Modulating effect of human growth hormone on tumour necrosis factor ...
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Modulating effect of human growth hormone on tumour necrosis factor ...
concentrations in 15 children with isolated growth hormone deficiency (GHD), age range 5.1â13.9 .... and during GH treatment confirm the immunomodula-.
European Journal of Endocrinology (1998) 138 640–643
ISSN 0804-4643
Modulating effect of human growth hormone on tumour necrosis factor-a and interleukin-1b Mauro Bozzola, Mara De Amici, Marco Zecca, Rose Marie Schimpff 1 and Robert Rapaport2 Department of Paediatrics, University of Pavia, Italy, 1INSERM U 339, Paris, France and 2University of Medicine and Dentistry of New Jersey Medical School, Newark, New Jersey, USA (Correspondence should be addressed to M Bozzola, Department of Paediatrics, University of Pavia, P. le Golgi 2, I-27100 Pavia, Italy)
Abstract We measured serum tumour necrosis factor-a (TNF-a) as well as interleukin-1b (IL-1b) and GH concentrations in 15 children with isolated growth hormone deficiency (GHD), age range 5.1–13.9 years, before and 4 and 24 h after the first GH injection (0.1 IU/kg s.c.). No differences were found in basal concentrations of serum TNF-a and IL-1b between GHD children (10.0161.55 pg/ml and 2.1460.16 ng/ml respectively) and sex- and age-matched controls (11.5762.16 pg/ml and 3.7861.46 ng/ml respectively). In GHD children, serum TNF-a and IL-1b values had significantly increased (P < 0.002) 4 h (26.7565.57 pg/ml and 2.9960.21 ng/ml respectively) and decreased again 24 h after GH administration. Likewise, serum GH levels had significantly increased 4 h (from 1.2960.69 to 48.71613.35 ng/ml, P
