granules in red blood cells following conditional deletion of the Abcb7 gene in the bone marrow compartment. See the related article by Pondarre et al, beginning on page 3567. INSIDE BLOOD 3125
Filgrastim therapy: a bone of contention E. G. Blanchard and S. J. Corey
JOURNAL OF THE AMERICAN
CONTENTS
3126
Genomics in myeloma: the philosopher’s stone? A. Rosenwald
SOCIETY OF HEMATOLOGY
3127
Karyng about karyotyping in adult ALL F. R. Appelbaum
3128
Unraveling CML phase by phase J. Goldman
3128
Inside-out, outside-in: what’s the difference?
3129
MEGAprofiles provide big insights into platelet function
E. F. Plow and Y.-Q. Ma W. F. Bahou 3130
Serotonin: a real blast for T cells J. Gordon and N. M. Barnes
3131
The CBFB-MYH11 butterfly effect in hematopoiesis A. J. van Wijnen and G. S. Stein
3132
Multiple myeloma and FISH (but no CHIPS) R. Fonseca
3133
Spectrin unfolding mutations: kinks in the links L. L. Peters
3134
Nonmyeloablative allotransplantation for myeloma: light and shade M. Cavo
3135
Win-WNT pathway in ALL G. J. L. Kaspers
3137
Blood orchestrates a leukocyte integrin trio J. S. Bennett
PLENARY PAPER 3139
Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor M. Leo´n-Ponte, G. P. Ahern, and P. J. O’Connell
PERSPECTIVE 3147
Clinical trials with adult stem/progenitor cells for tissue repair: let’s not overlook some essential precautions D. J. Prockop and S. D. Olson
REVIEW ARTICLE 3152
Diamond-Blackfan anemia: erythropoiesis lost in translation J. Flygare and S. Karlsson
REVIEW IN TRANSLATIONAL HEMATOLOGY 3161
The cytoprotective protein C pathway L. O. Mosnier, B. V. Zlokovic, and J. H. Griffin
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CONTINUED ON viii
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
3173
Brief report Influence of ERK activation on decreased chemotaxis of mature human cord blood monocyte–derived dendritic cells to CCL19 and CXCL12 G. Li, S. Basu, M.-K. Han, Y.-J. Kim, and H. E. Broxmeyer
CLINICAL TRIALS AND OBSERVATIONS
3177
Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib G. Mulligan, C. Mitsiades, B. Bryant, F. Zhan, W. J. Chng, S. Roels, E. Koenig, A. Fergus, Y. Huang, P. Richardson, W. L. Trepicchio, A. Broyl, P. Sonneveld, J. D. Shaughnessy Jr, P. L. Bergsagel, D. Schenkein, D.-L. Esseltine, A. Boral, and K. C. Anderson
3189
Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial A. V. Moorman, C. J. Harrison, G. A. N. Buck, S. M. Richards, L. M. Secker-Walker, M. Martineau, G. H. Vance, A. M. Cherry, R. R. Higgins, A. K. Fielding, L. Foroni, E. Paietta, M. S. Tallman, M. R. Litzow, P. H. Wiernik, J. M. Rowe, A. H. Goldstone, and G. W. Dewald, on behalf of the Medical Research Council (MRC)/National Cancer Research Institute (NCRI) Adult Leukaemia Working Party of the United Kingdom and the Eastern Cooperative Oncology Group
3198
TⴚBⴙNKⴙ severe combined immunodeficiency caused by complete deficiency of the CD3 subunit of the T-cell antigen receptor complex J. L. Roberts, J. P. H. Lauritsen, M. Cooney, R. E. Parrott, E. O. Sajaroff, C. M. Win, M. D. Keller, J. H. Carpenter, J. Carabana, M. S. Krangel, M. Sarzotti, X.-P. Zhong, D. L. Wiest, and R. H. Buckley
3207
Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis J. Cortes, P. Rousselot, D.-W. Kim, E. Ritchie, N. Hamerschlak, S. Coutre, A. Hochhaus, F. Guilhot, G. Saglio, J. Apperley, O. Ottmann, N. Shah, P. Erben, S. Branford, P. Agarwal, A. Gollerkeri, and M. Baccarani
3214
Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia E. Jabbour, S. O’Brien, H. Kantarjian, G. Garcia-Manero, A. Ferrajoli, F. Ravandi, M. Cabanillas, and D. A. Thomas
3219
Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia P. Scheinberg, S. H. Fischer, L. Li, O. Nunez, C. O. Wu, E. M. Sloand, J. I. Cohen, N. S. Young, and A. J. Barrett
HEMATOPOIESIS 3225
Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach H. Raslova, A. Kauffmann, D. Sekkaı¨, H. Ripoche, F. Larbret, T. Robert, D. T. Le Roux, G. Kroemer, N. Debili, P. Dessen, V. Lazar, and W. Vainchenker
3235
Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection A. D. Gregory, L. A. Hogue, T. W. Ferkol, and D. C. Link
3244
Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis M. J. Heikens, T. M. Cao, C. Morita, S. L. DeHart, and S. Tsai
3253
MafB negatively regulates RANKL-mediated osteoclast differentiation K. Kim, J. H. Kim, J. Lee, H. M. Jin, H. Kook, K. K. Kim, S. Y. Lee, and N. Kim
viii
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CONTINUED ON xi
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
3260
Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins I. C. Macaulay, M. R. Tijssen, D. C. Thijssen-Timmer, A. Gusnanto, M. Steward, P. Burns, C. F. Langford, P. D. Ellis, F. Dudbridge, J.-J. Zwaginga, N. A. Watkins, C. E. van der Schoot, and W. H. Ouwehand
3270
Tissue-type plasminogen activator–mediated shedding of astrocytic low-density lipoprotein receptor–related protein increases the permeability of the neurovascular unit
3279
Vitamin K–containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7
R. Polavarapu, M. C. Gongora, H. Yi, S. Ranganthan, D. A. Lawrence, D. Strickland, and M. Yepes
L. J. Schurgers, K. J. F. Teunissen, K. Hamulya´k, M. H. J. Knapen, H. Vik, and C. Vermeer 3284
Structure-function analysis reveals discrete 3 integrin inside-out and outside-in signaling pathways in platelets Z. Zou, H. Chen, A. A. Schmaier, R. O. Hynes, and M. L. Kahn
3291
Thromboxane receptor blockade improves the antiatherogenic effect of thromboxane A2 suppression in LDLR KO mice T. Cyrus, Y. Yao, T. Ding, J. M. Dogne´, and D. Pratico`
3297
Brief report X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation V. N. Tubman, J. E. Levine, D. R. Campagna, R. Monahan-Earley, A. M. Dvorak, E. J. Neufeld, and M. D. Fleming
IMMUNOBIOLOGY 3300
Selective deletion of antigen-specific CD8ⴙ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin P. R. Hess, C. Barnes, M. D. Woolard, M. D. L. Johnson, J. M. Cullen, E. J. Collins, and J. A. Frelinger
3308
TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation C. Qian, H. An, Y. Yu, S. Liu, and X. Cao
3316
The Pten/PI3K pathway governs the homeostasis of V␣14iNKT cells H. Kishimoto, T. Ohteki, N. Yajima, K. Kawahara, M. Natsui, S. Kawarasaki, K. Hamada, Y. Horie, Y. Kubo, S. Arase, M. Taniguchi, B. Vanhaesebroeck, T. W. Mak, T. Nakano, S. Koyasu, T. Sasaki, and A. Suzuki
3325
Nonmalignant T cells stimulate growth of T-cell lymphoma cells in the presence of bacterial toxins A. Woetmann, P. Lovato, K. W. Eriksen, T. Krejsgaard, T. Labuda, Q. Zhang, A.-M. Mathiesen, C. Geisler, A. Svejgaard, M. A. Wasik, and N. Ødum
