RESEARCH ARTICLE
Maternal chorioamnionitis and neurodevelopmental outcomes in preterm and very preterm neonates: A meta-analysis Dongqiong Xiao1,2, Tingting Zhu1,2, Yi Qu1,2*, Xiaoyun Gou1,2, Qun Huang1,2, Xihong Li1,2, Dezhi Mu ID1,2* 1 Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China, 2 Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China
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*
[email protected] (YQ);
[email protected] (DM)
Abstract Context
OPEN ACCESS Citation: Xiao D, Zhu T, Qu Y, Gou X, Huang Q, Li X, et al. (2018) Maternal chorioamnionitis and neurodevelopmental outcomes in preterm and very preterm neonates: A meta-analysis. PLoS ONE 13 (12): e0208302. https://doi.org/10.1371/journal. pone.0208302 Editor: Cheryl S. Rosenfeld, University of Missouri Columbia, UNITED STATES Received: September 20, 2017 Accepted: November 15, 2018 Published: December 11, 2018 Copyright: © 2018 Xiao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
No consensus exists regarding the association between maternal chorioamnionitis and neurodevelopmental outcomes in preterm and very preterm neonates.
Objectives To investigate whether maternal chorioamnionitis affects neurodevelopmental outcomes and to identify the factors that may explain these effects.
Data sources We used Ovid Medline, EMBASE and Web of Science to conduct a meta-analysis of studies published in English before August 25, 2017, with titles or abstracts that discussed an association between maternal chorioamnionitis and mental/motor development.
Study selection Among the 603 initially identified studies, we selected those that addressed an association between maternal chorioamnionitis and mental/motor development according to our preselected inclusion criteria as follows: (1) the study compared infants with and without exposure to maternal chorioamnionitis and (2) the neurodevelopmental outcome was followed up using the Bayley Scales of Infant Development 2nd edition.
Data Availability Statement: All relevant data are within the paper and its Supporting Information files.
Data synthesis
Funding: This work was supported by the National Science Foundation of China (No. 81330016, 81630038, 81771634), the Major State Basic Research Development Program (2017YFA0104200), grants from the Science and Technology Bureau of Sichuan Province (2016TD0002).
Our meta-analysis included 10 studies. According to a random effect model, infants with maternal chorioamnionitis exposure had poorer mental development (d = -2.25 [95%CI, -4.33, -0.17], p
