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0.173
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. 8.69. ID 8. 0.0774. 1.35. 0.802. 1.68. 0.264. 4.55. 0.0336. 0.301. 1.89. 4.69.
Table S2 List of parameter values of selected set IDs (obtained by Cluster Newton method). a) Tamoxifen
Parameters (Unit) ID 1 ID 2 ID 3 ID 4 ID 5 ID 6 ID 7 ID 8 Median CV (%) Parameters (Unit) ID 1 ID 2 ID 3 ID 4 ID 5 ID 6 ID 7 ID 8 Median CV (%)
Vcentral (L/kg) 0.410 0.259 0.137 0.747 0.0920 0.178 0.0959 0.0754 0.157 92.2 CLNDMTby3A,hep (L/h/kg) 1.59 1.58 1.96 3.94 2.31 1.72 2.68 2.79 2.13 34.7
SFKp 5.92 6.53 7.84 4.26 5.77 7.37 6.84 4.40 6.23 21.2
ka (1/h) 3.70 1.16 2.31 1.58 1.93 4.17 2.43 2.99 2.37 40.8
CL4OHTby2D6,hep (L/h/kg) 0.233 0.348 0.352 0.328 0.429 0.317 0.411 0.309 0.338 17.9
kbile (1/h) 1.49 0.113 1.32 0.0966 0.353 4.15 0.325 1.22 0.785 119 CL4OHTby2C9,hep (L/h/kg) 0.174 0.260 0.263 0.245 0.320 0.237 0.307 0.230 0.252 17.9
PSdif (L/h/kg) 0.527 0.840 2.14 1.11 0.877 0.626 0.345 0.193 0.733 72.9 CL4OHTbyOther,hep (L/h/kg) 0.0335 0.0501 0.0506 0.0471 0.0616 0.0456 0.0590 0.0444 0.0486 17.9
kfeces (1/h) 0.0224 0.0029 0.0111 0.0228 0.0201 0.0229 0.00208 0.0339 0.0212 63.8
CLR (L/h/kg) 0.00583 0.000129 0.0191 0.000275 0.00101 0.000215 0.000772 0.00362 0.000889 167 CLOther,hep (L/h/kg) 0.966 0.844 0.994 0.173 1.06 0.608 1.57 1.48 0.98 46.7
CLbile (L/h/kg) 7.02 0.0281 0.112 0.0259 0.652 0.191 2.00 0.389 0.290 184 CLNDMTby3A,ent (L/h/kg) 0.0281 0.570 0.258 0.246 0.0869 0.203 0.0430 0.0164 0.145 102
b) NDMT Parameters (Unit) ID 1 ID 2 ID 3 ID 4 ID 5 ID 6 ID 7 ID 8 Median CV (%)
Vcentral (L/kg) 0.129 0.333 0.194 0.0765 0.0760 0.583 0.316 0.413 0.255 67.6
SFkp 1.01 1.02 6.33 1.07 1.04 1.02 4.93 2.03 1.05 91.7
ka (1/h) 1.50 7.18 9.50 2.12 0.484 3.78 3.96 2.51 3.15 78.3
kbile (1/h) 0.655 0.233 4.32 0.398 1.16 0.111 1.03 0.534 0.595 130
PSdif (L/h/kg) 1.06 2.35 2.01 0.748 0.338 0.0588 0.200 1.60 0.904 82.6
kfeces (1/h) 0.0681 0.0375 0.00255 0.0858 0.0126 0.0404 0.00434 0.00105 0.0251 102
CLbile (L/h/kg) 0.0457 4.58 6.28 0.118 0.071 0.194 0.571 0.642 0.382 156
CLENDby2D6,hep (L/h/kg) 0.263 0.43 0.454 0.511 0.530 0.204 0.448 0.730 0.451 36.3
CLOtherby3A,hep (L/h/kg) 0.242 0.440 0.423 0.517 0.564 0.809 0.536 0.682 0.527 32.5
CLOtherby3A (L/h/kg) 0.199 0.00952 0.0196 0.233 0.178 0.0609 0.479 0.0892 0.133 97.2
c) 4-OHT Parameters (Unit) ID 1 ID 2 ID 3 ID 4 ID 5 ID 6 ID 7 ID 8 Median CV(%) Parameters (Unit) ID 1 ID 2 ID 3 ID 4 ID 5 ID 6 ID 7 ID 8 Median CV (%)
Vcentral (L/kg) 0.0876 0.0753 0.0988 0.195 0.0861 0.549 0.0769 0.0811 0.0868 105 CLEND by 3A,hep (L/h/kg) 12.1 13.7 5.94 22.6 6.34 11.2 18.8 9.43 11.6 46.5