3333
Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell–natural killer cell crosstalk
3342
Notch activity synergizes with B-cell–receptor and CD40 signaling to enhance B-cell activation
J. Xu, A. K. Chakrabarti, J. L. Tan, L. Ge, A. Gambotto, and N. L. Vujanovic
M. Thomas, M. Calamito, B. Srivastava, I. Maillard, W. S. Pear, and D. Allman 3351
HIV inhibits CD4ⴙ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells
3360
Vav proteins control MyD88-dependent oxidative burst
A. Boasso, J.-P. Herbeuval, A. W. Hardy, S. A. Anderson, M. J. Dolan, D. Fuchs, and G. M. Shearer A. V. Miletic, D. B. Graham, V. Montgrain, K. Fujikawa, T. Kloeppel, K. Brim, B. Weaver, R. Schreiber, R. Xavier, and W. Swat 3369
Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells E. O. Kvale, Y. Fløisand, F. Lund-Johansen, H. Rollag, L. Farkas, S. Ghanekar, P. Brandtzaeg, F. L. Jahnsen, and J. Olweus
3377
Combined deficiencies in Bruton tyrosine kinase and phospholipase C␥2 arrest B-cell development at a pre-BCRⴙ stage S. Xu, K.-G. Lee, J. Huo, T. Kurosaki, and K.-P. Lam
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3385
Synaptotagmin (Syt) IX is an essential determinant for protein sorting to secretory granules in mast cells Y. Haberman, I. Ziv, Y. Gorzalczany, K. Hirschberg, L. Mittleman, M. Fukuda, and R. Sagi-Eisenberg
3393
Cell-free production of scFv fusion proteins: an efficient approach for personalized lymphoma vaccines G. Kanter, J. Yang, A. Voloshin, S. Levy, J. R. Swartz, and R. Levy
NEOPLASIA 3400
ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia D. B. Shankar, J. Li, P. Tapang, J. O. McCall, L. J. Pease, Y. Dai, R.-Q. Wei, D. H. Albert, J. J. Bouska, D. J. Osterling, J. Guo, P. A. Marcotte, E. F. Johnson, N. Soni, K. Hartandi, M. R. Michaelides, S. K. Davidsen, S. J. Priceman, J. C. Chang, K. Rhodes, N. Shah, T. B. Moore, K. M. Sakamoto, and K. B. Glaser
3409
Members of the glutathione and ABC-transporter families are associated with clinical outcome in patients with diffuse large B-cell lymphoma C. Andreadis, P. A. Gimotty, P. Wahl, R. Hammond, J. Houldsworth, S. J. Schuster, and T. R. Rebbeck
3417
A novel PAX5-ELN fusion protein identified in B-cell acute lymphoblastic leukemia acts as a dominant negative on wild-type PAX5 M. Bousquet, C. Broccardo, C. Quelen, F. Meggetto, E. Kuhlein, G. Delsol, N. Dastugue, and P. Brousset
3424
Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner ¨ . Uluc¸kan, E. A. Morgan, M. C. Eagleton, J. L. Prior, D. Piwnica-Worms, A. C. Hirbe, O K. Trinkaus, A. Apicelli, and K. Weilbaecher
3432
CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus L. Zhao, J. L. Cannons, S. Anderson, M. Kirby, L. Xu, L. H. Castilla, P. L. Schwartzberg, R. Bosselut, and P. P. Liu
3441
Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo G.-B. Zhou, H. Kang, L. Wang, L. Gao, P. Liu, J. Xie, F.-X. Zhang, X.-Q. Weng, Z.-X. Shen, J. Chen, L.-J. Gu, M. Yan, D.-E. Zhang, S.-J. Chen, Z.-Y. Wang, and Z. Chen
3451
Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) T. Akasaka, T. Balasas, L. J. Russell, K.-j. Sugimoto, A. Majid, R. Walewska, E. L. Karran, D. G. Brown, K. Cain, L. Harder, S. Gesk, J. I. Martin-Subero, M. G. Atherton, M. Bru¨ggemann, M. J. Calasanz, T. Davies, O. A. Haas, A. Hagemeijer, H. Kempski, M. Lessard, D. M. Lillington, S. Moore, F. Nguyen-Khac, I. Radford-Weiss, C. Schoch, S. Struski, P. Talley, M. J. Welham, H. Worley, J. C. Strefford, C. J. Harrison, R. Siebert, and M. J. S. Dyer
