received: 29 June 2016 accepted: 08 December 2016 Published: 16 January 2017
MicroRNA-19b is a potential biomarker of increased myocardial collagen cross-linking in patients with aortic stenosis and heart failure Javier Beaumont1,2,*, Begoña López1,2,*, Susana Ravassa1,2, Nerea Hermida3, Gorka San José1,2, Idoia Gallego1,2, Félix Valencia4, Juan José Gómez-Doblas4, Eduardo de Teresa4, Javier Díez1,2,5 & Arantxa González1,2 This study analyzed the potential associations of 7 myocardial fibrosis-related microRNAs with the quality of the collagen network (e.g., the degree of collagen fibril cross-linking or CCL) and the enzyme lysyl oxidase (LOX) responsible for CCL in 28 patients with severe aortic stenosis (AS) of whom 46% had a diagnosis of chronic heart failure (HF). MicroRNA expression was analyzed in myocardial and blood samples. From the studied microRNAs only miR-19b presented a direct correlation (p
