Manual of Clinical Nutrition

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All rights reserved. MANUAL OF CLINICAL NUTRITION MANAGEMENT. Table of Contents. I. Normal Nutrition and Modified Diets. A. Normal Nutrition .
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Clinical Nutrition Management

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MANUAL OF CLINICAL NUTRITION MANAGEMENT Table of Contents I. Normal Nutrition and Modified Diets A. Normal Nutrition .........................................................................................................................

Statement on Nutritional Adequacy ..................................................................................................................................A-1 Estimated Energy Requirement (EER): Male and Females Under 30 Years of Age .....................................A-2 Estimated Energy Requirement (EER): Men And Women 30 Years of Age ....................................................A-2 Estimated Calorie Requirements (Kcal): Each Gender and Age Group at Three Levels of Physical Activity .......................................................................................................................................................................................A-3 Dietary Reference Intakes (DRIs): Recommended Intakes for Individuals, Macronutrients ..................A-4 Dietary Reference Intakes (DRIs): Recommended Intakes for Individuals, Vitamins ................................A-5 Dietary Reference Intakes (DRIs): Recommended Intakes for Individuals, Elements ...............................A-6 Dietary Reference Intakes (DRIs): Estimated Average Requirements ..............................................................A-7 Dietary Reference Intakes (DRIs): Tolerable Upper Intake Levels, Vitamins ................................................A-8 Dietary Reference Intakes (DRIs): Tolerable Upper Intake Levels, Elements ................................................A-9 Food Fortification and Dietary Supplements ............................................................................................................. A-10 Regular Diet – Adult .............................................................................................................................................................. A-11 High-Protein, High-Calorie Diet ....................................................................................................................................... A-13 Nutrition Management During Pregnancy and Lactation .................................................................................... A-14 Nutrition and The Older Adult .......................................................................................................................................... A-22 Mechanical Soft (Dental Soft) Diet .................................................................................................................................. A-28 Pureed Diet ................................................................................................................................................................................ A-30 Nutrition Management of Fluid Intake and Hydration .......................................................................................... A-32 Vegetarian Diets ...................................................................................................................................................................... A-36 Kosher Guidelines .................................................................................................................................................................. A-40

B. Transitional Diets .......................................................................................................................

Clear Liquid Diet ........................................................................................................................................................................B-1 Full Liquid Diet ...........................................................................................................................................................................B-3 Full Liquid Blenderized Diet .................................................................................................................................................B-4 Nutrition Management of Dysphagia ................................................................................................................................B-6 Dumping Syndrome Diet ..................................................................................................................................................... B-15 Nutrition Management in Bariatric Surgery ............................................................................................................... B-17 Specialized Nutrition Support Therapy ........................................................................................................................ B-33 Enteral Nutrition Support Therapy for Adults .......................................................................................................... B-35 Parenteral Nutrition Support for Adults ...................................................................................................................... B-50

C. Modification of Carbohydrate and Fat .................................................................................

Medical Nutrition Therapy for Diabetes Mellitus........................................................................................................ C-1 Medical Nutrition Therapy for Gestational Diabetes ..................................................................................... C-15 Dietary Management With the Exchange System ........................................................................................... C-21 Sugar in Moderation Diet .................................................................................................................................................... C-35 Calorie-Controlled Diet for Weight Management ..................................................................................................... C-36 Medical Nutrition Therapy for Disorders of Lipid Metabolism ......................................................................... C-40 Fat-Controlled Diet ................................................................................................................................................................ C-55 Medium-Chain Triglycerides (Mct) ................................................................................................................................ C-57

D. Modification of Fiber..................................................................................................................

Fiber-Restricted Diets............................................................................................................................................................. D-1 High-Fiber Diet .......................................................................................................................................................................... D-4 Dietary Fiber Content of Foods................................................................................................................................ D-11 Gastrointestinal Soft Diet .................................................................................................................................................... D-14

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E. Pediatric Diets ................................................................................................................................

Nutrition Management of the Full-Term Infant ........................................................................................................... E-1 Infant Formula Comparison Chart ............................................................................................................................ E-4 Nutrition Management of the Toddler and Preschool Child .................................................................................. E-7 Nutrition Management of the School-Aged Child ........................................................................................................ E-9 Nutrition Management of the Adolescent.................................................................................................................... E-12 Ketogenic Diet .......................................................................................................................................................................... E-14

F. Modification of Minerals .............................................................................................................

Sodium-Controlled Diet .......................................................................................................................................................... F-1 No Added Salt Diet (4,000-Mg Sodium Diet) ........................................................................................................ F-4 Food Guide — 3,000-Mg Sodium Diet ..................................................................................................................... F-5 2,000 Mg And 1,500 Mg Sodium Restricted Diet Patterns ............................................................................. F-6 Food Guide — 1,000-Mg Sodium Diet ..................................................................................................................... F-8 Nutrition Management of Potassium Intake .............................................................................................................. F-10 Potassium Content of Common Foods...................................................................................................................F-11 Nutrition Management of Phosphorus Intake ........................................................................................................... F-12 Phosphorous Content of Common Foods .............................................................................................................F-13 Nutrition Management of Calcium Intake ................................................................................................................... F-14 Calcium Content of Common Foods .......................................................................................................................F-15

G. Modification of Protein ...............................................................................................................

Protein-Controlled Diet for Acute and Refractory Hepatic Encephalopathy ..................................................G-1 Protein-Based Exchanges .............................................................................................................................................. G-5 Medical Nutrition Therapy for Chronic Kidney Disease ..........................................................................................G-7 Meal Patterns Using Healthy Food Guide ............................................................................................................ G-27 Simplified Renal Diet ............................................................................................................................................................. G-28

H. Diets for Sensitivity/Miscellaneous Intolerances .............................................................

Gluten-Free Diet ........................................................................................................................................................................ H-1 Food Guide – Gluten-Free Diet ....................................................................................................................................H-6 Tyramine-Restricted Diet ...................................................................................................................................................H-10 Lactose-Controlled Diet .......................................................................................................................................................H-12 Nutrition Management of Food Hypersensitivities .................................................................................................H-16

II. NUTRITION ASSESSMENT/INTERVENTION

Body Weight Evaluation and Indicators of Nutrition-Related Problems ........................................................ II-1 Stature Determination ............................................................................................................................................................ II-5 Body Mass Index (BMI) .......................................................................................................................................................... II-6 Determining Ideal Body Weight (IBW) Based on Height to Weight: The Hamwi Method...................... II-7 Standard Body Weight (SBW) Determination Based On NHANES II................................................................. II-8 Determination of Frame Size ............................................................................................................................................... II-9 Estimation of Ideal Body Weight and Body Mass Index for Amputees .......................................................... II-10 Estimation of Energy Expenditures ................................................................................................................................ II-12 Estimation of Protein Requirements ............................................................................................................................. II-17 Laboratory Indices of Nutritional Status ..................................................................................................................... II-18 Classification of Some Anemias ........................................................................................................................................ II-20 Diagnostic Criteria for Diabetes Mellitus ..................................................................................................................... II-21 Major Nutrients: Functions and Sources ...................................................................................................................... II-23 Physical Signs of Nutritional Deficiencies ................................................................................................................... II-26 Food and Medication Interactions .................................................................................................................................. II-27 Herb and Medication Interactions .................................................................................................................................. II-34

III. CLINICAL NUTRITION MANAGEMENT

Introduction ............................................................................................................................................................................... III-1 Anticoagulant Therapy .......................................................................................................................................................... III-3 Burns ............................................................................................................................................................................................. III-6 Cancer ........................................................................................................................................................................................ III-10 Chronic Obstructive Pulmonary Disease ................................................................................................................... III-16 Corticosteroid Therapy ...................................................................................................................................................... III-20 Monitoring in Diabetes Mellitus ..................................................................................................................................... III-21

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Diabetes Mellitus: Considerations for Exercise .............................................................................................. III-23 Diabetes Mellitus: Considerations for Acute Illness ..................................................................................... III-25 Diabetes Mellitus: Gastrointestinal Complications ....................................................................................... III-27 Diabetes Mellitus: Oral Glucose-Lowering Medications and Insulin .................................................... III-29 Diabetes Mellitus: Fat Replacers and Nutritive/Nonnutritive Sweeteners ....................................... III-32 Dysphagia ................................................................................................................................................................................. III-35 Relationship of Dysphagia to the Normal Swallow ...................................................................................... III-37 Enteral Nutrition: Management of Complications ................................................................................................. III-38 Gastroesophageal Reflux Disease (GERD) ................................................................................................................. III-40 Heart Failure ........................................................................................................................................................................... III-42 HIV Infection and AIDS....................................................................................................................................................... III-46 Hypertension .......................................................................................................................................................................... III-62 Hypertriglyceridemia ......................................................................................................................................................... III-70 Hypoglycemia ......................................................................................................................................................................... III-72 Inborn Errors of Metabolism ........................................................................................................................................... III-74 Iron Deficiency Anemia ...................................................................................................................................................... III-77 Nephrotic Syndrome ........................................................................................................................................................... III-79 Obesity and Weight Management ................................................................................................................................. III-81 Pancreatitis.............................................................................................................................................................................. III-89 Parenteral Nutrition (PN): Metabolic Complications ........................................................................................... III-94 Calculating Total Parenteral Nutrition ........................................................................................................................ III-99 Peptic Ulcer .......................................................................................................................................................................... III-103 Pneumonia ............................................................................................................................................................................ III-104 Pressure Ulcers ................................................................................................................................................................... III-106 Management of Acute Kidney Injury and Chronic Kidney Disease (Stage V) ......................................... III-110 Nutrition Care Outcomes and Interventions In CKD (Stage V) Renal Replacement Therapy III-116 Wilson’s Disease ................................................................................................................................................................. III-119

IV. APPENDIX

Caffeine and Theobromine Content of Selected Foods and Beverages ........................................................... IV-1 Metric/English Conversions of Weight and Measures ............................................................................................ IV-2 Milligram/Milliequivalent Conversions ........................................................................................................................ IV-2 Salicylate Content of Selected Foods ............................................................................................................................... IV-3

INDEX

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I. NORMAL NUTRITION AND MODIFIED DIETS A. Normal Nutrition Statement on Nutritional Adequacy ........................................................................................................... A-1 Estimated Energy Requirement (EER):Male and Females Under 30 Years of Age..................... A-2 Estimated Energy Requirement (EER): Men and Women 30 Years Of Age................................... A-2 Estimated Calorie Requirements (Kcal): Each Gender and Age Group at Three Levels of Physical Activity.......................................................................................................................................... A-3 Dietary Reference Intakes (DRIs): Recommended Intakes for Individuals, Macronutrients A-4 Dietary Reference Intakes (DRIs): Recommended Intakes for Individuals, Vitamins ............. A-5 Dietary Reference Intakes (DRIs): Recommended Intakes for Individuals, Elements ............ A-6 Dietary Reference Intakes (DRIs): Estimated Average Requirements .......................................... A-7 Dietary Reference Intakes (DRIs): Tolerable Upper Intake Levels, Vitamins ............................. A-8 Dietary Reference Intakes (DRIs): Tolerable Upper Intake Levels, Elements ............................ A-9 Food Fortification and Dietary Supplements ....................................................................................... A-10 Regular Diet – Adult ....................................................................................................................................... A-11 Food Guide For Americans (1800-2000 Calorie Pattern)............................................................... A-12 High-Protein, High-Calorie Diet ................................................................................................................ A-13 Nutrition Management During Pregnancy and Lactation ................................................................ A-14 Daily Food Group Guidelines ....................................................................................................................... A-14 Table A-1: Guidelines For Weight Gain After The First Trimester Of Pregnancy .................. A-14 Nutrition And The Older Adult .................................................................................................................. A-22 Table A-2: Contributors To Unintended Weight Loss and Malnutrition in Older Adults ... A-25 Mechanical Soft (Dental Soft) Diet ............................................................................................................ A-28 Food Guide – Mechanical Soft (Dental Soft) Diet ................................................................................. A-29 Pureed Diet ....................................................................................................................................................... A-30 Food Guide – Pureed Diet .............................................................................................................................. A-30 Nutrition Management Of Fluid Intake And Hydration .................................................................... A-32 Fluid Content Of The Regular Diet - Sample .......................................................................................... A-33 Vegetarian Diets.............................................................................................................................................. A-36 Kosher Guidelines .......................................................................................................................................... A-40 Food Guide – Kosher Diet .............................................................................................................................. A-41

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STATEMENT ON NUTRITIONAL ADEQUACY The Dietary Reference Intakes (DRIs) of the Food and Nutrition Board of the Institute of Medicine, National Academy of Sciences, are used as the standard for determining the nutritional adequacy of the regular and modified diets outlined in this manual. DRIs reference values that are quantity estimates of nutrient intakes to be used for planning and assessing diets for healthy people. The DRIs consist of four reference intakes:    

Recommended Daily Allowances (RDA), a reference to be used as a goal for the individual. Tolerable Upper Intake Level (UL), the intake level given to assist in advising individuals of what intake levels may result in adverse effects if habitually exceeded. Estimated Average Requirement (EAR), the intake level which data indicates that the needs for 50% of individuals consuming this intake will not be met. Adequate Intake (AI), a recommended intake value for a group or groups of healthy people based on fewer data and substantially more judgment than used in establishing an EAR and subsequently the RDA.

An AI is given when the RDA cannot be set. Both of these reference intakes are to be used as goals in planning and assessing diets for healthy individuals (1,2). The DRIs do not cover special needs for nutrients due to various disease conditions. DRIs are reference values appropriate for both assessing population intakes and planning diets for healthy people (1,2). When referring to energy, use Estimated Energy Intake (EER). EER is the average dietary energy intake that is predicted to maintain energy balance in a healthy adult of a defined age, gender, weight, height and level of physical activity, consistent with good health. For children, pregnant and lactating women, the EER includes the needs associated with deposition of tissues or the secretion of milk at rates consistent with good health (3). The sample menus throughout this manual have been planned to provide the recommended DRIs for men, 31 to 50 years of age, unless indicated otherwise, and have been analyzed by a nutrient analysis software program. For specific values, refer to the following tables of recommended DRIs from the Food and Nutrition Board of the National Academy of Sciences. However, it is acknowledged that nutrient requirements vary widely. The dietitian can establish an adequate intake on an individual basis. Nutrient analysis of the menus is available from Webtrition and reflects available nutrient information. Webtrition pulls nutrient information from either the USDA Standard Reference database (which includes 36 of the 41 RDA/DRI nutrients) or the manufactures information (manufactures are required only to provide 13 of the 41 RDA/DRI nutrients). Because of this, nutritional analysis data may be incomplete for some foods and/or some nutrients that are listed in the DRI. The Menu Nutrient Analysis Report in Webtrition uses a (+) to indicate a partial nutritional value and a (-) to indicate no nutritional value available. The DRIs are provided in a series of reports (3-7). Full texts of reports are available at www.nap.edu. References 1. Yates AA, Schlicker SA, Suitor CW. Dietary Reference Intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc. 1998;98:699-706. 2. Trumbo P, Yates A, Schlicker S, Poos M. Dietary Reference Intakes: Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. J Am Diet Assoc. 2001;101(3):294-301. 3. Institute of Medicine’s Food and Nutrition Board. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. (Macronutrients). Washington, DC: National Academy of Sciences, 2005: 107-180. 4. Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Food and Nutrition Board, Washington, DC: National Academy Press;1997. 5. Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Food and Nutrition Board, Washington, DC: National Academy Press;1998. 6. Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Cartotenoids. Food and Nutrition Board, Washington, DC: National Academy Press;2000. 7. Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Molybdenum, Nickel, Silicon, Vandium and Zinc. Food and Nutrition Board. Washington, DC: National Academy Press; 2001.