3462
Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia J. Roma´n-Go´mez, L. Cordeu, X. Agirre, A. Jime´nez-Velasco, E. San Jose´-Eneriz, L. Garate, M. J. Calasanz, A. Heiniger, A. Torres, and F. Prosper
3470
Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells G. A. Bartholomeusz, M. Talpaz, V. Kapuria, L. Y. Kong, S. Wang, Z. Estrov, W. Priebe, J. Wu, and N. J. Donato
3479
Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph) S. S. Wang, S. L. Slager, P. Brennan, E. A. Holly, S. De Sanjose, L. Bernstein, P. Boffetta, J. R. Cerhan, M. Maynadie, J. J. Spinelli, B. C. H. Chiu, P. L. Cocco, F. Mensah, Y. Zhang, A. Nieters, L. Dal Maso, P. M. Bracci, A. S. Costantini, P. Vineis, R. K. Severson, E. Roman, W. Cozen, D. Weisenburger, S. Davis, S. Franceschi, C. La Vecchia, L. Foretova, N. Becker, A. Staines, M. Vornanen, T. Zheng, and P. Hartge
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3489
Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Mye´lome H. Avet-Loiseau, M. Attal, P. Moreau, C. Charbonnel, F. Garban, C. Hulin, S. Leyvraz, M. Michallet, I. Yakoub-Agha, L. Garderet, G. Marit, L. Michaux, L. Voillat, M. Renaud, B. Grosbois, G. Guillerm, L. Benboubker, M. Monconduit, C. Thieblemont, P. Casassus, D. Caillot, A.-M. Stoppa, J.-J. Sotto, M. Wetterwald, C. Dumontet, J.-G. Fuzibet, I. Azais, V. Dorvaux, M. Zandecki, R. Bataille, S. Minvielle, J.-L. Harousseau, T. Facon, and C. Mathiot
3496
Brief report Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia S. Picard, K. Titier, G. Etienne, E. Teilhet, D. Ducint, M.-A. Bernard, R. Lassalle, G. Marit, J. Reiffers, B. Begaud, N. Moore, M. Molimard, and F.-X. Mahon
3500
Brief report MALT lymphoma and extranodal diffuse large B-cell lymphoma are targeted by aberrant somatic hypermutation A. J. A. Deutsch, A. Aigelsreiter, P. B. Staber, A. Beham, W. Linkesch, C. Guelly, R. I. Brezinschek, M. Fruhwirth, W. Emberger, M. Buettner, C. Beham-Schmid, and P. Neumeister
3505
Brief report Chemotherapy exposure increases leukemia cell stiffness W. A. Lam, M. J. Rosenbluth, and D. A. Fletcher
3509
Brief report Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML Z. Zeng, D. D. Sarbassov, I. J. Samudio, K. W. L. Yee, M. F. Munsell, C. E. Jackson, F. J. Giles, D. M. Sabatini, M. Andreeff, and M. Konopleva
PHAGOCYTES 3513
The -tail domain (TD) regulates physiologic ligand binding to integrin CD11b/CD18 V. Gupta, A. Gylling, J. L. Alonso, T. Sugimori, P. Ianakiev, J.-P. Xiong, and M. A. Arnaout
3521
Generation of activation-specific human anti-␣M2 single-chain antibodies as potential diagnostic tools and therapeutic agents S. U. Eisenhardt, M. Schwarz, N. Schallner, J. Soosairajah, N. Bassler, D. Huang, C. Bode, and K. Peter
3529
Natural history and early diagnosis of LAD-1/variant syndrome T. W. Kuijpers, R. van Bruggen, N. Kamerbeek, A. T. J. Tool, G. Hicsonmez, A. Gurgey, ¨ . Sanal, C. Niemeyer, and D. Roos A. Karow, A. J. Verhoeven, K. Seeger, O
RED CELLS 3538
