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15 APRIL 2007 VOLUME 109, NUMBER 8. CONTENTS. COVER FIGURE. Iron-stained peripheral blood smear of an Abcb7fl. Mx1-Cre mouse. Note the.
blood

15 APRIL 2007

䡠 VOLUME 109, NUMBER 8

COVER FIGURE

Iron-stained peripheral blood smear of an Abcb7 fl ⴙ Mx1-Cre mouse. Note the presence of siderotic granules in red blood cells following conditional deletion of the Abcb7 gene in the bone marrow compartment. See the related article by Pondarre et al, beginning on page 3567. INSIDE BLOOD 3125

Filgrastim therapy: a bone of contention E. G. Blanchard and S. J. Corey

JOURNAL OF THE AMERICAN

CONTENTS

3126

Genomics in myeloma: the philosopher’s stone? A. Rosenwald

SOCIETY OF HEMATOLOGY

3127

Karyng about karyotyping in adult ALL F. R. Appelbaum

3128

Unraveling CML phase by phase J. Goldman

3128

Inside-out, outside-in: what’s the difference?

3129

MEGAprofiles provide big insights into platelet function

E. F. Plow and Y.-Q. Ma W. F. Bahou 3130

Serotonin: a real blast for T cells J. Gordon and N. M. Barnes

3131

The CBFB-MYH11 butterfly effect in hematopoiesis A. J. van Wijnen and G. S. Stein

3132

Multiple myeloma and FISH (but no CHIPS) R. Fonseca

3133

Spectrin unfolding mutations: kinks in the links L. L. Peters

3134

Nonmyeloablative allotransplantation for myeloma: light and shade M. Cavo

3135

Win-WNT pathway in ALL G. J. L. Kaspers

3137

Blood orchestrates a leukocyte integrin trio J. S. Bennett

PLENARY PAPER 3139

Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor M. Leo´n-Ponte, G. P. Ahern, and P. J. O’Connell

PERSPECTIVE 3147

Clinical trials with adult stem/progenitor cells for tissue repair: let’s not overlook some essential precautions D. J. Prockop and S. D. Olson

REVIEW ARTICLE 3152

Diamond-Blackfan anemia: erythropoiesis lost in translation J. Flygare and S. Karlsson

REVIEW IN TRANSLATIONAL HEMATOLOGY 3161

The cytoprotective protein C pathway L. O. Mosnier, B. V. Zlokovic, and J. H. Griffin

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CHEMOKINES, CYTOKINES, AND INTERLEUKINS

3173

Brief report Influence of ERK activation on decreased chemotaxis of mature human cord blood monocyte–derived dendritic cells to CCL19 and CXCL12 G. Li, S. Basu, M.-K. Han, Y.-J. Kim, and H. E. Broxmeyer

CLINICAL TRIALS AND OBSERVATIONS

3177

Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib G. Mulligan, C. Mitsiades, B. Bryant, F. Zhan, W. J. Chng, S. Roels, E. Koenig, A. Fergus, Y. Huang, P. Richardson, W. L. Trepicchio, A. Broyl, P. Sonneveld, J. D. Shaughnessy Jr, P. L. Bergsagel, D. Schenkein, D.-L. Esseltine, A. Boral, and K. C. Anderson

3189

Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial A. V. Moorman, C. J. Harrison, G. A. N. Buck, S. M. Richards, L. M. Secker-Walker, M. Martineau, G. H. Vance, A. M. Cherry, R. R. Higgins, A. K. Fielding, L. Foroni, E. Paietta, M. S. Tallman, M. R. Litzow, P. H. Wiernik, J. M. Rowe, A. H. Goldstone, and G. W. Dewald, on behalf of the Medical Research Council (MRC)/National Cancer Research Institute (NCRI) Adult Leukaemia Working Party of the United Kingdom and the Eastern Cooperative Oncology Group

3198

TⴚBⴙNKⴙ severe combined immunodeficiency caused by complete deficiency of the CD3␨ subunit of the T-cell antigen receptor complex J. L. Roberts, J. P. H. Lauritsen, M. Cooney, R. E. Parrott, E. O. Sajaroff, C. M. Win, M. D. Keller, J. H. Carpenter, J. Carabana, M. S. Krangel, M. Sarzotti, X.-P. Zhong, D. L. Wiest, and R. H. Buckley