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ESTIMATED ENERGY REQUIREMENT (EER) FOR MALE AND FEMALES UNDER 30 YEARS OF AGE Age 2-6 mo 7-12 mo 1-3 y 4-8 y 9-13 y 14-18 y 19-30 y

Body Mass Median Reference Reference Index (kg/m2)a Heightbcm(in) Weighta kg (lb) 62(24) 6(13) 62(24) 6(13) 71(28) 9(20) 71(28) 9(20) 86(34) 12(27) 86(34) 12(27) 115(45) 20(44) 115(45) 20(44) 17.2 144(57) 36(79) 17.4 144(57) 37(81) 20.5 174(68) 61(134) 20.4 163(64) 54(119) 22.5 177(70) 70(154) 21.5 163(64) 57(126)

Sex M F M F M F M F M F M F M F

Kcal/day 570 520 743 676 1046 992 1,742 1,642 2,279 2,071 3,152 2,368 3,607c 2,403c

aTaken

from new data on male and female median body mass index and height-for-age data from the Centers for Disease Control and Prevention National Center for Health Statistics Growth Charts (Kuczmarski, et al., 2000). bCalculated from CDC/NCHS Growth Charts (Kuczmarski et al., 2000); median body mass index and median height for ages 4 through 19 years. cSubtract 10 kcal/day for males and 7 kcal/day for females for each year of age above 19 years. Adapted from: Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: National Academies Press, 2002.

ESTIMATED ENERGY REQUIREMENT (EER) FOR MEN AND WOMEN 30 YEARS OF AGEa Height (m[in])

PAL b

Weight for BMI of 18.5 kg/m2 (kg [lb])

Weight for BMI of 24.99 kg/m2 (kg [lb])

1.50 Sedentary (59) Low active Active Very Active

41.6 (92)

56.2 (124)

1,848 2,009 2,215 2,554

2,080 2,267 2,506 2,898

1,625 1,803 2,025 2,291

1,762 1,956 2,198 2,489

1.65 Sedentary (65) Low active Active Very Active

50.4 (111)

68.0 (150)

2,068 2,254 2,490 2,880

2,349 2,566 2,842 3,296

1,816 2,016 2,267 2,567

1,982 2,202 2,477 2,807

1.80 (71)

59.9 (132)

81.0 (178)

2,301 2,513 2,782 3,225

2,635 2,884 3,200 3,720

2,015 2,239 2,519 2,855

2,221 2.459 2,769 3,141

Sedentary Low active Active Very Active

EER, Men (kcal/day)c EER, Women (kcal/day)c BMI of BMI of BMI of BMI of 18.5 kg/m2 24.99 kg/m2 18.5 kg/m2 24.99 kg/m2

aFor

each year below 30, add 7 kcal/day for women and 10 kcal/day for men. For each year above 30, subtract 7 kcal/day for women and 10kcal/day for men. bPhysical activity level. cDerive from the following regression equations based on doubly labeled water data: Adult man: EER=661.8-9.53xAge (y)xPAx(15.91xWt [kg]+539.6xHt[m] Adult woman EER=354.1 – 6.91xAge(y)xPAx(9.36xWt [kg] + 726xHt [m]) Where PA refers to coefficient for Physical Activity Levels (PAL) PAL=total energy expenditure + basal energy expenditure. PA=1.0 if PAL >1.0 < 1.4 (sedentary). PA=1.12 if PAL > 1.4 1.6 1.9 < 2.5 (very active). Source: Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (2002). This report may be accessed via www.nap.edu. Copyright 2002 by the National Academy of Sciences. All rights reserved.

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ESTIMATED CALORIE REQUIREMENTS (IN KILOCALORIES) FOR EACH GENDER AND AGE GROUP AT THREE LEVELS OF PHYSICAL ACTIVITY (1) a Estimated amounts of calories needed to maintain energy balance for various gender and age groups at three different levels of physical activity. The estimates are rounded to the nearest 200 calories and were determined using the Institute of Medicine equation. Gender Child Female d

Male

Age (years) 2-3 4-8 9-13 14-18 19-30 31-50 51+ 4-8 9-13 14-18 19-30 31-50 51+

Sedentaryb 1,000—1,200 c 1,200-1,400 1,400-1,600 1,800 1,800-2,000 1,800 1,600 1,200-1,400 1,600-2,000 2,000-2,400 2,400-2,600 2,200-2,400 2,000-2,200

Activity Level b Moderately Active 1,000-1,400c 1,400-1,600 1,600-2,000 2,000 2,000-2,200 2,000 1,800 1,400-1,600 1,800-2,200 2,400-2,800 2,600-2,800 2,400-2,600 2,200-2,400

Active 1,000-1,400c 1,400-1,800 1,800-2,200 2,400 2,400 2,200 2,000-2,200 1,600-2,000 2,000-2,600 2,800-3,200 3,000 2,800-3,000 2,400-2,800

aBased on Estimated Energy Requirements (EER) equations, using reference heights (average) and reference weights (healthy) for each

age/gender group. For children and adolescents, reference height and weight vary. For adults, the reference man is 5 feet 10 inches tall and weighs 154 pounds. The reference woman is 5 feet 4 inches tall and weighs 126 pounds. EER equations are from the Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington (DC): The National Academies Press; 2002. bSedentary means a lifestyle that includes only the light physical activity associated with typical day-to-day life. Moderately active means a lifestyle that includes physical activity equivalent to walking about 1.5 to 3 miles per day at 3 to 4 miles per hour, in addition to the light physical activity associated with typical day-to-day life. Active means a lifestyle that includes physical activity equivalent to walking more than 3 miles per day at 3 to 4 miles per hour, in addition to the light physical activity associated with typical day-to-day life. cThe calorie ranges shown are to accommodate needs of different ages within the group. For children and adolescents, more calories are needed at older ages. For adults, fewer calories are needed at older ages. dEstimates for females do not include women who are pregnant or breastfeeding. Reference Dietary Guidelines for Americans 2010. Available at: http://www.cnpp.usda.gov/Publications/DietaryGuidelines/2010/PolicyDoc/PolicyDoc.pdf Accessed Jan 31, 2011.

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DIETARY REFERENCE INTAKES (DRIS): RECOMMENDED INTAKES FOR INDIVIDUALS, MACRONUTRIENTS Life Stage Group Infants 0–6 mo 7–12 mo Children 1–3 y 4–8 y Males 9–13 y 14–18 y 19–30 y 31–50 y 51–70 y > 70 y Females 9–13 y 14–18 y 19–30 y 31–50 y 51–70 y > 70 y Pregnancy 14–18 y 19–30 y 31–50 y Lactation 14–18 y 19–30 y 31–50 y

Food and Nutrition Board, Institute of Medicine, National Academies Total Total Linoleic α-Linolenic Proteinb Watera Carbohydrate Fiber Fat Acid Acid (g/d) (g/d) (g/d) (g/d) (g/d) (g/d) (L/d) 0.7* 0.8*

60* 95*

ND ND

31* 30*

1.3* 1.7*

130 130

19* 25*

ND ND

2.4* 3.3* 3.7* 3.7* 3.7* 3.7*

130 130 130 130 130 130

31* 38* 38* 38* 30* 30*

2.1* 2.3* 2.7* 2.7* 2.7* 2.7*

130 130 130 130 130 130

3.0* 3.0* 3.0* 3.8* 3.8* 3.8*

4.4* 4.6*

0.5* 0.5*

9.1* 11.0c

7* 10*

0.7* 0.9*

13 19

ND ND ND ND ND ND

12* 16* 17* 17* 14* 14*

1.2* 1.6* 1.6* 1.6* 1.6* 1.6*

34 52 56 56 56 56

26* 26* 25* 25* 21* 21*

ND ND ND ND ND ND

10* 11* 12* 12* 11* 11*

1.0* 1.1* 1.1* 1.1* 1.1* 1.1*

34 46 46 46 46 46

175 175 175

28* 28* 28*

ND ND ND

13* 13* 13*

1.4* 1.4* 1.4*

71 71 71

210 210 210

29* 29* 29*

ND ND ND

13* 13* 13*

1.3* 1.3* 1.3*

71 71 71

NOTE: This table presents Recommended Dietary Allowances (RDAs) in bold type and Adequate Intakes (AIs) in ordinary type followed by an asterisk (*). RDAs and AIs may both be used as goals for individual intake. RDAs are set to meet the needs of almost all (97 to 98 percent) individuals in a group. For healthy infants fed human milk, the AI is the mean intake. The AI for other life stage and gender groups is believed to cover the needs of all individuals in the group, but lack of data or uncertainty in the data prevent being able to specify with confidence the percentage of individuals covered by this intake. a Total water includes all water contained in food, beverages, and drinking water. b Based on 0.8 g/kg body weight for the reference body weight. c Change from 13.5 in prepublication copy due to calculation error.

Dietary Reference Intakes (DRIs): Additional Macronutrient Recommendations Food and Nutrition Board, Institute of Medicine, National Academies Macronutrient Recommendation Dietary cholesterol As low as possible while consuming a nutritionally adequate diet Trans fatty acids As low as possible while consuming a nutritionally adequate diet Saturated fatty acids As low as possible while consuming a nutritionally adequate diet Added sugars Limit to no more than 25% of total energy SOURCE: Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (2002).

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Dietary Reference Intakes (DRIs): Recommended Dietary Allowances and Adequate Intakes, Vitamins Food and Nutrition Board, Institute of Medicine, National Academies

Vit A (µg/d)a

Vit C (mg/d)

Vit D (µg/d)b,c

Vit E (mg/d) d

Vit K (µg/d)

Thiamin (mg/d)

Riboflavin (mg/d)

Niacin (mg/d)e

Vit B6 (mg/d)

Folate (µg/d)f

Vit B12 (µg/d)

Pantothenic Acid (mg/d)

Biotin (µg/d)

Cholineg (mg/d)

400* 500*

40* 50*

15* 15*

4* 5*

2.0* 2.5*

0.2* 0.3*

0.3* 0.4*

2* 4*

0.1* 0.3*

65* 80*

0.4* 0.5*

1.7* 1.8*

5* 6*

125* 150*

300 400

15 25

15* 15*

6 7

30* 55*

0.5 0.6

0.5 0.6

6 8

0.5 0.6

150 200

0.9 1.2

2* 3*

8* 12*

200* 250*

9–13 y 14–18 y 19–30 y 31–50 y 51–70 y > 70 y

600 900 900 900 900 900

45 75 90 90 90 90

15* 15* 15* 15* 15* 20*

11 15 15 15 15 15

60* 75* 120* 120* 120* 120*

0.9 1.2 1.2 1.2 1.2 1.2

0.9 1.3 1.3 1.3 1.3 1.3

12 16 16 16 16 16

1.0 1.3 1.3 1.3 1.7 1.7

300 400 400 400 400 400

1.8 2.4 2.4 2.4 2.4i 2.4i

4* 5* 5* 5* 5* 5*

20* 25* 30* 30* 30* 30*

375* 550* 550* 550* 550* 550*

Females 9–13 y 14–18 y 19–30 y 31–50 y 51–70 y > 70 y

600 700 700 700 700 700

45 65 75 75 75 75

15* 15* 15* 15* 15* 20*

11 15 15 15 15 15

60* 75* 90* 90* 90* 90*

0.9 1.0 1.1 1.1 1.1 1.1

0.9 1.0 1.1 1.1 1.1 1.1

12 14 14 14 14 14

1.0 1.2 1.3 1.3 1.5 1.5

300 400i 400i 400i 400 400

1.8 2.4 2.4 2.4 2.4h 2.4h

4* 5* 5* 5* 5* 5*

20* 25* 30* 30* 30* 30*

375* 400* 425* 425* 425* 425*

750 770 770

80 85 85

15* 15* 15*

15 15 15

75* 90* 90*

1.4 1.4 1.4

1.4 1.4 1.4

18 18 18

1.9 1.9 1.9

600j 600j 600j

2.6 2.6 2.6

6* 6* 6*

30* 30* 30*

450* 450* 450*

1,200 1,300 1,300

115 120 120

15* 15* 15*

19 19 19

75* 90* 90*

1.4 1.4 1.4

1.6 1.6 1.6

17 17 17

2.0 2.0 2.0

500 500 500

2.8 2.8 2.8

7* 7* 7*

35* 35* 35*

550* 550* 550*

Life Stage Group Manual of Clinical Nutrition Management

Infants 0–6 mo 7–12 mo Children 1–3 y 4–8 y Males

A-5

Pregnancy 14–18 y 19–30 y 31–50 y Lactation 14–18 y 19–30 y 31–50

Copyright  2013 Compass Group, Inc. All rights reserved.

NOTE: This table (taken from the DRI reports, see www.nap.edu) presents Recommended Dietary Allowances (RDAs) in bold type and Adequate Intakes (AIs) in ordinary type followed by an asterisk (*). An RDA is the average daily dietary intake level; sufficient to meet the nutrient requirements of nearly all (97 to 98 percent) healthy individuals in a group. It is calculated from an Estimated Average Requirement (EAR). If sufficient scientific evidence is not available to establish an EAR, and thus calculate an RDA, an AI is developed. For healthy breastfed infants, the AI is the mean intake. The AI for other life stage and gender groups is believed to cover needs of all healthy individuals in the group, but lack of data or uncertainty in the data prevent being able to specify with confidence the percentage of individuals covered by this intake. a As retinol activity equivalents (RAEs). 1 RAE = 1 mg retinol, 12 mg b-carotene, 24 mg a-carotene, or 24 mg b-cryptoxanthin. The RAE for dietary provitamin A carotenoids is twofold greater than retinol equivalents (RE), whereas the RAE for preformed vitamin A is the same as RE. b As cholecalciferol. 1 µg cholecalciferol = 40 IU vitamin D. c In the absence of adequate exposure to sunlight. d As a-tocopherol. a-Tocopherol includes RRR-a-tocopherol, the only form of a-tocopherol that occurs naturally in foods, and the 2R-stereoisomeric forms of a-tocopherol (RRR-, RSR-, RRS-, and RSS-a-tocopherol) that occur in fortified foods and supplements. It does not include the 2S-stereoisomeric forms of a-tocopherol (SRR-, SSR-, SRS-, and SSS-a-tocopherol), also found in fortified foods and supplements. e As niacin equivalents (NE). 1 mg of niacin = 60 mg of tryptophan; 0–6 months = preformed niacin (not NE). f As dietary folate equivalents (DFE). 1 DFE = 1 µg food folate = 0.6 µg of folic acid from fortified food or as a supplement consumed with food = 0.5 µg of a supplement taken on an empty stomach. g Although AIs have been set for choline, there are few data to assess whether a dietary supply of choline is needed at all stages of the life cycle, and it may be that the choline requirement can be met by endogenous synthesis at some of these stages. h Because 10 to 30 percent of older people may malabsorb food-bound B12, it is advisable for those older than 50 years to meet their RDA mainly by consuming foods fortified with B12 or a supplement containing B12. i In view of evidence linking folate intake with neural tube defects in the fetus, it is recommended that all women capable of becoming pregnant consume 400 µg from supplements or fortified foods in addition to intake of food folate from a varied diet. j It is assumed that women will continue consuming 400 µg from supplements or fortified food until their pregnancy is confirmed and they enter prenatal care, which ordinarily occurs after the end of the periconceptional period— the critical time for formation of the neural tube. SOURCES: Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride (1997); Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid,Biotin, and Choline (1998); Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids (2000); Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (2001); Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate (2005); and Dietary Reference Intakes for Calcium and Vitamin D (2011). These reports may be accessed via www.nap.edu.

