Low gestational weight gain and the risk of preterm birth and low ...

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gain and preterm birth and low birthweight in singletons in developing and devel- ... creases in preterm birth
A C TA Obstetricia et Gynecologica

A CTA REVI EW

Low gestational weight gain and the risk of preterm birth and low birthweight: a systematic review and meta-analyses ZHEN HAN1 , OLHA LUTSIV2 , SOHAIL MULLA2 , ALLISON ROSEN2 , JOSEPH BEYENE5 & SARAH D. MCDONALD6 , on behalf of the Knowledge Synthesis Group 1

Department of Obstetrics and Gynecology, First Affiliated Hospital of Xi’an Jiao Tong University, Shaanxi Province, P.R. China, 2 Faculty of Health Sciences, McMaster University, Hamilton, Canada, 5 Department Clinical Epidemiology and Biostatistics (CE&B), McMaster University, Hamilton, Ontario, Canada, 6 Division of Maternal-Fetal Medicine, Departments of Obstetrics & Gynecology, Diagnostic Imaging, and Clinical Epidemiology and Biostatistics (CE&B), McMaster University, Hamilton, Canada

Key words Low birthweight, low gestational weight gain, meta-analysis, preterm birth, systematic review Correspondence Dr. Sarah D. McDonald, McMaster University, Division of Maternal-Fetal Medicine, Departments of Obstetrics & Gynecology and Diagnostic Imaging and Clinical Epidemiology & Biostatistics (CE&B), 1200 Main St. West, HSC 3N52B, Hamilton, ON L8N 3Z5. E-mail: [email protected] Conflicts of interest The authors have stated explicitly that there are no conflicts of interest in connection with this article. Received: 24 September 2010 Accepted: 27 March 2011 DOI: 10.1111/j.1600-0412.2011.01185.x

Abstract Background. Low gestational weight gain is common, with potential adverse perinatal outcomes. Objective. To determine the relation between low gestational weight gain and preterm birth and low birthweight in singletons in developing and developed countries. Data sources. Medline, EMBASE and reference lists were searched, identifying 6 283 titles and abstracts. Methods of study selection. Following the MOOSE consensus statement, two assessors independently reviewed titles, abstracts, full articles, extracted data and assessed quality. Results. Fifty-five studies, 37 cohort and 18 case-control, were included, involving 3 467 638 women. In the cohort studies (crude data, generally supported where available by adjusted data and case-control studies), women with low total gestational weight gain had increases in preterm birth