3207

Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis J. Cortes, P. Rousselot, D.-W. Kim, E. Ritchie, N. Hamerschlak, S. Coutre, A. Hochhaus, F. Guilhot, G. Saglio, J. Apperley, O. Ottmann, N. Shah, P. Erben, S. Branford, P. Agarwal, A. Gollerkeri, and M. Baccarani

3214

Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia E. Jabbour, S. O’Brien, H. Kantarjian, G. Garcia-Manero, A. Ferrajoli, F. Ravandi, M. Cabanillas, and D. A. Thomas

3219

Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia P. Scheinberg, S. H. Fischer, L. Li, O. Nunez, C. O. Wu, E. M. Sloand, J. I. Cohen, N. S. Young, and A. J. Barrett

HEMATOPOIESIS 3225

Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach H. Raslova, A. Kauffmann, D. Sekkaı¨, H. Ripoche, F. Larbret, T. Robert, D. T. Le Roux, G. Kroemer, N. Debili, P. Dessen, V. Lazar, and W. Vainchenker

3235

Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection A. D. Gregory, L. A. Hogue, T. W. Ferkol, and D. C. Link

3244

Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis M. J. Heikens, T. M. Cao, C. Morita, S. L. DeHart, and S. Tsai

3253

MafB negatively regulates RANKL-mediated osteoclast differentiation K. Kim, J. H. Kim, J. Lee, H. M. Jin, H. Kook, K. K. Kim, S. Y. Lee, and N. Kim

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

3260

Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins I. C. Macaulay, M. R. Tijssen, D. C. Thijssen-Timmer, A. Gusnanto, M. Steward, P. Burns, C. F. Langford, P. D. Ellis, F. Dudbridge, J.-J. Zwaginga, N. A. Watkins, C. E. van der Schoot, and W. H. Ouwehand

3270

Tissue-type plasminogen activator–mediated shedding of astrocytic low-density lipoprotein receptor–related protein increases the permeability of the neurovascular unit

3279

Vitamin K–containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7

R. Polavarapu, M. C. Gongora, H. Yi, S. Ranganthan, D. A. Lawrence, D. Strickland, and M. Yepes

L. J. Schurgers, K. J. F. Teunissen, K. Hamulya´k, M. H. J. Knapen, H. Vik, and C. Vermeer 3284

Structure-function analysis reveals discrete ␤3 integrin inside-out and outside-in signaling pathways in platelets Z. Zou, H. Chen, A. A. Schmaier, R. O. Hynes, and M. L. Kahn

3291

Thromboxane receptor blockade improves the antiatherogenic effect of thromboxane A2 suppression in LDLR KO mice T. Cyrus, Y. Yao, T. Ding, J. M. Dogne´, and D. Pratico`

3297

Brief report X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation V. N. Tubman, J. E. Levine, D. R. Campagna, R. Monahan-Earley, A. M. Dvorak, E. J. Neufeld, and M. D. Fleming

IMMUNOBIOLOGY 3300

Selective deletion of antigen-specific CD8ⴙ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin P. R. Hess, C. Barnes, M. D. Woolard, M. D. L. Johnson, J. M. Cullen, E. J. Collins, and J. A. Frelinger

3308

TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation C. Qian, H. An, Y. Yu, S. Liu, and X. Cao

3316

The Pten/PI3K pathway governs the homeostasis of V␣14iNKT cells H. Kishimoto, T. Ohteki, N. Yajima, K. Kawahara, M. Natsui, S. Kawarasaki, K. Hamada, Y. Horie, Y. Kubo, S. Arase, M. Taniguchi, B. Vanhaesebroeck, T. W. Mak, T. Nakano, S. Koyasu, T. Sasaki, and A. Suzuki