Dietary Reference Intakes (DRIs): Recommended Dietary Allowances and Adequate Intakes, Elements Manual of Clinical Nutrition Management

Food and Nutrition Board, Institute of Medicine, National Academies

A-6 Copyright  2013 Compass Group, Inc. All rights reserved.

Life Stage Group

Calcium (mg/d)

Chromium (µg/d)

Copper (µg/d)

Fluoride (mg/d)

Iodine (µg/d)

Iron (mg/d)

Magnesium (mg/d)

Manganese (mg/d)

Molybdenum (µg/d)

Phosphorus (mg/d)

Selenium (µg/d)

Zinc (mg/d)

Potassium (g/d)

Sodium (g/d)

Chloride (g/d)

Infants 0–6 mo 7–12 mo Children

200* 260*

0.2* 5.5*

200* 220*

0.01* 0.5*

110* 130*

0.27* 11

30* 75*

0.003* 0.6*

2* 3*

100* 275*

15* 20*

2* 3

0.4* 0.7*

0.12* 0.37*

0.18* 0.57*

1–3 y 4–8 y Males

700* 1,000*

11* 15*

340 440

0.7* 1*

90 90

7 10

80 130

1.2* 1.5*

17 22

460 500

20 30

3 5

3.0* 3.8*

1.0* 1.2*

1.5* 1.9*

9–13 y 14–18 y 19–30 y 31–50 y 51–70 y > 70 y Females

1,300* 1,300* 1,000* 1,000* 1,000* 1,200*

25* 35* 35* 35* 30* 30*

700 890 900 900 900 900

2* 3* 4* 4* 4* 4*

120 150 150 150 150 150

8 11 8 8 8 8

240 410 400 420 420 420

1.9* 2.2* 2.3* 2.3* 2.3* 2.3*

34 43 45 45 45 45

1,250 1,250 700 700 700 700

40 55 55 55 55 55

8 11 11 11 11 11

4.5* 4.7* 4.7* 4.7* 4.7* 4.7*

1.5* 1.5* 1.5* 1.5* 1.3* 1.2*

2.3* 2.3* 2.3* 2.3* 2.0* 1.8*

9–13 y 14–18 y 19–30 y 31–50 y 51–70 y > 70 y Pregnancy

1,300* 1,300* 1,000* 1,000* 1,200* 1,200*

21* 24* 25* 25* 20* 20*

700 890 900 900 900 900

2* 3* 3* 3* 3* 3*

120 150 150 150 150 150

8 15 18 18 8 8

240 360 310 320 320 320

1.6* 1.6* 1.8* 1.8* 1.8* 1.8*

34 43 45 45 45 45

1,250 1,250 700 700 700 700

40 55 55 55 55 55

8 9 8 8 8 8

4.5* 4.7* 4.7* 4.7* 4.7* 4.7*

1.5* 1.5* 1.5* 1.5* 1.3* 1.2*

2.3* 2.3* 2.3* 2.3* 2.0* 1.8*

14–18 y 19–30 y 31–50 y Lactation

1,300* 1,000* 1,000*

29* 30* 30*

1,000 1,000 1,000

3* 3* 3*

220 220 220

27 27 27

400 350 360

2.0* 2.0* 2.0*

50 50 50

1,250 700 700

60 60 60

12 11 11

4.7* 4.7* 4.7*

1.5* 1.5* 1.5*

2.3* 2.3* 2.3*

14–18 y 19–30 y 31–50 y

1,300* 1,000* 1,000*

44* 45* 45*

1,300 1,300 1,300

3* 3* 3*

290 290 290

10 9 9

360 310 320

2.6* 2.6* 2.6*

50 50 50

1,250 700 700

70 70 70

13 12 12

5.1* 5.1* 5.1*

1.5* 1.5* 1.5*

2.3* 2.3* 2.3*

NOTE: This table (taken from the DRI reports, see www.nap.edu) presents Recommended Dietary Allowances (RDAs) in bold type and Adequate Intakes (AIs) in ordinary type followed by an asterisk (*). An RDA is the average daily dietary intake level; sufficient to meet the nutrient requirements of nearly all (97 to 98 percent) healthy individuals in a group. It is calculated from an Estimated Average Requirement (EAR). If sufficient scientific evidence is not available to establish an EAR, and thus calculate an RDA, an AI is developed. For healthy breastfed infants, the AI is the mean intake. The AI for other life stage and gender groups is believed to cover needs of all healthy individuals in the group, but lack of data or uncertainty in the data prevent being able to specify with confidence the percentage of individuals covered by this intake.

SOURCES: Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride (1997); Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid,Biotin, and Choline (1998); Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids (2000); Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (2001); Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate (2005); and Dietary Reference Intakes for Calcium and Vitamin D (2011). These reports may be accessed via www.nap.edu.

.

Dietary Reference Intakes (DRIs): Estimated Average Requirements Manual of Clinical Nutrition Management

Food and Nutrition Board, Institute of Medicine, National Academies Life Stage Group

A-7

Infants 0 to 6 mo 6–12 mo Children 1–3 y 4–8 y Males 9–13 y 14–18 y 19–30 y 31–50 y 51–70 y > 70 y Females 9–13 y 14–18 y 19–30 y 31–50 y 51–70 y > 70 y Pregnancy 14–18 y 19–30 y 31–50 y Lactation 14–18 y 19–30 y 31–50 y

Calcium

CHO (g/d)

(mg/d)

Protein (g/kg/d)

Vit A

Vit C

Vit D

Vit E

(mg/d)a

(mg/d)

( µg/d)

(mg/d) b

Thiamin

(mg/d)

Riboflavin

Niacin

Vit B6

Folate

(mg/d)c

(mg/d)

(mg/d)d

(mg/d)

Vit B12

(mg/d)

Copper

Iodine

Iron

(mg/d)

(mg/d)

(mg/d)

Magnesium (mg/d)

1.0

Molybdenum (mg/d)

Phosphorus (mg/d)

Selenium

Zinc (mg/d)

(mg/d)

6.9

2.5

Copyright  2013 Compass Group, Inc. All rights reserved.

500 800

100 100

0.87 0.76

210 275

13 22

10 10

5 6

0.4 0.5

0.4 0.5

5 6

0.4 0.5

120 160

0.7 1.0

260 340

65 65

3.0 4.1

65 110

13 17

380 405

17 23

2.5 4.0

1,100 1,100 800 800 800 1,000

100 100 100 100 100 100

0.76 0.73 0.66 0.66 0.66 0.66

445 630 625 625 625 625

39 63 75 75 75 75

10 10 10 10 10 10

9 12 12 12 12 12

0.7 1.0 1.0 1.0 1.0 1.0

0.8 1.1 1.1 1.1 1.1 1.1

9 12 12 12 12 12

0.8 1.1 1.1 1.1 1.4 1.4

250 330 320 320 320 320

1.5 2.0 2.0 2.0 2.0 2.0

540 685 700 700 700 700

73 95 95 95 95 95

5.9 7.7 6 6 6 6

200 340 330 350 350 350

26 33 34 34 34 34

1,055 1,055 580 580 580 580

35 45 45 45 45 45

7.0 8.5 9.4 9.4 9.4 9.4

1,100 1,100 800 800 1,000 1,000

100 100 100 100 100 100

0.76 0.71 0.66 0.66 0.66 0.66

420 485 500 500 500 500

39 56 60 60 60 60

10 10 10 10 10 10

9 12 12 12 12 12

0.7 0.9 0.9 0.9 0.9 0.9

0.8 0.9 0.9 0.9 0.9 0.9

9 11 11 11 11 11

0.8 1.0 1.1 1.1 1.3 1.3

250 330 320 320 320 320

1.5 2.0 2.0 2.0 2.0 2.0

540 685 700 700 700 700

73 95 95 95 95 95

5.7 7.9 8.1 8.1 5 5

200 300 255 265 265 265

26 33 34 34 34 34

1,055 1,055 580 580 580 580

35 45 45 45 45 45

7.0 7.3 6.8 6.8 6.8 6.8

1,000 800 800

135 135 135

0.88 0.88 0.88

530 550 550

66 70 70

10 10 10

12 12 12

1.2 1.2 1.2

1.2 1.2 1.2

14 14 14

1.6 1.6 1.6

520 520 520

2.2 2.2 2.2

785 800 800

160 160 160

23 22 22

335 290 300

40 40 40

1,055 580 580

49 49 49

10.5 9.5 9.5

1,000 800

160 160

1.05 1.05

885 900

96 100

10 10

16 16

1.2 1.2

1.3 1.3

13 13

1.7 1.7

450 450

2.4 2.4

209 209

7 6.5

300 255

35 36

1,055 580

59 59

10.9 10.4

800

160

1.05

900

100

10

16

1.2

1.3

13

1.7

450

2.4

985 1,00 0 1,00 0

209

6.5

265

36

580

59

10.4

NOTE: An Estimated Average Requirements (EAR), is the average daily nutrient intake level estimated to meet the requirements of half of the healthy individuals in a group. EARs have not been established for vitamin K, pantothenic acid, biotin, choline, chromium, fluoride, manganese, or other nutrients not yet evaluated via the DRI process. a As retinol activity equivalents (RAEs). 1 RAE = 1 µg retinol, 12 µg b-carotene, 24 µg a-carotene, or 24 µg β-cryptoxanthin. The RAE for dietary provitamin A carotenoids is two-fold greater than retinol equivalents (RE), whereas the RAE for preformed vitamin A is the same as RE. b As α-tocopherol. α-Tocopherol includes RRR-α-tocopherol, the only form of α-tocopherol that occurs naturally in foods, and the 2R-stereoisomeric forms of α-tocopherol (RRR-, RSR-, RRS-, and RSS-α-tocopherol) that occur in fortified foods and supplements. It does not include the 2S-stereoisomeric forms of α-tocopherol (SRR-, SSR-, SRS-, and SSS-α-tocopherol), also found in fortified foods and supplements. c As niacin equivalents (NE). 1 mg of niacin = 60 mg of tryptophan. d As dietary folate equivalents (DFE). 1 DFE = 1 µg food folate = 0.6 µg of folic acid from fortified food or as a supplement consumed with food = 0.5 µg of a supplement taken on an empty stomach. SOURCES: Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride (1997); Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid,Biotin, and Choline (1998); Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids (2000); Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (2001); Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (2002/2005); and Dietary Reference Intakes for Calcium and Vitamin D (2011). These reports may be accessed via www.nap.edu.

Dietary Reference Intakes (DRIs): Tolerable Upper Intake Levels, Vitamins Manual of Clinical Nutrition Management

Food and Nutrition Board, Institute of Medicine, National Academies

Life Stage

A-8 Copyright  2013 Compass Group, Inc. All rights reserved.

Vitamin C

Vitamin D

(mg/d)

(mg/d)

600 600

NDe ND

25 37.5

ND ND

ND ND

ND ND

ND ND

ND ND

ND ND

ND ND

ND ND

ND ND

600 900

400 650

62.5 75

200 300

ND ND

ND ND

ND ND

10 15

30 40

300 400

ND ND

1,700 2,800 3,000 3,000 3,000 3,000

1,200 1,800 2,000 2,000 2,000 2,000

100 100 100 100 100 100

600 800 1,000 1,000 1,000 1,000

ND ND ND ND ND ND

ND ND ND ND ND ND

ND ND ND ND ND ND

20 30 35 35 35 35

60 80 100 100 100 100

600 800 1,000 1,000 1,000 1,000

9-13 y 14-18 y 19-30 y 31-50 y 51-70 y > 70 y Pregnancy

1,700 2,800 3,000 3,000 3,000 3,000

1,200 1,800 2,000 2,000 2,000 2,000

100 100 100 100 100 100

600 800 1,000 1,000 1,000 1,000

ND ND ND ND ND ND

ND ND ND ND ND ND

ND ND ND ND ND ND

20 30 35 35 35 35

60 80 100 100 100 100

14–18 y 19-30 y 31-50 y Lactation 14–18 y 19-30 y 31-50 y

2,800 3,000 3,000

1,800 2,000 2,000

100 100 100

800 1,000 1,000

ND ND ND

ND ND ND

ND ND ND

30 35 35

2,800 3,000 3,000

1,800 2,000 2,000

100 100 100

800 1,000 1,000

ND ND ND

ND ND ND

ND ND ND

30 35 35

Group

Vitamin A (µg/d)a

Vitamin E (mg/d)b,c

Vitamin K

Thiamin

Riboflavin

Niacin (mg/d)c

Vitamin B6

Choline

Carote-

(g/d)

noids d

ND ND

ND ND

ND ND

ND ND

ND ND

1.0 1.0

ND ND

ND ND ND ND ND ND

ND ND ND ND ND ND

ND ND ND ND ND ND

2.0 3.0 3.5 3.5 3.5 3.5

ND ND ND ND ND ND

600 800 1,000 1,000 1,000 1,000

ND ND ND ND ND ND

ND ND ND ND ND ND

ND ND ND ND ND ND

2.0 3.0 3.5 3.5 3.5 3.5

ND ND ND ND ND ND

80 100 100

800 1,000 1,000

ND ND ND

ND ND ND

ND ND ND

3.0 3.5 3.5

ND ND ND

80 100 100

800 1,000 1,000

ND ND ND

ND ND ND

ND ND ND

3.0 3.5 3.5

ND ND ND

(mg/d)

Folate (mg/d)

Vitamin B12

Pantothenic

Biotin

Acid

c

Infants 0-6 mo 7-12 mo Children 1-3 y 4-8 y Males 9-13 y 14-18 y 19-30 y 31-50 y 51-70 y > 70 y Females

NOTE: A Tolerable Upper Intake Level (UL) is the highest level of daily nutrient intake that is likely to pose no risk of adverse effects to almost all individuals in the general population. Unless otherwise specified, the UL represents total intake from food, water, and supplements. Due to lack of suitable data, ULs could not be established for vitamin K, thiamin, riboflavin, vitamin B12, pantothenic acid, biotin, carotenoids. In the absence of ULs, extra caution may be warranted in consuming levels above recommended intakes. Members of the general population should be advised not to routinely exceed the UL. The UL is not meant to apply to individuals who are treated with the nutrient under medical supervision or to individuals with predisposing conditions that modify their sensitivity to the nutrient. a As

preformed vitamin A only. α-tocopherol; applies to any form of supplemental α-tocopherol. d The ULs for vitamin E, niacin, and folate apply to synthetic forms obtained from supplements, fortified foods, or a combination of the two. d b-Carotene supplements are advised only to serve as a provitamin A source for individuals at risk of vitamin A deficiency. e ND = Not determinable due to lack of data of adverse effects in this age group and concern with regard to lack of ability to handle excess amounts. Source of intake should be from food only to prevent high levels of intake. SOURCES: Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride (1997); Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (1998); Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids (2000); and Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (2001); and Dietary Reference Intakes for Calcium and Vitamin D (2011). These reports may be accessed via www.nap.edu. b As

.

