Jan 9, 2013 - We quantified Sox2 and Tbr2 positive cells and their proliferation in 5 ... dorsal cortical SVZ and ganglionic eminence, just as for Sox2 and Tbr2 ...
University of Connecticut
DigitalCommons@UConn Articles - Research
University of Connecticut Health Center Research
1-2013
Neurogenesis Continues in the Third Trimester of Pregnancy and Is Suppressed by Premature Birth Nada Zecevic University of Connecticut School of Medicine and Dentistry
Follow this and additional works at: http://digitalcommons.uconn.edu/uchcres_articles Part of the Medicine and Health Sciences Commons Recommended Citation Zecevic, Nada, "Neurogenesis Continues in the Third Trimester of Pregnancy and Is Suppressed by Premature Birth" (2013). Articles Research. 198. http://digitalcommons.uconn.edu/uchcres_articles/198
NIH Public Access Author Manuscript J Neurosci. Author manuscript; available in PMC 2013 July 15.
NIH-PA Author Manuscript
Published in final edited form as: J Neurosci. 2013 January 9; 33(2): 411–423. doi:10.1523/JNEUROSCI.4445-12.2013.
Neurogenesis Continues in the Third Trimester of Pregnancy and Is Suppressed by Premature Birth Sabrina Malik, MD1, Govindaiah Vinukonda, PhD1, Linnea R. Vose, PhD1, Daniel Diamond, BS1, Bala B.R. Bhimavarapu, MD2, Furong Hu, BA1, Muhammad T. Zia, MD1, Robert Hevner, MD, PhD3, Nada Zecevic, MD, PhD4, and Praveen Ballabh, MD1,2 1Department of Pediatrics, New York Medical College-Westchester Medical Center, Valhalla, NY 2Cell
Biology and Anatomy, New York Medical College-Westchester Medical Center, Valhalla, NY
3Department
of Neurological Surgery, University of Washington, Seattle, Washington
4Department
of Neuroscience, University of Connecticut Health Center, Farmington, CT
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Abstract
NIH-PA Author Manuscript
Premature infants exhibit neurodevelopmental delay and reduced growth of the cerebral cortex. However, the underlying mechanisms have remained elusive. Therefore, we hypothesized that neurogenesis in the ventricular and subventricular zones of the cerebral cortex would continue in the third trimester of pregnancy, and that preterm birth would suppress neurogenesis. To test our hypotheses, we evaluated autopsy materials from human fetuses and preterm infants of 16–35 gestational weeks (gw). We noted that both cycling and non-cycling Sox2+ radial glial cells as well as Tbr2+ intermediate progenitors were abundant in human preterm infants until 28 gw. However, their densities consistently decreased from 16 through 28 gw. To determine the effect of premature birth on neurogenesis, we employed a rabbit model and compared preterm (E29, 3 days old) and term pups (E32,
