Milled Stress Reduces Morphine-Induced ... - Semantic Scholar

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of their children to the behavioral properties of morphine, sulpiride and dextromethorphan were investigated in the F2 generation. Twenty four pregnant NMRI ...
Iranian Journal of Pharmaceutical Research (2011), 10 (2): 347-354 Received: January 2010 Accepted: May 2010

Copyright © 2011 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services

Original Article

Milled Stress Reduces Morphine-Induced Locomotion in F2 NMRI Mice Hassan Ghoshoonia*, Pooya Payandeh Mehrb, Seyyed Hosein Salimic, /HLOD*ROPDQHVKd, Ahamadreza Dehpourb and Hedayat Sahraeia a

Neuroscience Research Center, Baqyiatallah (A.S.) University of Medical Sciences, Tehran, Iran. bDepartment of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. cDepartment of Psychology, School of Medicine, Baqyiatallah (A.S.) University of Medical Sciences, Tehran, Iran. dMolecular Biology Research Center, Baqyiatallah (A.S.) University of Medical Sciences, Tehran, Iran. Abstract In the present study, the effects of pregnant NMRI mice restraint stress on the responsibility of their children to the behavioral properties of morphine, sulpiride and dextromethorphan were investigated in the F2 generation. Twenty four pregnant NMRI female mice (W: 25 g) were divided into the experimental and control groups (n = 12/group). Animals in the experimental group were kept in the restraint F\OLQGHU ,' FP/ FP IRUPLQGD\IRUFRQVHFXWLYHGD\VZKLOHWKHFRQWUROJURXS did not receive stress. On the 8th day, blood samples were taken from the retro-orbital of both JURXSVIRUFRUWLFRVWHURQHPHDVXUHPHQW (/