Dietary Reference Intakes (DRIs): Tolerable Upper Intake Levels, Elements Manual of Clinical Nutrition Management

Food and Nutrition Board, Institute of Medicine, National Academies

Life Stage Group

Copper

Fluoride

Iodine

Iron

Magnesiumb

Manganese

Molybdenum

Nickel

Phosphorus

Selenium

(µg/d)

(mg/d)

(µg/d)

(mg/d)

(mg/d)

(mg/d)

(µg/d)

(mg/d)

(g/d)

(µg/d)

ND ND

ND ND

0.7 0.9

ND ND

40 40

ND ND

ND ND

ND ND

ND ND

ND ND

45 60

2,500 2,500

ND ND

1,000 3,000

1.3 2.2

200 300

40 40

65 110

2 3

300 600

0.2 0.3

3 3

11 17 20 20 20 20

3,000 3,000 2,500 2,500 2,000 2,000

ND ND ND ND ND ND

5,000 8,000 10,000 10,000 10,000 10,000

10 10 10 10 10 10

600 900 1,100 1,100 1,100 1,100

40 45 45 45 45 45

350 350 350 350 350 350

6 9 11 11 11 11

1,100 1,700 2,000 2,000 2,000 2,000

0.6 1.0 1.0 1.0 1.0 1.0

ND ND ND ND ND ND

11 17 20 20 20 20

3,000 3,000 2,500 2,500 2,000 2,000

ND ND ND ND ND ND

5,000 8,000 10,000 10,000 10,000 10,000

10 10 10 10 10 10

600 900 1,100 1,100 1,100 1,100

40 45 45 45 45 45

350 350 350 350 350 350

6 9 11 11 11 11

1,100 1,700 2,000 2,000 2,000 2,000

ND ND ND

17 20 20

3,000 2,500 2.500

ND ND ND

8,000 10,000 10,000

10 10 10

900 1,100 1,100

45 45 45

350 350 350

9 11 11

1,700 2,000 2,000

Arsenica

Boron

Calcium

(mg/d)

(mg/d)

NDe ND

ND ND

1,000 1,500

ND ND

3 6

ND ND ND ND ND ND

Chromium

Vanadiumd

Zinc

Sodium

Chloride

(mg/d)d

(mg/d)

(g/d)

(g/d)

ND ND

ND ND

4 5

ND ND

ND ND

90 150

ND ND

ND ND

7 12

1.5 1.9

2.3 2.9

4 4 4 4 4 3

280 400 400 400 400 400

ND ND ND ND ND ND

ND ND 1.8 1.8 1.8 1.8

23 34 40 40 40 40

2.2 2.3 2.3 2.3 2.3 2.3

3.4 3.6 3.6 3.6 3.6 3.6

0.6 1.0 1.0 1.0 1.0 1.0

4 4 4 4 4 3

280 400 400 400 400 400

ND ND ND ND ND ND

ND ND 1.8 1.8 1.8 1.8

23 34 40 40 40 40

2.2 2.3 2.3 2.3 2.3 2.3

3.4 3.6 3.6 3.6 3.6 3.6

1.0 1.0 1.0

3.5 3.5 3.5

400 400 400

ND ND ND

ND ND ND

34 40 40

2.3 2.3 2.3

3.6 3.6 3.6

Siliconc

Infants 0-6 mo 7-12 mo Children 1-3 y 4-8 y Males 9-13 y 14-18 y 19-30 y 31-50 y 51-70 y >70 y Females

A-9

9-13 y 14-18 y 19-30 y 31-50 y 51-70 y >70 y Pregnancy 14–18 y 19-30 y 31-50 y Lactation

Copyright  2013 Compass Group, Inc. All rights reserved.

14–18 y ND 17 3,000 ND 8,000 10 900 45 350 9 1,700 1.0 4 400 ND ND 34 2.3 3.6 19-30 y ND 20 2,500 ND 10,000 10 1,100 45 350 11 2,000 1.0 4 400 ND ND 40 2.3 3.6 31-50 y ND 20 2,500 ND 10,000 10 1,100 45 350 11 2,000 1.0 4 400 ND ND 40 2.3 3.6 NOTE: A Tolerable Upper Intake Level (UL) is the highest level of daily nutrient intake that is likely to pose no risk of adverse effects to almost all individuals in the general population. Unless otherwise specified, the UL represents total intake from food, water, and supplements. Due to lack of suitable data, ULs could not be established for vitamin K, thiamin, riboflavin, vitamin B12, pantothenic acid, biotin, carotenoids. In the absence of ULs, extra caution may be warranted in consuming levels above recommended intakes. Members of the general population should be advised not to routinely exceed the UL. The UL is not meant to apply to individuals who are treated with the nutrient under medical supervision or to individuals with predisposing conditions that modify their sensitivity to the nutrient. a Although the UL was not determined for arsenic, there is no justification for adding arsenic to food or supplements. b The ULs for magnesium represent intake from a pharmacological agent only and do not include intake from food and water. c Although silicon has not been shown to cause adverse effects in humans, there is no justification for adding silicon to supplements. d Although vanadium in food has not been shown to cause adverse effects in humans, there is no justification for adding vanadium to food and vanadium supplements should be used with caution. The UL is based on adverse effects in laboratory animals and this data could be used to set a UL for adults but not children and adolescents. e ND = Not determinable due to lack of data of adverse effects in this age group and concern with regard to lack of ability to handle excess amounts. Source of intake should be from food only to prevent high levels of intakes. SOURCES: Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride (1997); Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (1998); Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids (2000); Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (2001); Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate (2005); and Dietary Reference Intakes for Calcium and Vitamin D (2011). These reports may be accessed via http://www.nap.edu/.

FOOD FORTIFICATION AND DIETARY SUPPLEMENTS POSITION OF THE ACADEMY OF NUTRITION AND DIETETICS* “It is the position of the American Dietetic Association (ADA)* that the best nutritional strategy for promoting optimal health and reducing the risk of chronic disease is to wisely choose a wide variety of foods. Additional vitamins and minerals from fortified foods and/or supplements can help some people meet their nutritional needs as specified by science-based nutrition standards such as the Dietary Reference Intakes (DRIs) (1,2).” Recommendations regarding supplementation and the therapeutic use of vitamins and minerals for treating specific conditions may be found in the corresponding sections of this manual. The latest recommendations from the Food and Nutrition Board for the first time include recommendations that supplements or fortified foods be used to obtain desirable amounts of some nutrients, eg, folic acid and calcium, in certain population groups. Under the Dietary Supplement Health and Education Act of 1994, manufacturers must adhere to restrictions regarding the types of claims that are allowed on product labels. Statements regarding the efficacy of specific products in the treatment or prevention of particular conditions are prohibited. A claim statement is allowed if the “statement claims a benefit related to a classical nutrient deficiency disease and discloses the prevalence of such disease in the United States, describes the role of a nutrient or dietary ingredient intended to affect the structure or function in humans, characterizes the documented mechanism by which a nutrient or dietary ingredient acts to maintain such structure or function, or describes general well-being from consumption of a nutrient or dietary ingredient (1).” The manufacturer must specify that the claims are truthful and not misleading. The following statement must also accompany any claims, “This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease (1)”. In addition, all supplements must have the identity and strength of contents listed on the label, and meet appropriate specifications for quality, purity and composition (3). *The American Dietetic Association (ADA) is now known as The Academy of Nutrition and Dietetics (AND). References 1. Position of the American Dietetic Association: Nutrient Supplementation. J Am Diet Assoc. 2009; 109:2073-2085. 2. Position of the American Dietetic Association: Functional foods. J Am Diet Assoc. 2009;109: 735-746. 3. Dietary Supplement Health and Education Act of 1994. Public Law (S.784)(1994)(codified at 42 USC 287C-11).

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REGULAR DIET – ADULT Description The diet includes a wide variety of foods to meet nutritional requirements and individual preferences of healthy adults. It is used to promote health and reduce the risks of developing major, chronic, or nutritionrelated disease. Indications The diet is served when specific dietary modifications are not required. Nutritional Adequacy The diet can be planned to meet the Dietary Reference Intakes (DRIs) as outlined in Section IA: Statement on Nutritional Adequacy. The diet uses the 1800 - 2,000 kilocalorie level as the standard reference level for adults. Specific calorie levels may need to be adjusted based on age, gender and physical activity. How to Order the Diet Order as “Regular Diet,” indicating any special instructions. Planning the Diet The Dietary Guidelines for Americans and portion sizes use the USDA Food Guide and the DASH (Dietary Approaches to Stopping Hypertension) Eating Plan as the basis for planning the menu (1). The Dietary Guidelines are intended for all Americans, healthy and those at increased risk of chronic disease. However, modifications may be required while treating patients who are ill, as the main goal is to encourage food intake, which frequently requires “comfort foods,” such as soup, sandwiches, and other foods the patient is accustomed to. With that consideration, the number of servings of foods from each food group may differ from the recommendations. However, the meal will still be planned to meet the DRIs whenever possible. Dietary Guidelines for Americans encompasses two overarching concepts (1):  

Maintain calorie balance over time to achieve and sustain a healthy weight Focus on consuming nutrient-dense foods and beverages within basic food groups while controlling calorie and sodium intake

Recommended healthy eating pattern:        

Daily sodium intake to less than 2,300 mg and further reduce intake to 1,500 mg among person who are 51 and older and any age who are African American or have hypertension diabetes, or chronic kidney disease. At the same time, consume foods with more potassium, dietary fiber, calcium and vitamin D. Increase daily intake of fruits and vegetables, whole grains, and nonfat or low-fat milk and milk products. Consume less than 10 percent of calories from saturated fatty acids by replacing with monounsaturated and polyunsaturated fatty acids. Oils should replace solid fats when possible. Keep trans fat as low as possible. Reduce the intake of calories from solid fats and added sugars. Limit consumption of foods that contain refined grains, especially refined grain foods that contain solid fats, added sugars, and sodium. If you drink alcoholic beverages, do so in moderation, for only adults of legal age. Keep food safe to eat.

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Regular Diet - Adult

FOOD GUIDE FOR AMERICANS (1800-2000 calorie pattern) (1) Food Group Fruits

Recommended Daily 3 – 4 servings Consume citrus fruits, melons, berries, and other fruits regularly

Vegetables

5 servings Dark-green leafy vegetables: 3 cups/week Orange vegetables: 2 cups/week Legumes: 3 cups/week Starchy vegetables: 3 cups/week Other vegetable: 6 ½ cups/week

Grains

Medium-size orange, apple, or banana ½ cup of chopped, cooked, or canned fruit (no sugar added) ½ cup of 100% fruit juice 1 cup of raw leafy vegetables: spinach, lettuce ½ cup of other vegetables, cooked or chopped raw ½ cup of vegetable juice

6 servings Whole-grain products: 3 daily Other grains: 3 daily

1 slice of bread 2 large or 4 small crackers ½ cup cooked cereal, rice, or pasta 1 cup ready-to-eat cereal 1 small roll or muffin ½ English muffin, bagel, hamburger bun, or large roll

Meat, Poultry, Fish, Dry Beans, Eggs, and Nuts

5-5 ½ ounces day Choose fish, dry beans, peas, poultry without skin, and lean meat

Milk, Yogurt, and Cheese

3 servings Choose skim milk and nonfat yogurt Choose part-skim and lowfat cheeses

Oils

5 tsp daily Oils and soft margarines include vegetables oils and soft vegetable oil table spreads that are low in saturated fat and are trans-free

Breakfast Orange Juice Oatmeal Scrambled Egg Biscuit Margarine Jelly Lowfat Milk Coffee

Serving Size

1 ounce of cooked fish, poultry, or lean meat ¼ cup cooked dry beans or tofu 1 egg 1 Tbsp peanut butter ½ ounce nuts or seeds 1 cup of milk or yogurt 1 ½ ounces of natural cheese (Mozzarella, Swiss, Cheddar) 2 ounces of processed cheese (American)

SAMPLE MENU Noon Rotisserie Baked Chicken Rice Pilaf Steamed Broccoli with Carrots Whole-wheat Roll Margarine Fruit Cup Lowfat Milk Iced Tea

Evening Braised Beef and Noodles Seasoned Green Beans Sliced Tomato Salad French Dressing Peach halves Dinner Roll Margarine Lowfat Milk

References 1. Dietary Guidelines for Americans 2010. Available at: http://www.cnpp.usda.gov/Publications/DietaryGuidelines/2010/PolicyDoc/PolicyDoc.pdf. Accessed Jan 31, 2011.

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HIGH-PROTEIN, HIGH-CALORIE DIET Description Additional foods and supplements are added to meals or between meals to increase protein and energy intake. Indications A high-protein, high-calorie diet is served when protein and energy requirements are increased by stress, protein loss (protein losing enteropathy, nephrotic syndrome), and catabolism. This diet may be indicated in patients with:       

protein-energy malnutrition failure to thrive cancer burns cystic fibrosis human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) chronic gastrointestinal diseases

This diet may also be indicated in preparation for surgery. An increase in energy is required to promote the efficient utilization of proteins for anabolism. Nutritional Adequacy The diet can be planned to meet the Dietary Reference Intakes (DRIs) as outlined in Section IA: Statement on Nutritional Adequacy. How to Order the Diet Order as “High-Protein, High-Calorie Diet.” The dietitian determines a target level of protein and energy to meet individual needs based on guidelines as stated in Section II: Estimation of Protein Requirements. Planning the Diet The diet is planned as a Regular Diet with addition of between-meal supplements that increase energy intake by at least 500 kcal and protein intake by 25 g for adults. Examples of high-protein, high-energy supplements are milk shakes, eggnogs, puddings, custards, and commercial supplements. For children, the diet generally should provide 120% to 150% of the Dietary Reference Intakes (DRIs) for energy and protein. The actual amounts of energy and protein provided will depend on the child’s or adolescent’s age, height, weight, medical status, and nutrition goals.