3325

Nonmalignant T cells stimulate growth of T-cell lymphoma cells in the presence of bacterial toxins A. Woetmann, P. Lovato, K. W. Eriksen, T. Krejsgaard, T. Labuda, Q. Zhang, A.-M. Mathiesen, C. Geisler, A. Svejgaard, M. A. Wasik, and N. Ødum

3333

Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell–natural killer cell crosstalk

3342

Notch activity synergizes with B-cell–receptor and CD40 signaling to enhance B-cell activation

J. Xu, A. K. Chakrabarti, J. L. Tan, L. Ge, A. Gambotto, and N. L. Vujanovic

M. Thomas, M. Calamito, B. Srivastava, I. Maillard, W. S. Pear, and D. Allman 3351

HIV inhibits CD4ⴙ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells

3360

Vav proteins control MyD88-dependent oxidative burst

A. Boasso, J.-P. Herbeuval, A. W. Hardy, S. A. Anderson, M. J. Dolan, D. Fuchs, and G. M. Shearer A. V. Miletic, D. B. Graham, V. Montgrain, K. Fujikawa, T. Kloeppel, K. Brim, B. Weaver, R. Schreiber, R. Xavier, and W. Swat 3369

Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells E. O. Kvale, Y. Fløisand, F. Lund-Johansen, H. Rollag, L. Farkas, S. Ghanekar, P. Brandtzaeg, F. L. Jahnsen, and J. Olweus

3377

Combined deficiencies in Bruton tyrosine kinase and phospholipase C␥2 arrest B-cell development at a pre-BCRⴙ stage S. Xu, K.-G. Lee, J. Huo, T. Kurosaki, and K.-P. Lam

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3385

Synaptotagmin (Syt) IX is an essential determinant for protein sorting to secretory granules in mast cells Y. Haberman, I. Ziv, Y. Gorzalczany, K. Hirschberg, L. Mittleman, M. Fukuda, and R. Sagi-Eisenberg

3393

Cell-free production of scFv fusion proteins: an efficient approach for personalized lymphoma vaccines G. Kanter, J. Yang, A. Voloshin, S. Levy, J. R. Swartz, and R. Levy

NEOPLASIA 3400

ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia D. B. Shankar, J. Li, P. Tapang, J. O. McCall, L. J. Pease, Y. Dai, R.-Q. Wei, D. H. Albert, J. J. Bouska, D. J. Osterling, J. Guo, P. A. Marcotte, E. F. Johnson, N. Soni, K. Hartandi, M. R. Michaelides, S. K. Davidsen, S. J. Priceman, J. C. Chang, K. Rhodes, N. Shah, T. B. Moore, K. M. Sakamoto, and K. B. Glaser

3409

Members of the glutathione and ABC-transporter families are associated with clinical outcome in patients with diffuse large B-cell lymphoma C. Andreadis, P. A. Gimotty, P. Wahl, R. Hammond, J. Houldsworth, S. J. Schuster, and T. R. Rebbeck

3417

A novel PAX5-ELN fusion protein identified in B-cell acute lymphoblastic leukemia acts as a dominant negative on wild-type PAX5 M. Bousquet, C. Broccardo, C. Quelen, F. Meggetto, E. Kuhlein, G. Delsol, N. Dastugue, and P. Brousset

3424

Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner ¨ . Uluc¸kan, E. A. Morgan, M. C. Eagleton, J. L. Prior, D. Piwnica-Worms, A. C. Hirbe, O K. Trinkaus, A. Apicelli, and K. Weilbaecher

3432

CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus L. Zhao, J. L. Cannons, S. Anderson, M. Kirby, L. Xu, L. H. Castilla, P. L. Schwartzberg, R. Bosselut, and P. P. Liu

3441

Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo G.-B. Zhou, H. Kang, L. Wang, L. Gao, P. Liu, J. Xie, F.-X. Zhang, X.-Q. Weng, Z.-X. Shen, J. Chen, L.-J. Gu, M. Yan, D.-E. Zhang, S.-J. Chen, Z.-Y. Wang, and Z. Chen