SFkp 1.01 1.02 6.33 1.07 1.04 1.02 4.93 2.03 1.05 91.7 CL4OHTG by UGT,hep (L/h/kg) 0.489 3.98 15.5 7.76 0.188 0.0709 0.0899 11.9 2.23 122
ka (1/h) 0.651 2.32 0.490 0.198 0.795 0.108 0.510 0.125 0.500 111 CLOther by 3A,hep (L/h/kg) 1.07 0.135 0.0223 0.0254 11.0 2.46 0.0269 0.0574 0.0963 205
kbile (1/h) 0.105 1.79 3.39 0.259 4.71 0.729 0.190 0.742 0.736 114
PSdif (L/h/kg) 0.759 0.207 0.339 0.104 0.0720 4.04 0.221 1.19 0.280 154 CLOther,hep (L/h/kg) 0.219 0.124 1.20 0.162 1.55 2.33 1.00 0.000683 0.612 102
kfeces (1/h) 0.187 0.162 0.0895 0.227 0.0529 0.0104 0.690 0.0265 0.126 122 CLENDby3A,ent (L/h/kg) 1.78 12.0 5.77 13.8 2.31 10.8 15.4 8.85 9.81 57.9
CLR (L/h/kg) 0.000132 0.000121 0.000314 0.000158 0.000369 0.000165 0.00129 0.0114 0.000240 225 CL4OHTG by UGT,ent (L/h/kg) 0.469 0.170 0.427 0.640 0.0116 0.0633 0.0212 0.184 0.177 94.6
CLbile (L/h/kg) 5.68 2.80 0.156 1.00 14.6 5.18 7.57 1.87 3.99 96.2 CLOther by 3A,ent (L/h/kg) 0.833 0.134 0.0208 0.00109 0.227 1.15 0.0135 0.0529 0.0933 144
d) 4-OHT glucuronide Parameters (Unit) ID 1 ID 2 ID 3 ID 4 ID 5 ID 6 ID 7 ID 8 Median CV (%)
Vcentral (L/kg) 0.0812 0.720 0.114 0.0792 0.0760 0.105 0.361 0.0756 0.0933 114
ka (1/h) 3.28 0.427 0.217 2.44 0.374 3.12 0.280 0.0458 0.400 111
SFKp 1.45 5.83 1.03 1.27 4.25 1.72 2.38 1.08 1.58 73.7
kbile (1/h) 2.62 0.278 0.0602 0.811 0.360 0.103 2.20 5.50 0.585 127
PSdif (L/h/kg) 1.12 0.369 0.684 1.26 0.244 3.50 3.42 0.0624 0.900 103
CLR (L/h/kg) 0.00701 0.00429 0.00230 0.00137 0.00164 0.000383 0.000356 0.000613 0.00150 103
CLbile (L/h/kg) 36.4 14.0 0.493 0.0986 15.5 28.5 0.309 18.5 14.8 95.7
kdeg (1/h) 0.769 0.354 1.77 0.125 0.183 1.43 0.743 0.418 0.581 82.1
e) Endoxifen Parameters (Unit) ID 1 ID 2 ID 3 ID 4 ID 5 ID 6 ID 7 ID 8 Median CV (%)
Vcentral (L/h) 0.0779 0.0756 0.0886 0.102 0.157 0.165 0.916 0.0774 0.0955 139
SFkp 1.04 3.52 2.13 1.63 1.02 1.65 2.17 1.35 1.64 44.9
ka (1/h) 0.427 1.50 3.39 4.20 0.0649 0.0972 0.458 0.802 0.630 116
kbile (1/h) 4.13 0.734 4.78 0.228 1.94 0.315 0.127 1.68 1.21 104
PSdif (L/h/kg) 0.0570 6.47 0.0314 1.27 0.0950 3.45 0.101 0.264 0.183 159
PSact,ent (L/h/kg) 1.10 1470 2.35 304 0.254 95.1 10.3 4.55 7.40 216
CLR (L/h/kg) 0.00110 0.0433 0.0113 0.000115 0.000492 0.000588 0.000162 0.0336 0.000845 153
kfeces (1/h) 0.246 0.0626 0.345 0.483 0.371 0.181 0.00823 0.301 0.273 64.0
CLbile (L/h/kg) 4.20 1.31 2.77 2.69 6.51 0.855 1.36 1.89 2.29 69.4
CLOther,hep (L/h/kg) 0.134 0.935 5.26 4.70 0.736 0.673 6.60 4.69 2.81 87.2
CLOther,ent (L/h/kg) 31.4 3.09 8.50 0.212 0.0657 30.7 8.69 15.6 8.59 103
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