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NUTRITION MANAGEMENT DURING PREGNANCY AND LACTATION Description Diets for pregnant or lactating women include additional servings of food from the Regular Diet to meet the increased requirement for nutrients during pregnancy and lactation. Nutritional Adequacy The food patterns will meet the Dietary Reference Intakes (DRIs) for pregnancy and lactation, as outlined in Section IA: Statement on Nutritional Adequacy, except for the iron requirements in the second and third trimesters of pregnancy. Factors that may increase nutritional requirements above the estimated demands of pregnancy include: poor nutritional status; young maternal age; multiple pregnancy; closely spaced births; breast-feeding during pregnancy; continued high level of physical activity; certain disease states; and the use of cigarettes, alcohol, and legal or illegal drugs. Dietary intake of iron, folate, zinc, protein, and calcium should be carefully assessed for adequacy (1). Supplementation is justified when evidence suggests that the inadequate intake of specific nutrients can increase the risk of an adverse effect on the mother, fetus, or pregnancy outcome. Vegetarians who exclude all animal products need 2 mg of vitamin B 12 daily (1). Also see Section IA: Vegetarian Diets. How to Order the Diet Order as “Regular Diet – Pregnancy” or “Regular Diet – Lactation.” Any special instructions should be indicated in the diet order. Planning the Diet Daily Food Group Guidelines (2) No. of Servings Food Group Grains, Breads, and Cereals Fruits Vegetables Low-fat Meat, Poultry, Fish, and Eggs Low-fat Milk, Yogurt, Cheese Fats, Oils, and Sweets

Pregnant Women Lactating Women nine six to eleven three two to four four three to five two or more (6 oz) two or more (7-8 oz) three or four four or five As needed to provide energy

Specific Nutrient Requirements During Pregnancy Weight gain: The National Academy of Sciences’ Food and Nutrition Board has stated that the optimal weight gain during pregnancy depends on the mother’s weight at the beginning of pregnancy (1). The target range for weight gain is associated with a full-term, healthy baby, weighing an average of 3.1 to 3.6 kg (6.8 to 7.9 lb) (3). The optimum weight gain for a woman of normal prepregnancy weight for her height (body mass index (BMI), 19.8 to 26 kg/m2) who is carrying a single fetus is 25 to 35 lbs; however, there are individual differences based on maternal anthropometry and ethnic decent (3). The pattern of weight gain is more significant than the absolute weight gain. The desired pattern of weight gain is approximately 3 to 8 lb in the first trimester and about 1 lb/week during the last two trimesters. The BMI, defined as weight divided by the height squared (kg/m2) (2), is a better indicator of maternal nutritional status than is weight alone. Recommendations for weight gain during pregnancy should be individualized according to the prepregnancy BMI (1,3). (See Section II: Body Mass Index.) To identify the BMI categories and appropriate weight gain, use Table A-1 (1). Table A-1: Guidelines for Weight Gain After the First Trimester of Pregnancy (1,3,4) BMI (kg/m2) Recommended Weight Gain Intervention Suggested 3.5 lb/wk, 30.0 Individualized 2.5 lb/wk (obese)

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Overall Weight Gain 28-40 lb 25-35 lb 15-25 lb 11-20 lb

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Nutrition Management During Pregnancy and Lactation

Table A-1: Guidelines for Weight Gain After the First Trimester of Pregnancy (1,3,4) BMI (kg/m2) Recommended Weight Gain Intervention Suggested Twin pregnancy Individualized Individualized Normal BMI Overweight Obese Individualized Triplet pregnancy Individualized

Overall Weight Gain 37-54 lb 31-50 lb 25-42 lb 45-55 lb (4)

The updated Institue of Medicine (IOM) guidelines are based on the World Health Organization (WHO) BMI categories and formulated as a range of weight gain for each category of prepregnancy BMI (1). The recommended weight gain ranges for short women and for racial or ethnic groups are the same as those for the whole population (1). In addition, teenagers who are pregnant should use the adult BMI categories to determine their weight gain range until more research is done to determine whether special categories are needed for them (1). Women who are pregnant with twins are given provisional guidelines (1). Those in the normal weight range should aim to gain 37 to 54 lbs; overweight, 31 to 50 lbs; and obese, 25 to 42 lbs (1). For women pregnant with triplets, a weight gain of 45-55 lbs has been suggested (4). The newer guidelines include a specific and relatively narrow range of recommended gain for obese women (1). For many women, this will mean gaining less weight, which may be particularly challenging for women who are overweight or obese at conception (1). Energy: The total energy needs during pregnancy range between 2,200 and 2,900 kcal/day for most women (3,5). However, the mother’s age, prepregnancy BMI, rate of weight gain, and physiologic appetite must be considered when determining individual needs (3). Based on a review of evidence, an average additional intake of approximately 340 to 452 kcal/day is suggested in the second and third trimesters (6). For normal weight and overweight women in developed countries, the additional energy need may actually be less than 300 kcal/day, especially in sedentary women (3). Appropriate weight gain and appetite are better indicators of energy sufficiency than the amount of energy consumed (3). It has been suggested that an additional 500 kcal/day for a twin pregnancy is added to the calculated needs. There is no absolute recommendation in the literature for the amount of additional energy needed for a multiple pregnancy. The indication is to add 500 kcal/day in the first trimester as soon as the multiple pregnancy is diagnosed, because these pregnancies usually do not go to term and the goal is to maximize the early weight gain (4). Pregnant women should consume a variety of foods according to the Dietary Guidelines to meet nutrient needs and gain the recommended amounts of weight (3). MyPyramid guidelines include MyPyramid for Moms, which contains food plans for pregnant women (3). Protein: The 2002 DRIs list the recommended daily allowances for protein for all age groups during pregnancy and lactation to be 1.1 g/kg per day or an additional 25 g/day in addition to the 0.8 g/kg per day for a nonpregnant state (6). On average, this recommendation equates to approximately 71 g, but for women with greater energy needs, the protein needs may need to be adjusted. For a twin pregnancy, an additional 50 g/day of protein above the recommended daily allowance of 0.8 g/kg per day for a nonpregnant state is suggested during the second and third trimesters (6). Protein utilization depends on energy intake. Therefore, adequate energy intake is important so that protein may be spared. Vitamins and minerals: A multivitamin and mineral supplement is recommended in several circumstances (1,3). Pregnant women who smoke or abuse alcohol or drugs should take a multivitamin and mineral supplement (3). For women infected with the human immunodeficiency virus, especially women who receive antiretroviral treatment, a supplement containing B-complex, vitamin E, and vitamin C may slow the progression of disease and reduce complications (3). A multivitamin and mineral supplement is also recommended for women with iron deficiency anemia or poor-quality diets and women who consume animal products rarely or not at all (3). B12 supplementation is recommended for persons who follow a vegetarian diet pattern, including the lacto-ovo vegetarian diet pattern (3). Women carrying two or more fetuses are also advised to consume a multivitamin and mineral supplement (3). Additional nutrients that may need to be supplemented include folic acid, iron, zinc, copper, calcium, and vitamin D. The Food and Nutrition Board recommends the use of supplements or fortified foods to obtain desirable amounts of some nutrients, such as iron. The Food and Nutrition Board also recommends 400 g/day of synthetic folic acid from fortified foods, supplements, or both for women who are trying to become pregnant and 600 g/day for women who are pregnant (7). Iron: To meet the DRI of 27 mg/day of ferrous iron during pregnancy, a low-dose supplement is recommended at the first prenatal visit (1,3,6). An iron supplement containing 150 mg of ferrous sulfate, 300 Manual of Clinical Nutrition Management

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Nutrition Management During Pregnancy and Lactation

mg of ferrous gluconate, or 100 mg of ferrous fumarate can fulfill this additional need. Iron deficiency anemia is the most common anemia during pregnancy. If the maternal iron stores are low, 60 to 120 mg of iron may be recommended (4), in addition to a multivitamin supplement containing 15 mg of zinc and 2 mg of copper, since iron may interfere with the absorption of zinc and copper (3). If the laboratory values indicate macrocytic anemia, vitamin B12 and folate levels should be assessed. Zinc and copper: Iron can interfere with the absorption of other minerals. Therefore, women who take daily supplements with more than 30 mg of iron should add 15 mg of zinc and 2 mg of copper (3). These amounts of zinc and copper are routinely found in prenatal vitamins. Folate: The DRI for folate for women 19 to 50 years of age is 600 g/day (7,8). This level of folate should be consumed through synthetic folic acid from fortified foods or supplements or both, in addition to the intake of folate from a varied diet (3,6). Compared to naturally occurring folate found in foods, the folic acid contained in fortified foods and supplements is almost twice as well absorbed, so that 1 g from these sources is equivalent to 1.7 g of dietary folate (3). Women who take folic acid at the time of conception are less likely to give birth to a child with neural tube defects (9-12). To ensure that blood vitamin levels are adequate at the time of neural tube closure, supplementation should begin at least 1 month before conception (3). Women who take multivitamins containing folic acid 1 to 2 months before conception have a reduced risk of having a child with orofacial clefts (13). Research also indicates that abnormal folate metabolism may play a role in Down syndrome and other birth defects (3). Women who have delivered an infant with neural tube defects may need to consume more than the recommended amount of dietary folate equivalents (3). Until more evidence is available, it is recommended that women older than 19 years of age not exceed the tolerable upper limit of 1,000 g/day of folate from foods, fortified foods, and supplements (3). Although extensive public education about the importance of folic acid has occurred in the past decade, the percentage of women who take folic acid remains low at approximately 33% (3). Dietitians should provide nutrition education and counseling as to the importance of folic acid consumption, especially for women who are nonwhite, Hispanic, low-income, or young or who lack a high school education (3). Calcium: Due to the increased efficiency of calcium absorption during pregnancy, calcium requirements for pregnant women are similar to the requirements for women who are not pregnant. A daily intake of 1,000 mg is recommended for pregnant and lactating women (13) older than 19 years (300 to 500 mg/day) (16,17). A more recent prospective study found that fetal growth restriction occurred at caffeine intakes greater than 100 mg/day (18). Until further evidence provides guidelines for setting a specific limit on caffeine intake, women should be educated on the risks associated with caffeine consumption and the potential need to limit caffeine based on predisposing risk factors (3,19). Olestra: Studies of the fat substitute olestra conclude that pregnant or breast-feeding women should not consume products containing olestra. Olestra causes gastrointestinal distress and diarrhea, which may lead to the loss of the fat-soluble vitamins A, D, E, and K (20). Nonnutritive Sweeteners: The FDA has approved seven nonnutritive sweeteners for general use: aspartame, acesulfame-K, luo han guo extract, neotame, saccharin, sucralose, and stevia. All FDA-approved nutritive and nonnutritive sweeteners approved for use by the general public, includes pregnant and lactating women. The FDA and expert communities have concluded that these sweeteners are safe, based on studies of the effects of these sweeteners on the fetus and the reproductive abilities of females and males (21). Thus, consumption of acesulfame-K, aspartame, saccharin, sucralose, stevia, luo han guo, and neotame within the acceptable daily intakes is safe during pregnancy (21). Research continues to indicate that aspartame is safe during pregnancy, although women with phenylketonuria should exercise caution with this sweetener because they need to closely monitor their intake of phenylalanine (3,21). There is limited evidence that saccharin can pass through the placenta and that it remains in fetal tissues; therefore, women should moderate their intake of this sweetener (3). In a study in 2010, an association between intakes of nonnutritive sweetened carbonated and noncarbonated soft drinks and preterm birth was found among Danish women (21). Women who consumed one or more nonnutritive sweetened soft drink per day were significantly more likely to deliver preterm (21). The association was stronger for carbonated beverages with aspartame and acesulfame-K compared to noncarbonated beverages. This finding has not been confirmed in other studies to date (21). Herbal and alternative therapies: Very few randomized clinical trials have examined the safety and efficacy of alternative therapies during pregnancy (3). Several herbal and botanical supplements are harmful if used during pregnancy (3). The American Academy of Pediatrics recommends that pregnant women limit their consumption of herbal teas. Women who opt to consume herbal teas should limit their intake to two 8-oz servings per day and choose herbal teas in filtered tea bags (3). Fish: Due to the high levels of mercury in certain types of fish and mercury’s adverse effects on the fetus, the US Department of Health and Human Services and the US Environmental Protection Agency suggest limiting the type and amount of fish consumed during pregnancy (3). Pregnant women should avoid consuming shark, swordfish, king mackerel, or tilefish. Twelve ounces or less per week of fish and shellfish lower in mercury, such as shrimp, canned light tuna, salmon, pollock, and catfish, is safe (3). Consumption of albacore (“white”) tuna should be limited to 6 oz/week, because this type of tuna contains more mercury than canned light tuna (3). If no information regarding fish caught from local water sources is available, pregnant women should limit their consumption of these fish to 6 oz/week and not consume any other fish during that week (3). Foodborne Illness During Pregnancy Pregnant women and their fetuses are at higher risk of developing foodborne illness (3). Pathogens such as Listeria monocytogenes, Salmonella, and Toxoplasma gondii cause foodborne illness (3). Proper food storage and preparation techniques should be reviewed to ensure safety (3). Unpasteurized foods and raw or undercooked meat, poultry, or fish should be avoided to reduce the risk of exposure to pathogens (3). Careful sanitation methods should be used, and pets should not be handled before or during food preparation (3). Risk Factors During Pregnancy (1,3) Women should be evaluated for factors that may put them at risk for adverse maternal and/or fetal outcomes while they are pregnant. If any of the following risks are identified, appropriate medical and nutritional monitoring should be provided throughout the pregnancy.

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Nutrition Management During Pregnancy and Lactation

Risk factors at the onset of pregnancy:     

Adolescence: younger than 15 years old at time of conception or less than 3 years since the onset of menses Older than 35 years of age Three or more pregnancies within 2 years History of poor obstetric or fetal performance Low income

       

Unusual dietary practices Smoking Excessive alcohol intake Recreational drug usea Chronic systemic disease Obesity Prepregnancy BMI 29.9 kg/m2 Multiple gestation

aRecreational

drugs or over-the-counter medications or dietary supplements that have adverse effects (eg, laxatives, antacids, or herbal remedies containing teratogens)

Risk factors during pregnancy (1,3):        

Hemoglobin level 350 mcg/day orally or 1,000 mcg/month intramuscularly or 3,000 mcg every 6 months intramuscularly or 500 mcg/week intranasally aPatients bFor

with preoperative or postoperative biochemical deficiencies require additional supplementation (1). menstruating women

Adapted from: Mechanick JI, Kushner RF, Sugerman HJ, Gonzalez-Campoy JM, Collazo-Clavell ML, Guven S, Spitz AF, Apovian CM, Livingston EH, Brolin R, Sarwer DB, Anderson WA, Dixon J. Executive summary of the recommendations of the American Association of Clinical Endocrinologists, the Obesity Society, and American Society for Metabolic & Bariatric Surgery medical guidelines for clinical practice for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient. Endocr Pract. 2008;14:331.

