Neuronal chloride regulation via KCC2 is modulated through a ...

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Apr 27, 2017 - GABAB receptor protein complex. 2. 3. 4. Authors: Rebecca Wright1,4, .... C.terminus KCC2 (Millipore, 07.432), rabbit anti.β.tubulin (Sigma, ...
This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version.

Research Articles: Cellular/Molecular

Neuronal chloride regulation via KCC2 is modulated through a GABAB receptor protein complex Rebecca Wright1,4, Sarah E. Newey1,4, Andrei Ilie1, Winnie Wefelmeyer1, Joseph V. Raimondo1, Rachel Ginham2, R. A. Jeffrey Mcllhinney2 and Colin J. Akerman1 1

Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK

2

MRC Anatomical Neuropharmacology Unit, Mansfield Road, Oxford, OX1 3TH, UK

DOI: 10.1523/JNEUROSCI.2164-16.2017 Received: 6 July 2016 Revised: 31 March 2017 Accepted: 6 April 2017 Published: 27 April 2017

Author contributions: R.W., S.N., A.I., R.J.M., and C.J.A. designed research; R.W., S.N., A.I., W.W., J.V.R., and R.J.M. performed research; R.W., S.N., A.I., W.W., J.V.R., R.J.M., and C.J.A. analyzed data; R.W., S.N., A.I., R.J.M., and C.J.A. wrote the paper; R.D. contributed unpublished reagents/analytic tools. 4

These authors contributed equally to this work

We would like to thank Piotr Bregestovski (INMED, Marseille) for the generous gift of Cl-Sensor cDNA, Demelza Vinnicombe for technical assistance and Julia White for her support and help. This work was supported by grants from the Medical Research Council (G0601503) and the Biotechnology and Biological Sciences Research Council (BB/E0154761). The research leading to these results has received funding from the European Research Council under the European Community's Seventh Framework Programme (FP7/2007-2013), ERC grant agreement number 243273. In addition, RW, AI and WW were supported by Wellcome Trust Doctoral Fellowships, SEN was supported by a Royal Society Dorothy Hodgkin Fellowship, JVR was supported by the Rhodes Trust, RG was supported by a GlaxoSmitKline Studentship and RAJM was supported by the Medical Research Council. Correspondence: [email protected] +44 (0)1865 271872 Cite as: J. Neurosci ; 10.1523/JNEUROSCI.2164-16.2017 Alerts: Sign up at www.jneurosci.org/cgi/alerts to receive customized email alerts when the fully formatted version of this article is published. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process. Copyright © 2017 Wright et al.

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