3451

Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) T. Akasaka, T. Balasas, L. J. Russell, K.-j. Sugimoto, A. Majid, R. Walewska, E. L. Karran, D. G. Brown, K. Cain, L. Harder, S. Gesk, J. I. Martin-Subero, M. G. Atherton, M. Bru¨ggemann, M. J. Calasanz, T. Davies, O. A. Haas, A. Hagemeijer, H. Kempski, M. Lessard, D. M. Lillington, S. Moore, F. Nguyen-Khac, I. Radford-Weiss, C. Schoch, S. Struski, P. Talley, M. J. Welham, H. Worley, J. C. Strefford, C. J. Harrison, R. Siebert, and M. J. S. Dyer

3462

Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia J. Roma´n-Go´mez, L. Cordeu, X. Agirre, A. Jime´nez-Velasco, E. San Jose´-Eneriz, L. Garate, M. J. Calasanz, A. Heiniger, A. Torres, and F. Prosper

3470

Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells G. A. Bartholomeusz, M. Talpaz, V. Kapuria, L. Y. Kong, S. Wang, Z. Estrov, W. Priebe, J. Wu, and N. J. Donato

3479

Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph) S. S. Wang, S. L. Slager, P. Brennan, E. A. Holly, S. De Sanjose, L. Bernstein, P. Boffetta, J. R. Cerhan, M. Maynadie, J. J. Spinelli, B. C. H. Chiu, P. L. Cocco, F. Mensah, Y. Zhang, A. Nieters, L. Dal Maso, P. M. Bracci, A. S. Costantini, P. Vineis, R. K. Severson, E. Roman, W. Cozen, D. Weisenburger, S. Davis, S. Franceschi, C. La Vecchia, L. Foretova, N. Becker, A. Staines, M. Vornanen, T. Zheng, and P. Hartge

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3489

Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Mye´lome H. Avet-Loiseau, M. Attal, P. Moreau, C. Charbonnel, F. Garban, C. Hulin, S. Leyvraz, M. Michallet, I. Yakoub-Agha, L. Garderet, G. Marit, L. Michaux, L. Voillat, M. Renaud, B. Grosbois, G. Guillerm, L. Benboubker, M. Monconduit, C. Thieblemont, P. Casassus, D. Caillot, A.-M. Stoppa, J.-J. Sotto, M. Wetterwald, C. Dumontet, J.-G. Fuzibet, I. Azais, V. Dorvaux, M. Zandecki, R. Bataille, S. Minvielle, J.-L. Harousseau, T. Facon, and C. Mathiot

3496

Brief report Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia S. Picard, K. Titier, G. Etienne, E. Teilhet, D. Ducint, M.-A. Bernard, R. Lassalle, G. Marit, J. Reiffers, B. Begaud, N. Moore, M. Molimard, and F.-X. Mahon

3500

Brief report MALT lymphoma and extranodal diffuse large B-cell lymphoma are targeted by aberrant somatic hypermutation A. J. A. Deutsch, A. Aigelsreiter, P. B. Staber, A. Beham, W. Linkesch, C. Guelly, R. I. Brezinschek, M. Fruhwirth, W. Emberger, M. Buettner, C. Beham-Schmid, and P. Neumeister

3505

Brief report Chemotherapy exposure increases leukemia cell stiffness W. A. Lam, M. J. Rosenbluth, and D. A. Fletcher

3509

Brief report Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML Z. Zeng, D. D. Sarbassov, I. J. Samudio, K. W. L. Yee, M. F. Munsell, C. E. Jackson, F. J. Giles, D. M. Sabatini, M. Andreeff, and M. Konopleva

PHAGOCYTES 3513

The ␤-tail domain (␤TD) regulates physiologic ligand binding to integrin CD11b/CD18 V. Gupta, A. Gylling, J. L. Alonso, T. Sugimori, P. Ianakiev, J.-P. Xiong, and M. A. Arnaout

3521

Generation of activation-specific human anti-␣M␤2 single-chain antibodies as potential diagnostic tools and therapeutic agents S. U. Eisenhardt, M. Schwarz, N. Schallner, J. Soosairajah, N. Bassler, D. Huang, C. Bode, and K. Peter