Studies have found a significant correlation between eating habits (quality of food consumed) and laboratory values (1,15,20). In a study of patients who received a Roux-en-Y gastric bypass, the mean levels of serum iron saturation, vitamin B12, and folic acid were significantly higher in patients who ate meat than in patients who did not eat meat (15). Iron status continued to decline 6 to 8 years after surgery, depending on eating behavior (15). Oral vitamin and mineral supplementation significantly improved the nutritional status of the study patients (15). Patients who have biliopancreatic diversion or biliopancreatic diversion with duodenal switch procedures should be evaluated frequently to assess benefits or improvements in nutritional outcomes following bariatric surgery (1). Fluids: Adequate consumption of fluids is essential to prevent dehydration. A minimum of 6 cups (48 oz) should be consumed per day, with a goal of consuming 64 oz/day (1,5,20). Patients should initially consume 2 to 3 oz at a time and gradually increase their fluid intake to 3 to 4 oz at a time 8 weeks after surgery (1,5,20). Once pureed or solid foods are introduced into the diet, fluids should be consumed at least 30 minutes before meals and should consist of water or energy-controlled (low-sugar, low-fat, or diet) beverages. The patient should delay drinking beverages with food; rather, the patient should wait at least 30 minutes after meals to prevent increasing the transit time of food through the pouch, which may lead to nausea and vomiting (1). After 6 to 9 months, most patients can tolerate drinking fluids with meals. Intake of caffeine-containing beverages and carbonated beverages should be individualized according to the patient’s tolerance. Volume, consistency, and timing: The volume and consistency of foods depend on the postoperative stage and individual tolerance. Initially after gastric bypass surgery, the stomach can hold only 1 to 2 oz (2 to 4 tbsp). Over time, the stomach pouch will stretch until it can hold 4 to 8 oz (or about ½ to 1 cup). The Bariatric Diet progresses in stages from clear liquids (1 to 2 days) to full liquids and pureed foods (4 to 6 weeks) and then to soft and regular foods (6 to 8 weeks). The timing of progression varies among patients, so it is appropriate for individuals to adjust their own progress depending on how they feel. Four to six small meals per day may be better tolerated long term; however, coordinating the meals with fluid intake may be challenging and should be individualized (5). After the pouch matures (6 months), most food consistencies can be tolerated. (Refer to Table B-2.) Food intolerances: Patient reports have indicated common postoperative intolerances to specific foods (2325). Red meat, milk, and high-fiber foods are among the foods most commonly reported as not well tolerated. One study found meat intolerance in 51% of patients during postoperative months 0 to 12; 60.3% of patients at 13 to 24 months; 59.5% of patients at 25 to 72 months; and 55.1% of patients at 73 to 96 months (15). Soft breads are often not tolerated. However, crispy breads and crackers (eg, well-toasted breads, Melba toast, and low-fat crackers) are generally better tolerated. Milk intolerance may be caused by an intolerance to fat or a secondary lactose deficiency related to the surgical procedure (1,5,23-25). Fat-free milk in small amounts is suggested to improve tolerance. Individual meal planning should be accommodated to meet nutrient-specific needs if certain foods are not tolerated.

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Nutrition Management in Bariatric Surgery

Postoperative Bariatric Diet Meal Planning The following meal planning and behavior modification recommendations should be given to the patient after surgery (1). The meal plan must be individualized based on the type of procedure performed, postoperative stage, and individual tolerance to food volume and consistency (1,5,). The following stages and meal patterns are based on a review of bariatric surgery programs and published practice guidelines (1,5,23-25). Stage 1 (postoperative days 1 and 2) Days 1 to 2: Bariatric Clear Liquids  Provide six to eight small feedings of clear liquid foods. Begin with sips of water, then add bouillon or clear broth, unsweetened juices, diet gelatin, and flat (no fizz) diet soda. In general, avoid carbonated beverages.  Portion: Sip 2 to 3 oz (1 to 2 tbsp) at a time.  Water: Sip 2 to 3 oz at a time throughout the day.  The combined volume of six to eight small feedings and the water intake should be at least 48 to 64 oz/day (6 to 8 cups) to meet hydration needs.  If the patient tolerates Bariatric Clear Liquids well, progress to Bariatric Full Liquids and then Bariatric Pureed/Soft Diet (see below). Stage 2 (postoperative day 3 and discharge diet) Days 3 to 4: Bariatric Full Liquids  Provide six to eight small feedings per day. Begin with high-protein liquids such as diet instant breakfast (using fat-free milk), GlucernaTM , or specialized high-protein (low-fat, sugar-free, or 15 g of sugar per serving) (1) instant breakfast prepared with fat-free milk Soup

Egg drop soup, reduced-fat cream soups, broth, bouillon, low-fat soups with added protein powder or strained meat

All others

Breads, cereals, rice, and pasta

Cooked, refined/strained cereals (with no added sugar) Soft diet: Add pasta, rice, toasted breads, Melba toast, and crackers. Choose items with 75% of their total daily energy intake by parenteral nutrition (Grade II) (1). Protein needs are also higher than the RDA for these patients. Limited evidence suggests that more than 2.2 g protein per kg may be needed to maintain nitrogen balance (Grade II) (1). Further research is needed to define protein requirements in this population. In the past, patients undergoing HCT or chemotherapy were often prescribed a neutropenic diet which was based on the premise of limiting foods with high bacteria content (2). Neutropenia, a potentially serious side effect of both HCT and chemotherapy, and major risk for infections can be life threatening in oncology patients. It has been suggested that low bacterial foods and beverages can prevent the occurrence of infections and infection-related deaths in cancer patients receiving chemotherapy or HCT. The evidence supporting this practice is lacking and the actual efficacy of the neutropenic diet remains unknown (2, 10). In one study it was shown that a higher rate of infections was observed in the HCT group of patients who received the neutropenic diet compared to HCT patients receiving a regular diet (10). In addition, there is a wide variability in defining the foods allowed on the diet and inconsistency in applying the diet among institutions (2,10,11). Considering the evidence, the neutropenic diet has been removed from the Morrison Manual of Clinical Nutrition. The evidence now suggests dietitians should advocate and educate patients undergoing HCT or chemotherapy on standard food safety guidelines to reduce risk and exposure to foods, beverages, and food preparation methods that could place them at increased risk for infection and food-borne illness. The dietitian should advocate the selection of low-microbial foods and beverages while encouraging proper washing and handling of fresh fruits and vegetables (2). High-microbial foods such as those unpasteurized or raw (uncooked or undercooked foods) should be avoided until immunity is restored or treatment is complete (12). If graft-versus-host disease (GVHD) symptoms are present it is prudent to avoid lactose, high amounts of fat (fried foods, rich sauces, and rich desserts), and high amounts of fiber (including legumes, nuts, and whole grain cereals with > 3 grams fiber/serving) (12). *The Academy of Nutrition and Dietetics has assigned grades, ranging from Grade I (good/strong) to Grade V (insufficient evidence), to evidence and conclusion statements. The grading system is described in Section III: Clinical Nutrition Management A Reference Guide, page III-1.

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Cancer References 1. Oncology Evidence-Based Nutrition Practice Guideline. Academy of Nutrition and Dietetics Evidence Analysis Library. Chicago, Ill: Academy of Nutrition and Dietetics; 2007. Available at: http://www.andevidencelibrary.com. Accessed January 16, 2013. Under revision. 2. Oncology. In: Nutrition Care Manual. Academy of Nutrition and Dietetics; Updated annually. Available at: nutritioncaremanual.org. Accessed January 16, 2013.. 3. Coghlin Dickson TM, Wong RM, Offrin RS, Shizuru JA, Johnston LJ, Hu WW, Blume KG, Stockerl-Goldstein KE. Effect of oral glutamine supplementation during bone marrow transplantation. J Parenter Enteral Nutr. 2000;24:61-66. 4. Biswal B, Zakaria A, Ahmad N. Topical application of honey in the management of radiation mucositis: a preliminary study. Support Care Cancer. 2003;11:242-248. 5. Ripamonti C, Zecca E, Brunelli C, Fulfaro F, Villa S, Balzarini A, Bombardieri E, De Conno F. A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation. Cancer. 1998;82:1938-1945. 6. Del Piano M, Ballare M, Montino F, Orsello M, Garello E, Ferrari P, Masini C, Strozzi G, Sforza F. Clinical experience with probiotics in the elderly on total enteral nutrition. J Clin Gastroenterol. 2004;38(6 Suppl):S111-S114. 7. Kozelsky T, Meyers G, Sloan J, Shanahan T, Dick S, Moore R, Engeler G, Frank A, McKane T, Urias R, Pilepich M, Novotny P, Martenson J. Phase III double-blind study of glutamine versus placebo for the prevention of acute diarrhea in patients receiving pelvic radiation therapy. J Clin Oncol. 2003;21:1669-1674. 8. Savarese D, Savy G, Vahdat L, Wischmeyer P, Corey B. Prevention of chemotherapy and radiation toxicity with glutamine. Cancer Treat Rev. 2003;29:501-513. 9. Inui A. Cancer anorexia-cachexia syndrome. Current issues in research and management. CA Cancer J Clin. 2002;52:72-91. 10. Trifilio S, Helenowski l, Giel M, Gobel B, Pi J, Greenberg D, Mehta J. Questioning the role of a neutropenic diet following hematopoetic stem cell transplantation. Biol Blood Marrow Transplant. 2012; 9:1385-1390. 11. Moody K, Finlay J, Mancuso C, Charlson M. Feasibility and safety of a pilot randomized trial of infection rate: neutropenic diet versus standard food safety guidelines. J Pediatr Hematol Oncol. 2006;28:126-132. 12. Low Microbial Nutrition Therapy. In: Nutrition Care Manual. Academy of Nutrition and Dietetics; Updated annually. Available at: nutritioncaremanual.org. Accessed February 5, 2013.

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CHRONIC OBSTRUCTIVE PULMONARY DISEASE Discussion Chronic obstructive pulmonary disease (COPD) is an incurable condition that results in progressive obstruction and inflammation of the airways. COPD is the umbrella term for chronic bronchitis, emphysema, and a range of lung disorders. COPD results from airway obstruction and reduced expiratory flow (1). As COPD progresses, the work of breathing increases to 10 to 20 times that of a person with normal lung function (2). The main symptoms of COPD include dyspnea, possibly accompanied by wheezing, and a persistent cough with sputum production (2). Other symptoms include physical signs, such as a barrel chest related to hyperinflation of the lungs, and hypoxemia and hypercapnia (2). Severe COPD can lead to cyanosis caused by a lack of oxygen in the blood. In some cases, cyanosis can lead to heart failure as a result of the extra work required by the heart to get blood flow to the lungs (3). Patients with COPD often experience compromised nutrition status caused by inadequate nutritional intake and the inability to meet energy expenditure requirements (2). In addition, fat-free mass and bone mineral density are lower in people with COPD (4). The malnutrition associated with COPD has been termed pulmonary cachexia syndrome (2). Patients with pulmonary cachexia syndrome have a progressive reduction in lean body mass due to factors associated with medical management, including medications, and changes in metabolism and energy intake (2). The prevalence of malnutrition, as indicated by a body mass index (BMI) less than 20 kg/m 2, may be as high as 30% in persons with COPD, and the risk of COPD-related death doubles with weight loss (5). The most common cause of COPD is exposure to tobacco smoke. Tobacco smoking accounts for an estimated 80% to 90% of the risk for developing COPD (6-8). Other risk factors are secondhand smoking, air pollution, and occupational exposure. Alpha1-antitrypsin deficiency, the only known genetic abnormality that causes COPD, accounts for less than 1% of COPD cases in the United States (7). Pulmonary function tests, or spirometry, are used to diagnose COPD (2). Forced vital capacity (FVC) is the amount of air that can be forcibly blown out after full inspiration, and forced expiratory volume in one second (FEV1) is the amount of air that can be forcibly blown out in one second. Both measurements are used to determine airway obstruction. A ratio of FEV1 to FVC that is less than 0.70 is a diagnostic indicator of COPD (8). The major treatment goals for persons with COPD are to maximize functional capacity, prevent secondary medical complications, and improve quality of life (2,8). To achieve these treatment goals, medical management of COPD includes smoking cessation or avoidance of environmental smoke and pollution; pharmacologic therapy (eg, bronchodilators, corticosteroids or steroids, antibiotics, and diuretics); pulmonary rehabilitation through aerobic exercise and upper extremity strength training or oxygen therapy; and maintenance of nutritional status (2,7-9). Nutrition Assessment and Diagnosis Malnutrition is associated with the wasting and subsequent weakness of respiratory muscles (2,8). Eight studies of the weight and body composition of persons with COPD were recently reviewed (9). The prevalence of malnutrition (as defined by a BMI 60 minutes) (1,2). An individual may be at risk for hypoglycemia up to 24 hours after the exercise bout (1,2). Individuals who prefer to consume carbohydrates to prevent hypoglycemia during exercise should test their blood glucose prior to exercising, and consume an amount of food (15 grams carbohydrate) which will prevent hypoglycemia but not cause hyperglycemia (2). The following general guidelines can be helpful in regulating the glycemic response to exercise in type 1 diabetes (1):  Avoid exercise if fasting glucose levels are > 250 mg/dL and ketosis is present, and use caution if glucose levels are > 300 mg/dL and no ketosis is present  Ingest added carbohydrate if pre-exercise glucose levels are < 100 mg/dL Type 2 Diabetes: Supplemental food before and during exercise is not needed to prevent hypoglycemia and is not recommended, except under conditions of strenuous, prolonged exercise, such as endurance sports (2). For individuals taking sulfonylureas, there is a slightly increased risk of hypoglycemia during exercise, and supplemental energy intake may be required in some cases (2). The need may be determined by glucose selfmonitoring. Individuals with type 2 diabetes who use insulin should also monitor their blood glucose levels closely during and after exercise. Several strategies may be used to avert hypoglycemia during or after vigorous, prolonged, or nonhabitual exercise. These involve the consumption of supplemental carbohydratecontaining foods before, during, and after exercise, as well as adjustment of insulin dosage and timing (1,2). *The Academy of Nutrition and Dietetics has assigned grades, ranging from Grade I (good/strong) to Grade V (insufficient evidence), to evidence and conclusion statements. The grading system is described in Section III: Clinical Nutrition Management A Reference Guide, page III-1. References 1. Physical activity recommendations. In: Standards of medical care in diabetes-2013. Diabetes Care. 2013;36(suppl 1):24S-25S. . 2. American Diabetes Association. Nutrition recommendations and interventions for diabetes. Diabetes Care. 2008;31 (suppl 1): 61S78S. Manual of Clinical Nutrition Management

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Diabetes Mellitus 3. 4.

Diabetes Mellitus Type 1 & 2 Evidence-Based Nutrition Practice Guideline. The Academy of Nutrition and Dietetics, 2008. In: The Academy of Nutritin and Dietetics Evidence Analysis Library at http://www.andevidencelibrary.com. Accessed Feburary 5, 2013. Delvin JT, Ruderman N. Diabetes and exercise: the risk-benefit profile revisited. In Handbook of Exercise in Diabetes. Ruderman N, Devlin JT, Shcneider SH, Krisra A, eds. Alexandria, Va: American Diabetes Association; 2002.

Bibliography Colberg SR, Sigal RJ, Fernhall Bo, Regensteiner JG, Blissmer BJ, Rubin RR, Chasan-Taber L, Albright AL, Braun B. Exercise and type 2 diabetes: The American College of Sports Medicine and the American Diabetes Association: Joint Position Statement. Diabetes Care. 2010;33:e147-e167.

