Biomedical Research 6 (3) 185-189, 1985. Nicotinamide prevents the development of cyclophosphamide- induced diabetes mellitus in male non-obese diabetic ...
Biomedical Research 6 (3) 185-189, 1985
Nicotinamide prevents the development of cyclophosphamideinduced diabetes mellitus in male non-obese diabetic (NOD) mice HIROMU NAKAJIMA‘, HIROKO FUJINO-KURIHARA1, TOSHIAKI HANAFUSAI, KENTARO YAMADA1, ATSUSHI MIYAZAKI‘, JUNICHIRO MIYAGAWA‘, KYOHEI NoNAKA‘, SEIICHIRO TARU1‘ and YOSHIHIRO TOCHINO2 1The Second Department of Internal Medicine, Osaka University Medical School, Fukushimaku, Osaka 553, and 2Shionogi Research Laboratories, Fukushimaku, Osaka 553, Japan
ABSTRACT
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Single intraperitoneal administration of cyclophosphamide (200 mg/kg) to male nonobese diabetic (NOD) mice resulted in a significant increase in the incidence ofovert dia-
betes mellitus up to 90% around 2 weeks alter the injection (P
