Kinetic profiles of intraepithelial and invasive prostatic ... - Springer Link
Recommend Documents
Currently, high-grade prostatic intraepithelial neoplasia. (PIN) is the most likely precursor of invasive prostatic carcinoma (PCa) [2, 3] and has been reported both ...
Feb 1, 2011 - Gregg, J., EGF Mediated Regulation of EGR1 In Prostate Cancer Cells, PhD .... Judd, D. B. et al, Color 2ND Edition, Wiley (New York) 1963.
estramustine and etoposide followed by concurrent estramustine and definitive radiotherapy for locally advanced prostate cancer: feasibility and preliminary ...
Dec 15, 2008 - disease, with prostatic intraepithelial neoplasia (PIN) and invasive adenocarcinomas ... high-grade PIN lesions as well as invasive carcinoma.
increasing grades of prostatic intraepithelial neoplasia ... The terminology 'prostatic intraepithelial ... sociated with carcinoma when of high grade.2125 Thymi-.
Basal cell hyperplasia (BCH) versus high grade prostatic intraepithelial neoplasia (HGPIN) in tiny prostatic needle biopsies: Unusual diagnostic dilemma.
Feb 25, 2010 - human PIN and adenocarcinoma cellsâatypical changes in ... physiologically during cell proliferation in most cell types, is generally tolerated by cells .... glandular architecture of the PIN lesions in Lo-MYC mice generally .... Als
Jul 1, 1995 - Allelic Loss on Chromosome 8pl2-21 in Microdissected Prostatic ... prostatic epithelium, high grade prostatic intraepithelial neoplasia (PIN),.
The only method of detection is biopsy; PIN does not significantly elevate serum prostate-specific antigen (PSA) concentration or its derivatives and cannot be ...
Grading of prostatic adenocarcinoma: current state and prognostic implications. Jennifer Gordetsky1,2 and Jonathan Epstein3,4*. Abstract. Background: Despite ...
Abstract. We evaluated 71 muscle-invasive transitional cell carcinomas (TCCs) of the bladder by tumor compartments. Kinetic parameters included mitotic.
Intraepithelial neoplasia describes the atypical proliferations observed in the squamous epithelium, ... those of the breast, pancreas and endometrium (2-4). The.
Oct 21, 2006 - in Prostatic Intraepithelial Neoplasia and Prostatic Carcinoma. Bożo KRUSLIN ... Thirty-seven consecutive cases with high-grade intraep-.
Abstract. High-grade prostatic intraepithelial neoplasia. (HGPIN) is considered to be an important precursor for pros- tatic adenocarcinoma. The present study ...
from lesions with high-grade prostatic intraepithelial neoplasia (HGPIN), a possible precursor of prostatic cancer (PCA), and from. PCA. A total of 193 lesions, ...
Dec 22, 2008 - and strong AMACR staining (red) in neoplastic acinar cells. C. Adenocarcinoma with no basal cell staining but strong AMACR staining in acinar ...
2Department of Cancer Biology, Vanderbilt-Ingram Comprehensive Cancer Center and ... of Pathology, Vanderbilt-Ingram Comprehensive Cancer Center and Vanderbilt .... increased nuclear atypia in AP and VP, satisfying key criteria for NCI ...
[PDF]High-grade Prostatic Intraepithelial Neoplasia of the Prostatehttps://www.researchgate.net/...High-grade_Prostatic_Intraepithelial_Neoplasia...Prost...CachedSimilarby DL Zynger - â2009 - âCited by 36 - âRelated articlesDec 22, 2008 - Risk
Oct 1, 2006 - epithelium of the mutant mice, as well as in CASP prostate epithelial .... distinguishing low-grade versus high-grade PIN, are well established.
Jul 2, 2008 - Abstract. Introduction The management of the regional lymph nodes in penile cancer patients, particularly when these lymph nodes are ...
Khan SA, Hu K-N, Marder C, Smith NL. Hemorrhoidal bleeding following transrectal prostatic biopsy: etiology and management. Dis Colon Rectum 1982 ...
Sep 24, 2014 - The following were used: AMACR (catalog number. 107916; Santa .... coupler of mitochondrial oxidative phosphorylation. The recruitment of ...... 4:209e221. 15. Jiang Z, Li C, Fischer A, Dresser K, Woda BA: Using an AMACR.
Background. High-grade intraepithelial neoplasia (HGPIN) is the only lesion regarded as precursor of prostatic carcino- ma, though its frequency is unknown in ...
Sep 24, 2014 - (R.G.P. for work conducted at the Sidney Kimmel Cancer Center), the .... culture media (Dulbecco,s modified Eagle,s medium) sup- plemented with 10% FBS, ...... 2. Whittle JR, Powell MJ, Popov VM, Shirley LA, Wang C,.
Kinetic profiles of intraepithelial and invasive prostatic ... - Springer Link
PIN only (in a background of nodular hyperplasia) and 20 with co- existent low-grade ..... al neoplasia (PIN) and atypical adenomatous hyperplasia. (AAH) of the ...
Michael Koch · Manuel de Miguel · Heinz Höfler Salvador J. Diaz-Cano
Kinetic profiles of intraepithelial and invasive prostatic neoplasias: the key role of down-regulated apoptosis in tumor progression
Received: 7 July 1999 / Accepted: 18 November 1999
Abstract The cell kinetic of prostatic intraepithelial neoplasia (PIN) is poorly understood. Herein we report the kinetic pattern of PIN, both not associated (primary) and associated (secondary) with coexistent invasive carcinoma (PCa). Surgical specimens collected in 20 cases of primary PIN, 20 of secondary PIN and 20 of PCa were studied by MIB-1 immunostaining, in situ endlabeling (ISEL) and DNA histogram analysis, and the cell density in each case was estimated using the formula N=(nπ/4)2. Fifty high-power fields (HPF), or the complete lesion if smaller, were screened in each lesion, and both mean and standard deviation were recorded. Statistical differences were studied by means of Fisher’s exact test. ISEL indices were significantly (P