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Diabetes Mellitus

DIABETES MELLITUS: CONSIDERATIONS FOR ACUTE ILLNESS Monitoring Achieving stringent glycemic control during concurrent illness (eg, acute illness, trauma, or surgery) may reduce mortality and morbidity in the hospital setting (1). Therefore, targeting glucose control in the hospital setting has the potential for improved mortality, morbidity, and health care outcomes (1). During acute illness, records should be kept of blood glucose levels and ketone tests as well as weight loss, temperature, insulin dose and time given, and any other medications that were given (1). Individuals with diabetes must be appropriately monitored for diabetic ketoacidosis (acidosis accompanied by the accumulation of ketone bodies in the tissues and fluids). Although diabetic ketoacidosis occurs most often in people with type 1 diabetes, people with type 2 diabetes can develop ketoacidosis during illness. Ill patients with type 1 diabetes should check urine ketones and blood glucose every 3 to 4 hours, more frequently if the blood glucose level is high or if the patient is pregnant. If patients with type 1 diabetes have blood glucose levels that are higher than 240 mg/dL two times in a row, the urine or blood should be tested for ketones. Blood glucose readings >240 mg/dL and moderate to large amounts of ketones are a danger signal for diabetic ketoacidosis. Patients with diabetic ketoacidosis (DKA) require additional insulin and immediate management of fluids and electrolytes (2). Persons with type 2 diabetes are vulnerable to hyperosmolar hyperglycemic nonketotic state (HHS) (3). This condition presents with a glucose of > 600 mg/dL, serum osmolality > 320 mOsm, serum bicarbonate > 15 mEq/L along with lethargy and possible coma (3). Ketones in the urine and blood are trace or absent because the presence of some insulin inhibits lipolysis. Patients should be immediately managed with intravenous fluids, electrolyte management and insulin (3). Approaches for the Hospital Setting Guidelines for patients with type 1 or type 2 diabetes mellitus: 1. Contact physician when vomiting or diarrhea continues for 3 to 4 hours (1). 2. For insulin-requiring patients or patients who are pregnant, test urine for ketones. Contact physician when test shows a moderate to large amount of ketones (1,2). 3. For diabetic critical-care patients, contact physician when blood glucose level remains above 180 mg/dL even after supplemental insulin (as arranged with physician). In critically ill patients insulin therapy should be initiated for treatment of persistant hyperglycemia starting at a threshold of no greater than 180 mg/dL (1). Once insulin therapy is started, a glucose range of 140 to 180 mg/dL is recommended for the majority of critically ill patients (1). Critical-care patients will usually require intravenous insulin protocol that has demonstrated efficacy and safety in achieving desired glucose range without increasing risk for hypglycemia (1). 4. For diabetic noncritically ill patients there is no clear evidence for specific blood glucose goals (1). If treated with insulin, the premeal blood glucose levels should generally be < 140 mg/dL with random blood glucose < 180 mg/dL provided these targets can be safely achieved without risking hypoglycemia (1). More stringent targets may be appropriate in stable patients with previous tight control. Less stringent targets may be appropriate in those with severe comorbidities (1). 5. Contact physician when signs of ketoacidosis—dehydration, drowsiness, abdominal or chest pain, difficulty breathing, sunken eyes, or fruity breath—are present (2). 6. Contact physician when temperature is greater than 100ºF or when the patient is unable to take fluids for 3 to 4 hours (1). 7. The patient should avoid physical exertion and rest at a comfortable room temperature. Management Medication: The patient should take insulin or oral glucose-lowering medication regardless of the ability to eat normal amounts (1). During acute illness, an associated increase in levels of counterregulatory hormones may increase insulin requirements (1). Scheduled prandial insulin doses should be given in relation to meals and should be adjusted according to point-of-care glucose levels. The traditional sliding-scale insulin regimens are ineffective and not recommended (1). For people with type 2 diabetes who normally do not need insulin, the presence of infection may necessitate short-term use of insulin. Records should be kept of blood glucose levels and ketone tests as well as weight loss, temperature, insulin dose and time given, and any other medicines that were given (1). The patient should follow the physician’s instructions for changing the insulin or medication regimen.

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Diabetes Mellitus

Intake of food and fluid: Ingestion of carbohydrate, especially if the blood glucose level is less than 100 mg/dL, is important during acute illness (1). In adults, ingestion of approximately 150 to 200 g carbohydrate daily (at least 50 g, or three to four carbohydrate choices, every 3 to 4 hours) should be sufficient, along with medication adjustments to keep glucose in the goal range, prevent hypoglycemia, and prevent starvation ketosis (1). (See “Carbohydrate Replacement for Acute Illness, Missed Meals, or Delayed Meals” in Section IC: “Medical Nutrition Therapy for Diabetes Mellitus”.) Adequate intake of fluids is also very important. Electrolytes, especially sodium and potassium, may be lost after vomiting, diarrhea, and diaphoresis. Salty liquids, such as soup and broth, can replenish sodium. Fruit juices, milk, yogurt, ice cream, and cream soups (made with milk) can supply potassium. Caffeinated beverages should be avoided, as these can worsen dehydration. References 1. American Diabetes Association. Standards of medical care in diabetes-2013. Diabetes Care. 2013;36(suppl 1):11S-66S. 2. American Diabetes Association. Hyperglycemic crises in diabetes: position statement. Diabetes Care. 2004: 27(suppl 1):S94-S102. 3. Type 2 Diabetes. In: Nutrition Care Manual; Updated annually. The Academy of Nutrition and Dietetics. Available at: www.http://nutritioncaremanual.org. Accessed February 5, 2013.

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Diabetes Mellitus

DIABETES MELLITUS: GASTROINTESTINAL COMPLICATIONS Gastroparesis Gastroparesis, also known as diabetic gastropathy, is characterized by an abnormal delay in the emptying of foods, particularly solid foods, from the stomach (1). Gastroparesis occurs when the vagus nerve, which controls the movement of food from the stomach through the digestive tract, is damaged (1). As a result, the muscles of the stomach and intestines do not work normally and food moves slowly or stops moving through the digestive tract (1). The most common cause of gastroparesis is diabetes mellitus, and it is usually attributed to autonomic neuropathy (1). Symptoms associated with gastroparesis include nausea, vomiting undigested food, early satiety, bloating, abdominal pain, and wide fluctuations in blood glucose levels (2). Approaches: The following approaches are used for the medical management of gastroparesis (1).  Improve the patient’s glycemic control, as hyperglycemia slows the rate of gastric emptying (1,2).  Make changes to the patient’s insulin therapy, such as providing a bolus of insulin after eating instead of before eating (3).  Consider the use of metoclopramide (Reglan), a dopamine antagonist with a central antiemetic effect. This medication stimulates stomach muscle contractions to assist in stomach emptying and reduces nausea and vomiting (1). Gastrointestinal side effects associated with metoclopramide include diarrhea.  Consider the use of erythromycin (EryPed), an antibiotic and motilin receptor agonist that increases stomach muscle contractions. Side effects associated with erythromycin are nausea, vomiting, diarrhea, abdominal pain and cramps, increased liver function tests, and jaundice.  In severe cases, consider jejunostomy enteral feeding or gastric neurostimulators (1).  Recommend postprandial exercise, such walking, because exercise increases solid-meal gastric emptying in healthy individuals (1). Because of limited evidence for the nutrition management of gastroparesis, dietary approaches and recommendations are based on professional judgement and logical interpretation of gastric physiology (1). Patients vary tremendously in their abilities to tolerate different types of foods, so recommendations must be individualized. A certain amount of trial and learning is involved. Common food modifications for patients with gastroparesis are designed to speed-up gastric emptying. These modifications include:  Lower the fiber content of the diet; especially avoid fibrous vegetables (such as oranges and broccoli) and poorly digestible solids with limited gastric motility to reduce the risk of bezoar formation (1). Eat small, frequent, balanced meals (six to seven per day) and avoid large meals.  Replace solid foods with liquid foods or blenderized meals (4). Puree or grind up solid foods, such as meats, so that they may be better tolerated. Some individuals tolerate solids for the first one to two small meals and then do better with liquids for the remainder of the day.  Avoid high-fat foods and extra fats such as butter, margarine, gravy, or mayonnaise that are added to foods. Some individuals tolerate high-fat liquids such as whole milk and ice cream. Fat appears to be a potent inhibitor of gastric emptying (1).  Sit up while eating and for 30 minutes after meals. Walking after meals may enhance stomach emptying. Nausea and Vomiting Possible causes of nausea and vomiting include neuropathy (gastroparesis), ketosis, and morning nausea secondary to nocturnal hypoglycemia. Approaches: The following approaches are used to relieve nausea and vomiting.  Morning nausea caused by overnight hypoglycemia will usually be relieved by eating breakfast.  Nausea and vomiting caused by ketosis will improve with metabolic stabilization.  For patients with nausea and vomiting caused by gastroparesis, an antiemetic drug should be part of the treatment plan. Constipation The incidence of constipation is believed to be much higher in individuals with diabetes than in nondiabetic individuals. Constipation in diabetes is related to problems with the autonomic nervous system (5). The Nutrition Care Manual from the Academy of Nutrition and Dietetics provides a detailed discussion of constipation in people with diabetes (1).

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Approaches: The following approaches should be used for diabetic patients with constipation.  To determine the cause of constipation, assess the patient’s fluid intake and the insoluble fiber content of the patient’s diet. Also, assess the physical activity level and general physical and mental well-being of the patient.  Review the patient’s list of medications (prescription and nonprescription) for medicines that cause constipation. Note a history of laxative use (frequency and duration).  Consider recommending a formal evaluation if constipation is potentially secondary to other endocrinologic, neurologic, or gastrointestinal disorders. If laxatives are recommended, carefully consider which type to recommend. Refer to the paper by Haines for a discussion of treating constipation in patients with diabetes (5). References 1. Gastroparesis in diabetes mellitus. In: Nutrition Care Manual. Academy of Nutrition and Dietetics; Updated annually. Available at: http://www.nutritioncaremanual.org. Accessed February 5, 2013. 2. Camilleri M. Diabetic gastroparesis. N Engl J Med. 2007;356:820-829. 3. Pharmacotherapy in type 1 and type 2 diabetes. In: Nutrition Care Manual. Academy of Nutrition and Dietetics; Updated annually. Available at: http://www.nutritioncaremanual.org. Accessed February 5, 2013. 4. National Digestive Disease Information Clearinghouse. Gastroparesis. Available at: http:www.digestive.niddk.nih.gov. Accessed December 12, 2008. 5. Haines S. Treating constipation in the patient with diabetes. Diabetes Educ. 1995;21:223-232.

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Diabetes Mellitus

DIABETES MELLITUS: ORAL GLUCOSE-LOWERING MEDICATIONS AND INSULIN Table III-7: Glucose-Lowering Agents (1-3) Generic Name Trade Classification Name(s)a Chlorpropamideb Diabinese Sulfonylurea Glyburideb DiaBeta, Sulfonylurea Micronase, Glynase Glipizideb Glucotrol, Sulfonylurea Glucotrol XL Glimepirideb Amaryl Sulfonylurea Nateglinideb Starlix Nonsulfonylurea Repaglinideb Prandin Nonsulfonylurea Metformin Glucophage Biguanide Glucophage XR Biguanide Glyburide-Metformin Glucovance Sulfonylurea-Biguanide (combination drug) Pioglitazone Actos Thiazolidinedione Rosiglitazone Avandia Thiazolidinedione Acarbose Precose -glucosidase inhibitor Miglitol Glyset -glucosidase inhibitor Sitagliptin Januvia Dipeptidyl peptidase IV inhibitor Exenatide Byetta Incretin mimetic Pramlintide Symlin Amylinomimetic

Onset (h)

Duration (h)

1 1.5 1.5 1.5 1 1 2-3 0.33 0.25-0.5 1-3 0.5-3

24-72 12-24 12-24 24 12-16 24 12-24 1-4 1 6-12 12-24

Half-life, 6.2

24-48

0.5, peak 2-4 1 Immediate Immediate

24 12-24 6 6

1

24

0.5-1 0.5

6 6

aAll product names are registered trademarks of their respective companies. bThese oral hypoglycemic agents have the potential to cause hypoglycemia, since their mode of action increases the release of

insulin from the pancreas. Patients who take these oral agents may require snacks if there is more than 4 to 5 hours between meals. A bedtime snack may also be necessary and should be evaluated as part of the individualized meal plan (4).

Discussion Newer oral or injectable glucose-lowering medications, alone or in combination, provide numerous treatment options for achieving glycemic control (1,2). A combination of two or three medications may be used by persons with type 2 diabetes that is not adequately controlled by nutrition therapy (1,2). If glycemic control is not attained, insulin, either alone or in combination with oral medication, may be necessary. The transition to insulin often begins with long-acting insulin given at bedtime to control fasting glucose levels and glucoselowering medication given during the day to control daytime and postprandial glucose levels (1,2). Many patients with type 2 diabetes require two or more insulin injections daily to achieve glycemic control (1). Some of these patients will attain better glycemic control with three or four daily insulin injections or with an insulin pump (1-3). An algorithm for the treatment of type 2 diabetes has been established by the American Diabetes Association and European Association for the Study of Diabetes (4). This algorithm recommends the initiation of metformin therapy at diagnosis, along with lifestyle intervention that includes medical nutrition therapy (1,4,5). The algorithm calls for the addition of another oral agent or insulin if the percentage of hemoglobin A1c goal exceeds 7% (1,5). Glucose-Lowering Medications Commonly used glucose-lowering medications and their onset and duration are listed in Table III-7. Each class of drug has a different mechanism of action, as described below (1-3). Insulin secretagogues (sulfonylureas and nonsulfonylureas): These drugs promote insulin secretion by the beta cells of the pancreas. Sulfonylureas are metabolized by the liver and cleared by the kidney (except glimepiride); therefore, caution is needed for patients who have impaired renal function (2). Patients should be informed that missed meals or snacks could cause hypoglycemia (2). In addition, these medications are associated with an increase in appetite and possible weight gain (2). Compared with sulfonylureas, nonsulfonylureas cause less weight gain and have an earlier onset, shorter duration (1 to 6 hours), and a Manual of Clinical Nutrition Management III-29 Copyright © 2013 Compass Group, Inc.