Pathogenic proline mutation in the linker between spectrin repeats: disease caused by spectrin unfolding C. P. Johnson, M. Gaetani, V. Ortiz, N. Bhasin, S. Harper, P. G. Gallagher, D. W. Speicher, and D. E. Discher
3544
Endothelial Lu/BCAM glycoproteins are novel ligands for red blood cell ␣41 integrin: role in adhesion of sickle red blood cells to endothelial cells W. El Nemer, M.-P. Wautier, C. Rahuel, P. Gane, P. Hermand, F. Galacte´ros, J.-L. Wautier, J.-P. Cartron, Y. Colin, and C. Le Van Kim
3552
RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload P. Cavadini, G. Biasiotto, M. Poli, S. Levi, R. Verardi, I. Zanella, M. Derosas, R. Ingrassia, M. Corrado, and P. Arosio
3560
Molecular basis of glutathione reductase deficiency in human blood cells N. M. Kamerbeek, R. van Zwieten, M. de Boer, G. Morren, H. Vuil, N. Bannink, C. Lincke, K. M. Dolman, K. Becker, R. H. Schirmer, S. Gromer, and D. Roos
3567
Brief report Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis C. Pondarre, D. R. Campagna, B. Antiochos, L. Sikorski, H. Mulhern, and M. D. Fleming
STEM CELLS IN HEMATOLOGY
3570
Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential H. Araki, K. Yoshinaga, P. Boccuni, Y. Zhao, R. Hoffman, and N. Mahmud
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TRANSPLANTATION 3579
Enhanced T-cell reconstitution by hematopoietic progenitors expanded ex vivo using the Notch ligand Delta1 M. H. Dallas, B. Varnum-Finney, P. J. Martin, and I. D. Bernstein
3588
Reduced-intensity conditioning for myeloma: lower nonrelapse mortality but higher relapse rates compared with myeloablative conditioning C. Crawley, S. Iacobelli, B. Bjo¨rkstrand, J. F. Apperley, D. Niederwieser, and G. Gahrton, for the Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
3595
Patients with adenosine deaminase deficiency surviving after hematopoietic stem cell transplantation are at high risk of CNS complications M. Ho¨nig, M. H. Albert, A. Schulz, M. Sparber-Sauer, C. Schu¨tz, B. Belohradsky, T. Gu¨ngo¨r, M. T. Rojewski, H. Bode, U. Pannicke, D. Lippold, K. Schwarz, K.-M. Debatin, M. S. Hershfield, and W. Friedrich
3603
Brief report Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors A. Lundqvist, J. P. McCoy, L. Samsel, and R. Childs
CORRESPONDENCE 3607
Vitamin K supplementation during oral anticoagulation: cautions
3607
Response: vitamin K supplementation during oral anticoagulation: no real cause for concern
3608
Acute thrombocytopenia caused by sensitivity to the glucuronide conjugate of acetaminophen
3609
Imatinib increases the intracellular concentration of nilotinib, which may explain the observed synergy between these drugs
3610
Survival of genetic subtypes of relapsed myeloma may be modulated by secondary events
3611
The serum-free light chain assay cannot replace 24-hour urine protein estimation in patients with plasma cell dyscrasias
D. W. Stafford, H. R. Roberts, and C. Vermeer
E. Sconce, H. Wynne, and F. Kamali
D. W. Bougie, A. I. Benito, L. I. Sanchez-Abarca, R. Torres, J. Birenbaum, and R. H. Aster
D. L. White, V. A. Saunders, S. R. Quinn, P. W. Manley, and T. P. Hughes W. J. Chng, G. Mulligan, B. Bryant, and L. Bergsagel
S. Singhal, R. Stein, E. Vickrey, and J. Mehta ERRATUM 3234
Erratum in Schmidt et al. Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia. Blood. 2006;107:2061-2069.
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