3529

Natural history and early diagnosis of LAD-1/variant syndrome T. W. Kuijpers, R. van Bruggen, N. Kamerbeek, A. T. J. Tool, G. Hicsonmez, A. Gurgey, ¨ . Sanal, C. Niemeyer, and D. Roos A. Karow, A. J. Verhoeven, K. Seeger, O

RED CELLS 3538

Pathogenic proline mutation in the linker between spectrin repeats: disease caused by spectrin unfolding C. P. Johnson, M. Gaetani, V. Ortiz, N. Bhasin, S. Harper, P. G. Gallagher, D. W. Speicher, and D. E. Discher

3544

Endothelial Lu/BCAM glycoproteins are novel ligands for red blood cell ␣4␤1 integrin: role in adhesion of sickle red blood cells to endothelial cells W. El Nemer, M.-P. Wautier, C. Rahuel, P. Gane, P. Hermand, F. Galacte´ros, J.-L. Wautier, J.-P. Cartron, Y. Colin, and C. Le Van Kim

3552

RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload P. Cavadini, G. Biasiotto, M. Poli, S. Levi, R. Verardi, I. Zanella, M. Derosas, R. Ingrassia, M. Corrado, and P. Arosio

3560

Molecular basis of glutathione reductase deficiency in human blood cells N. M. Kamerbeek, R. van Zwieten, M. de Boer, G. Morren, H. Vuil, N. Bannink, C. Lincke, K. M. Dolman, K. Becker, R. H. Schirmer, S. Gromer, and D. Roos

3567

Brief report Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis C. Pondarre, D. R. Campagna, B. Antiochos, L. Sikorski, H. Mulhern, and M. D. Fleming

STEM CELLS IN HEMATOLOGY

3570

Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential H. Araki, K. Yoshinaga, P. Boccuni, Y. Zhao, R. Hoffman, and N. Mahmud

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TRANSPLANTATION 3579

Enhanced T-cell reconstitution by hematopoietic progenitors expanded ex vivo using the Notch ligand Delta1 M. H. Dallas, B. Varnum-Finney, P. J. Martin, and I. D. Bernstein

3588

Reduced-intensity conditioning for myeloma: lower nonrelapse mortality but higher relapse rates compared with myeloablative conditioning C. Crawley, S. Iacobelli, B. Bjo¨rkstrand, J. F. Apperley, D. Niederwieser, and G. Gahrton, for the Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)

3595

Patients with adenosine deaminase deficiency surviving after hematopoietic stem cell transplantation are at high risk of CNS complications M. Ho¨nig, M. H. Albert, A. Schulz, M. Sparber-Sauer, C. Schu¨tz, B. Belohradsky, T. Gu¨ngo¨r, M. T. Rojewski, H. Bode, U. Pannicke, D. Lippold, K. Schwarz, K.-M. Debatin, M. S. Hershfield, and W. Friedrich

3603

Brief report Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors A. Lundqvist, J. P. McCoy, L. Samsel, and R. Childs

CORRESPONDENCE 3607

Vitamin K supplementation during oral anticoagulation: cautions

3607

Response: vitamin K supplementation during oral anticoagulation: no real cause for concern

3608

Acute thrombocytopenia caused by sensitivity to the glucuronide conjugate of acetaminophen

3609

Imatinib increases the intracellular concentration of nilotinib, which may explain the observed synergy between these drugs

3610

Survival of genetic subtypes of relapsed myeloma may be modulated by secondary events

3611

The serum-free light chain assay cannot replace 24-hour urine protein estimation in patients with plasma cell dyscrasias

D. W. Stafford, H. R. Roberts, and C. Vermeer

E. Sconce, H. Wynne, and F. Kamali

D. W. Bougie, A. I. Benito, L. I. Sanchez-Abarca, R. Torres, J. Birenbaum, and R. H. Aster

D. L. White, V. A. Saunders, S. R. Quinn, P. W. Manley, and T. P. Hughes W. J. Chng, G. Mulligan, B. Bryant, and L. Bergsagel

S. Singhal, R. Stein, E. Vickrey, and J. Mehta ERRATUM 3234

Erratum in Schmidt et al. Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia. Blood. 2006;107:2061-2069.

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