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Diabetes Mellitus

reduced risk of hypoglycemia (2). Nonsulfonylureas are an option for patients who have erratic meal schedules and are concerned about weight gain (2). Insulin sensitizers (biguanides, thiazolidinediones, and -glucosidase inhibitors): These drugs enhance insulin action. To be effective, these drugs require the presence of endogenous or exogenous insulin. Biguanides provide enhanced insulin sensitivity by inhibiting hepatic gluconeogenesis and, to a lesser extent, glycogenolysis. Metformin, the only biguanide, causes weight loss and does not cause hypoglycemia when it is used as a monotherapy (2). Metformin can cause gastrointestinal side-effects such as abdominal pain, nausea, diarrhea, and metallic taste. Starting with small doses of medication and limiting foods such as cauliflower, cabbage, broccoli, lentils, and legumes may lessen these side effects (2). Patients who have compromised renal function or who are at risk for dehydration or chronic heart failure should be closely monitored for the risk of lactic acidosis associated metformin (2). Thiazolidinediones enhance insulin sensitivity by increasing the efficiency of the glucose transporters. Thiazolidinediones, particularly pioglitazone, beneficially affect lipids by decreasing triglyceride levels, increasing the high-density lipoprotein cholesterol level, and increasing the particle size of low-density lipoprotein cholesterol (2). The main side effects of thiazolidinediones are weight gain and mild edema; therefore, an energy-controlled diet and sodium modification may be warranted (2). The -glucosidase inhibitors inhibit enzymes that digest carbohydrates in the small intestine. This inhibition results in delayed carbohydrate absorption and lowered postprandial glucose responses. The glucosidase inhibitors should be taken before carbohydrate-containing meals or snacks and should not be taken when meals are missed (2). These medications should be avoided by persons who have severe renal or hepatic impairment or any gastrointestinal disease. The side effects of -glucosidase inhibitors include bloating, abdominal cramps, flatulence, and diarrhea (2). Dipeptidyl peptidase IV inhibitors: These drugs inhibit dipeptidyl peptidase IV, the enzyme that degrades endogenously secreted incretins (2). Because of this mechanism, increased levels of incretin hormones result in increased insulin secretion. The most common side effects are headaches and nasopharyngitis (2). Sitagliptin, the first dipeptidyl peptidase inhibitor IV approved for use as a monotherapy or in combination with a thiazolidinedione or metformin, is metabolized in the liver but excreted in the urine. In patients with renal insufficiency, the dose should be decreased by 50% to 75% (2). Incretin mimetics: These drugs mimic the glucose-lowering effects of the incretin hormone, a glucagon-like peptide that occurs naturally in the body. Exenatide (Byetta) represents a new class of injectable medications for people with type 2 diabetes who take metformin or sulfonylurea agents. Exenatide is an amino-acid peptide that has many of the glucose-lowering effects of incretin (1,3). The glucose-lowering effects of this drug result from a delay in gastric emptying and enhanced glucose-dependent insulin secretion from the beta cells. But, these effects occur only in the presence of elevated glucose levels and decreased insulin production (3). Exenatide is usually injected twice a day, at breakfast and the evening meal. It can be taken up to 60 minutes before a meal, but taking the medication 30 or more minutes prior to a meal may increase the sense of satiety early in the meal, resulting in decreased energy intake (1,3). Because the mechanism slows gastric emptying, a feeling of fullness may be experienced during meals and can cause nausea or early satiety (2). Exenatide is associated with a degree of weight loss over a 2-year period (3). Amylinomimetics: These drugs counter the effects of amylin deficiency. Amylin is a hormone secreted with insulin by the pancreatic beta cells in response to food intake. Amylin lowers glucose levels by slowing gastric emptying and decreasing postprandial hepatic glucose release, which is related to a decrease in glucagon production from the pancreatic alpha cells and is dependent on the glucose level (2,3). Pramlintide (Symlin), an injectable drug, is a form of amylin. Pramlintide is approved as an adjunct therapy to insulin therapy in patients who have type 1 or type 2 diabetes and have not achieved optimal glucose control (3). Pramlintide, which must be injected separately from insulin, should be given with each meal or snack that exceeds 250 kcal of energy or 30 g of carbohydrate (3).

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Table III-8: Human Insulins (1-3) Insulina Rapid-Acting: Lispro (Humalog) Aspart (NovoLog) Glulisine (Apidra) Short-Acting: Regular Intermediate-Acting: NPHb (Humulin N) Long-Acting: Glargine (Lantus) (3) Detemir (Levemir) Mixtures: NPHb/ Regular: 70/30; 50/50 Aspart (NovoLog Mix) 70/30 Lispro (Humalog Mix) 70/30

Onset (h)

Peak (h)

Effective Duration (h)

Maximum Duration (h)

0.25-0.5 0.25-0.5 0.25-0.5

1-2 1-2 1-2

1-4 1-4 1-4

4 4 4

0.5-1

2-3

6

6-8

2-4

6-10

10-16

12-16

1.1 1-2

None 5-14

24 14-23

24+ 14-23

0.5-1 0.1-0.2 0.1-0.2

Dual 1-3 1-3

10-16 3-5 3-5

14-18 5 5

aGeneric names are listed first, and representative trade names are listed in parentheses. All product names are registered trademarks of

their respective companies. bNPH (neutral protamine Hagedorn) is also called isophane insulin suspension.

Insulins Persons with type 1 diabetes obtain the best glycemic control with replacement insulin that mimics normal insulin action (1). The basal or background insulin dose is the amount of insulin required in the postabsorptive state to restrain endogenous glucose output, primarily from the liver (1). The bolus (mealtime) insulin doses mimic what happens when individuals without diabetes eat the normal physiologic pattern of insulin secretion; the plasma glucose and insulin concentrations increase rapidly, peak in 30 to 60 minutes, and return to basal concentrations within 2 to 3 hours (1). Insulin glargine (Lantus) is a basal insulin that is injected once a day, often at bedtime (3). However, it can be injected at any time during the 24-hour period if it is given consistently at the chosen time. Glargine cannot be mixed with other insulins. Insulin detemir (Levemir) has a duration of action of approximately 17 hours, and therefore may need to be given twice a day. Detemir does have a slight peak, but the peak is extremely predictable, unlike the sometimes erratic peak of NPH (1,3). Rapid-acting insulins are given at meals, often with the use of an insulin pen. On occasion, rapid-acting insulin may be given after meals, most often for children with unpredictable eating habits or adults with gastroparesis (1). Insulin-pump therapy provides basal rapid-acting or short-acting insulin pumped continuously by a mechanical device in micro amounts through a subcutaneous catheter. In addition, bolus doses are given before meals. Intensive insulin therapy increases the risk of hypoglycemia and weight gain in persons with type 1 diabetes mellitus (6). Skipped or delayed meals, reduced carbohydrate intake at meals, or increased physical activity without the appropriate insulin adjustments are the major causes of hypoglycemia (6). Alcohol may also induce hypoglycemia and mask symptoms related to hypoglycemia (6). Weight gain occurs with intensive insulin therapy because less energy is lost from glycosuria as glycemic control improves (6). Frequency of hypoglycemia and the extra energy used for its treatment may also contribute to weight gain (6). Strategies to prevent weight gain include more frequent weight checks, a decreased daily energy intake, additional physical activity, and review of the appropriate treatment of hypoglycemia. References 1. Pharmacotherapy in type 1 and type 2 diabetes. In: Nutrition Care Manual. Academy of Nutrition and Dietetics; Updated annually. Available at: http://www.nutritioncaremanual.org. Accessed February 5, 2013. 2. Fonseca VA, Kulkarni KD. Management of type 2 diabetes: oral agents, insulin, and injectables. J Am Diet Assoc. 2008;108:S29-S33. 3. Stuart N, ed. Medications and diabetes: new helps and old friends. On the Cutting Edge. [Diabetes Care and Education newsletter.] 2006; 27:1-32. 4. American Diabetes Association. Standards of medical care in diabetes–2013. Diabetes Care. 2013;36(suppl 1):11S-66S. 5. Nathan DM, Buse JB, Davidson MB, Heine RJ, Holman RR, Sherwin R, Zinman B. Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2006;29:1963-1972. 6. Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-986. Manual of Clinical Nutrition Management

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DIABETES MELLITUS: FAT REPLACERS AND NUTRITIVE/NONNUTRITIVE SWEETENERS Discussion The goal of medical nutrition therapy for diabetes mellitus is to improve overall metabolic outcomes (glucose and lipids levels), provide appropriate energy to maintain desirable body weight, and improve overall health through optimal nutrition (1). The appropriateness of specific modified food products for a given individual should depend on the relative priority of lipid management, control of carbohydrate intake, and the need for weight management (2). Fat Replacers Fat replacers are compounds that replicate the functional and sensory properties of fats or mimic one or more characteristics of fat in a food. There are four categories of fat replacers: carbohydrate-based molecules composed of simple or complex carbohydrate, gums, and gels (also carbohydrate-based); protein-based molecules composed of whey protein or milk and egg protein; fat-based molecules, which may include chemical alteration of fatty acids to provide fewer calories or no calories; and a combination, usually consisting of a carbohydrate and protein or carbohydrate and lipids (2,3). Fat replacers vary in energy density. Carbohydrate-based fat replacers provide up to four kcal/g, but because they are often mixed with water they typically provide one to two kcal/g (3). Protein-based replacers provide one to four kcal/g, while fat-based replacers provide zero to nine kcal/g (3). Olestra, a noncaloric fat-based ingredient, was approved by the Food and Drug Administration (FDA) in January 1996 as a fat substitute. Because the molecule used in olestra is too large to be absorbed by the gastrointestinal tract, it adds no energy to food. For a period of time, products that contained olestra, such as potato chips, were required to display a list of possible side effects. These possible side effects included decreased absorption of certain nutrients (vitamins A, D, E, and K and carotenoids), loose stools, and abdominal cramping (3). However, scientific review has led the FDA to conclude that the warning is no longer warranted (3,4). It is the position of the Academy of Nutrition and Dietetics that, within the context of a healthy dietary pattern, fat substitutes, when used judiciously, may provide some flexibility in dietary planning, although additional research is needed to fully determine their long-term health effects (2,3). Fat replacers that are fibers, such as inulin, lupin fiber, or B-glucan, may increase diet quality in that they add to the intake of dietary fiber (3). In one study of men with diabetes, diets encouraging foods containing fiber-based fat and sugar replacers, together with lifestyle changes, caused a greater increase in high-density lipoprotein cholesterol and larger decreases in hemoglobin A1C, weight, and body mass index than were seen with the standard treatment plan (5). On a population level, replacing one to two g fat/day with fat replacers and fatmodified foods can potentially prevent weight gain and associated chronic disease and assist in promoting healthful eating behaviors (2,3). Although fat replacers are used to replace the fat content of foods, these foods are not always consistently lower in energy content because some of the fat in the foods may be replaced by increasing the sugar content of the food (3). Individuals with diabetes should be encouraged to self-monitor their intake of fat-modified foods and become educated as to how these foods should be used in the context of a well-balanced eating program (3). Sweeteners Sweetening agents may be categorized as nutritive (those containing energy) and nonnutritive (those that do not contain energy). Nutritive sweeteners include glucose, galactose, maltose, sucrose, fructose, corn-based sweetner, agave nectar and sugar alcohols (eg, sorbitol, mannitol, xylitol, isomalt, maltitol, lactitol, and starch hydrolysates). Seven nonnutritive sweeteners have been approved by the FDA: acesulfame K, aspartame, Luo han guo extract, neotame, saccharin, , stevia, and sucralose (6). Nutritive sweeteners: The available evidence from clinical studies demonstrates that sucrose does not increase glycemia any more than isocaloric amounts of starch (2,6). People with diabetes do not need to restrict sucrose and sucrose-containing foods based on a concern about aggravating hyperglycemia. However, if sucrose is included in the food or meal plan, it should be substituted for other carbohydrate sources or, if added, be adequately covered with insulin or other glucose-lowering medication (2). Fructose produces a smaller rise in plasma glucose than sucrose and other starches (2). Fructose reduces postprandial glycemia when it replaces sucrose or starch in the diabetic diet (2). However, fructosesweetened products may make a major contribution of energy to the daily intake and cannot be considered Manual of Clinical Nutrition Management

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Diabetes Mellitus

“free” foods. Consumption of large amounts of fructose (15% to 20% of daily energy intake [90th percentile of the usual intake]) has been shown to increase fasting total and low-density lipoprotein cholesterol in subjects with diabetes (2). Therefore, consumption of fructose in large amounts may have adverse effects on plasma lipids. Using fructose as a sweetening agent is not recommended for people with diabetes because of this effect (2). Sorbitol, mannitol, isomalt, maltitol, lactitol, and starch hydrolysates are considered polyols and are frequently listed on the product’s nutrition facts label as “sugar alcohols” (2). Sugar alcohols are used in food as sweeteners and bulking agents. Because sugar alcohols are only partially absorbed from the small intestine, the claim of reduced energy values per gram is allowed (2). In some studies, ingestion of sugar alcohols (approximately 50 g) by healthy and diabetic patients produced a lower glycemic response after ingestion of fructose, sucrose, or glucose (2). Consumption in larger than recommended amounts of 10 to 15 g/day (eg, >30 g or greater of polyols or sugar alcohols including lactitol, isomalt, and xylitol) may result in significant increases in flatulence, borborygmus, colic, defecation frequency, loose watery stools (Grade* III) (2,6). Use of sugar alcohols as sweetners has also shown to reduce the risk of dental caries (2). Kilocalories from sugar alcohols vary but average about two kcal/g on food labels. When calculating carbohydrate content of foods containing sugar alcohols, substraction of half the sugar alcohol grams from total carbohydrate grams is appropriate (2,7). Nonnutritive sweeteners: Acesulfame-K (Sunette, Sweet One, Sweet & Safe), Aspartame (NutraSweet, Equal, Sugar Twin), Luo han guo extract, neotame, saccharin (Sweet’n Low, Sweet Twin, Necta Twin), Stevia (Truvia, PureVia) , sucralose (Splenda), are approved by the FDA for use in the United States (6). The FDA also establishes the acceptable daily intake (ADI) for all food additives. It is defined as “the amount of a food additive that can be safely consumed on a daily basis over a person’s lifetime without any adverse effects and includes a 100-fold safety factor.” Actual intake by individuals with diabetes for all nonnutritive sweeteners is well below the ADI (2). It is unknown whether use of nonnutritive sweeteners improves long-term glycemic control or assists in weight loss (2). In a limited number of studies, nonnutritive sweetners had no effect on changes in blood lipid profiles and glycemic response in adults with diabetes (Grade II)* (8). No studies in children were identified (Grade III) (8). Studies to determine the effects of nonnutritive sweeteners during pregnancy and lactation have been conducted in animals. No adverse effects have been reported (6,9). Nonnutritive sweeteners are safe for people with diabetes when consumed within the ADI levels established by the FDA (Grade II) (2,8). Limited research in humans, from peer reviewed journals, supports the safety of nonnutritive sweeteners for the general population. Considering the lack of high quality studies, continuing postmarket surveillance of the safety of non-nutritive sweeteners is prudent (Grade III) (8). Using non-nutritive sweeteners in either a calorie restricted or ad libitum diet will affect overall energy balance only if the nonnutritive sweeteners are substituted for higher calorie food or beverages (Grade II) (8). Technically, aspartame should not be listed as a noncaloric sweetener since it is equivalent in kilocalories to table sugar. However, aspartame is so sweet (about 160 to 220 times sweeter than sucrose) that the small amount consumed in normal use has virtually no kilocalories to consider (6). Aspartame is a dipeptide formed by the synthetic combination of two amino acids. After it has been metabolized, aspartame converts into phenylalanine, aspartic acid, and methanol. Because aspartame is a phenylalanine source, it should not be consumed by individuals with phenylketonuria (6). Neotame is similar to aspartame but is 30 to 50 times sweeter and does not require special labeling for phenylketonuria since a small percentage (